Effect of the proline analogue baikiain on proline metabolism in Salmonella typhimurium.

Abstract:

:A proline analogue, 4,5-dehydro-l-pipecolic acid (baikiain) induces the formation in Salmonella typhimurium of the two enzymes catalyzing the degradation of proline, proline oxidase and Delta(1)-pyrroline-5-carboxylic acid (P5C) dehydrogenase. The level of induction by 20 mm baikiain is about 10% of the maximum level induced by proline. Since the analogue is a substrate of proline oxidase the first enzyme of the proline catabolic pathway, the oxidation derivative rather than baikiain itself might be the actual effector. Baikiain is also an inducer of proline oxidase in Escherichia coli K-12 and E. coli W. An additional effect of this analogue on proline degradation in S. typhimurium is inhibition of P5C dehydrogenase. At a concentration of 5 x 10(-4)m, baikiain inhibits completely the growth of strains constitutive for proline oxidase. This inhibition, which can be overcome by proline, occurs in the presence or absence of P5C dehydrogenase activity. Three spontaneously occurring mutants resistant to baikiain were isolated from constitutive strains. All are pleiotropic-negative for the proline-degrading enzymes. The sites of these mutations are linked to the put region. Although the mechanism of toxicity has not been determined, baikiain provides a simple and direct selection for obtaining mutants unable to degrade proline. In addition, it allows selection for strains with an inducible rather than constitutive phenotype.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Dendinger S,Brill WJ

doi

10.1128/JB.112.3.1134-1141.1972

subject

Has Abstract

pub_date

1972-12-01 00:00:00

pages

1134-41

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

112

pub_type

杂志文章
  • Preparations and properties of ribonucleic acid polymerase from Acinetobacter calcoaceticus.

    abstract::Deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase (EC 2.7.7.6) from Acinetobacter calcoaceticus was purified to apparent homogeneity and its properties were compared with those of the Escherichia coli B enzyme. The molecular weights of the two native active enzymes as well as their alpha and beta...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.125.2.435-443.1976

    authors: Kleppe RK,Kleppe K

    更新日期:1976-02-01 00:00:00

  • Purification and properties of pyridoxal-5'-phosphate-dependent histidine decarboxylases from Klebsiella planticola and Enterobacter aerogenes.

    abstract::Histidine decarboxylases from Klebsiella planticola and Enterobacter aerogenes were purified to homogeneity and compared with the histidine decarboxylase from Morganella morganii. All three enzymes required pyridoxal 5'-phosphate as a coenzyme, showed optimal activity at pH 6.5, decarboxylated only histidine among the...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.169.9.3963-3968.1987

    authors: Guirard BM,Snell EE

    更新日期:1987-09-01 00:00:00

  • Transcriptomic analysis of the sulfate starvation response of Pseudomonas aeruginosa.

    abstract::Pseudomonas aeruginosa is an opportunistic pathogen that causes a number of infections in humans, but is best known for its association with cystic fibrosis. It is able to use a wide range of sulfur compounds as sources of sulfur for growth. Gene expression in response to changes in sulfur supply was studied in P. aer...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00889-07

    authors: Tralau T,Vuilleumier S,Thibault C,Campbell BJ,Hart CA,Kertesz MA

    更新日期:2007-10-01 00:00:00

  • Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron.

    abstract:UNLABELLED:The role of chromosomal toxin-antitoxin (TA) systems, which are ubiquitous within the genomes of free-living bacteria, is still debated. We have scanned the Vibrio cholerae N16961 genome for class 2 TA genes and identified 18 gene pair candidates. Interestingly, all but one are located in the chromosome 2 su...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00108-15

    authors: Iqbal N,Guérout AM,Krin E,Le Roux F,Mazel D

    更新日期:2015-07-01 00:00:00

  • EnvZ functions through OmpR to control porin gene expression in Escherichia coli K-12.

    abstract::The regulatory proteins OmpR and EnvZ are both required to activate expression of the genes for the major outer membrane porin proteins, OmpF and OmpC, of Escherichia coli K-12. Here we show that OmpR, under certain conditions, could activate porin expression in the complete absence of EnvZ. In addition, the pleiotrop...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.170.1.439-441.1988

    authors: Slauch JM,Garrett S,Jackson DE,Silhavy TJ

    更新日期:1988-01-01 00:00:00

  • Repression of cytosine deaminase by pyrimidines in Salmonella typhimurium.

    abstract::The synthesis of cytosine deaminase in Salmonella typhimurium is repressed by pyrimidines. This repression is mediated by both a uridine and a cytidine compound, indicating a distinct difference in the regulation of synthesis of cytosine deaminase from the regulation of the de novo pyrimidine pathway enzymes. A salvag...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.149.3.1171-1174.1982

    authors: West TP,O'Donovan GA

    更新日期:1982-03-01 00:00:00

  • Polyethylene glycol-facilitated transformation of Bacteroides fragilis with plasmid DNA.

    abstract::A method for the transformation of Bacteroides fragilis with plasmid DNA was developed by using the clindamycin resistance plasmid pBFTM10 as the source of transforming DNA. The method was technically simple to perform and resulted in an average of 4.2 X 10(3) transformants per microgram of pBFTM10 added. A method for...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.164.1.466-469.1985

    authors: Smith CJ

    更新日期:1985-10-01 00:00:00

  • Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A.

    abstract::Chloromuconate cycloisomerases of bacteria utilizing chloroaromatic compounds are known to convert 3-chloro-cis,cis-muconate to cis-dienelactone (cis-4-carboxymethylenebut-2-en-4-olide), while usual muconate cycloisomerases transform the same substrate to the bacteriotoxic protoanemonin. Formation of protoanemonin req...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.183.15.4551-4561.2001

    authors: Kaulmann U,Kaschabek SR,Schlömann M

    更新日期:2001-08-01 00:00:00

  • Isolation and analysis of the Xanthomonas alkyl hydroperoxide reductase gene and the peroxide sensor regulator genes ahpC and ahpF-oxyR-orfX.

    abstract::From Xanthomonas campestris pv. phaseoli, we have isolated by two independent methods genes involved in peroxide detoxification (ahpC and ahpF), a gene involved in peroxide sensing and transcription regulation (oxyR), and a gene of unknown function (orfX). Amino acid sequence analysis of AhpC, AhpF, and OxyR showed hi...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.179.12.3944-3949.1997

    authors: Loprasert S,Atichartpongkun S,Whangsuk W,Mongkolsuk S

    更新日期:1997-06-01 00:00:00

  • Draft genome sequence of Gordonia neofelifaecis NRRL B-59395, a cholesterol-degrading actinomycete.

    abstract::We report a draft sequence of the genome of Gordonia neofelifaecis NRRL B-59395, a cholesterol-degrading actinomycete isolated from fresh feces of a clouded leopard (Neofelis nebulosa). As predicted, the reported genome contains several gene clusters for cholesterol degradation. This is the second available genome seq...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.05531-11

    authors: Ge F,Li W,Chen G,Liu Y,Zhang G,Yong B,Wang Q,Wang N,Huang Z,Li W,Wang J,Wu C,Xie Q,Liu G

    更新日期:2011-09-01 00:00:00

  • Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling.

    abstract::The nucleotide messenger cyclic di-GMP (c-di-GMP) plays a central role in the regulation of motility, virulence, and biofilm formation in many pathogenic bacteria. EAL domain-containing phosphodiesterases are the major signaling proteins responsible for the degradation of c-di-GMP and maintenance of its cellular level...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00560-12

    authors: Chen MW,Kotaka M,Vonrhein C,Bricogne G,Rao F,Chuah ML,Svergun D,Schneider G,Liang ZX,Lescar J

    更新日期:2012-09-01 00:00:00

  • Contribution of the mannan backbone of cryptococcal glucuronoxylomannan and a glycolytic enzyme of Staphylococcus aureus to contact-mediated killing of Cryptococcus neoformans.

    abstract::The fungal pathogen Cryptococcus neoformans is killed by the bacterium Staphylococcus aureus, and the killing is inhibited by soluble capsular polysaccharides. To investigate the mechanism of killing, cells in coculture were examined by scanning and transmission electron microscopy. S. aureus attached to the capsule o...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00412-07

    authors: Ikeda R,Saito F,Matsuo M,Kurokawa K,Sekimizu K,Yamaguchi M,Kawamoto S

    更新日期:2007-07-01 00:00:00

  • Identification and characterization of IS1411, a new insertion sequence which causes transcriptional activation of the phenol degradation genes in Pseudomonas putida.

    abstract::A new insertion sequence (IS element), IS1411, was identified downstream of the phenol degradation genes pheBA that originated from plasmid DNA of Pseudomonas sp. strain EST1001. According to sequence analysis, IS1411 belongs to a new family of IS elements that has recently been named the ISL3 family (J. Mahillon and ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.180.20.5306-5312.1998

    authors: Kallastu A,Hõrak R,Kivisaar M

    更新日期:1998-10-01 00:00:00

  • Effect of bacteriophage lambda infection on synthesis of groE protein and other Escherichia coli proteins.

    abstract::We used two-dimensional gel electrophoresis to quantitate the changes in rates of synthesis that follow phage lambda infection for 21 Escherichia coli proteins, including groE and dnaK proteins. Although total protein synthesis and the rates of synthesis of most individual E. coli proteins decreased after infection, s...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.149.3.1050-1063.1982

    authors: Drahos DJ,Hendrix RW

    更新日期:1982-03-01 00:00:00

  • The periplasmic, group III catalase of Vibrio fischeri is required for normal symbiotic competence and is induced both by oxidative stress and by approach to stationary phase.

    abstract::The catalase gene, katA, of the sepiolid squid symbiont Vibrio fischeri has been cloned and sequenced. The predicted amino acid sequence of KatA has a high degree of similarity to the recently defined group III catalases, including those found in Haemophilus influenzae, Bacteroides fragilis, and Proteus mirabilis. Ups...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.180.8.2087-2092.1998

    authors: Visick KL,Ruby EG

    更新日期:1998-04-01 00:00:00

  • Expression of a gene in a 400-base-pair fragment of colicin plasmid ColE2-P9 is sufficient to cause host cell lysis.

    abstract::The colicin E2 immunity (ceiB) and lysis (celB) genes of colicin plasmid ColE2-P9 were cloned as a 900-base-pair insert under the control of the lac promoter in high-copy-number plasmid pUR222. Hosts carrying this plasmid were immune to colicin E2, produced increased amounts of immunity protein (molecular weight, 9,00...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.156.1.109-114.1983

    authors: Pugsley AP,Schwartz M

    更新日期:1983-10-01 00:00:00

  • Suppressed nonsense mutations in the araC gene of Escherichia coli provide three novel variant proteins.

    abstract::A total of 400 suppressible mutations have been isolated in the araC gene of Escherichia coli. Based on deletion mapping, growth patterns when suppressed, and intragenic recombination, 37 mutants have been determined to contain unique mutations. Rapid plate assays were developed to test for each of the three AraC prot...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.154.3.1329-1338.1983

    authors: Schecter JB

    更新日期:1983-06-01 00:00:00

  • Cell division mutations in the blue-green bacterium Agmenellum quadruplicatum strain BG1: a comparison of the cell wall.

    abstract::The peptidoglycan from two types of filamentous cell division mutants of Agmenellum quadruplicatum strain BG1 has been compared to that of the parent organism. Small variations in the total peptidoglycan composition on a dry-weight basis were found in the mutants. The reduced level of peptidoglycan in the serpentine m...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.111.2.614-621.1972

    authors: Ingram LO,Van Baalen C,Fisher WD

    更新日期:1972-08-01 00:00:00

  • Negative regulator of sigma G-controlled gene expression in stationary-phase Bacillus subtilis.

    abstract::In some media, Bacillus subtilis can maintain a prolonged stationary growth phase; however, in other media, nutrient depletion triggers a complex differentiation that culminates in production of a dormant endospore. This differentiation requires the expression of many genes. We found that during the stationary phase i...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.172.2.709-715.1990

    authors: Rather PN,Coppolecchia R,DeGrazia H,Moran CP Jr

    更新日期:1990-02-01 00:00:00

  • Proton magnetic resonance spectroscopy of Klebsiella capsular polysaccharides.

    abstract::The presence of acetate and pyruvate groups in Klebsiella capsular polysaccharides may be demonstrated and estimated quantitatively by running the proton magnetic resonance spectrum of the polysaccharide (as sodium salt) in deuterium oxide at 95 C. Such spectra also permit an assessment to be made of the number of alp...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.113.3.1345-1347.1973

    authors: Bebault GM,Choy YM,Dutton GG,Funnell N,Stephen AM,Yang MT

    更新日期:1973-03-01 00:00:00

  • Role of CodY in regulation of the Bacillus subtilis hut operon.

    abstract::Bacillus subtilis mutants deficient in amino acid repression of the histidine utilization (hut) operon were isolated by transposon mutagenesis. Genetic characterization of these mutants indicated that they most likely contained transposon insertions within the codVWXY operon. The codY gene is required for nutritional ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.178.13.3779-3784.1996

    authors: Fisher SH,Rohrer K,Ferson AE

    更新日期:1996-07-01 00:00:00

  • Genetic mapping of arg1 and arg8 in Saccharomyces cerevisiae by trisomic analysis combined with interallelic complementation.

    abstract::Through use of multiply disomic strains, the genes arg1 and arg8 were excluded from all of chromosomes I to XVII except (i) XV and (ii) IX and XV, respectively. Further aneuploid analyses showed that these two genes were on the same chromosome. By tetrad analysis, arg1 was shown to be linked to SUP3 on the left arm of...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.141.1.270-274.1980

    authors: Hilger F,Mortimer RK

    更新日期:1980-01-01 00:00:00

  • Suppression of conformation-compromised mutants of Salmonella enterica serovar Typhimurium MelB.

    abstract::The crystal structure of the Na(+)-coupled melibiose permease of Salmonella enterica serovar Typhimurium (MelBSt) demonstrates that MelB is a member of the major facilitator superfamily of transporters. Arg residues at positions 295, 141, and 363 are involved in interdomain interactions at the cytoplasmic side by gove...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01868-14

    authors: Amin A,Ethayathulla AS,Guan L

    更新日期:2014-09-01 00:00:00

  • Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110.

    abstract::Molecular typing of Mycobacterium tuberculosis by using IS6110 shows low discrimination when there are fewer than five copies of the insertion sequence. Using a collection of such isolates from a study of the epidemiology of tuberculosis in London, we have shown a substantial degree of congruence between IS6110 patter...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.185.8.2555-2562.2003

    authors: Dale JW,Al-Ghusein H,Al-Hashmi S,Butcher P,Dickens AL,Drobniewski F,Forbes KJ,Gillespie SH,Lamprecht D,McHugh TD,Pitman R,Rastogi N,Smith AT,Sola C,Yesilkaya H

    更新日期:2003-04-01 00:00:00

  • Characterization of CamH from Methanosarcina thermophila, founding member of a subclass of the {gamma} class of carbonic anhydrases.

    abstract::The homotrimeric enzyme Mt-Cam from Methanosarcina thermophila is the archetype of the gamma class of carbonic anhydrases. A search of databases queried with Mt-Cam revealed that a majority of the homologs comprise a putative subclass (CamH) in which there is major conservation of all of the residues essential for the...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01164-09

    authors: Zimmerman SA,Tomb JF,Ferry JG

    更新日期:2010-03-01 00:00:00

  • Genome sequence of proteorhodopsin-containing sea ice bacterium Glaciecola punicea ACAM 611T.

    abstract::Here, we report the draft genome sequence of Antarctic sea ice bacterium Glaciecola punicea ACAM 611(T), the type species of the genus Glaciecola. A blue-light-absorbing proteorhodopsin gene is present in the 3.08-Mb genome. This genome sequence can facilitate the study of the physiological metabolisms and ecological ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00463-12

    authors: Qin QL,Xie BB,Shu YL,Rong JC,Zhao DL,Zhang XY,Chen XL,Zhou BC,Zhang YZ

    更新日期:2012-06-01 00:00:00

  • Identification of formate dehydrogenase-specific mRNA species and nucleotide sequence of the fdhC gene of Methanobacterium formicicum.

    abstract::The overlapping fdhA and fdhB genes of Methanobacterium formicicum, which encode the alpha and beta subunits, respectively, of formate dehydrogenase, were cotranscribed as part of an approximately 4.5-kb transcript. An additional gene (fdhC) upstream of fdhA was cotranscribed with fdhA and fdhB. The deduced amino acid...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.174.15.4997-5004.1992

    authors: White WB,Ferry JG

    更新日期:1992-08-01 00:00:00

  • Yield coefficients of Thiobacillus neapolitanus in continuous culture.

    abstract::Thiobacillus neapolitanus, when grown in continuous culture with thiosulfate limiting growth, possessed an apparent maximal molar growth yield of 8.0 g (dry weight) per mole of thiosulfate. The substrate requirement for energy of maintenance was the highest yet reported, amounting to 21.8 mmoles of thiosulfate per g p...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.93.3.874-878.1967

    authors: Hempfling WP,Vishniac W

    更新日期:1967-03-01 00:00:00

  • Rhizobium (Sinorhizobium) meliloti phn genes: characterization and identification of their protein products.

    abstract::In Escherichia coli, the phn operon encodes proteins responsible for the uptake and breakdown of phosphonates. The C-P (carbon-phosphorus) lyase enzyme encoded by this operon which catalyzes the cleavage of C-P bonds in phosphonates has been recalcitrant to biochemical characterization. To advance the understanding of...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.181.2.389-395.1999

    authors: Parker GF,Higgins TP,Hawkes T,Robson RL

    更新日期:1999-01-01 00:00:00

  • Differential expression of two catechol 1,2-dioxygenases in Burkholderia sp. strain TH2.

    abstract::Burkholderia sp. strain TH2, a 2-chlorobenzoate (2CB)-degrading bacterium, metabolizes benzoate (BA) and 2CB via catechol. Two different gene clusters for the catechol ortho-cleavage pathway (cat1 and cat2) were cloned from TH2 and analyzed. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot an...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.184.20.5714-5722.2002

    authors: Suzuki K,Ichimura A,Ogawa N,Hasebe A,Miyashita K

    更新日期:2002-10-01 00:00:00