Inhalation reference dose (RfDi): an application of interspecies dosimetry modeling for risk assessment of insoluble particles.

Abstract:

:Accurate extrapolation of animal toxicity data for human health risk assessment requires determination of the effective dose to the target tissue and the sensitivity of the target tissue to that dose. The methodology for deriving reference doses [the U.S. Environmental Protection Agency's (EPA) benchmark values for gauging systemic toxicity] for oral exposures has not included dosimetry modeling. Dosimetry data facilitate evaluation of concentration-response data with respect to the dose-response relationships used in quantitative risk assessment. Extension of this methodology to derivation of inhalation reference doses (RfDi) should account for the dynamics of the respiratory system as the portal of entry. Predictive physiologically based modeling of the inhalation of reactive gases has recently been demonstrated (Overton and Miller 1988). Models that describe the deposition of hygroscopic particles and account for chemical factors that affect clearance mechanisms and gas uptake are under development. This paper presents a method for calculating a dosimetric adjustment factor based on the values for the initial deposited dose of insoluble particles in an animal species and in humans. The ratio of these two values serves as a scaling factor that can be applied in the R f D methodology to account for the dosimetric differences in the inhaled deposited dose. This application for insoluble particles illustrates the feasibility of interspecies dosimetry calculations for extrapolating the toxicological results of inhaled agents to human exposure conditions for more accurate risk estimation.

journal_name

Health Phys

journal_title

Health physics

authors

Jarabek AM,Menache MG,Overton JH Jr,Dourson ML,Miller FJ

doi

10.1097/00004032-198907001-00022

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

177-83

eissn

0017-9078

issn

1538-5159

journal_volume

57 Suppl 1

pub_type

杂志文章
  • Considerations related to the decontamination of houses in Goiânia: limitations and implications.

    abstract::We are considering some aspects related to the decontamination activities of about 50 houses affected by 137Cs in Goiânia. We describe the way these contaminations occurred, the instruments used, and the procedures. We also discuss the dose limits established for decontamination and the consequences resulting from thi...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199101000-00014

    authors: da Silva CJ,Delgado JU,Luiz MT,Cunha PG,Barros PD

    更新日期:1991-01-01 00:00:00

  • Security of radioactive material at academic institutions.

    abstract::In recent years, regulatory emphasis on the prevention of loss, theft and intentional misuse of radioactive materials at academic institutions has forced radiation safety personnel to devote increasing amounts of time and effort to address security issues. NRC regulations require that radioactive materials used or sto...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200311002-00009

    authors: Farley DV,Normandin RD,Martz MD,Langhorst SM

    更新日期:2003-11-01 00:00:00

  • Recalibration of the Cameco mobile lung counter.

    abstract::The Cameco lung counter has been recalibrated using the Lawrence Livermore National Laboratory torso phantom using an extended lung set (i.e., longer than the original set). The previous calibration had used the Japanese Atomic Energy Research Institute torso phantom. The new calibration had lower counting efficiencie...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000346306.54221.28

    authors: Kramer GH,Hauck B,Allen SA

    更新日期:2009-06-01 00:00:00

  • Fifty years of plutonium exposure to the Manhattan Project plutonium workers: an update.

    abstract::Twenty-six white male workers who did the original plutonium research and development work at Los Alamos have been examined periodically over the past 50 y to identify possible health effects from internal plutonium depositions. Their effective doses range from 0.1 to 7.2 Sv with a median value of 1.25 Sv. As of the e...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199710000-00004

    authors: Voelz GL,Lawrence JN,Johnson ER

    更新日期:1997-10-01 00:00:00

  • Fallout from Nuclear Weapons Tests: Environmental, Health, Political, and Sociological Considerations.

    abstract::The process of nuclear fission, which was discovered in 1938, opened the door to the production of nuclear weapons, which were used in 1945 by the United States against Japan in World War II, and to the detonation of >500 nuclear weapons tests in the atmosphere by the United States, the former Soviet Union, the United...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001237

    authors: Bouville A

    更新日期:2020-04-01 00:00:00

  • Future role of the NCRP in radiation health protection.

    abstract::The predecessor organizations of the National Council on Radiation Protection and Measurements (NCRP) were established in 1929 (the U.S. Advisory Committee on X-Ray and Radium Protection) and in 1946 (the National Committee on Radiation Protection and Measurements). In 1964, the NCRP was formally chartered by the U.S....

    journal_title:Health physics

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/00004032-200409000-00014

    authors: Tenforde TS

    更新日期:2004-09-01 00:00:00

  • Defining molecular and cellular responses after low and high linear energy transfer radiations to develop biomarkers of carcinogenic risk or therapeutic outcome.

    abstract::The variability in radiosensitivity across the human population is governed in part by genetic factors. The ability to predict therapeutic response, identify individuals at greatest risk for adverse clinical responses after therapeutic radiation doses, or identify individuals at high risk for carcinogenesis from envir...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0b013e3182692085

    authors: Story M,Ding LH,Brock WA,Ang KK,Alsbeih G,Minna J,Park S,Das A

    更新日期:2012-11-01 00:00:00

  • Visualizing High-Order Decay after Disequilibria.

    abstract::High-order decay equations are often difficult to study without significant care taken with variables and assumptions. As parent and progeny activities evolve over time, the effects of uncertainties and approximations confound the quality and interpretation of results. Of particular concern is the situation when decay...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000926

    authors: Wilson CA 4th,Hendrickson KR,Hamideh AM,Matthews KL 2nd,Wang WH

    更新日期:2018-12-01 00:00:00

  • Measuring Workload with Paired Detectors.

    abstract::Linear accelerator workloads for each available photon energy are important quantities to know for radiation safety considerations, and presented is a technique to measure the workload using paired detectors. The signals from the two detectors can give sufficient information to separate the signal contributions from 6...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000984

    authors: Corns R,Schroeder C,Sandhu G,Henderson K,McKay I

    更新日期:2019-09-01 00:00:00

  • Sorption of tin on human teeth.

    abstract::The sorption of tin ions on human teeth from water and other drinks has been studied by the radioactive tracer technique using the isotope 113Sn (T(1/2) = 115.1 d) as a tracer. The tooth holds a minimum amount of tin from coffee and a maximum amount is held from water and from tea with sugar. The same technique was al...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200201000-00014

    authors: Helal AA,Alian GA,Madbouly HA

    更新日期:2002-01-01 00:00:00

  • An investigation of voxel geometries for MCNP-based radiation dose calculations.

    abstract::Voxelized geometry such as those obtained from medical images is increasingly used in Monte Carlo calculations of absorbed doses. One useful application of calculated absorbed dose is the determination of fluence-to-dose conversion factors for different organs. However, confusion still exists about how such a geometry...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000234039.58356.de

    authors: Zhang J,Bednarz B,Xu XG

    更新日期:2006-11-01 00:00:00

  • On the discrepancy between epidemiologic studies in individuals of lung cancer and residential radon and Cohen's ecologic regression.

    abstract::There is still substantial confusion in the radiation effects community about the inherent limitations of ecologic analysis. As a result, inordinate attention has been given to the discrepant results of Cohen, in which a negative estimate is observed for the regression of county mortality rates for lung cancer on esti...

    journal_title:Health physics

    pub_type: 评论,杂志文章

    doi:10.1097/00004032-199807000-00001

    authors: Lubin JH

    更新日期:1998-07-01 00:00:00

  • Psychosocial and health impacts of uranium mining and milling on Navajo lands.

    abstract::The uranium industry in the American Southwest has had profoundly negative impacts on American Indian communities. Navajo workers experienced significant health problems, including lung cancer and nonmalignant respiratory diseases, and psychosocial problems, such as depression and anxiety. There were four uranium proc...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182243a7a

    authors: Dawson SE,Madsen GE

    更新日期:2011-11-01 00:00:00

  • Secondary Neutron Doses to Pediatric Patients During Intracranial Proton Therapy: Monte Carlo Simulation of the Neutron Energy Spectrum and its Organ Doses.

    abstract::Proton therapy has the physical advantage of a Bragg peak that can provide a better dose distribution than conventional x-ray therapy. However, radiation exposure of normal tissues cannot be ignored because it is likely to increase the risk of secondary cancer. Evaluating secondary neutrons generated by the interactio...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000461

    authors: Matsumoto S,Koba Y,Kohno R,Lee C,Bolch WE,Kai M

    更新日期:2016-04-01 00:00:00

  • Fallout 3H in human tissue at Akita, Japan.

    abstract::The 3H concentration in Japanese human tissue samples is reported in this paper. Four brain, 10 liver, and nine lung samples from 11 cases were collected from Akita Prefecture in northern Japan from January to July 1986. The median of free-water 3H concentration was similar in these tissues and agreed well with the co...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198910000-00006

    authors: Hisamatsu S,Takizawa Y,Itoh M,Ueno K,Katsumata T,Sakanoue M

    更新日期:1989-10-01 00:00:00

  • Signal Processing and Its Effect on Scanning Efficiencies for a Field Instrument for Detecting Low-energy Radiation.

    abstract::Signal processing within a radiation detector affects detection efficiency. Currently, organizations such as private industry, the U.S. Navy, Army, and Air Force are coupling some detector systems with data collection devices to survey large land areas for radioactive contamination. As detector technology has advanced...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000298

    authors: Marianno CM

    更新日期:2015-07-01 00:00:00

  • The H-ARS Dose Response Relationship (DRR): Validation and Variables.

    abstract::Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality. To investigate this in a murine model of the hematopoietic acute radiation syndrom...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000354

    authors: Plett PA,Sampson CH,Chua HL,Jackson W,Vemula S,Sellamuthu R,Fisher A,Feng H,Wu T,MacVittie TJ,Orschell CM

    更新日期:2015-11-01 00:00:00

  • Design of a positionally sensitive laser-heated thermoluminescent detector system.

    abstract::The design and performance of a positionally sensitive system for the laser read-out of dosimetric information contained in LiF chips and a specially designed composite detector having a thin LiF layer is reported. A 2 cm X 3 cm X 0.254 mm LiF layer was successfully manufactured with a glass backing; however, this was...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199010000-00004

    authors: Kearfott KJ,Grupen-Shemansky ME

    更新日期:1990-10-01 00:00:00

  • Do the risks justify action?

    abstract::The key issues that have been raised at the meeting on Cosmic Radiation Doses to Air Crew and Astronauts are identified. The paper summarizes the radiation environment and radiation risks associated with exposures to both groups. Finally, the summary concludes that the risks do justify action. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200011000-00023

    authors: Clarke RH

    更新日期:2000-11-01 00:00:00

  • An investigation into the prevalence of thyroid disease on Kwajalein Atoll, Marshall Islands.

    abstract::The prevalence of thyroid nodules and thyroid cancer was studied in the indigenous population residing on Ebeye Island, Kwajalein Atoll, in the Republic of the Marshall Islands. This island, centrally located in the nation, is home to about 25% of the nation's population, many who have migrated there from other atolls...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199707000-00017

    authors: Takahashi T,Trott KR,Fujimori K,Simon SL,Ohtomo H,Nakashima N,Takaya K,Kimura N,Satomi S,Schoemaker MJ

    更新日期:1997-07-01 00:00:00

  • Measurement of absorbed dose in water irradiated by 2.5-GeV bremsstrahlung.

    abstract::Plane shields made of Pb with a water tank behind them were irradiated by 2.5-GeV bremsstrahlung. The longitudinal distribution of the absorbed dose in water was measured using a scintillation counter. The results are compared with Monte Carlo calculations and published depth dose tables. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198707000-00007

    authors: Ban S,Hirayama H,Miura S

    更新日期:1987-07-01 00:00:00

  • Ingestion of 226Ra from activated paints on military equipment: transfer factors and doses.

    abstract::The use of 226Ra-activated markings was specific for military equipment some decades ago and the extent of possible internal exposure of former military personnel due to ingestion of 226Ra is an issue of discussion. Whole- or partial-body counts are not sensitive enough to trace an overexposure due to a possible 226Ra...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181d18d2e

    authors: Schirmer A

    更新日期:2010-10-01 00:00:00

  • Direct-immersion and water-extraction methods for measuring tritium contamination of concrete.

    abstract::In the process of decommissioning a tritium-handling laboratory, direct-immersion and water-extraction methods for measuring tritium contamination in concrete were compared to a heating-cooling method. For this evaluation, concrete pieces chipped from contaminated concrete walls and floors were used. The direct-immers...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000261159.98536.85

    authors: Kawano T,Kuroyanagi M,Tabei T

    更新日期:2007-08-01 00:00:00

  • Environmental measurements in an emergency: this is not a drill.

    abstract::Emergency responders from the Department of Energy are trained regularly to assess the environmental consequences of a radiological or nuclear incident. While drills and exercises are highly effective tools in rehearsing for an emergency, the accidents at the Fukushima Daiichi Nuclear Power Plants presented real-world...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31824c5ae4

    authors: Musolino SV,Clark H,McCullough T,Pemberton W

    更新日期:2012-05-01 00:00:00

  • Imaging radiation induced muscular necrosis with antimyosin-scintigraphy and computed tomography.

    abstract::Radiations accidents involving high exposures require accurate assessment of radiation dose for correct surgical or medical management. Techniques involving computed tomography and antimyosin-antibody scintigraphy were evaluated in an experimental model of acute localized irradiation overexposure to 192Ir. Ten rabbits...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200001000-00009

    authors: Albérini JL,Lefaix JL,Bansard JY,Bourguet P

    更新日期:2000-01-01 00:00:00

  • Biological dosimetry after extensive diagnostic x-ray exposure.

    abstract::The yield of chromosome aberrations (dicentric and ring chromosomes) was determined for five patients who had been extensively exposed to diagnostic x rays. Remarkably high aberration yields were obtained for each of them leading to correspondingly high equivalent whole body doses ("biological dosimetry"). The contrib...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199502000-00012

    authors: Weber J,Scheid W,Traut H

    更新日期:1995-02-01 00:00:00

  • Development of 241Am lung monitoring system using an imaging plate.

    abstract::A new 241Am lung monitoring system without shielding was devised by using an imaging plate system. The Lawrence Livermore National Laboratory's realistic torso phantom containing a 241Am lung was covered by imaging plates sealed in lightproof bags. The imaging plate system displayed 241Am lung images characteristic of...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000258917.88579.a3

    authors: Hirota M,Kurihara O,Takada C,Takasaki K,Momose T,Deji S,Ito S,Saze T,Nishizawa K

    更新日期:2007-07-01 00:00:00

  • Mitigating radiation-induced toxicity: an overview of new approaches developed at the French Military Biomedical Research Institute.

    abstract::Acute radiation syndrome represents the clinical response of radiation-sensitive key tissues (i.e., hematopoietic, gastrointestinal and neurovascular) following exposure to high doses of ionizing radiation. In this context, the hematopoietic syndrome remains the first therapeutic challenge. Today, identifying new drug...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0000000000000039

    authors: Drouet M,Hérodin F

    更新日期:2014-06-01 00:00:00

  • Suitability of air sampling locations downstream of bends and static mixing elements.

    abstract::The revised standard for sampling effluent air from stacks and ducts of the nuclear industry places limits on the non-uniformity of velocity and contaminant profiles at the sampling location; namely, the coefficients of variation must not exceed 20% over an area that encompasses at least the center 2/3 of the cross se...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199912000-00015

    authors: McFarland AR,Gupta R,Anand NK

    更新日期:1999-12-01 00:00:00

  • Criteria for the administration of KI for thyroid blocking of radioiodine.

    abstract::Scientific data are reviewed to evaluate the risks of radioiodine uptake and to compare those risks with the benefits and risks of low milligram doses of stable potassium iodide (KI). The limit of 25 rad to the thyroid due to radioiodine uptake is adopted as the "break-even" point above which 130-mg KI doses should be...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-198502000-00001

    authors: Meck RA,Chen MS,Kenny PJ

    更新日期:1985-02-01 00:00:00