Abstract:
:The beta-globin gene of a patient with mRNA-deficient beta o-thalassemia has been sequenced. We find a single nucleotide deletion in amino acid codon 44 that produces a UGA terminator at codon 60. We have previously shown that the beta-globin mRNA of this patient is correctly spliced and polyadenylated, but rapidly turns over with a half-life of less than 30 min. We suggest that the rapid mRNA turnover is influenced by the deletion of this single nucleotide as well as by the nonsense codon.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Kinniburgh AJ,Maquat LE,Schedl T,Rachmilewitz E,Ross Jdoi
10.1093/nar/10.18.5421subject
Has Abstractpub_date
1982-09-25 00:00:00pages
5421-7issue
18eissn
0305-1048issn
1362-4962journal_volume
10pub_type
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journal_title:Nucleic acids research
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更新日期:2010-07-01 00:00:00
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journal_title:Nucleic acids research
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