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Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer.

Abstract：

:Increasing numbers of targeted drugs are used in hormone receptor (HR)-positive metastatic breast cancer (MBC) to overcome or delay resistance to endocrine therapy. This study will systemically review the progress made in endocrine therapy combined with targeted therapy in the treatment of HR-positive MBC. From the "AI (aromatase inhibitor) era" represented by aromatase inhibitors, we have gradually entered the "post-AI era" represented by fulvestrant. Under the guidance of research on the molecular mechanism of endocrine therapy resistance, the "combination of endocrine therapy and targeted therapy" era is approaching. The development of drugs that target endocrine therapy resistance has concentrated on cyclin-dependent kinase 4/6 inhibitors, histone deacetylase inhibitors, and inhibitors of drug targets in the phosphatidylinositol 3 kinase-protein kinase B-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway, providing new strategies for HR-positive MBC. Exploring biomarkers to guide the more precise use of targeted drugs in endocrine therapy for MBC is the focus of current and future research.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Bian L,Xu FR,Jiang ZF

doi

10.1097/CM9.0000000000000923

subject

Has Abstract

pub_date

2020-10-05 00:00:00

pages

2338-2345

issue

19

eissn

0366-6999

issn

2542-5641

pii

00029330-202010050-00014

journal_volume

133

pub_type

杂志文章

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