Effects of phagocytosis and colchicine on the distribution of lectin-binding sites on cell surfaces.

abstract：:Many processes in nature are modeled using compartmental systems (reservoir/pool/box systems). Usually, they are expressed as a set of first-order differential equations describing the transfer of matter across a network of compartments. The concepts of age of matter in compartments and the time required for particles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metzler H,Müller M,Sierra CA

更新日期：2018-02-06 00:00:00

abstract：:In both randomly moving Dictyostelium and mammalian cells, phosphatidylinositol (3,4,5)-trisphosphate and F-actin are known to propagate as waves at the membrane and act to push out the protruding edge. To date, however, the relationship between the wave geometry and the patterns of amoeboid shape change remains elusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi D,Ishihara S,Oonuki T,Honda-Kitahara M,Kaneko K,Sawai S

更新日期：2013-03-26 00:00:00

abstract：:Charcot-Marie-Tooth disease type 4C (CMT4C) is an early-onset, autosomal recessive form of demyelinating neuropathy. The clinical manifestations include progressive scoliosis, delayed age of walking, muscular atrophy, distal weakness, and reduced nerve conduction velocity. The gene mutated in CMT4C disease, SH3TC2/KIA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnaud E,Zenker J,de Preux Charles AS,Stendel C,Roos A,Médard JJ,Tricaud N,Kleine H,Luscher B,Weis J,Suter U,Senderek J,Chrast R

更新日期：2009-10-13 00:00:00

abstract：:In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase accompanied by higher Beck Depression Inventory and seasonality s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang L,Hirano A,Hsu PK,Jones CR,Sakai N,Okuro M,McMahon T,Yamazaki M,Xu Y,Saigoh N,Saigoh K,Lin ST,Kaasik K,Nishino S,Ptáček LJ,Fu YH

更新日期：2016-03-15 00:00:00

abstract：:A determinanat for chloramphenicol resistance, cam, initially detected on a resistance transfer factor (RTF) and since transferred to phage P1, may be acquired from P1 by coliphage lambda. Lambdapcam are obtained when a lambda prophage is induced in bacteria which also harbor P1 cam prophage. Lambdacam formation is no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gottesman MM,Rosner JL

更新日期：1975-12-01 00:00:00

abstract：:Eukaryotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA mismatch repair (MMR). Nucleotide selectivity and proofreading are affected by the balance and concentration of deoxyribonucleotide (dNTP) pools, which are strictly regulated by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt TT,Reyes G,Gries K,Ceylan CÜ,Sharma S,Meurer M,Knop M,Chabes A,Hombauer H

更新日期：2017-05-30 00:00:00

abstract：:The potential involvement of ceramide-related signaling processes in the induction of apoptosis by tumor necrosis factor alpha was assessed by multiple biochemical strategies in the human leukemic cell lines HL-60 and U937 and the murine fibrosarcoma cell lines L929/LM and WEHI 164/13. Exposure of these cells to tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis WD,Kolesnick RN,Fornari FA,Traylor RS,Gewirtz DA,Grant S

更新日期：1994-01-04 00:00:00

abstract：:The GroE chaperonins assist substrate protein (SP) folding by cycling through several conformational states. With each cycle the SP is, in turn, captured, unfolded, briefly encapsulated (t1/2 ∼ 1 s), and released by the chaperonin complex. The protein-folding functional form is the US-football-shaped GroEL:GroES2 comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fei X,Ye X,LaRonde NA,Lorimer GH

更新日期：2014-09-02 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve in anesthetized guinea pigs induced a rapid increase in respiratory insufflation pressure, suggesting increased airway resistance. After intravenous administration of a substance P (SP) antagonist, [D-Arg(1),D-Pro(2),D-Trp(7,9),Leu(11)]SP, the insufflation pressure re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundberg JM,Saria A,Brodin E,Rosell S,Folkers K

更新日期：1983-02-01 00:00:00

abstract：:Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jönsson H,Heisler MG,Shapiro BE,Meyerowitz EM,Mjolsness E

更新日期：2006-01-31 00:00:00

abstract：:Biological carbon fixation is limited by the supply of Fe in vast regions of the global ocean. Dissolved Fe in seawater is primarily sourced from continental mineral dust, submarine hydrothermalism, and sediment dissolution along continental margins. However, the relative contributions of these three sources to the Fe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horner TJ,Williams HM,Hein JR,Saito MA,Burton KW,Halliday AN,Nielsen SG

更新日期：2015-02-03 00:00:00

abstract：:Antibodies to chromatin proteins of Novikoff hepatoma cells formed precipitin bands in the double-diffusion immunoprecipitation assay with chromatin proteins of Novikoff hepatoma, Walker 256 carcinosarcoma, and 18-day fetal rat liver. The antigen used for preparation of antiserum was the chromatin proteins initially e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeoman LC,Jordan JJ,Busch RK,Taylor CW,Savage HE,Busch H

更新日期：1976-09-01 00:00:00

abstract：:In the cytoplasm of well-spread cultured normal fibroblasts, actin is organized into a network of cables that run the length of the cell just inside the adherent cell membrane. A diffuse matrix replaces the cables in fibroblasts that have become tumorigenic as a result of oncogenic transformation. We have found a simi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopelovich L,Conlon S,Pollack R

更新日期：1977-07-01 00:00:00

abstract：:Hepatitis E virus is responsible for both sporadic and epidemic hepatitis in developing countries. The nonenveloped virus is 27-34 nm in diameter and has been shown to contain a single-strand, positive-sense, polyadenylylated RNA genome of approximately 7.5 kilobases. The nucleotide sequence of the Burma strain of hep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaur M,Hyams KC,Purdy MA,Krawczynski K,Ching WM,Fry KE,Reyes GR,Bradley DW,Carl M

更新日期：1992-05-01 00:00:00

abstract：:Heme oxygenase (decyclizing) [heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating), EC 1.14.99.3] is greatly induced in the kidney by the administration of nickel or tin. Manganese, when administered simultaneously with nickel or tin in an equimolar amount, substantially inhibited the ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drummond GS,Kappas A

更新日期：1979-10-01 00:00:00

abstract：:Surface topography profoundly influences cell adhesion, differentiation, and stem cell fate control. Numerous studies using a variety of materials demonstrate that nanoscale topographies change the intracellular organization of actin cytoskeleton and therefore a broad range of cellular dynamics in live cells. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lou HY,Zhao W,Li X,Duan L,Powers A,Akamatsu M,Santoro F,McGuire AF,Cui Y,Drubin DG,Cui B

更新日期：2019-11-12 00:00:00

abstract：:To test whether a 30S ribosomal subunitformylmethionyl-tRNA-mRNA complex is an obligatory intermediate in protein synthesis, 70S ribosomes from Escherichia coli were crosslinked with the bifunctional imidoester, dimethylsuberimidate. Crosslinked ribosomes contained covelently joined 30S and 50S subunits, as judged by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slobin LI

更新日期：1972-12-01 00:00:00

abstract：:Toxin-antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging from plasmid stabilization to biofilm formation and persistence. In these systems, the expression/activity of the toxin is counteracted by an antitoxin, which, in type I systems, is an antisense RNA. While the regulatory me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Mortaji L,Tejada-Arranz A,Rifflet A,Boneca IG,Pehau-Arnaudet G,Radicella JP,Marsin S,De Reuse H

更新日期：2020-12-08 00:00:00

abstract：:Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Crowther RA,Jakes R,Hasegawa M,Goedert M

更新日期：1998-05-26 00:00:00

abstract：:Human C5a, a complement-derived anaphylatoxin, is a potent mediator of human leukocyte chemotaxis. Using a homogeneous preparation of C5a that was 125I-labeled, we have demonstrated the presence of a specific cellular receptor for this glycoprotein on intact human polymorphonuclear leukocytes. Cellular uptake of the r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chenoweth DE,Hugli TE

更新日期：1978-08-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family has recently expanded by the identification and cloning of three additional members, namely VEGF-B, VEGF-C, and VEGF-D. In this study we demonstrate that VEGF-B binds selectively to VEGF receptor-1/Flt-1. This binding can be blocked by excess VEGF, indicating that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olofsson B,Korpelainen E,Pepper MS,Mandriota SJ,Aase K,Kumar V,Gunji Y,Jeltsch MM,Shibuya M,Alitalo K,Eriksson U

更新日期：1998-09-29 00:00:00

abstract：:Livers of a natural population of winter flounder from a contaminated site in Boston Harbor were examined for the presence of oncogenes by transfection of DNA into NIH 3T3 mouse fibroblasts. Tissues analyzed contained histopathologic lesions including abnormal vacuolation, biliary proliferation, and, in many cases, he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMahon G,Huber LJ,Moore MJ,Stegeman JJ,Wogan GN

更新日期：1990-01-01 00:00:00

abstract：:The Raf-1 serine/threonine kinase is a key protein involved in the transmission of many growth and developmental signals. In this report, we show that autoinhibition mediated by the noncatalytic, N-terminal regulatory region of Raf-1 is an important mechanism regulating Raf-1 function. The inhibition of the regulatory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cutler RE Jr,Stephens RM,Saracino MR,Morrison DK

更新日期：1998-08-04 00:00:00

abstract：:We investigated the effects of beta-estradiol on the locomotor behavior of female mice in a radial maze. Data comprising the total distance traveled during each arm entry were obtained from video records of six consecutive daily recording sessions. Distributions of these data were bimodal for both ovariectomized contr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coop AD,Stavarache MA,Pfaff DW,Reeke GN

更新日期：2006-10-17 00:00:00

abstract：:Forests play a key role in the carbon balance of terrestrial ecosystems. One of the main uncertainties in global change predictions lies in how the spatiotemporal dynamics of forest productivity will be affected by climate warming. Here we show an increasing influence of climate on the spatial variability of tree grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shestakova TA,Gutiérrez E,Kirdyanov AV,Camarero JJ,Génova M,Knorre AA,Linares JC,Resco de Dios V,Sánchez-Salguero R,Voltas J

更新日期：2016-01-19 00:00:00

abstract：:Quiescent BALB/c 3T3 cells exposed briefly to a platelet-derived growth factor (PDGF) become "competent" to replicate their DNA but do not "progress" into S phase unless incubated with growth factors contained in platelet-poor plasma. Plasma from hypophysectomized rats is deficient in progression activity; it does not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiles CD,Capone GT,Scher CD,Antoniades HN,Van Wyk JJ,Pledger WJ

更新日期：1979-03-01 00:00:00

abstract：:A temperature-sensitive ras allele has an effective lethal phase at 29 degrees C about 12 hr after pupation and a temperature-sensitive period for lethality beginning midway through the third larval instar and ending around pupation. The mutation also alters the quantity of pteridines present in the eyes, testes, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grigliatti T,Suzuki DT

更新日期：1970-11-01 00:00:00

abstract：:Development of the vertebrate eye has been found to require the activity of several genes encoding homeodomain proteins (Freund, C., Horsford, D. J. & McInnes, R. R. (1996) Hum. Mol. Genet. 5, 1471-1488). Some of these genes, or portions thereof, are highly conserved across phyla. In this paper, we report the identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furukawa T,Kozak CA,Cepko CL

更新日期：1997-04-01 00:00:00

abstract：:The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a monoclonal antibody (mAb) and, to a lesser extent, OKT4 mAb to the CD4 cell receptor for human immunodeficiency virus type 1 (HIV-1). The effect was seen within 1 min at an ATA concentration ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schols D,Baba M,Pauwels R,Desmyter J,De Clercq E

更新日期：1989-05-01 00:00:00

abstract：:There is great interest in understanding the mechanisms of expression underlying long-term potentiation (LTP). They are agreed to involve an increase in synaptic efficacy, which is described by three multiplicative parameters: p, the probability of neurotransmitter release; n, the number of active release sites; and q...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz PE

更新日期：1997-05-27 00:00:00