Vaginal carriage and neonatal acquisition of Clostridium difficile.

Abstract:

:The relationship between vaginal carriage and subsequent neonatal acquisition of Clostridium difficile was investigated. Vaginal carriage of C. difficile was detected in 11% of women attending the Department of Genital Medicine Clinic. C. difficile was isolated from the vagina in 18% of 50 mothers before delivery, and 8% after delivery; 62% of their babies had positive faecal cultures. Eight of nine of the babies whose mothers had positive cultures before delivery became colonised with C. difficile, while 23 of 41 babies whose mothers had negative cultures became colonised. This suggests that both the vagina and the environment may act as sources of neonatal acquisition of C. difficile. Broth enrichment culture proved a more sensitive method for isolating C. difficile from the vagina than direct plate culture and should be used in such investigations.

journal_name

J Med Microbiol

authors

Tabaqchali S,O'Farrell S,Nash JQ,Wilks M

doi

10.1099/00222615-18-1-47

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

47-53

issue

1

eissn

0022-2615

issn

1473-5644

journal_volume

18

pub_type

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