Selective Shielding of Bone Marrow: An Approach to Protecting Humans from External Gamma Radiation.

Abstract:

:The current feasibility of protecting emergency responders through bone marrow selective shielding is highlighted in the recent OECD/NEA report on severe accident management. Until recently, there was no effective personal protection from externally penetrating gamma radiation. In Chernobyl, first-responders wore makeshift lead sheeting, whereas in Fukushima protective equipment from gamma radiation was not available. Older protective solutions that use thin layers of shielding over large body surfaces are ineffective for energetic gamma radiation. Acute exposures may result in Acute Radiation Syndrome where the survival-limiting factor up to 10 Gy uniform, homogeneous exposure is irreversible bone marrow damage. Protracted, lower exposures may result in malignancies of which bone marrow is especially susceptible, being compounded by leukemia's short latency time. This highlights the importance of shielding bone marrow for preventing both deterministic and stochastic effects. Due to the extraordinary regenerative potential of hematopoietic stem cells, to effectively prevent the deterministic effects of bone marrow exposure, it is sufficient to protect only a small fraction of this tissue. This biological principle allows for a new class of equipment providing unprecedented attenuation of radiation to select marrow-rich regions, deferring the hematopoietic sub-syndrome of Acute Radiation Syndrome to much higher doses. As approximately half of the body's active bone marrow resides within the pelvis region, shielding this area holds great promise for preventing the deterministic effects of bone marrow exposure and concomitantly reducing stochastic effects. The efficacy of a device that selectively shields this region and other radiosensitive organs in the abdominal area is shown here.

journal_name

Health Phys

journal_title

Health physics

authors

Waterman G,Kase K,Orion I,Broisman A,Milstein O

doi

10.1097/HP.0000000000000688

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

195-208

issue

3

eissn

0017-9078

issn

1538-5159

pii

00004032-201709000-00004

journal_volume

113

pub_type

杂志文章
  • Cost-Benefit of Final Radiological Survey Versus Radioactive Waste Disposal.

    abstract::ABSTRACT A significant portion of the cost for D&D is related to low-level waste disposal, decontamination, and final radiological survey. For that reason, a careful cost-benefit analysis must be performed weighing the cost of decontaminating and radiologically surveying the building media for release against the cost...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:

    authors: Barroso J,Roberts S

    更新日期:2003-02-01 00:00:00

  • On the discrepancy between epidemiologic studies in individuals of lung cancer and residential radon and Cohen's ecologic regression.

    abstract::There is still substantial confusion in the radiation effects community about the inherent limitations of ecologic analysis. As a result, inordinate attention has been given to the discrepant results of Cohen, in which a negative estimate is observed for the regression of county mortality rates for lung cancer on esti...

    journal_title:Health physics

    pub_type: 评论,杂志文章

    doi:10.1097/00004032-199807000-00001

    authors: Lubin JH

    更新日期:1998-07-01 00:00:00

  • Tenth Warren K. Sinclair keynote address-the Fukushima nuclear power plant accident and comprehensive health risk management.

    abstract::Just two years have passed since the Tokyo Electric Power Company-Fukushima Daiichi Nuclear Power Plant (NPP) accident, a multidimensional disaster that combined to destroy the local infrastructure on which the safety system depended and gave a serious impact to the world. Countermeasures including evacuation, shelter...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000007

    authors: Yamashita S

    更新日期:2014-02-01 00:00:00

  • An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation.

    abstract::A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experiment...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199107000-00009

    authors: Zukhbaya TM,Smirnova OA

    更新日期:1991-07-01 00:00:00

  • Mayak Worker Dosimetry System 2008 (MWDS-2008): assessment of internal dose from measurement results of plutonium activity in urine.

    abstract::A new modification of the prior human lung compartment plutonium model, Doses-2005, has been described. The modified model was named "Mayak Worker Dosimetry System-2008" (MWDS-2008). In contrast to earlier models developed for workers at the Mayak Production Association (Mayak PA), the new model more correctly describ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31827dbf60

    authors: Khokhryakov VV,Khokhryakov VF,Suslova KG,Vostrotin VV,Vvedensky VE,Sokolova AB,Krahenbuhl MP,Birchall A,Miller SC,Schadilov AE,Ephimov AV

    更新日期:2013-04-01 00:00:00

  • Uses of therapeutic x rays in medicine.

    abstract::Treatment of diseases with x rays began within months of Roentgen's discovery, and within four years x rays were being used successfully for the treatment of skin cancers. Deep-seated cancers began to be treated successfully in the 1920's with the advent of "deep" x-ray units and, especially, once supervoltage therapy...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/00004032-199511000-00004

    authors: Orton CG

    更新日期:1995-11-01 00:00:00

  • Measurement of outdoor terrestrial gamma radiation in the Sultanate of Oman.

    abstract::The terrestrial gamma radiation level was determined throughout the Sultanate of Oman over a 3-y period. The dose rate at 1 m above the ground was measured at 512 locations using a compensated Geiger-Miller detector. The activity concentration of soil/rock samples, collected from 112 locations, was determined by gamma...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200206000-00016

    authors: Goddard CC

    更新日期:2002-06-01 00:00:00

  • New technologies in radiation therapy: ensuring patient safety, radiation safety and regulatory issues in radiation oncology.

    abstract::New technologies such as intensity modulated and image guided radiation therapy, computer controlled linear accelerators, record and verify systems, electronic charts, and digital imaging have revolutionized radiation therapy over the past 10-15 y. Quality assurance (QA) as historically practiced and as recommended in...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000326334.64242.46

    authors: Amols HI

    更新日期:2008-11-01 00:00:00

  • An updated radiation protection program prospectus based on 20 years of data describing program drivers and activities.

    abstract::In 1992, the University of Texas Health Science Center at Houston (UTHSCH) Radiation Safety Program began assembling data on a monthly basis that described various program drivers and associated activities. At the end of calendar year 2002, a decade of data had been collected, so the information was summarized into a ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000130

    authors: Emery RJ,Gutierrez JM

    更新日期:2014-08-01 00:00:00

  • Does tributyl phosphate influence the radiation risk of a highly proliferating system--the early mouse embryo in vitro?

    abstract::Two-cell mouse embryos were exposed in vitro to tributyl phosphate, x rays, or a combination of both. In-vitro development of the embryos was followed microscopically (cleavage to four- and eight-cell embryos, formation of morulae and blastocysts, and hatching of blastocysts). Effects on proliferation were estimated b...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198712000-00009

    authors: Müller WU,Streffer C,Markoski L

    更新日期:1987-12-01 00:00:00

  • An investigation of voxel geometries for MCNP-based radiation dose calculations.

    abstract::Voxelized geometry such as those obtained from medical images is increasingly used in Monte Carlo calculations of absorbed doses. One useful application of calculated absorbed dose is the determination of fluence-to-dose conversion factors for different organs. However, confusion still exists about how such a geometry...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000234039.58356.de

    authors: Zhang J,Bednarz B,Xu XG

    更新日期:2006-11-01 00:00:00

  • Estimation of individualized radiation risk from chronic occupational exposure in Russia.

    abstract::Internationally, the upper limit of acceptable individualized risk from occupational exposure for nuclear industry workers is determined by the death probability 10(-3) y(-1). The same risk value of 10(-3) y(-1) is established by the radiation safety standards currently in force in Russia. The United Nations Scientifi...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000346702.02932.7d

    authors: Ivanov VK,Tsyb AF,Panfilov AP,Agapov AM,Kaidalov OV,Korelo AM,Maksioutov A,Chekin SY,Kashcheyeva PV

    更新日期:2009-08-01 00:00:00

  • Radiological findings of accidental radiation injury of the fingers: a case report.

    abstract::This case report describes the medical follow-up of a 46-y-old (at the time of exposure) man who in 1971 accidentally exposed the fingers of his right hand to gamma-ray radiation from an iridium source that was used for nondestructive testing [estimated radiation dose: 26 Gy to 90 Gy (2,600 rad to 9,000 rad)]. No prom...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200101000-00012

    authors: Nakagawa K,Kozuka T,Akahane M,Suzuki G,Akashi M,Hosoi Y,Aoki Y,Ohtomo K

    更新日期:2001-01-01 00:00:00

  • High 222Rn levels, enhanced surface deposition, increased diffusion coefficient, humidity, and air change effects.

    abstract::Measurements have been made of surface deposition rates for 218Po radon decay products in a small (0.283m3) aluminum test chamber for 222Rn levels from 1 to 1,600 kBq m-3. an increase in macroscopic surface deposition rate has been found to be induced by the high 222Rn concentrations. A distinct 222Rn level threshold ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199603000-00008

    authors: Leonard BE

    更新日期:1996-03-01 00:00:00

  • Radiation doses to local populations near nuclear weapons test sites worldwide.

    abstract::Nuclear weapons testing was conducted in the atmosphere at numerous sites worldwide between 1946 and 1980, which resulted in exposures to local populations as a consequence of fallout of radioactive debris. The nuclear tests were conducted by five nations (United States, Soviet Union, United Kingdom, France, and China...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-200205000-00016

    authors: Simon SL,Bouville A

    更新日期:2002-05-01 00:00:00

  • Summer outdoor radon variations in Canada and their relation to soil moisture.

    abstract::In the summers of 1990 and 1991, outdoor 222Rn detectors were installed for 3 mo in 78 communities across Canada. The 1990 measurements showed large regional variations with the average outdoor levels for the provinces of Manitoba (59 Bq m-3) and Saskatchewan (61 Bq m-3) exceeding the average indoor levels of 55 Bq m-...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199402000-00009

    authors: Grasty RL

    更新日期:1994-02-01 00:00:00

  • Indoor 222Rn concentrations in Central Asturias.

    abstract::A survey of the 222Rn concentrations in 106 homes in the four main towns of the Central Asturias region was carried out over three years. A total of 1,014 measurements was obtained using passive radon charcoal canisters. The 222Rn concentrations fit a log-normal distribution law, with a geometric mean of 23 Bq m(-3). ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199605000-00010

    authors: Pérez Iglesias JM,Alvarez Alvarez MC,Dopico Vivero MT,Garzón Ruipérez L

    更新日期:1996-05-01 00:00:00

  • Real Time in Situ Gamma Radiation Measurements of the Plume Evolution from the Full-Scale Radiological Dispersal Device Field Trials.

    abstract::During the Full-Scale Radiological Dispersal Device Field Trials carried out in Suffield in 2012, several suites of detection and sampling equipment were used to measure and characterize the explosive dispersal of the short half-life radioactive tracer Lanthanum-140 ((140)La). The equipment deployed included networks ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000497

    authors: Korpach E,Berg R,Erhardt L,Lebel L,Liu C

    更新日期:2016-05-01 00:00:00

  • Measurement of the attenuation coefficient for Livermore Thoracic Phantom lungs fabricated using contemporary materials.

    abstract::The University of Cincinnati has reproduced the original formulation for the Livermore Thoracic Phantom lungs using contemporary materials and has adopted the linear attenuation coefficient as the primary quality assurance parameter for evaluating the performance capabilities of these new lung phantoms. The Livermore ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199407000-00005

    authors: Spitz H,Glover S,Liu N,Smith B,Hickman D,Kruchten D,Anderson L

    更新日期:1994-07-01 00:00:00

  • Improved confidence intervals when the sample is counted an integer times longer than the blank.

    abstract::Past computer solutions for confidence intervals in paired counting are extended to the case where the ratio of the sample count time to the blank count time is taken to be an integer, IRR. Previously, confidence intervals have been named Neyman-Pearson confidence intervals; more correctly they should have been named ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31820448c4

    authors: Potter WE,Strzelczyk JJ

    更新日期:2011-05-01 00:00:00

  • Principles for Non-Ionizing Radiation Protection.

    abstract::In this statement, the International Commission on Non-Ionizing Radiation Protection (ICNIRP) presents its principles for protection against adverse health effects from exposure to non-ionizing radiation. These are based upon the principles for protection against ionizing radiation of the International Commission for ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001252

    authors:

    更新日期:2020-05-01 00:00:00

  • Modeling the resuspension of radionuclides in Ukrainian regions impacted by Chernobyl fallout.

    abstract::Following the 1986 Chernobyl event, large amounts of radioactive materials were deposited in nearby areas. Concentrations of various radionuclides were measured in air and surface soil. To study the resuspension of radioactive particulate, three different exposure situations were developed on the basis of the collecte...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199701000-00010

    authors: Nair SK,Miller CW,Thiessen KM,Garger EK,Hoffman FO

    更新日期:1997-01-01 00:00:00

  • Trends in Estimated Thyroid, Salivary Gland, Brain, and Eye Lens Doses From Intraoral Dental Radiography Over Seven Decades (1940 TO 2009).

    abstract::The purpose of this study is to support retrospective dose estimation for epidemiological studies by providing estimates of historical absorbed organ doses to the brain, lens of the eye, salivary glands, and thyroid from intraoral dental radiographic examinations performed from 1940 to 2009. We simulated organ doses t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001138

    authors: Fontana RC,Pasqual E,Miller DL,Simon SL,Cardis E,Thierry-Chef I

    更新日期:2020-02-01 00:00:00

  • Cesium-137 in Montana soils.

    abstract::Fallout 137Cs levels in soil were measured at 11 diverse sites throughout Montana. Concentrations in near-surface samples ranged from 20-200 mBq g-1 (0.51-5.41 pCi g-1). Most of the 137Cs was in the top 10 cm of soil. Deeper occurrences were attributed to disturbances by animals and to interstitial flow of small sedim...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198912000-00010

    authors: Arnalds O,Cutshall NH,Nielsen GA

    更新日期:1989-12-01 00:00:00

  • Uranium in vitro bioassay action level used to screen workers for chronic inhalation intakes of uranium mill tailings.

    abstract::A uranium in vitro bioassay (urinalysis) action level was derived for use at the Department of Energy's Uranium Mill Tailings Remedial Action Project sites to identify chronic inhalation intakes of uranium mill tailings causing 0.5 mSv (50 mrem) annual effective dose equivalent. All radionuclides in the 238U decay cha...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199210000-00003

    authors: Reif RH,Turner JB,Carlson DS

    更新日期:1992-10-01 00:00:00

  • Gas mixing for achieving suitable conditions for single point aerosol sampling in a straight tube: experimental and numerical results.

    abstract::Experimental measurements of velocity and tracer gas concentration are taken in a straight tube to evaluate the effectiveness of mixing in achieving conditions as required by ANSI N13.1-1999 for single point extractive sampling from stacks and ducts of nuclear facilities. Mixing is evaluated for inlet turbulent intens...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200301000-00007

    authors: Anand M,McFarland AR,Rajagopal KR

    更新日期:2003-01-01 00:00:00

  • Bioassay and laboratory survey scheduling based on radioisotope inventory.

    abstract::Bioassay and laboratory survey schedules can be generated using a radioisotope inventory program. This paper discusses the use of laboratory activity, past performance and operational factors for laboratory survey frequency determination, and use of laboratory activity for bioassay scheduling. Mayo Clinic has recently...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:

    authors: Classic KL,Gross GP

    更新日期:1990-08-01 00:00:00

  • Tests of the linear, no-threshold dose-response relationship for high-LET radiation.

    abstract::It is pointed out that induction of lung cancer by exposure to Rn daughters, applied at high doses to miners and at low doses to exposures in homes, provides a very stringent and sensitive test of the linear, no-threshold dose-response relationship for high-LET radiation, because this relationship predicts that a subs...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198705000-00015

    authors: Cohen BL

    更新日期:1987-05-01 00:00:00

  • Analysis of personnel exposures in neutron therapy facilities.

    abstract::In conventional radiation-therapy facilities, radiation doses to medical personnel originate from the leakage radiation of 60Co teletherapy systems or from photoneutrons produced during the operation of x-ray generators at energies over 10 MeV in unsuitably shielded therapy rooms. In neutron-therapy facilities, during...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198402000-00016

    authors: Rosenberg I,Awschalom M,Ten Haken RK,Bennett BR

    更新日期:1984-02-01 00:00:00

  • Assessing the renal toxicity of Capstone depleted uranium oxides and other uranium compounds.

    abstract::The primary target for uranium toxicity is the kidney. The most frequently used guideline for uranium kidney burdens is the International Commission on Radiological Protection value of 3 microg U g(-1) kidney, a value that is based largely upon chronic studies in animals. In the present effort, a risk model equation w...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000338421.07312.ed

    authors: Roszell LE,Hahn FF,Lee RB,Parkhurst MA

    更新日期:2009-03-01 00:00:00