Abstract:
:Free cytoplasmic mRNPs were isolated from human placenta. An activity of RNase was associated with these particles but was mostly inhibited by a labile protein inhibitor. Both RNase and RNase inhibitor were extractable from mRNPs by 0.5 M KCl. The nature of the association of the RNase-RNase inhibitor complex with mRNPs makes it suitable as a putative system for control of expression and turnover of mRNPs and therefore of protein synthesis.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Gileadi O,Lorberboum H,de Groot N,Hochberg AAdoi
10.1007/BF00775355subject
Has Abstractpub_date
1984-01-01 00:00:00pages
241-4issue
4eissn
0301-4851issn
1573-4978journal_volume
9pub_type
杂志文章abstract::Etiological factors for coronary artery disease (CAD) involve a wide range of gene and environmental interactions. One of the systems being implicated in the pathophysiology of CAD is the renin-angiotensin system (RAS). However, the genetic polymorphisms of this system have not been widely studied in Iranian patients ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2596-1
更新日期:2013-08-01 00:00:00
abstract::The transforming growth factor-β (TGF-β) signaling pathway is conserved across animals, and knowledge of its roles during the molt cycle in crustaceans is presently very limited. This study investigates the roles of the TGF-β receptor in molting-related muscle growth in Eriocheir sinensis. Using the RT-PCR and RACE te...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05108-8
更新日期:2020-01-01 00:00:00
abstract::The present study examined partial cytochrome b gene sequence of mitochondrial DNA for polymorphism and its suitability to determine the genetic differentiation in wild Labeo rohita. The 146 samples of L. rohita were collected from nine distant rivers; Satluj, Brahmaputra, Son, Chambal Mahanadi, Rapti, Chauka, Bhagira...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1140-4
更新日期:2012-04-01 00:00:00
abstract::Chrysanthemum indicum L. is a traditional oriental medicinal herb prepared as a tea from flowers that have been used in China and South Korea since ancient times. It has a long history in the treatment of hypertension, inflammation, and respiratory diseases. Among Chrysanthemum species, C. indicum has more active chem...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05844-2
更新日期:2020-10-01 00:00:00
abstract::The conserved M2 protein of influenza A virus is considered as a promising candidate target for a broad-spectrum, recombinant influenza A vaccine. In the present study, the open reading frame (ORF) of avian influenza A/chicken/Iran/101/1998 (H9N2) M2 gene was amplified then cloned in pAED4, prokaryotic expression vect...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9851-5
更新日期:2010-07-01 00:00:00
abstract::Apoptotic response in hepatocellular carcinoma (HCC) cells is impaired because of interconnectivity of proteins into complexes and signaling networks that are highly divergent in time and space. TNF-related apoptosis-inducing ligand (TRAIL) has emerged as an attractive anticancer agent reported to selectively induce a...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-014-3577-8
更新日期:2014-10-01 00:00:00
abstract::Sex hormone-binding globulin (SHBG) is a plasma glycoprotein that plays an important role in breast cancer pathophysiology and risk definition, since it regulates the bioavailable fraction of circulating estradiol. Epidemiological studies have evaluated the association between SHBG Asp327Asn polymorphism and breast ca...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-012-1680-2
更新日期:2012-08-01 00:00:00
abstract::The epidermal growth factor receptor (EGFR) is an important receptor tyrosine kinase member in animals, which plays versatile functions in development, growth, tissue regeneration etc. Current knowledge on EGFR is poor in bivalve mollusks. In this study, we cloned and analyzed an EGFR gene from the Pacific oyster Cras...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3130-9
更新日期:2014-05-01 00:00:00
abstract::Knowledge in the area of genetic diversity could aid in providing useful information in the selection of material for breeding such as hybridization programs and quantitative trait loci mapping. To this end, 50 Nicotiana tabacum genotypes were genotyped with 21 primer combination of amplified fragment length polymorph...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3194-6
更新日期:2014-05-01 00:00:00
abstract::Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurys...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4374-6
更新日期:2018-12-01 00:00:00
abstract::The interferon-inducible human MxA protein plays an important role in innate defense against an array of viruses. One might expect allelic diversity at the MxA locus to influence the timing and magnitude of its expression or even the range of viruses whose biological cycle is inhibited by the encoded product. Here we ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1708-7
更新日期:2012-08-01 00:00:00
abstract::Telomerase activity is repressed in normal human somatic cells, but is activated in most cancers, suggesting that telomerase may be an important target for cancer therapy. Agents that interact selectively with telomerase are anticipated to exert specific action on cancer cells. In this study, we evaluated maleimide de...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1757-y
更新日期:2012-09-01 00:00:00
abstract::Our previous studies have shown that miR-125b-5p was highly expressed and significantly upregulated during abdominal fat deposition in chickens. However, the role of miR-125b in the regulation of adipogenesis is not clear in chickens. Therefore, we evaluated the effects of miR-125b-5p on preadipocyte proliferation and...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-06080-4
更新日期:2021-01-04 00:00:00
abstract::Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are common syndromes characterized by diffuse, acute injury to the alveolar epithelium and pulmonary vascular endothelial cells, with high mortality rate for there are no effective pharmacological therapies. Peroxisome proliferators-activated recept...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0647-4
更新日期:2011-11-01 00:00:00
abstract::The interaction between ovalbumin (OVA) and three purine alkaloids (caffeine, theophylline and diprophylline) was investigated by the aid of intrinsic and synchronous fluorescence, ultraviolet-vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra techniques. Results showed that ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2418-x
更新日期:2013-04-01 00:00:00
abstract::RACK1 is a crucial scaffold and anchoring protein, which plays a vital role in multiple signaling pathways of tumorigenesis. The aim of the present study was to identify the correlation between expressions of RACK1 and malignant degrees in colorectal carcinoma (CRC) patients. All together 157 CRC patients were enrolle...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3201-y
更新日期:2014-05-01 00:00:00
abstract::The oligochaete earthworm, Eudrilus eugeniae is capable of regenerating both anterior and posterior segments. The present study focuses on the transcriptome analysis of earthworm E. eugeniae to identify and functionally annotate the key genes supporting the anterior blastema formation and regulating the anterior regen...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-06044-8
更新日期:2020-12-11 00:00:00
abstract::The blue swimming crab (Portunus pelagicus) is a valuable marine fishery resource in Indo-West Pacific Ocean. So far, rare genetic resource of this species is available. In this report, the restriction-site associated DNA (RAD) approach was employed to mine the genomic information and identify molecular markers in P. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4339-9
更新日期:2018-12-01 00:00:00
abstract::Rice bran oil is good quality edible oil, rich in antioxidants and comprised typically of oleic-linoleic type fatty acids. However, presence of a highly lipolytic enzyme Phospholipase D alpha1 (OsPLDα1) increases free fatty acid content in the oil which further leads to stale flavor and rancidity of the oil, making it...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05144-4
更新日期:2020-01-01 00:00:00
abstract::The aim of this study was to describe the microbial communities in the distal gut of wild wolves (Canis lupus). Fecal samples were collected from three healthy unrelated adult wolves captured at the nearby of Dalai Lake Nature Reserve in Inner Mongolia of China. The diversity of fecal bacteria was investigated by cons...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0060-z
更新日期:2010-12-01 00:00:00
abstract::Experiments with 5'-azacytidine and hematopoietic growth factor approved for the transformation of human mesenchymal cells into hematopoietic cells have demonstrated that cell fate can be dramatically altered by changing the epigenetic state of cells. Here, we demonstrate that umbilical cord-derived human mesenchymal ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3351-y
更新日期:2014-07-01 00:00:00
abstract::The aim of this study was to characterise the effects of ischemic preconditioning (IP) on heart function parameters (ΔST and ΔT), activities of serum creatine kinase (CK), lactate dehydrogenase (LDH), and levels of serum nitric oxide (NO), malondialdehyde (MDA), and myocardium Caspase-3 mRNA, SOCS-1, SOCS-3, tumor nec...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2677-1
更新日期:2013-10-01 00:00:00
abstract::1-aminocyclopropane-1-carboxylic acid oxidase (ACO) enzyme is a member of the Fe II-dependent family of oxidases/oxygenases which require Fe(2+) as a cofactor, ascorbate as a cosubstrate and CO(2) as an activator. This enzyme catalyses the terminal step in the plant signaling of ethylene biosynthetic pathway. A 948 bp...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2178-7
更新日期:2013-02-01 00:00:00
abstract::The ATP-binding cassette transporter ABCG2 (also known as breast cancer resistance protein, BCRP) belongs to the ATP-binding cassette (ABC) family of transmembrane drug transporters, playing a crucial role in the protection of various cells and tissues against xenotoxins and/or endotoxins. Recently, several studies ha...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-9955-y
更新日期:2011-06-01 00:00:00
abstract::The complete mitochondrial genome of Pseudochauhanea macrorchis was determined and compared with other monogenean mitochondrial genomes from GenBank. The circular genome was 15,031 bp in length and encoded 36 genes (12 protein-coding genes, two ribosomal RNAs, and 22 transfer RNAs) typically found in flatworms. Struct...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1659-z
更新日期:2012-08-01 00:00:00
abstract::Rat liver chromatin activated by partial hepatectomy is more susceptible to the action of DNAse I than control chromatin isolated from intact liver. The study on the transfer of chromatin material to the acid-soluble fraction reveals a higher rate of activated chromatin degradation. Activated chromatin shows also an i...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00782891
更新日期:1979-12-31 00:00:00
abstract::Schizophrenia is a chronic and neuropsychiatric disease that affects about 0.5-1% of the world's population. An increase in dopamine and dopamine D2 receptor (DRD2) gene products has been well described in schizophrenic patients. Several groups have studied the relationship between dopaminergic hyperactivity and cellu...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0244-6
更新日期:2011-02-01 00:00:00
abstract::Recently, differentiated somatic cells had been reprogrammed to pluripotential state in vitro, and various tissue cells had been elicited from those cells. Epigenetic modifications allow differentiated cells to perpetuate the molecular memory needed for the cells to retain their identity. DNA methylation and histone d...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9489-3
更新日期:2010-03-01 00:00:00
abstract::CYP1B1 encodes an estrogen enzyme that oxidizes 17β-estradiol to 4-hydroxyestradiol. The evidence demonstrates there may be a relationship between CYP1B1 and thyroid function. To date, no study has evaluated if genetic polymorphisms that regulate concentrations of serum FT3 and FT4 contribute to Polycyctic Ovary Syndr...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2406-1
更新日期:2013-04-01 00:00:00
abstract::The complete coding sequences of three porcine genes-SDHB, SNRPA and CRYBB1 were amplified using the reverse transcriptase polymerase chain reaction (RT-PCR) based on the conserved coding sequence information of the mouse or other mammals and highly homologous pig ESTs. These three genes were then deposited into GenBa...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9229-0
更新日期:2009-04-01 00:00:00