Effect of indomethacin on the incidence of experimental Escherichia coli pyelonephritis.

abstract：:Anthrax lethal toxin (LeTx), consisting of protective antigen (PA) and lethal factor (LF), rapidly kills primary mouse macrophages and macrophage-like cell lines such as RAW 264.7. LF is translocated by PA into the cytosol of target cells, where it acts as a metalloprotease to cleave mitogen-activated protein kinase k...

journal_title：Infection and immunity

authors： Tang G,Leppla SH

更新日期：1999-06-01 00:00:00

abstract：:Controversy persists over the role that the capsular polysaccharide plays in the pathogenesis of Staphylococcus aureus infections. To address this issue, we compared the mouse virulence of S. aureus Reynolds and capsule-defective mutant strains cultivated under conditions of high or low capsule expression. Strain Reyn...

journal_title：Infection and immunity

authors： Thakker M,Park JS,Carey V,Lee JC

更新日期：1998-11-01 00:00:00

abstract：:Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely ...

journal_title：Infection and immunity

authors： Keller CC,Kremsner PG,Hittner JB,Misukonis MA,Weinberg JB,Perkins DJ

更新日期：2004-08-01 00:00:00

abstract：:Clostridium perfringens type B causes enteritis and enterotoxemia in domestic animals. By definition, these bacteria must produce alpha toxin (CPA), beta toxin (CPB) and epsilon toxin (ETX) although most type B strains also produce perfringolysin O (PFO) and beta2 toxin (CPB2). A recently identified Agr-like quorum-se...

journal_title：Infection and immunity

authors： Chen J,McClane BA

更新日期：2012-09-01 00:00:00

abstract：:We previously demonstrated that plasmid-deficient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2). We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx...

journal_title：Infection and immunity

authors： O'Connell CM,AbdelRahman YM,Green E,Darville HK,Saira K,Smith B,Darville T,Scurlock AM,Meyer CR,Belland RJ

更新日期：2011-03-01 00:00:00

abstract：:The scrub typhus 58-kilodalton (kDa) antigen (Sta58) of Rickettsia tsutsugamushi is a major protein antigen often recognized by humans infected with scrub typhus rickettsiae. A 2.9-kilobase HindIII fragment containing a complete sta58 gene was cloned in Escherichia coli and found to express the entire Sta58 antigen an...

journal_title：Infection and immunity

authors： Stover CK,Marana DP,Dasch GA,Oaks EV

更新日期：1990-05-01 00:00:00

abstract：:Four pneumococcal genes (phtA, phtB, phtD, and phtE) encoding a novel family of homologous proteins (32 to 87% identity) were identified from the Streptococcus pneumoniae genomic sequence. These open reading frames were selected as potential vaccine candidates based upon their possession of hydrophobic leader sequence...

journal_title：Infection and immunity

authors： Adamou JE,Heinrichs JH,Erwin AL,Walsh W,Gayle T,Dormitzer M,Dagan R,Brewah YA,Barren P,Lathigra R,Langermann S,Koenig S,Johnson S

更新日期：2001-02-01 00:00:00

abstract：:Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clus...

journal_title：Infection and immunity

authors： Russell-Lodrigue KE,Andoh M,Poels MW,Shive HR,Weeks BR,Zhang GQ,Tersteeg C,Masegi T,Hotta A,Yamaguchi T,Fukushi H,Hirai K,McMurray DN,Samuel JE

更新日期：2009-12-01 00:00:00

abstract：:An inhibitory factor from Actinobacillus actinomycetemcomitans Y4 was isolated, and its properties indicated that it was a bacteriocin (actinobacillicin). The bacteriocin was active against Streptococcus sanguis strains, Streptococcus uberis (FDC1), and Actinomyces viscosus T14 as well as other strains of A. actinomyc...

journal_title：Infection and immunity

authors： Hammond BF,Lillard SE,Stevens RH

更新日期：1987-03-01 00:00:00

abstract：:In bacterial infections, mononuclear and polymorphonuclear phagocytes are key components of host defenses. Recent investigations have indicated that chemokines are able to recruit and activate phagocytes. In particular, interleukin-8 (IL-8) attracts polymorphonuclear leukocytes (PMNs), while monocyte chemoattractant p...

journal_title：Infection and immunity

authors： Tonetti MS,Imboden MA,Gerber L,Lang NP,Laissue J,Mueller C

更新日期：1994-09-01 00:00:00

abstract：:Fusobacterium nucleatum is a common oral anaerobe involved in periodontitis that is known to translocate and cause intrauterine infections. In the oral environment, F. nucleatum adheres to a large diversity of species, facilitating their colonization and creating biological bridges that stabilize the multispecies dent...

journal_title：Infection and immunity

authors： Coppenhagen-Glazer S,Sol A,Abed J,Naor R,Zhang X,Han YW,Bachrach G

更新日期：2015-03-01 00:00:00

abstract：:Current evidence indicates that Mycobacterium avium infection in patients with AIDS is acquired mostly through the gastrointestinal (GI) tract and that M. avium binds to and invades GI mucosal cells in vitro. Since M. avium is exposed to specific environmental conditions in the GI tract such as changes in pH, low oxyg...

journal_title：Infection and immunity

authors： Bermudez LE,Petrofsky M,Goodman J

更新日期：1997-09-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a major cause of traveler's diarrhea as well as of endemic diarrhea and stunting in children in developing areas. However, a small-mammal model has been badly needed to better understand and assess mechanisms, vaccines, and interventions. We report a murine model of ETEC diar...

journal_title：Infection and immunity

authors： Bolick DT,Medeiros PHQS,Ledwaba SE,Lima AAM,Nataro JP,Barry EM,Guerrant RL

更新日期：2018-06-21 00:00:00

abstract：:Oral spirochetes possess many potential virulence factors, including the capacity for tissue invasion and persistence despite a vigorous host immune response. In an attempt to identify treponemal immunoreactive components, sera derived from individuals with advanced periodontal disease were used as a reagent to isolat...

journal_title：Infection and immunity

authors： Heinzerling HF,Olivares M,Burne RA

更新日期：1997-06-01 00:00:00

abstract：:Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...

journal_title：Infection and immunity

authors： Pitts MG,Combs TA,D'Orazio SEF

更新日期：2018-03-22 00:00:00

abstract：:Menstrually associated toxic shock syndrome (TSS) is attributed primarily to the effects of staphylococcal exotoxin toxic shock syndrome toxin 1 (TSST-1). A region of the 194-amino-acid toxin spanning residues 115 through 144 constitutes a biologically active site. Several point mutations in the TSST-1 gene in that re...

journal_title：Infection and immunity

authors： Bonventre PF,Heeg H,Cullen C,Lian CJ

更新日期：1993-03-01 00:00:00

abstract：:Ferrets which had been orally dosed with 5 mg of Staphylococcal enterotoxin B (SEB) responded with an increase in subcutaneous temperature. At 75 min, the subcutaneous temperature was significantly higher (+ 0.9 degrees C +/- 0.38 degrees C, P < 0.007) than in control animals. Animals dosed with 1 or 2 mg of SEB respo...

journal_title：Infection and immunity

authors： Wright A,Andrews PL,Titball RW

更新日期：2000-04-01 00:00:00

abstract：:The role of antibody in protection against infection with Cryptococcus neoformans is undefined. In this paper we describe the development of opsonic activity in the cerebrospinal fluid (CSF) of rabbits in response to cryptococcal meningitis. The opsonin appeared to be immunoglobulin G (IgG); the activity was heat stab...

journal_title：Infection and immunity

authors： Hobbs MM,Perfect JR,Granger DL,Durack DT

更新日期：1990-07-01 00:00:00

abstract：:Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium Anaplasma phagocytophilum. The critical role of gamma interferon (IFN-gamma) for induction of severe inflammatory histopathology, even in the absence of a significant bacterial load, was previously demonstrated in a murine model of...

journal_title：Infection and immunity

authors： Choi KS,Webb T,Oelke M,Scorpio DG,Dumler JS

更新日期：2007-06-01 00:00:00

abstract：:Changes in periodontal status are associated with shifts in the composition of the bacterial community in the periodontal pocket. The relative abundances of several newly recognized microbial species, including Filifactor alocis, as-yet-unculturable organisms, and other fastidious organisms have raised questions on th...

journal_title：Infection and immunity

authors： Aruni AW,Zhang K,Dou Y,Fletcher H

更新日期：2014-08-01 00:00:00

abstract：:Live or heat-killed cells of Streptococcus mutans specifically adhere to dextran previously synthesized on glass surfaces by the action of extracellular dextransucrase. ...

journal_title：Infection and immunity

authors： Kuramitsu HK

更新日期：1974-04-01 00:00:00

abstract：:Pseudomonas aeruginosa can invade corneal epithelial cells and translocates multilayered corneal epithelia in vitro, but it does not penetrate the intact corneal epithelium in vivo. In healthy corneas, the epithelium is separated from the underlying stroma by a basement membrane containing extracellular matrix protein...

journal_title：Infection and immunity

authors： Alarcon I,Kwan L,Yu C,Evans DJ,Fleiszig SM

更新日期：2009-08-01 00:00:00

abstract：:This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of CD4+ T cells by in vivo...

journal_title：Infection and immunity

authors： Hörnqvist E,Goldschmidt TJ,Holmdahl R,Lycke N

更新日期：1991-10-01 00:00:00

abstract：:The purpose of this investigation was to examine gamma interferon potentiation of lipopolysaccharide (LPS) responses in human monocytes by using phenol-water-extracted (unfractionated) and highly purified LPS preparations isolated from Bacteroides intermedius and Salmonella typhimurium. Phenol-water-extracted LPS prep...

journal_title：Infection and immunity

authors： Nichols FC,Peluso JF,Tempro PJ,Garrison SW,Payne JB

更新日期：1991-01-01 00:00:00

abstract：:Adoptive immunity is poorly expressed in normal syngeneic mice. This phenomenon was studied by using experimental antituberculosis immunity as a model system representing pure cell-mediated immunity. Expression of adoptive immunity was facilitated by pretreating recipients with sublethal ionizing radiation (500 rads) ...

journal_title：Infection and immunity

authors： Lefford MJ

更新日期：1983-07-01 00:00:00

abstract：:Salmonellae possess the ability to adhere to and invade macrophages and in so doing trigger a number of intracellular events that are associated with cellular activation. As an initial approach to defining the mechanisms by which invasive salmonellae alter macrophage function, we have explored the impact of Salmonella...

journal_title：Infection and immunity

authors： Mizel SB,Kucera LS,Richardson SH,Ciacci F,Iyer NP

更新日期：1995-05-01 00:00:00

abstract：:Salmonella typhimurium SH5014 porins induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin 1 alpha (IL-1 alpha), and IL-6 by human monocytes and of gamma interferon (IFN-gamma) and IL-4 by human lymphocytes. Porins at 1 microgram/ml induce the greatest release of TNF-alpha, IL-1 alpha, and IL-6 by...

journal_title：Infection and immunity

authors： Galdiero F,de L'ero GC,Benedetto N,Galdiero M,Tufano MA

更新日期：1993-01-01 00:00:00

abstract：:Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is transferable with bone marrow dendritic cells (BMDCs). SFB cause an increase in serum amyloid A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs. Here we further explored the role of bone marrow in SFB-mediat...

journal_title：Infection and immunity

authors： Burgess SL,Saleh M,Cowardin CA,Buonomo E,Noor Z,Watanabe K,Abhyankar M,Lajoie S,Wills-Karp M,Petri WA Jr

更新日期：2016-09-19 00:00:00

abstract：:Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a strong Th1 response that leads to skin lesion development. In areas where L. braziliensis transmission is endemic, up to 15% of healthy subjects have tested positive for delayed-type hypersensitivity to soluble leishmania antigen (SLA...

journal_title：Infection and immunity

authors： Cardoso TM,Machado Á,Costa DL,Carvalho LP,Queiroz A,Machado P,Scott P,Carvalho EM,Bacellar O

更新日期：2015-03-01 00:00:00

abstract：:The superoxide anion (O2-)-generating activity of guinea pig macrophages stimulated by wheat germ agglutinin (WGA), immune complexes, or phorbol myristate acetate (PMA) was studied after short- and long-term exposures of the cells to muramyl dipeptide (MDP) or lipopolysaccharide (LPS). Neither MDP nor LPS alone induce...

journal_title：Infection and immunity

authors： Yagawa K,Kaku M,Ichinose Y,Nagao S,Tanaka A,Tomoda A

更新日期：1984-07-01 00:00:00