Abstract:
:The highest prevalence rates of hepatitis C virus infection in the world have been recently reported among Egyptian blood donors and frequent recipients of transfusions and other blood products. This is the first report, however, demonstrating hepatitis C as the most frequent association with chronic liver disease in Egypt. Of 1023 patients referred to the Liver Institute in Menoufia governorate for evaluation of chronic liver disease, 752 (73.5%) had antibodies to hepatitis C compared with 168 (16.4%) with hepatitis B surface antigen. Hepatitis C antibody was more common in patients with active schistosomiasis and patients without hepatitis B surface antigenaemia. Of 100 patients having liver biopsies, histological findings consistent with chronic viral hepatitis or its complications were found in 89 and antibody to hepatitis C was present in 75 (84.3%) of these patients with chronic hepatitis, active cirrhosis or hepatocellular carcinoma. These data pointing to the importance of hepatitis C as a cause of chronic liver disease in Egypt emphasise the necessity of studies delineating its routes of transmission in this country.
journal_name
Gutjournal_title
Gutauthors
Waked IA,Saleh SM,Moustafa MS,Raouf AA,Thomas DL,Strickland GTdoi
10.1136/gut.37.1.105subject
Has Abstractpub_date
1995-07-01 00:00:00pages
105-7issue
1eissn
0017-5749issn
1468-3288journal_volume
37pub_type
杂志文章相关文献
GUT文献大全abstract::Data concerning the effects of morphine on human pancreatic secretion are fragmentary and inconclusive. In the present study, we evaluated the effects of morphine on pure pancreatic secretion in nine subjects with external transduodenal drainage of the main pancreatic duct performed after biliary tract surgery. Intrav...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.9.739
更新日期:1982-09-01 00:00:00
abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309359
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. Howe...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2005.078303
更新日期:2006-06-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) levels have been measured in the serum of 490 patients and 93 normal controls using the double antibody radioimmunoassay technique. Levels were elevated in 71 of patients with carcinomata of the gastrointestinal tract and in 42% with other types of malignancy. In patients with non-neopla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.10.794
更新日期:1973-10-01 00:00:00
abstract::Psychological treatments are increasingly being used to help patients with the irritable bowel syndrome (IBS), but the efficacy of such treatments is still debated. This review indicates that there are three ways in which they might have been effective in published studies to date; relating bowel symptoms to stress, s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.30.11.1601
更新日期:1989-11-01 00:00:00
abstract::Colonic biopsy specimens were obtained from patients undergoing surgery for carcinoma of the rectum. Colonic resistance arteries (internal diameter 178-345 microns) were dissected out under the microscope and mounted in a microvascular myograph capable of measuring isometric tension development. Experiments were desig...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.12.1391
更新日期:1990-12-01 00:00:00
abstract::In man, the main pancreatic duct is normally derived from ventral and dorsal embryological buds of the pancreas. In a minority of people, failure of fusion of the two buds results in separate drainage of the dorsal and ventral pancreas, so that the accessory duct provides the main drainage for the gland. Patients with...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.12.1066
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bla...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.52.1.109
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2010.218271
更新日期:2011-07-01 00:00:00
abstract:UNLABELLED:Data on the natural history of elderly-onset inflammatory bowel disease (IBD) are scarce. METHODS:In a French population-based cohort we identified 841 IBD patients >60 years of age at diagnosis from 1988 to 2006, including 367 Crohn's disease (CD) and 472 ulcerative colitis (UC). RESULTS:Median age at dia...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-303864
更新日期:2014-03-01 00:00:00
abstract::Six cases of faecal stasis in active proctocolitis are reported. In each case the left colon was severely diseased but the right colon was unaffected. X-ray studies showed retention of barium in the right colon for as long as five weeks. In two patients subacute intestinal obstruction developed and in three patients c...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.3.4.301
更新日期:1962-12-01 00:00:00
abstract:BACKGROUND:Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-124) in hepatocellular carcinoma (HCC). OBJECTIVE:To determine the status of miR-124 expression and its underlying mechanisms in the pathogenesis of HCC. METHODS:The expression levels of miR-124 were first ex...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2011.239145
更新日期:2012-02-01 00:00:00
abstract::The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.2...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.3.270
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated. METHODS:Eleven adult...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2009.178558
更新日期:2010-01-01 00:00:00
abstract::A dodecapeptide of A-gliadin, which shares amino acid homologies with the E1b protein of adenovirus 12, was used to produce murine monoclonal antibodies. Five monoclonal antibodies were produced and were screened by enzyme linked immunosorbant assay, immunodot assay, and immunoblotting. The antibodies were tested agai...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.11.1504
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Almost 4% of the population suffer from food allergy which is an adverse reaction to food with an underlying immunological mechanism. AIMS:To characterise one of the most frequent IgE defined food allergens, fish parvalbumin. METHODS:Tissue and subcellular distribution of carp parvalbumin was analysed by i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.5.661
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:Colorectal cancer is the second most common cause of cancer death in Europe and North America. Alarm features are used to prioritize access to urgent investigation, but there is little information concerning their utility in the diagnosis of colorectal cancer. METHODS:A systematic review and meta-analysis of...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gut.2008.159723
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Non-selective cyclooxygenase (COX) inhibitors (non-steroidal anti-inflammatory drugs) inhibit large bowel carcinogenesis in patients with familial adenomatous polyposis (FAP). Their role in the duodenum of these patients is less certain. The disease modifying activity of specific COX-2 inhibitors has not bee...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.50.6.857
更新日期:2002-06-01 00:00:00
abstract::During the clinical investigation of patients with gastrointestinal disease by exhaled breath hydrogen measurement, the occurrence of inexplicable variations in recorded hydrogen values led to a search for extra intestinal factors which were capable of adversely influencing breath hydrogen concentration and impairing ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.12.1349
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:A non-invasive test for assessment of fat digestion has been developed based on the intraluminal hydrolysis of cholesteryl-[1-13C]octanoate by pancreatic esterase. AIMS:To determine the diagnostic performance of this breath test in the assessment of exocrine pancreatic function. METHODS:The test was perfor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.1.81
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Most direct understanding of enteric nerve (patho)physiology has been obtained by electrode and imaging techniques in animal models and human surgical samples. Until now, neuronal activity recordings from a more accessible human tissue source have remained a true challenge. OBJECTIVES:To record nerve activi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301777
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presenc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.128587
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.143271
更新日期:2008-08-01 00:00:00
abstract::Thirty two patients with active Crohn's disease were included in a controlled randomised trial to determine the efficacy and safety of polymeric enteral nutrition compared with steroids, to achieve and maintain clinical remission. The polymeric diet was administered through a fine bore nasogastric tube by continuous, ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.6.778
更新日期:1993-06-01 00:00:00
abstract::Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical poin...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.51.suppl_1.i67
更新日期:2002-07-01 00:00:00
abstract::The records of 113 consecutive patients with a suspected gastrointestinal motility disorder referred between January 1988 and July 1991 were retrospectively reviewed. The aims were to identify the prevalence of autonomic dysfunction in those with or without associated neurological disease and to determine the diagnost...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.3.397
更新日期:1993-03-01 00:00:00
abstract::The colonic biopsy specimens of 22 patients with colitis and positive stool cultures for Campylobacter jejuni were studied in order to obtain histological and immunohistochemical criteria to differentiate Campylobacter colitis from chronic inflammatory bowel disease. In addition we tried to identify Campylobacter incl...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.9.945
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVES:To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN:A randomised, double-blind, double-dummy, parallel group, multicentre, international, ph...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2008.154302
更新日期:2009-02-01 00:00:00
abstract::A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation ove...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.12.1011
更新日期:1971-12-01 00:00:00
abstract:BACKGROUND:The effect of histamine H2 receptor antagonists on gastric emptying is controversial. AIMS:To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. PATIENTS AND METHODS:Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (E...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.42.2.243
更新日期:1998-02-01 00:00:00