Effects of polyamines on the first division cycle of Xenopus laevis eggs.

abstract：:Bax∆2 is a functional pro-apoptotic Bax isoform having alterations in its N-terminus, but sharing the rest of its sequence with Baxα. Bax∆2 is unable to target mitochondria due to the loss of helix α1. Instead, it forms cytosolic aggregates and activates caspase 8. However, the functional domain(s) responsible for Bax...

journal_title：Experimental cell research

authors： Mañas A,Wang S,Nelson A,Li J,Zhao Y,Zhang H,Davis A,Xie B,Maltsev N,Xiang J

更新日期：2017-10-15 00:00:00

abstract：:During ovarian folliculogenesis granulosa cells divide while in contact with stromal cells and other granulosa cells. Following ovulation, however, they cease dividing and differentiate into large luteal cells. When cultured in monolayer, granulosa cells spontaneously differentiate into luteal cells, thus confounding ...

journal_title：Experimental cell research

authors： Lavranos TC,Rodgers HF,Bertoncello I,Rodgers RJ

更新日期：1994-04-01 00:00:00

abstract：:The stimulatory heterotrimeric Gs protein alpha subunit (Gsα) is a ubiquitous guanine nucleotide-binding protein that regulates the intracellular cAMP signaling pathway and consequently participates in a wide range of biological events. In the reproductive system, despite Gsα being associated with oocyte meiotic arres...

journal_title：Experimental cell research

authors： Xie Y,Wu B,Jin Y,Zhang A,Sun X,Zhang X,Gao X,Dong R,Li H,Gao J

更新日期：2018-09-15 00:00:00

abstract：:Müller cells are the predominant retinal glial cells. One of the key roles of Müller cells is in the uptake of the neurotransmitter glutamate and in its conversion to glutamine. Müller cell dysfunction due to oxidative stress elicited by high glutamate concentrations can lead to toxicity, which promote the pathogenesi...

journal_title：Experimental cell research

authors： Cheng Z,Zhang T,Zheng J,Ding W,Wang Y,Li Y,Zhu L,Murray M,Zhou F

更新日期：2019-10-01 00:00:00

abstract：:The segregation of the chick-specific HPRT gene was studied in three Chinese hamster-chick red blood cell hybrid lines. The three lines showed individual segregation kinetics, the segregation taking place in an exponential-like fashion. Bromodeoxyuridine becomes incorporated into the nuclear DNA and increases the spon...

journal_title：Experimental cell research

authors： Raskó I,Péter SL,Dallmann L,Bajszár G,Péter S,Burg K

更新日期：1978-05-01 00:00:00

abstract：:New methods have been developed for the purification and characterization of the cell wall degrading enzyme, lysin, which is released into the medium during the mating reaction of the biflagellated alga Chlamydomonas reinhardtii. A quantitative spectrophotometric assay that detects the number of cells losing walls was...

journal_title：Experimental cell research

authors： Buchanan MJ,Snell WJ

更新日期：1988-11-01 00:00:00

abstract：RATIONALE:Vessel formation is a crucial event in tissue repair after injury. Thus, one assumption of innovative therapeutic approaches is the understanding of its molecular mechanisms. Notwithstanding our knowledge of the role of Protein Kinase C epsilon (PKCε) in cardio-protection and vascular restenosis, its role in ...

journal_title：Experimental cell research

authors： Galli D,Carubbi C,Masselli E,Corradi D,Dei Cas A,Nouvenne A,Bucci G,Arcari ML,Mirandola P,Vitale M,Gobbi G

更新日期：2015-01-15 00:00:00

abstract：:Macrophage polarization plays a crucial role in regulating myocardial inflammation and injuries of coxsackievirus B3 (CVB3)-induced viral myocarditis (VM). It has been reported that miR-223 is a potent regulator of inflammatory responses that involved in macrophage polarization. However, the functional roles of miR-22...

journal_title：Experimental cell research

authors： Gou W,Zhang Z,Yang C,Li Y

更新日期：2018-05-01 00:00:00

abstract：:The C6 rat glioma cell line is shown to consist of a mixed population of cells which either contain vimentin (80% of the cells) or completely lack any cytoplasmic intermediate filament (IF) proteins. Subclones could be established with both phenotypes, indicating that these IF protein expression patterns represent sta...

journal_title：Experimental cell research

authors： Röser K,Bohn W,Giese G,Mannweiler K

更新日期：1991-12-01 00:00:00

abstract：:At Day 17 of in ovo development, chondrocyte hypertrophy including synthesis of collagen X takes place in a limited region within the cranial part of chick embryo sternum. Here we analyze in suspension culture the differences in response to single growth factors of chondrocytes derived from the cranial part versus cel...

journal_title：Experimental cell research

authors： Böhme K,Winterhalter KH,Bruckner P

更新日期：1995-01-01 00:00:00

abstract：:In many systems, events participating in cell division are controlled by intracellular pH (pHi). In Xenopus eggs, fertilization is accompanied by an increase in pHi which occurs concomitantly with an increase in protein synthesis and a reinitiation of DNA synthesis, leading the embryo to cell division. In this paper, ...

journal_title：Experimental cell research

authors： Grandin N,Charbonneau M

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Müller cell gliosis not only plays an important physiological role by maintaining retinal neuronal homeostasis but is also associated with multiple pathological events in the retina, including optic nerve crush (ONC) injury. Modulating Müller cell gliosis contributes to the creation of a permissive environme...

journal_title：Experimental cell research

authors： Li HJ,Sun ZL,Pan YB,Sun YY,Xu MH,Feng DF

更新日期：2019-02-15 00:00:00

abstract：:Fluorescence hybridization is a widely used technique in cell biology and pathology for detecting specific nucleic acid (DNA and RNA) sequences in fixed cells. This technique does not, however, provide dynamic information on the intracellular behavior of the targeted molecules. The aim of this work was to investigate ...

journal_title：Experimental cell research

authors： Paillasson S,Van De Corput M,Dirks RW,Tanke HJ,Robert-Nicoud M,Ronot X

更新日期：1997-02-25 00:00:00

abstract：:Prenucleolar bodies (PNBs) are transitory structures which serve as building blocks for nucleoli at the transition mitosis/interphase. The assembly of PNBs and their pathway are not clearly understood. To better understand these events, the behavior of the PNB-containing PM-Scl 100 protein was compared with that of ot...

journal_title：Experimental cell research

authors： Fomproix N,Hernandez-Verdun D

更新日期：1999-09-15 00:00:00

abstract：:Hepatoblastoma (HB) is a rare malignant embryonal liver tumor. Its pathogenesis has been associated with altered regulation of the IGF2 and H19 genes, and previous studies have suggested a correlation between abnormal methylation and altered expression of these genes in hepatoblastoma. Upregulation of the activity of ...

journal_title：Experimental cell research

authors： Eriksson T,Frisk T,Gray SG,von Schweinitz D,Pietsch T,Larsson C,Sandstedt B,Ekström TJ

更新日期：2001-10-15 00:00:00

abstract：:The K63-linked ubiquitination of RIP1 coordinates survival/death homeostasis by driving transcription of genes downstream of RelA. Previously, we demonstrated that EGF-dependent RelA transactivation overcomes hypoxia-initiated apoptosis, yet the underlying mechanisms remain mysterious. We report here that UBXN1 defici...

journal_title：Experimental cell research

authors： Song YK,Hu BC,Xu L,Liu JQ,Chen X,Zheng Y,Chen MH,Wang JZ,Sun RH,Mo SJ

更新日期：2019-05-01 00:00:00

abstract：:Pathological cardiac hypertrophy is a maladaptive response in a variety of organic heart disease (OHD), which is characterized by mitochondrial dysfunction that results from disturbed energy metabolism. SIRT3, a mitochondria-localized sirtuin, regulates global mitochondrial lysine acetylation and preserves mitochondri...

journal_title：Experimental cell research

authors： Yue Z,Ma Y,You J,Li Z,Ding Y,He P,Lu X,Jiang J,Chen S,Liu P

更新日期：2016-10-01 00:00:00

abstract：:The Cdc25 phosphatases play crucial roles in cell cycle progression by removing inhibitory phosphates from tyrosine and threonine residues of cyclin-dependent kinases. Cdc25A is an important regulator of the G1/S transition but functions also in the mitotic phase of the human cell cycle. In this paper, we investigate ...

journal_title：Experimental cell research

authors： Källström H,Lindqvist A,Pospisil V,Lundgren A,Rosenthal CK

更新日期：2005-02-01 00:00:00

abstract：:The insoluble cytoskeletal material remaining after detergent lysis of 'Normal' Murine Mammary Gland (NMuMG) cells, growing on plastic or collagen gel substrata, was analyzed by two-dimensional gel electrophoresis. The identity of the cytoskeletal elements was determined by their solubility properties, electrophoretic...

journal_title：Experimental cell research

authors： Hall HG,Bissell MJ

更新日期：1986-02-01 00:00:00

abstract：:Ring finger protein 6 (RNF6), a RING-domain E3 ubiquitin Ligase, functions as a potential tumor promoter in several caners. However, the function and clinical significance of RNF6 in hepatocellular carcinoma (HCC) remains unclear. Here, we found that high RNF6 expression was detected frequently in primary HCC tissues,...

journal_title：Experimental cell research

authors： Cai J,Xiong Q,Jiang X,Zhou S,Liu T

更新日期：2019-01-01 00:00:00

abstract：:A sufficient supply molecular oxygen is essential for the maintenance of physiologic metabolism and bioenergetic homeostasis for most metazoans. For this reason, mechanisms have evolved for eukaryotic cells to adapt to conditions where oxygen demand exceeds supply (hypoxia). These mechanisms rely on the modification o...

journal_title：Experimental cell research

authors： Cavadas MAS,Cheong A,Taylor CT

更新日期：2017-07-15 00:00:00

abstract：:Melanoma development is a multi-step process arising from a series of genetic and epigenetic events. Although the sequential stages involved in progression from melanocytes to malignant melanoma are clearly defined, our current understanding of the mechanisms leading to melanoma onset is still incomplete. Growing evid...

journal_title：Experimental cell research

authors： Serafino A,Balestrieri E,Pierimarchi P,Matteucci C,Moroni G,Oricchio E,Rasi G,Mastino A,Spadafora C,Garaci E,Vallebona PS

更新日期：2009-03-10 00:00:00

abstract：:Two SV40-transformed human cell lines, GM637, derived from a normal human subject, and GM5849, derived from a patient with ataxia-telangiectasia (A-T), were grown in increasing concentrations of the cytotoxic agent methotrexate (MTX). The GM637 line was naturally more resistant to methotrexate than was GM5849 and, ove...

journal_title：Experimental cell research

authors： Hahn P,Kapp LN,Painter RB

更新日期：1987-01-01 00:00:00

abstract：:The effects of hormonal promotion of T24-ras oncogene-transfected rat embryo fibroblasts (REF) were compared to cotransformation of these cells with adenovirus E1A and ras. Cotransfection of E1A + ras resulted in the appearance of morphologically transformed cells which were very efficiently established into cell line...

journal_title：Experimental cell research

authors： Marshall H,Martens I,Svensson C,Akusjärvi G,Linder S

更新日期：1991-05-01 00:00:00

abstract：:The male fetal lung begins to synthesize surfactant later in gestation than the female. This delay appears to be caused by androgens. We hypothesized that male fetal lung differentiation is delayed as a consequence of an extended phase of growth which is elicited by androgens. We observed that in vivo fetal lung prote...

journal_title：Experimental cell research

authors： Nielsen HC,Kirk WO,Sweezey N,Torday JS

更新日期：1990-05-01 00:00:00

abstract：:Incubating conditions which induced actin paracrystal-like intracellular structures (actin rods) were investigated by using several cell lines. We have found that an incubation of cells of a mouse fibroblastic cell line, C3H-2K, in an isotonic solution of NaCl containing 1 mM MgCl2, 1 mM CaCl2 and 10 mM MES, pH 6.5, i...

journal_title：Experimental cell research

authors： Iida K,Yahara I

更新日期：1986-06-01 00:00:00

abstract：:We have previously shown that following psoralen photoactivation (PUVA treatment) human dermal fibroblasts undergo long-term growth arrest as well as morphological and functional changes reminiscent of cellular senescence [ 1 ]. In the absence of molecular data on what constitutes normal senescence, it has been diffic...

journal_title：Experimental cell research

authors： Ma W,Wlaschek M,Brenneisen P,Schneider LA,Hommel C,Hellweg C,Sauer H,Wartenberg M,Herrmann G,Meewes C,Boukamp P,Scharffetter-Kochanek K

更新日期：2002-04-01 00:00:00

abstract：:Previous studies have established that Schwann cells (SC) in culture express an NGF receptor. In this study, cultures of fetal human SC were established from fetal nerves and various light microscopic (LM) and electron microscopic (EM) techniques were used to localize the NGF receptor on the SC. Results indicate that ...

journal_title：Experimental cell research

authors： Assouline JG,Pantazis NJ

更新日期：1989-06-01 00:00:00

abstract：:Synthetic tubugis are equally potent but more stable than their natural forms. Their anticancer potential was estimated on a solid melanoma in vitro and in vivo. Tubugi-1 induced the apoptosis in B16 cells accompanied with strong intracellular production of reactive species, subsequently imposing glutathione and thiol...

journal_title：Experimental cell research

authors： Drača D,Mijatović S,Krajnović T,Pristov JB,Đukić T,Kaluđerović GN,Wessjohann LA,Maksimović-Ivanić D

更新日期：2019-07-15 00:00:00

abstract：:Coagulation Factor (F)Xa is a serine protease that plays a crucial role during blood coagulation by converting prothrombin into active thrombin. Recently, however, it emerged that besides this role in coagulation, FXa induces intracellular signaling leading to different cellular effects. Here, we show that coagulation...

journal_title：Experimental cell research

authors： Borensztajn KS,Bijlsma MF,Groot AP,Brüggemann LW,Versteeg HH,Reitsma PH,Peppelenbosch MP,Spek CA

更新日期：2007-07-15 00:00:00