Abstract：
:The presence and origin of mast-cell precursors fixed in the skin tissue of mice were investigated. Giant granules of beige (C57BL/6-bh'/bg', Chediak-Higashi syndrome) mice were used to distinguish different populations of mast cells. Pieces of the skin were grafted from the intact WBB6F1 (WB X C57BL/6)F1-+/+ mice into the back of the WBB6F1-+/+ mice which had been irradiated and injected with bone marrow cells of C57BL/6-bg'/bg'leads to +/+ chimeras). Although the number of mast cells in the skin grafts decreased after the transplantation, the mast-cell precursors circulating in the bloodstream of bg'/bg' leads to +/+ chimeras (bg'/bg' type) did not seem to enter into the skin grafts, because most of mast cells were of +/+ type after the recovery of mast-cell number to pregrafting levels. As a considerable proportion of +/+-type mast cells was labeled with 3H-thymidine, the recovery of mast-cell number in the grafts was attributed to the proliferation and differentiation of +/+-type precursor cells fixed in the skin tissue of the donor. On the other hand, the skin of WBB6F1-W/Wv mice seemed to be depleted of fixed precursors, because most of mast cells were of bg'/bg'-type in skin grafted from WBB6F1-W/Wv mice to bgJ/bgJ leads to +/+ chimeras. Since the fixed precursor cells which proliferate and differentiate into mast cells after skin grafting may be transferred to WBB6F1-W/Wv mice by bone marrow transplantation, such precursor cells seem to have been derived from the bone marrow.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Matsuda H,Kitamura Y,Sonoda T,Imori Tdoi
10.1002/jcp.1041080315subject
Has Abstractpub_date
1981-09-01 00:00:00pages
409-15issue
3eissn
0021-9541issn
1097-4652journal_volume
108pub_type
杂志文章abstract：:Endothelial cells play a wide variety of critical roles in the control of vascular function. Indeed, since the early 1980s, the accumulating knowledge of the endothelial cell structure as well as of the functional properties of the endothelial cells shifted their role from a passive membrane or barrier to a complex ti...
journal_title：Journal of cellular physiology
pub_type： 杂志文章,评审
doi：10.1002/jcp.10333
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:In this study, we aimed to explore the effects of GAS5 single-nucleotide polymorphisms (SNPs) on GAS5 expression. And the signaling pathways underlying the function of GAS5 during the pathogenesis of prostate cancer (PC) were clarified. MATERIALS AND METHODS:Patients with PC were recruited and grouped accor...
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更新日期：2015-09-01 00:00:00
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更新日期：2019-08-01 00:00:00
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更新日期：1990-04-01 00:00:00
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更新日期：2020-12-10 00:00:00
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更新日期：2010-11-01 00:00:00
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更新日期：2019-08-01 00:00:00
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doi：10.1002/jcp.26375
更新日期：2018-06-01 00:00:00
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更新日期：2018-04-01 00:00:00
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更新日期：2000-08-01 00:00:00
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更新日期：1989-07-01 00:00:00
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