Abstract:
:This paper examines in humans the proposition emanating from studies in beagles that initial retention of radium varies in proportion to the calcium addition rate at the time of intake. Human calcium addition rates were scaled from those in beagles, the relative calcium accretion rates in the two species at equivalent stages of skeletal growth providing the scaling factor. The variation of radium retention with age was determined by fitting a modified power function to data on the retention of radium from about 30 to 15000 days following a series of therapeutic injections of 226Ra in humans ranging in age from 18 to 63 yr. The fractional retention R at t days following a single injection of 226Ra was described by R = (1 + t/d)-0.44. The age-dependent parameter d in the retention function was found to be proportional to the calcium addition rate at the time of injection in subjects receiving less than 200 micrograms 226Ra.
journal_name
Health Physjournal_title
Health physicsauthors
Parks NJ,Keane ATdoi
10.1097/00004032-198306001-00008subject
Has Abstractpub_date
1983-01-01 00:00:00pages
103-12eissn
0017-9078issn
1538-5159journal_volume
44 Suppl 1pub_type
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