当前位置： SCI文献检索 > CHINESE MEDICAL JOURNAL期刊下所有文献 > Menopausal depression: comparison of hormone replacement therapy and hormone replacement therapy plus fluoxetine.

Menopausal depression: comparison of hormone replacement therapy and hormone replacement therapy plus fluoxetine.

Abstract：

BACKGROUND:To compare the efficacy and safety of hormone replacement therapy (HRT) combined with fluoxetine, with HRT alone, in post-menopausal women suffering from depression. METHODS:A randomized, open-label, parallel trial was applied. HRT was administered to all patients for 2 cycles, with 14 days of estrogen therapy and 14 days of estrogen plus progesterone. Patients who were randomly assigned to the HRT plus fluoxetine group were given fluoxetine in combination with HRT. Hamilton Depression Rating Scale (HAMD), Kupperman Menopausal Index (KMI), and Clinical Global Impressions scale were used to measure the efficacy. RESULTS:One hundred and twenty-three post-menopausal patients with depression were enrolled in the study. Among them, 120 had at least one post-treatment visit and entered into the statistical analysis. The mean total HAMD scores were significantly lower, and the percentages of HAMD score reductions were higher in the HRT plus fluoxetine Group compared with the HRT Group, after at least 3 weeks of treatment, with an average difference of 5 points at the endpoint. The Clinical Global Impression-Severity and Clinical Global Impression-Improvement scores were significantly different in the 2 groups, in favor of the combination therapy. The mean total KMI was significantly lower in the Combination Group compared with the HRT Group, after at least 6 weeks of treatment, with an average 4.5-point difference between the groups. No statistically significant differences were found in most of the adverse events reported in the Combination Group compared with the HRT group, with the exception of 3 symptoms, i.e., dry mouth, loss of appetite, and abdominal distention. They were mild to moderate in severity. Two patients in the HRT group, but none in the combination group, dropped out due to adverse events. CONCLUSION:HRT plus fluoxetine therapy was effective in the treatment of menopausal depression with a satisfactory safety profile.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Liu P,He FF,Bai WP,Yu Q,Shi W,Wu YY,He DJ,Xiao JH,Zheng Y,Liao QP

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

189-94

issue

2

eissn

0366-6999

issn

2542-5641

journal_volume

117

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CHINESE MEDICAL JOURNAL文献大全