Somatic-cell mutations as a possible predictor of cancer risk.

Abstract:

:The somatic-mutation theory of carcinogenesis has received strong scientific support from results of recent studies on tumor-suppressor genes. We anticipated that people among the high risk for cancer group, either through exposure to various ionizing radiations or by virtue of unique genotypes, would also manifest increased frequencies of somatic mutation. This report presents the results of two somatic-mutation assays--at the erythrocyte glycophorin A (GPA) and lymphocyte T-cell receptor (TCR) genes--in various groups at high risk for cancer development, including atomic-bomb survivors, patients with various cancers, patients administered Thorotrast, and patients with genetic disorders that make them cancer prone. Although neither the GPA-mutation nor the TCR-mutation assay detects gene mutations directly related to carcinogenesis, increased mutation frequencies were detected by both assays in many individuals among the high-risk groups and among cancer patients. We have continued to follow up those individuals who show values of about three times higher than those of the control group. Thus, these assays may prove useful for identifying high-risk cancer groups and for estimating the effects of mutagens. Such information would constitute a valuable data base for epidemiological studies.

journal_name

Health Phys

journal_title

Health physics

authors

Akiyama M,Umeki S,Kusunoki Y,Kyoizumi S,Nakamura N,Mori T,Ishikawa Y,Yamakido M,Ohama K,Kodama T

doi

10.1097/00004032-199505000-00003

subject

Has Abstract,Author List Incomplete

pub_date

1995-05-01 00:00:00

pages

643-9

issue

5

eissn

0017-9078

issn

1538-5159

journal_volume

68

pub_type

杂志文章
  • Cancer mortality in counties near two former nuclear materials processing facilities in Pennsylvania, 1950-1995.

    abstract::There has been concern that living near nuclear installations might increase the risk of cancer, including childhood leukemia, in surrounding communities. Such concern has been voiced by residents in Armstrong and Westmoreland Counties in Western Pennsylvania in conjunction with the operation of two former nuclear mat...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200312000-00014

    authors: Boice JD Jr,Bigbee WL,Mumma MT,Blot WJ

    更新日期:2003-12-01 00:00:00

  • Real Time in Situ Gamma Radiation Measurements of the Plume Evolution from the Full-Scale Radiological Dispersal Device Field Trials.

    abstract::During the Full-Scale Radiological Dispersal Device Field Trials carried out in Suffield in 2012, several suites of detection and sampling equipment were used to measure and characterize the explosive dispersal of the short half-life radioactive tracer Lanthanum-140 ((140)La). The equipment deployed included networks ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000497

    authors: Korpach E,Berg R,Erhardt L,Lebel L,Liu C

    更新日期:2016-05-01 00:00:00

  • Radiation doses to critical groups since the early 1950s due to discharges of liquid radioactive waste from Sellafield.

    abstract::First, some of the early work is reviewed on exposure pathways in connection with proposed and early liquid radioactive waste discharges from Sellafield. The main historical features of these discharges, affected by relevant plant operations, are then briefly described. The important radiological exposure pathways res...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/00004032-199704000-00007

    authors: Hunt GJ

    更新日期:1997-04-01 00:00:00

  • Modeling population screening process for maximizing throughputs.

    abstract::Following a large-scale radiation emergency, affected populations will need to be screened soon after for potential contamination (external or internal). Effective management of the available resources can help maximize the screening throughputs. This paper reports the modeling results for screening throughputs in a p...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000114

    authors: Li C,Capello K,Jeng HA,Hauck B,Kramer GH

    更新日期:2014-05-01 00:00:00

  • Recalibration of the Cameco mobile lung counter.

    abstract::The Cameco lung counter has been recalibrated using the Lawrence Livermore National Laboratory torso phantom using an extended lung set (i.e., longer than the original set). The previous calibration had used the Japanese Atomic Energy Research Institute torso phantom. The new calibration had lower counting efficiencie...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000346306.54221.28

    authors: Kramer GH,Hauck B,Allen SA

    更新日期:2009-06-01 00:00:00

  • Characterization of exposures to workers covered under the U.S. Energy Employees Compensation Act.

    abstract::Since the mid-1940s, hundreds of thousands of workers have been engaged in nuclear weapons-related activities for the U.S. Department of Energy (DOE) and its predecessor agencies. In 2000, Congress promulgated the Energy Employees Occupational Illness Compensation Program Act of 2000 (EEOICPA), which provides monetary...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000008

    authors: Neton JW

    更新日期:2014-02-01 00:00:00

  • Use of alpha spectroscopy for conducting rapid surveys of transuranic activity on air sample filters and smears.

    abstract::This paper demonstrates the utility of a portable alpha Continuous Air Monitor (CAM) as a bench top scalar counter for multiple sample types. These include using the CAM to count fixed air sample filters and radiological smears. In counting radiological smears, the CAM is used very much like a gas flow proportional co...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000156959.35525.57

    authors: Hayes RB,Peña AM,Goff TE

    更新日期:2005-08-01 00:00:00

  • Light water reactor health physics.

    abstract::In this article an overview of the historical development of light water reactor health physics programs is presented. Operational health physics programs have developed and matured as experience in operating and maintaining light water reactors has been gained. Initial programs grew quickly in both size and complexit...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-200506000-00011

    authors: Prince RJ,Bradley SE

    更新日期:2005-06-01 00:00:00

  • Risks of radioactive material transportation accidents in Oregon.

    abstract::As a continuation of previous research on worst case transportation accidents involving radioactive material (Dodd and Humphries 1988a), and protective action guidance for radioactive material transportation accidents (Dodd and Humphries 1988b), this paper describes the risks from such accidents in Oregon. Radioactive...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198907000-00016

    authors: Humphries LL,Dodd B

    更新日期:1989-07-01 00:00:00

  • Application of optically stimulated luminescence to the dosimetry of recent radiation events involving low total absorbed doses.

    abstract::We determined the suitability of optically stimulated recombination luminescence in quartz for low-level dosimetry of recent events such as radiation accidents. Minimum detectable doses were determined for both fired and unfired quartz. Using a single aliquot technique, good detection of doses on the order of 0.01 Gy ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199310000-00007

    authors: Godfrey-Smith DI,Haskell EH

    更新日期:1993-10-01 00:00:00

  • Toxicity of 99Tc: can it represent a risk to man?

    abstract::The movement through the environment and the toxicity to plants of 99Tc have been studied. However, information is scanty on 99Tc toxicity to mammals even though this is the decisive criterion for assessing the consequences of releases of Tc. A critical tissue could be the thyroid because of its preferential accumulat...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198908000-00014

    authors: Gerber GB,Hegela M,Vankerkom J,Kirchmann R,Maisin JR,Lambiet-Collier M

    更新日期:1989-08-01 00:00:00

  • Estimating past exposure to indoor radon from household glass.

    abstract::CR-39 plastic was attached to household glass objects to learn whether residual radioactivity from radon decay products could be measured and correlated with cumulative radon exposures over defined time periods. Such an approach could be used to increase the completeness of exposure data collected in epidemiologic stu...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199304000-00005

    authors: Mahaffey JA,Parkhurst MA,James AC,Cross FT,Alavanja MC,Boice JD,Ezrine S,Henderson P,Brownson RC

    更新日期:1993-04-01 00:00:00

  • Determination of the isotopic composition of uranium in urine by inductively coupled plasma mass spectrometry.

    abstract::A simple method based on inductively coupled plasma mass spectrometry (ICP-MS) was developed to identify exposure to depleted uranium by measuring the isotopic composition of uranium in urine. Exposure to depleted uranium results in a decreased percentage of 235U in urine samples causing measurements to vary between n...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200002000-00003

    authors: Ejnik JW,Carmichael AJ,Hamilton MM,McDiarmid M,Squibb K,Boyd P,Tardiff W

    更新日期:2000-02-01 00:00:00

  • Long-term stewardship of the environmental legacy at restored sites within the Department of Energy nuclear weapons complex.

    abstract::It is readily apparent, as the Department of Energy Office of Environmental Management proceeds in remediating its vast network of contaminated nuclear weapons facilities, that final cleanup at many facilities will not be performed to a level allowing unrestricted use of the facility. Instead, these facilities must re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200311000-00005

    authors: Wells JR,Spitz HB

    更新日期:2003-11-01 00:00:00

  • On the reduction of error in alpha track detector measurements of indoor 222Rn.

    abstract::Small plastic chambers containing alpha track detectors are often used for measuring indoor concentrations of 222Rn. This paper reports an experimental assessment of sources of error in measurements made with alpha track detector-containing chambers. The results demonstrate the feasibility of a nondestructive test for...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199510000-00008

    authors: Dudney CS,Wilson DL,Bertini H,Gammage RB,Otten JA

    更新日期:1995-10-01 00:00:00

  • Cancer mortality around La Hague nuclear facilities.

    abstract::Cancer death rates from the Beaumont-Hague "canton," where a nuclear facility is located, were compared with those for the Manche "département." No significant increase was found in cancer deaths during 1970-1982 for leukemias and in 1975-1982 for all other types of malignant tumors. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198906000-00005

    authors: Dousset M

    更新日期:1989-06-01 00:00:00

  • Trabecula: A Random Generator of Computational Phantoms for Bone Marrow Dosimetry.

    abstract::This study was motivated by the efforts to evaluate radiation risk for leukemia incidence in the Techa River cohort, where the main bone marrow dose contributors were Sr (bone-seeking beta emitters). Energy deposition in bone marrow targets was evaluated by simulating radiation particle transport using computational p...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001127

    authors: Shishkina EA,Timofeev YS,Volchkova AY,Sharagin PA,Zalyapin VI,Degteva MO,Smith MA,Napier BA

    更新日期:2020-01-01 00:00:00

  • Parameters for modelling the interception and retention of deposits from atmosphere by grain and leafy vegetables.

    abstract::The Normalised Specific Activity (NSA), a quantity which relates the concentration of a contaminant per unit mass of vegetation to its daily rate of ground deposition, has been used as the basis for determining interception factors and retention half-lives for radioactive contaminants deposited on grain and leafy vege...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198211000-00006

    authors: Simmonds JR,Linsley GS

    更新日期:1982-11-01 00:00:00

  • Alternative goals and policy mechanisms for radiation protection.

    abstract::For decades, radiation protection philosophy and practice have been the domain of professionals trained in the physical and medical sciences. Radiation protection policy was formulated and implemented largely without consultation with or participation by other professional disciplines or the general public. Although, ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200104000-00020

    authors: Florig HK

    更新日期:2001-04-01 00:00:00

  • Radiation hormesis: challenging LNT theory via ecological and evolutionary considerations.

    abstract::Ecological and evolutionary considerations suggest that radiation hormesis is made up of two underlying components. The first (a) is background radiation hormesis based upon the background exposure to which all organisms are subjected throughout evolutionary time. The second and much larger component (b) is stress-der...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200204000-00011

    authors: Parsons PA

    更新日期:2002-04-01 00:00:00

  • Equations for modeling of grab samples of radon decay products.

    abstract::A mathematical model of the process of collecting and analyzing a grab sample of radon decay products in air can be useful for a number ofpurposes. Among them is predicting the observed counts of alpha particles and/or beta particles (1) under various conditions of radon decay product equilibrium; (2) for various samp...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200208001-00014

    authors: Jenkins PH

    更新日期:2002-08-01 00:00:00

  • Individual thyroid dose estimation for a case-control study of Chernobyl-related thyroid cancer among children of Belarus-part I: 131I, short-lived radioiodines (132I, 133I, 135I), and short-lived radiotelluriums (131MTe and 132Te).

    abstract::Large amounts of radioiodines were released into the atmosphere during the accident at the Chernobyl nuclear power plant on 26 April 1986. In order to investigate whether the thyroid cancers observed among children in Belarus could have been caused by radiation exposures from the Chernobyl accident, a team of Belarusi...

    journal_title:Health physics

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004032-200406000-00002

    authors: Gavrilin Y,Khrouch V,Shinkarev S,Drozdovitch V,Minenko V,Shemiakina E,Ulanovsky A,Bouville A,Anspaugh L,Voillequé P,Luckyanov N

    更新日期:2004-06-01 00:00:00

  • How long to air sample? Practical considerations for short-term air sampling.

    abstract::Transportable (e.g., "giraffe") air samplers can be used for both short-term "grab-sampling" situations involving a few minutes to several hours, as well as for long-term retrospective air sampling situations that typically last a week. It is the short-term coverage situation which begs the question: "how long a sampl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318204aa78

    authors: Justus AL

    更新日期:2011-08-01 00:00:00

  • In situ gamma spectrometry measurements and Monte Carlo computations for the detection of radioactive sources in scrap metal.

    abstract::A very limited number of field experiments have been performed to assess the relative radiation detection sensitivities of commercially available equipment used to detect radioactive sources in recycled metal scrap. Such experiments require the cooperation and commitment of considerable resources on the part of vendor...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000144567.83125.00

    authors: Clouvas A,Xanthos S,Takoudis G,Potiriadis C,Silva J

    更新日期:2005-02-01 00:00:00

  • Considerations related to the decontamination of houses in Goiânia: limitations and implications.

    abstract::We are considering some aspects related to the decontamination activities of about 50 houses affected by 137Cs in Goiânia. We describe the way these contaminations occurred, the instruments used, and the procedures. We also discuss the dose limits established for decontamination and the consequences resulting from thi...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199101000-00014

    authors: da Silva CJ,Delgado JU,Luiz MT,Cunha PG,Barros PD

    更新日期:1991-01-01 00:00:00

  • Estimating internal dose due to ingestion of radionuclides from Nevada Test Site fallout.

    abstract::The U.S. Department of Energy initiated the Radiation Exposure Review Project to provide a critical reexamination of radiation doses to people resulting from testing nuclear devices at the Nevada Test Site. One part of this effort focused on the dose resulting from the ingestion of contaminated food. The PATHWAY radio...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199610000-00007

    authors: Kirchner TB,Whicker FW,Anspaugh LR,Ng YC

    更新日期:1996-10-01 00:00:00

  • A Brief Review-EPR Dosimetry and the Use of Animal Teeth as Dosimeters.

    abstract::The technique of electron paramagnetic resonance dosimetry using tooth enamel was established in the late 1960s, and considerable research has been conducted to learn more about the benefits of using human teeth as dosimeters for the purpose of retrospective dose reconstruction. Comparatively few studies have been don...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0000000000000899

    authors: Harshman A,Johnson T

    更新日期:2018-11-01 00:00:00

  • Radiation dose implications of airborne contaminant deposition to humans.

    abstract::In nuclear accident consequence assessment, dose contributions from radionuclide deposition on the human body have in the past generally been either ignored or estimated on the basis of rather simple models. Recent experimental work has improved the state of knowledge of relevant processes and parameter ranges. The re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200202000-00007

    authors: Andersson KG,Fogh CL,Byrne MA,Roed J,Goddard AJ,Hotchkiss SA

    更新日期:2002-02-01 00:00:00

  • Autoclave inactivation of infectious radioactive laboratory waste contained within a charcoal filtration system.

    abstract::A model system was developed previously for disposal of solid laboratory waste that is both radioactive and heat sensitive, e.g., HIV. A double polypropylene bag with charcoal vent filter and absorbent was designed to meet requirements for both steam sterilization and disposal as solid radioactive waste. Earlier work ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199107000-00015

    authors: Stinson MC,Green BL,Marquardt CJ,Ducatman AM

    更新日期:1991-07-01 00:00:00

  • A method of discriminating transuranic radionuclides from radon progeny using low-resolution alpha spectroscopy and curve-fitting techniques.

    abstract::²²²Rn (radon) and ²²⁰Rn (thoron) progeny are known to interfere with determining the presence of long-lived transuranic radionuclides, such as plutonium and americium, and require from several hours up to several days for conclusive results. Methods are proposed that should expedite the analysis of air samples for det...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31824641a8

    authors: Konzen K,Brey R

    更新日期:2012-05-01 00:00:00