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Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.

Abstract：

:Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data are freely available without restriction. GDSC currently contains drug sensitivity data for almost 75 000 experiments, describing response to 138 anticancer drugs across almost 700 cancer cell lines. To identify molecular markers of drug response, cell line drug sensitivity data are integrated with large genomic datasets obtained from the Catalogue of Somatic Mutations in Cancer database, including information on somatic mutations in cancer genes, gene amplification and deletion, tissue type and transcriptional data. Analysis of GDSC data is through a web portal focused on identifying molecular biomarkers of drug sensitivity based on queries of specific anticancer drugs or cancer genes. Graphical representations of the data are used throughout with links to related resources and all datasets are fully downloadable. GDSC provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Yang W,Soares J,Greninger P,Edelman EJ,Lightfoot H,Forbes S,Bindal N,Beare D,Smith JA,Thompson IR,Ramaswamy S,Futreal PA,Haber DA,Stratton MR,Benes C,McDermott U,Garnett MJ

doi

10.1093/nar/gks1111

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

D955-61

issue

Database issue

eissn

0305-1048

issn

1362-4962

pii

gks1111

journal_volume

41

pub_type

杂志文章

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