The effect of gyrase inhibitors and cyclic AMP on induction and glucose repression of the 6-hydroxy-nicotine oxidases in Arthrobacter oxidans.

Abstract:

:The induction by D,L-nicotine of the enantiozymes 6-hydroxy-L-nicotine oxidase and 6-hydroxy-D-nicotine oxidase in Arthrobacter oxidans was differently affected by the inhibitors of Escherichia coli gyrase, novobiocin and nalidixic acid. These compounds inhibited 6-hydroxy-L-nicotine oxidase induction slightly, but led to an increase in the level of 6-hydroxy-D-nicotine oxidase activity. Furthermore, the specific repression by glucose of 6-hydroxy-D-nicotine oxidase synthesis was not abolished by the addition of cAMP but by that of novobiocin.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Brandsch R,Decker K

doi

10.1007/BF00521289

subject

Has Abstract

pub_date

1982-12-03 00:00:00

pages

274-7

issue

4

eissn

0302-8933

issn

1432-072X

journal_volume

133

pub_type

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