Precursor of mast cells fixed in the skin of mice.


:The presence and origin of mast-cell precursors fixed in the skin tissue of mice were investigated. Giant granules of beige (C57BL/6-bh'/bg', Chediak-Higashi syndrome) mice were used to distinguish different populations of mast cells. Pieces of the skin were grafted from the intact WBB6F1 (WB X C57BL/6)F1-+/+ mice into the back of the WBB6F1-+/+ mice which had been irradiated and injected with bone marrow cells of C57BL/6-bg'/bg'leads to +/+ chimeras). Although the number of mast cells in the skin grafts decreased after the transplantation, the mast-cell precursors circulating in the bloodstream of bg'/bg' leads to +/+ chimeras (bg'/bg' type) did not seem to enter into the skin grafts, because most of mast cells were of +/+ type after the recovery of mast-cell number to pregrafting levels. As a considerable proportion of +/+-type mast cells was labeled with 3H-thymidine, the recovery of mast-cell number in the grafts was attributed to the proliferation and differentiation of +/+-type precursor cells fixed in the skin tissue of the donor. On the other hand, the skin of WBB6F1-W/Wv mice seemed to be depleted of fixed precursors, because most of mast cells were of bg'/bg'-type in skin grafted from WBB6F1-W/Wv mice to bgJ/bgJ leads to +/+ chimeras. Since the fixed precursor cells which proliferate and differentiate into mast cells after skin grafting may be transferred to WBB6F1-W/Wv mice by bone marrow transplantation, such precursor cells seem to have been derived from the bone marrow.


J Cell Physiol


Matsuda H,Kitamura Y,Sonoda T,Imori T




Has Abstract


1981-09-01 00:00:00












  • Isolation, Characterization, and Establishment of Spontaneously Immortalized Cell Line HRPE-2S With Stem Cell Properties.

    abstract::The retinal pigment epithelium is a monolayer of highly specialized pigmented cells located between the neural retina and the Bruch's membrane of the choroid. RPE cells play a crucial role in the maintenance and function of the underlying photoreceptors. This study introduces a spontaneously arising human retinal pigm...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Shams Najafabadi H,Soheili ZS,Samiei S,Ahmadieh H,Ranaei Pirmardan E,Masoumi M

    更新日期:2017-10-01 00:00:00

  • Zinc finger E-box binding homeobox 1 and atherosclerosis: New insights and therapeutic potential.

    abstract::Zinc finger E-box binding homeobox 1 (ZEB1), an important transcription factor belonging to the ZEB family, plays a crucial role in regulating gene expression required for both normal physiological and pathological processes. Accumulating evidence has shown that ZEB1 participates in the initiation and progression of a...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Li H,Zou J,Yu XH,Ou X,Tang CK

    更新日期:2020-12-04 00:00:00

  • Reduction of DNA primase activity in aging but still proliferating cells.

    abstract::The basis of the well-known decline in cell proliferation with increasing passage number of human diploid fibroblast-like cell cultures is not known. It has been found that DNA synthesis was deficient in the remaining but still proliferating cells, but when appropriate corrections reflecting the remaining dividing cel...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Collins JM,Chu AK

    更新日期:1990-04-01 00:00:00

  • Calcium sources used by post-natal human myoblasts during initial differentiation.

    abstract::Increases in cytoplasmic Ca(2+) are crucial for inducing the initial steps of myoblast differentiation that ultimately lead to fusion; yet the mechanisms that produce this elevated Ca(2+) have not been fully resolved. For example, it is still unclear whether the increase comes exclusively from membrane Ca(2+) influx o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Arnaudeau S,Holzer N,König S,Bader CR,Bernheim L

    更新日期:2006-08-01 00:00:00

  • Modulatory effects of statins on the autophagy: A therapeutic perspective.

    abstract::Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such as aging, neurological disorders, cancer, and infection. Aut...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

    更新日期:2020-04-01 00:00:00

  • Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo.

    abstract::Endothelial cells are known to bind to laminin, and two peptides derived from the laminin A (CTFALRGDNP) and B1 (CDPGYIGSR) chains block the capillary-like tube formation on a laminin-rich basement membrane matrix, Matrigel. In the present study, we have used various in vitro and in vivo assays to investigate the angi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Grant DS,Kinsella JL,Fridman R,Auerbach R,Piasecki BA,Yamada Y,Zain M,Kleinman HK

    更新日期:1992-12-01 00:00:00

  • Influence of cyclosporine A on growth and extracellular matrix synthesis of human fibroblasts.

    abstract::Cyclosporine A (CyA) is a powerful nonsteroidal immunosuppressive agent used to prevent graft rejection of organ and bone marrow transplants. A major side effect observed can be attributed to the fibroblast and its functions: proliferation of fibroblasts and formation of fibrotic tissue in the gingiva (fibrous hyperpl...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Willershausen-Zönnchen B,Lemmen C,Schumacher U

    更新日期:1992-08-01 00:00:00

  • Role of p53 family members in apoptosis.

    abstract::p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apoptosis by interferi...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审


    authors: Sheikh MS,Fornace AJ Jr

    更新日期:2000-02-01 00:00:00

  • Modulation of drug resistance in homoharringtonine-resistant C-1300 neuroblastoma cells with cyclosporine A and dipyridamole.

    abstract::The development of resistance accounts for therapy failure in the majority of advanced cases of neuroblastoma in children. A new transplantable murine C-1300 neuroblastoma cell line was developed in vitro, by repeated exposure of a sensitive cell line to increasing, but sublethal, doses of Homoharringtonine (HHT). The...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tebbi CK,Chervinsky D,Baker RM

    更新日期:1991-09-01 00:00:00

  • GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Thomas JM,Wang X,Guo G,Li T,Dai B,Nucifora LG,Nucifora FC Jr,Liu Z,Xue F,Liu C,Ross CA,Smith WW

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Negendank W,Shaller C

    更新日期:1982-03-01 00:00:00

  • MiR-199a-3p inhibition facilitates cardiomyocyte differentiation of embryonic stem cell through promotion of MEF2C.

    abstract::MicroRNAs (miRNAs) is a small molecule (19-25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. However, the ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Chen HP,Wen J,Tan SR,Kang LM,Zhu GC

    更新日期:2019-12-01 00:00:00

  • Retromer promotes immune quiescence by suppressing Spätzle-Toll pathway in Drosophila.

    abstract::The Toll and Toll-like receptor signaling pathways are evolutionarily conserved pathways that regulate innate immunity in insects and mammals. While efforts have been made to clarify the signal transduction events that occur during infection, much less is known about the components that maintain immune quiescence. Her...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Zhou B,Yun EY,Ray L,You J,Ip YT,Lin X

    更新日期:2014-04-01 00:00:00

  • Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling.

    abstract::Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

    journal_title:Journal of cellular physiology

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    authors: Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

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  • Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF.

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    authors: Ohno-Matsui K,Morita I,Tombran-Tink J,Mrazek D,Onodera M,Uetama T,Hayano M,Murota SI,Mochizuki M

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    authors: Durieu-Trautmann O,Fédérici C,Créminon C,Foignant-Chaverot N,Roux F,Claire M,Strosberg AD,Couraud PO

    更新日期:1993-04-01 00:00:00

  • TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production.

    abstract::Priapism, a prolonged penile erection in the absence of sexual arousal, is common among patients with sickle cell disease (SCD). Hypogonadism is also common in patients with SCD. While the administration of exogenous testosterone reverses hypogonadism, it is contraceptive. We hypothesized that the stimulation of endog...

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    authors: Musicki B,Karakus S,La Favor JD,Chen H,Silva FH,Sturny M,Zirkin BR,Burnett AL

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  • Perlecan Heparan Sulfate Is Required for the Inhibition of Smooth Muscle Cell Proliferation by All-trans-Retinoic Acid.

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    authors: Tran-Lundmark K,Tannenberg P,Rauch BH,Ekstrand J,Tran PK,Hedin U,Kinsella MG

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  • Variations in the cell-free translating apparatus of cultured animal cells as a function of time during cell growth.

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    journal_title:Journal of cellular physiology

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    authors: Engelhardt DL,Sarnoski J

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  • Chemically and virally transformed cells able to grow without anchorage in serum-free medium: evidence for an autocrine growth factor.

    abstract::BA10-IR transformed cells, obtained by treating Syrian hamster embryo fibroblasts (HEF) with 7-methylbenz(a)anthracene and cultivated for a long period, are highly tumorigenic and grow in suspension as aggregates (spheroids) (Levy et al., 1976). They also grow in attached form or as spheroids in serum-free (S-) synthe...

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    authors: Xin LW,Jullien P,Lawrence DA,Pironin M,Vigier P

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  • CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR-4288-induced ELF3 inhibition.

    abstract::Circular RNAs (circRNAs) are reported to regulate the development and progression of multiple cancers. However, the functions of circRNAs in nasopharyngeal carcinoma (NPC) are unclear. In this study, we identified that circular homeodomain interacting protein kinase 3 (circHIPK3) was highly expressed in NPC tissues an...

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    pub_type: 杂志文章


    authors: Takafuji Y,Tatsumi K,Ishida M,Kawao N,Okada K,Matsuo O,Kaji H

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Moore BE,Colvin GA,Dooner MS,Quesenberry PJ

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  • FOXO3a is essential for murine endometrial decidualization through cell apoptosis during early pregnancy.

    abstract::Embryo implantation is essential for normal pregnancy, and the process of decidualization is critical for embryo implantation. However, the mechanism of decidualization during early pregnancy is still unknown. Forkhead box O3a (FOXO3a) is the most important functional transcription factor of the forkhead box family an...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Long J,Yang CS,He JL,Liu XQ,Ding YB,Chen XM,Tong C,Peng C,Wang YX,Gao RF

    更新日期:2019-04-01 00:00:00

  • Bafilomycin A1 inhibits lysosomal, phagosomal, and plasma membrane H(+)-ATPase and induces lysosomal enzyme secretion in macrophages.

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Tapper H,Sundler R

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  • Size-dependent hyaluronate degradation by cultured cells.

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    pub_type: 杂志文章


    authors: McGuire PG,Castellot JJ Jr,Orkin RW

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Xie Z,Tang Y,Man MQ,Shrestha C,Bikle DD

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Gupta RS,Chan DY,Siminovitch L

    更新日期:1978-12-01 00:00:00

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    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Kelemen E,Gulya E,Vass K

    更新日期:1978-06-01 00:00:00

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    abstract::The temperature sensitive leucyl-tRNA synthetase mutant tsHl and two revertants have been compared to the parental Chinese hamster ovary cells with respect to the effects of amino acid concentrations in the medium on growth. Elevating the leucine concentration 30- or 100-fold allowed tsHl to grow exponentially at 38.5...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章


    authors: Molnar SJ,Rauth AM

    更新日期:1979-02-01 00:00:00