The H-ARS Dose Response Relationship (DRR): Validation and Variables.

Abstract:

:Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality. To investigate this in a murine model of the hematopoietic acute radiation syndrome, 20 individual survival efficacy studies were grouped based on the severity of the administration (Admn) schedules of their medical countermeasure (MCM) into Admn 1 (no injections), Admn 2 (1-3 injections), or Admn 3 (29 injections or 6-9 oral gavages). Radiation doses ranged from LD30/30 to LD95/30. Thirty-day survival of vehicle controls in each group was used to construct radiation dose lethality response relationship (DRR) probit plots, which were compared statistically to the original DRR from which all LDXX/30 for the studies were obtained. The slope of the Admn 3 probit was found to be significantly steeper (5.190) than that of the original DRR (2.842) or Admn 2 (2.009), which were not significantly different. The LD50/30 for Admn 3 (8.43 Gy) was less than that of the original DRR (8.53 Gy, p < 0.050), whereas the LD50/30 of other groups were similar. Kaplan-Meier survival curves showed significantly worse survival of Admn 3 mice compared to the three other groups (p = 0.007). Taken together, these results show that stressful administration schedules of MCM can negatively impact survival and that dosing regimens should be considered when constructing DRR to use in survival studies.

journal_name

Health Phys

journal_title

Health physics

authors

Plett PA,Sampson CH,Chua HL,Jackson W,Vemula S,Sellamuthu R,Fisher A,Feng H,Wu T,MacVittie TJ,Orschell CM

doi

10.1097/HP.0000000000000354

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

391-8

issue

5

eissn

0017-9078

issn

1538-5159

pii

00004032-201511000-00005

journal_volume

109

pub_type

杂志文章
  • Uncertainty of (222)Rn concentrations in the usepa radiation and indoor environments National Laboratory Exposure Chamber.

    abstract::The U.S. Environmental Protection Agency (EPA) operates an environmentally controlled chamber for purposes of exposing various radon and decay product measurement equipment to known (222)Rn concentrations. Exposure durations range from 1 h to several months, and (222)Rn concentrations vary between 37 and 4,440 Bq m(-3...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182712e5a

    authors: Ronca-Battista M,Budd G,McLemore S

    更新日期:2013-02-01 00:00:00

  • Image quantification for radiation dose calculations--limitations and uncertainties.

    abstract::Radiation dose calculations in nuclear medicine depend on quantification of activity via planar and/or tomographic imaging methods. However, both methods have inherent limitations, and the accuracy of activity estimates varies with object size, background levels, and other variables. The goal of this study was to eval...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181e28cdb

    authors: Pereira JM,Stabin MG,Lima FR,Guimarães MI,Forrester JW

    更新日期:2010-11-01 00:00:00

  • Lifetime bone cancer dose-response relationships in beagles and people from skeletal burdens of 226Ra and 90Sr.

    abstract::The life-time tumor dose-response relationships observed in beagles injected with 226Ra or fed 90Sr at the University of California, Davis, provide a basis for understanding the induction of bone cancer for these bone-seeking radionuclides and for scaling to people. In these studies 385 dogs were exposed to graded dos...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00002

    authors: Raabe OG,Book SA,Parks NJ

    更新日期:1983-01-01 00:00:00

  • Worker protection implications of the solubility and human metabolism of modern uranium mill products in the U.S.

    abstract::This paper presents an analysis of the implications of some recent studies performed to characterize uranium products from modern uranium recovery facilities important for worker protection. Assumptions about the solubility (related to the molecular species being produced) of these materials in humans are critical to ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000136

    authors: Brown SH,Chambers DB

    更新日期:2014-11-01 00:00:00

  • Does tributyl phosphate influence the radiation risk of a highly proliferating system--the early mouse embryo in vitro?

    abstract::Two-cell mouse embryos were exposed in vitro to tributyl phosphate, x rays, or a combination of both. In-vitro development of the embryos was followed microscopically (cleavage to four- and eight-cell embryos, formation of morulae and blastocysts, and hatching of blastocysts). Effects on proliferation were estimated b...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198712000-00009

    authors: Müller WU,Streffer C,Markoski L

    更新日期:1987-12-01 00:00:00

  • Evaluation of two thermoluminescent detection systems for medical imaging environments.

    abstract::Thermoluminescent detectors (TLDs) can provide accurate and precise measurements for both patient and personnel dosimetry in the medical imaging environment. They have the advantages of tissue equivalency, an excellent dynamic range, and dose rate independence. In the work reported here, experiments with planar x-ray,...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199012000-00006

    authors: Kearfott KJ,Nabelssi BK,Rucker RH,Klingler GW

    更新日期:1990-12-01 00:00:00

  • Doses to workers in the United States nuclear weapons program due to external irradiation at the dawn of the atomic era (1940-1960).

    abstract::Radiation doses to workers at the Manhattan Engineer District (MED) and Atomic Energy Commission (AEC) sites due to external irradiation during 1940-1960 are reviewed. Categorized radiation dose data were available from AEC annual reports for some years. Annual individual radiation dose data for nine MED/AEC sites for...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199607000-00008

    authors: Strom DJ,Smith MH,Swinth KL,Pettengill HJ

    更新日期:1996-07-01 00:00:00

  • Radon-222 levels in New York State homes.

    abstract::Results are presented from a statewide survey that measured annual 222Rn concentrations in over 2000 single-family, owner-occupied homes in New York state. The participants were selected by a random-digit-dialing telephone interview approach developed by Mitofsky-Waksberg which allows inferences to be made from the sa...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199002000-00001

    authors: Perritt RL,Hartwell TD,Sheldon LS,Cox BG,Clayton CA,Jones SM,Smith ML,Rizzuto JE

    更新日期:1990-02-01 00:00:00

  • Acute Radiation-induced GI-ARS and H-ARS in a Canine Model of Mixed Neutron/Gamma Relative to Reference Co-60 Gamma Radiation: A Retrospective Study.

    abstract::Studies performed decades ago in the canine and nonhuman primate established the dose response relationships for the hematopoietic acute radiation syndrome in response to mixed neutron/gamma, x-radiation, and Co gamma radiation. There were no published studies that determined the dose response relationships for the ga...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001215

    authors: MacVittie TJ,Jackson W 3rd

    更新日期:2020-09-01 00:00:00

  • Radioactive contamination of the Adriatic Sea by 90Sr and 137Cs.

    abstract::Results of systematic long-term measurements of 90Sr and 137Cs in surface seawater, performed at four locations along the Croatian coast of the Adriatic Sea, are summarized. Observed trends in annual mean activity concentrations are discussed. 90Sr and 137Cs fallout activities affect seawater activity, the coefficient...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199302000-00006

    authors: Franić Z,Bauman A

    更新日期:1993-02-01 00:00:00

  • Radioactivity in zirconium oxide powders used in industrial applications.

    abstract::Recent work involving the decommissioning of a former ceramic manufacturing facility licensed by the Nuclear Regulatory Commission for activities involving depleted uranium oxide has uncovered the presence of unexpected high levels of natural radioactivity in non-licensed zirconium oxide powders also used in the same ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199106000-00009

    authors: Lischinsky J,Vigliani MA,Allard DJ

    更新日期:1991-06-01 00:00:00

  • Ambient environmental profile for the Savannah River Site.

    abstract::One of the steps that has been taken to expedite the radiation dose reconstruction process is the development of "site profiles." These reports, one of which has been prepared for each of the major U.S. Department of Energy nuclear sites, include detailed assessments of the dose rates at a given site due to on-site ex...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000265217.20406.c7

    authors: Rollins EM

    更新日期:2008-07-01 00:00:00

  • The combined impact on doses to man of multiple, authorized, radionuclide discharges for the year 1999 reaching the upper river thames, uk.

    abstract::Before issuing a new or revised authorization to discharge liquid radioactive waste to a river, past and current practice has been to assess the impact of each discharge on a site-by-site basis. This paper reports an assessment of the combined impact of all the (year 1999) authorized discharges in the upper River Tham...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200407000-00004

    authors: Hilton J,Harvey M,Simmonds J

    更新日期:2004-07-01 00:00:00

  • Development of a rapidly deployed Department of Energy emergency response element.

    abstract::The Federal Radiological Emergency Response Plan (FRERP) directs the Department of Energy (DOE) to maintain a viable, timely, and fully documented response option capable of supporting the responsible Lead Federal Agency in the event of a radiological emergency impacting any state or United States territory (e.g., CON...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200002001-00007

    authors: Tighe RJ,Riland CA,Hopkins RC

    更新日期:2000-02-01 00:00:00

  • Thoron Mitigation from Building Materials with Surface Barriers.

    abstract::Thoron (Rn) exhalation from building materials has become increasingly recognized as a potential source for radiation exposure in dwellings. However, few studies have focused on mitigation strategies to reduce exposure from thoron and its progeny. Therefore, the purpose of this study is to (1) determine the reduction ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000566

    authors: de With G,de Jong P,Donk JJ

    更新日期:2016-11-01 00:00:00

  • Preconceptional paternal exposure to depleted uranium: transmission of genetic damage to offspring.

    abstract::Depleted uranium (DU) is an alpha particle emitter and radioactive heavy metal used in military applications. Due to internalization of DU during military operations and the ensuing chronic internal exposure to DU, there are concerns regarding its potential health effects. Preconceptional paternal irradiation has been...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181cfe0dd

    authors: Miller AC,Stewart M,Rivas R

    更新日期:2010-09-01 00:00:00

  • U.S. radiation protection: role of national and international recommendations and opportunities for collaboration (harmony, not dissonance).

    abstract::For much of the 20th century, U.S. radiation protection policies were similar to those elsewhere in the world, in large part because the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) were closely aligned. In the 1970s, several U.S. r...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000236

    authors: Boyd MA

    更新日期:2015-02-01 00:00:00

  • LIFE: a sustainable solution for developing safe, clean fusion power.

    abstract::The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL) in California is currently in operation with the goal to demonstrate fusion energy gain for the first time in the laboratory-also referred to as "ignition." Based on these demonstration experiments, the Laser Inertial Fusion Ener...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31828d2fab

    authors: Reyes S,Dunne M,Kramer K,Anklam T,Havstad M,Mazuecos AL,Miles R,Martinez-Frias J,Deri B

    更新日期:2013-06-01 00:00:00

  • Cost-Benefit of Final Radiological Survey Versus Radioactive Waste Disposal.

    abstract::ABSTRACT A significant portion of the cost for D&D is related to low-level waste disposal, decontamination, and final radiological survey. For that reason, a careful cost-benefit analysis must be performed weighing the cost of decontaminating and radiologically surveying the building media for release against the cost...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:

    authors: Barroso J,Roberts S

    更新日期:2003-02-01 00:00:00

  • Lessons learned in dealing with self luminous exit signs.

    abstract::Self-luminous signs are generally licensed consumer products used to identifying exits, handicap accessibility areas, parking lots, no smoking areas, life boat locations, and emergency stair locations. While purchasers of these signs are exempt from the requirement of applying for a specific license, they are not exem...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000147794.96137.55

    authors: Linsley ME

    更新日期:2005-02-01 00:00:00

  • Operational Measures Taken for the Authorization of X-ray Generators Used in the Medical Sector in Cameroon.

    abstract::The use of x-ray generators for diagnostic radiology in the medical sector in Cameroon, Central Africa, is wide spread and on the increase in recent times. Regulatory control of x-ray machines used in medical sector has been achieved in the Littoral Region of Cameroon by means of notification and authorization systems...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000713

    authors: Beyala Ateba JF,Simo A,Moyo Ndontchueng M,Sabouang JF

    更新日期:2017-11-01 00:00:00

  • Radon exhalation rates and gamma doses from ceramic tiles.

    abstract::This study was carried out to assess the possible radiological hazard resulting from the use of zircon in glaze applied to tiles used in buildings. The 226Ra content of various stains and glazing compounds was measured using gamma spectroscopy and the 222Rn exhalation rates for these materials were measured using adso...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199812000-00007

    authors: O'Brien RS,Aral H,Peggie JR

    更新日期:1998-12-01 00:00:00

  • Radioactivity: conception to birth. The Health Physics Society 1995 Radiology Centennial Hartman Oration.

    abstract::Röntgen's description of his discovery of x rays was convincing and comprehensive. The response of the scientific community and public was immediate and intense. In contrast, the discovery of radioactivity was a muddled affair that excited little interest. While it would prove far more revolutionary than that of x ray...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/00004032-199605000-00001

    authors: Frame PW

    更新日期:1996-05-01 00:00:00

  • The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model.

    abstract::The development of medical countermeasures against the acute gastrointestinal subsyndrome of the acute radiation syndrome in humans requires well characterized and validated animal models. These models must adhere to the criteria of the U.S. Food and Drug Administration's Animal Rule and consider the natural history a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31826525f0

    authors: MacVittie TJ,Farese AM,Bennett A,Gelfond D,Shea-Donohue T,Tudor G,Booth C,McFarland E,Jackson W 3rd

    更新日期:2012-10-01 00:00:00

  • In vitro dissolution of respirable aerosols of industrial uranium and plutonium mixed-oxide nuclear fuels.

    abstract::Dissolution characteristics of mixed-oxide nuclear fuels are important considerations for prediction of biological behavior of inhaled particles. Four representative industrial mixed-oxide powders were obtained from fuel fabrication enclosures. Studies of the dissolution of Pu, Am and U from aerosol particles of these...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198312000-00001

    authors: Eidson AF,Mewhinney JA

    更新日期:1983-12-01 00:00:00

  • Past and future work on radiobiology mega-studies: a case study at Argonne National Laboratory.

    abstract::Between 1952 and 1992, more than 200 large radiobiology studies were conducted in research institutes throughout Europe, North America, and Japan to determine the effects of external irradiation and internal emitters on the lifespan and tissue toxicity development in animals. At Argonne National Laboratory, 22 externa...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181febad3

    authors: Haley B,Wang Q,Wanzer B,Vogt S,Finney L,Yang PL,Paunesku T,Woloschak G

    更新日期:2011-06-01 00:00:00

  • The Gaussian atmospheric transport model and its sensitivity to the joint frequency distribution and parametric variability.

    abstract::Reconstructed meteorological data are often used in some form of long-term wind trajectory models for estimating the historical impacts of atmospheric emissions. Meteorological data for the straight-line Gaussian plume model are put into a joint frequency distribution, a three-dimensional array describing atmospheric ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200201000-00008

    authors: Hamby DM

    更新日期:2002-01-01 00:00:00

  • Methodology for a bounding estimate of activation source-term.

    abstract::Sandia National Laboratories' Z-Machine is the world's most powerful electrical device, and experiments have been conducted that make it the world's most powerful radiation source. Because Z-Machine is used for research, an assortment of materials can be placed into the machine; these materials can be subjected to a r...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31827126f1

    authors: Culp T

    更新日期:2013-02-01 00:00:00

  • Radon awareness and mitigation in Vermont: a public health survey.

    abstract::Radon exposure is associated with an increased incidence of lung cancer, and elevated levels may be found in as many as 1 out of 15 homes. The U.S. EPA recommends testing homes for radon and mitigating over the advisory level of 4 picocuries per liter (4 pCi L(-1), or 148 Bq m(-3)). A sample population from a list of ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000254862.50407.4a

    authors: Riesenfeld EP,Marcy TW,Reinier K,Mongeon JA,Trumbo CW,Wemple BE,Kaminsky DA

    更新日期:2007-05-01 00:00:00

  • Lung, liver and bone cancer mortality after plutonium exposure in beagle dogs and nuclear workers.

    abstract::The Mayak Production Association (MPA) worker registry has shown evidence of plutonium-induced health effects. Workers were potentially exposed to plutonium nitrate [(239)Pu(NO(3))(4)] and plutonium dioxide ((239)PuO(2)). Studies of plutonium-induced health effects in animal models can complement human studies by prov...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181b97318

    authors: Wilson DA,Mohr LC,Frey GD,Lackland D,Hoel DG

    更新日期:2010-01-01 00:00:00