Abstract:
:The detailed conformational features and dynamics of the naturally occurring deoxyribotrinucleoside diphosphates d-TpTpT and d-TpTpC have been investigated at 20 degrees C and 80 degrees C in aqueous solution by nuclear magnetic resonance spectroscopy. The observed NMR parameters indicate that the conformational properties of the trimers are very similar to those of the constituent dimers and monomers, i.e., the monomers and dimers conserve their intrinsic conformational features when they become incorporated into oligomers. Model building indicate that the distant shieldings can originate from spatial configurations in which the central nucleotidyl unit is bulged out and the w'1w1, w'2w2 occupy /g+g+, g+g+/ domains.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Cheng DM,Dhingra MM,Sarma RHdoi
10.1093/nar/5.11.4399subject
Has Abstractpub_date
1978-11-01 00:00:00pages
4399-416issue
11eissn
0305-1048issn
1362-4962journal_volume
5pub_type
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