Forests synchronize their growth in contrasting Eurasian regions in response to climate warming.

abstract：:Design and synthesis of 3D metallic carbon that is stable under ambient conditions has been a long-standing dream. We predict the existence of such phases, T6- and T14-carbon, consisting of interlocking hexagons. Their dynamic, mechanical, and thermal stabilities are confirmed by carrying out a variety of state-of-the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Wang Q,Chen X,Jena P

更新日期：2013-11-19 00:00:00

abstract：:We have isolated and characterized the complete human villin gene. The villin gene is located on chromosome 2q35-36 in humans and on chromosome 1 in mice. Villin belongs to a family of calcium-regulated actin-binding proteins that share structural and functional homologies. The villin gene is expressed mainly in cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pringault E,Robine S,Louvard D

更新日期：1991-12-01 00:00:00

abstract：:Excited electronic states created by UV excitation of the diribonucleoside monophosphates ApA, ApG, ApC, ApU, and CpG were studied by the femtosecond transient-absorption technique. Bleach recovery signals recorded at 252 nm show that long-lived excited states are formed in all five dinucleosides. The lifetimes of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takaya T,Su C,de La Harpe K,Crespo-Hernández CE,Kohler B

更新日期：2008-07-29 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE), an autoimmune model of multiple sclerosis, is a complex disease influenced by genetic, intrinsic, and environmental factors. In this study, we questioned whether parent-of-origin effects influence EAE, using reciprocal F2 intercross progeny generated between EAE-susceptib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teuscher C,Noubade R,Spach K,McElvany B,Bunn JY,Fillmore PD,Zachary JF,Blankenhorn EP

更新日期：2006-05-23 00:00:00

abstract：:Severe combined immunodeficient (SCID) mice display an increased sensitivity to ionizing radiation compared with the parental, C.B-17, strain due to a deficiency in DNA double-strand break repair. The catalytic subunit of DNA-dependent protein kinase (DNA-PKCS) has previously been identified as a strong candidate for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fried LM,Koumenis C,Peterson SR,Green SL,van Zijl P,Allalunis-Turner J,Chen DJ,Fishel R,Giaccia AJ,Brown JM,Kirchgessner CU

更新日期：1996-11-26 00:00:00

abstract：:Loss of a whole chromosome 5 or a deletion of its long arm (5q) is a recurring abnormality in malignant myeloid neoplasms. To determine the location of genes on 5q that may be involved in leukemogenesis, we examined the deleted chromosome 5 homologs in a series of 135 patients with malignant myeloid diseases. By compa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Beau MM,Espinosa R 3rd,Neuman WL,Stock W,Roulston D,Larson RA,Keinanen M,Westbrook CA

更新日期：1993-06-15 00:00:00

abstract：:Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative disease with an abundant filamentous tau protein pathology. It belongs to the group of familial frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17), a major class of inherited dementing disorders whose gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Murrell JR,Goedert M,Farlow MR,Klug A,Ghetti B

更新日期：1998-06-23 00:00:00

abstract：:Work with non-human primates had previously demonstrated that the mid-dorsolateral frontal cortex, which comprises cytoarchitectonic areas 46 and 9, plays a critical role in the performance of non-spatial self-ordered working memory tasks, whereas the immediately adjacent posterior dorsolateral frontal cortex (area 8)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrides M,Alivisatos B,Evans AC,Meyer E

更新日期：1993-02-01 00:00:00

abstract：:P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase activities in the synthesis of steroid hormones. It has been suggested that different P450c17 isozymes mediate these activities in the adrenal gland and testis. We sequenced 423 of the 509 am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung BC,Picado-Leonard J,Haniu M,Bienkowski M,Hall PF,Shively JE,Miller WL

更新日期：1987-01-01 00:00:00

abstract：:Antisense RNA to the 27/32-kDa rat liver gap junction (GJ) protein was used to explore the role of GJs in preimplantation embryos. When all blastomeres of two- and four-cell embryos were injected with GJ antisense RNA, the percentage of embryos compacted at 60 hr of development was reduced to less than 20%, while 90% ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bevilacqua A,Loch-Caruso R,Erickson RP

更新日期：1989-07-01 00:00:00

abstract：:Current models of the formation and distribution of gold deposits on Earth are based on the long-standing paradigm that hydrogen sulfide and chloride are the ligands responsible for gold mobilization and precipitation by fluids across the lithosphere. Here we challenge this view by demonstrating, using in situ X-ray a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pokrovski GS,Kokh MA,Guillaume D,Borisova AY,Gisquet P,Hazemann JL,Lahera E,Del Net W,Proux O,Testemale D,Haigis V,Jonchière R,Seitsonen AP,Ferlat G,Vuilleumier R,Saitta AM,Boiron MC,Dubessy J

更新日期：2015-11-03 00:00:00

abstract：:A protein that specifically binds leukemia inhibitory factor (LIF) has been isolated from normal mouse serum by using four successive fractionation steps: chromatography on a LIF affinity matrix, anion-exchange chromatography, size-exclusion chromatography, and preparative native gel electrophoresis. The purified LIF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Layton MJ,Cross BA,Metcalf D,Ward LD,Simpson RJ,Nicola NA

更新日期：1992-09-15 00:00:00

abstract：:In the present study the complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein was determined. This protein whose biological function is unknown consists of a single polypeptide chain of 276 amino acid residues including 8 tryptophan residues and has a pyroglutamyl residue at the amino terminus. The loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki T,Gejyo F,Takagaki K,Haupt H,Schwick HG,Bürgi W,Marti T,Schaller J,Rickli E,Brossmer R

更新日期：1988-02-01 00:00:00

abstract：:Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell migration through actin cytoskeletal regulation. Given the traditional view of profilin1 as a promigratory molecule, it is difficult to reconcile observations that profilin1 is down-regulated in various invasive adenocarcinomas an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bae YH,Ding Z,Das T,Wells A,Gertler F,Roy P

更新日期：2010-12-14 00:00:00

abstract：:The strong consistency of least squares estimates in multiple regression models with independent errors is obtained under minimal assumptions on the design and weak moment conditions on the errors. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai TL,Robbins H,Wei CZ

更新日期：1978-07-01 00:00:00

abstract：:Natural killer T (NKT) cells provide an innate-type immune response upon T cell receptor interaction with CD1d-presented antigens. We demonstrate through equilibrium tetramer binding and antigen presentation assays with Valpha14i-positive NKT cell hybridomas that the Sphingomonas glycolipid alpha-galacturonosyl cerami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu D,Zajonc DM,Fujio M,Sullivan BA,Kinjo Y,Kronenberg M,Wilson IA,Wong CH

更新日期：2006-03-14 00:00:00

abstract：:Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groll M,Larionov OV,Huber R,de Meijere A

更新日期：2006-03-21 00:00:00

abstract：:HIV infection leads to a state of chronic immune activation and progressive deterioration in immune function, manifested most recognizably by the progressive depletion of CD4+ T cells. A substantial percentage of natural killer (NK) cells from patients with HIV infection are activated and express the natural cytotoxic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieillard V,Strominger JL,Debré P

更新日期：2005-08-02 00:00:00

abstract：:The partial purification of mouse mammary gland stem cells (MaSCs) using combinatorial cell surface markers (Lin(-)CD24(+)CD29(h)CD49f(h)) has improved our understanding of their role in normal development and breast tumorigenesis. Despite the significant improvement in MaSC enrichment, there is presently no methodolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： dos Santos CO,Rebbeck C,Rozhkova E,Valentine A,Samuels A,Kadiri LR,Osten P,Harris EY,Uren PJ,Smith AD,Hannon GJ

更新日期：2013-04-30 00:00:00

abstract：:In vitro tests for predicting the response of tumors to chemotherapeutic agents might be improved if they were modified to take into account tumor-cell heterogeneity. We have studied the heterogeneity of cellular growth rate and drug response in mouse fibroblast NIH 3T3 cells and in NIH 3T3 cells transformed with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuczek T,Axelrod DE

更新日期：1987-07-01 00:00:00

abstract：:The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines. In the present investigation we have studied the expression of these genes in biopsy specimens from human glioblastomas. Hyperplasia of the vascular endothelium is a pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermansson M,Nistér M,Betsholtz C,Heldin CH,Westermark B,Funa K

更新日期：1988-10-01 00:00:00

abstract：:The neural mechanisms used by the human brain to identify phonemes remain unclear. We recorded the EEG signals evoked by repeated presentation of 12 American English phonemes. A support vector machine model correctly recognized a high percentage of the EEG brain wave recordings represented by their phases, which were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang R,Perreau-Guimaraes M,Carvalhaes C,Suppes P

更新日期：2012-12-11 00:00:00

abstract：:Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a cytokine-like manner, presumably via signaling through a cell surface cyclophilin receptor. More recently, host-derived cyclophili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherry B,Zybarth G,Alfano M,Dubrovsky L,Mitchell R,Rich D,Ulrich P,Bucala R,Cerami A,Bukrinsky M

更新日期：1998-02-17 00:00:00

abstract：:Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats do not develop arthritis in response to the same SCW stimulus. To evaluate this difference in inflammat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberg EM,Hill JM,Chrousos GP,Kamilaris T,Listwak SJ,Gold PW,Wilder RL

更新日期：1989-04-01 00:00:00

abstract：:Flow separation and vortex shedding are some of the most common phenomena experienced by bluff bodies under relative motion with the surrounding medium. They often result in a recirculation bubble in regions with adverse pressure gradient, which typically reduces efficiency in vehicles and increases loading on structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bocanegra Evans H,Hamed AM,Gorumlu S,Doosttalab A,Aksak B,Chamorro LP,Castillo L

更新日期：2018-02-06 00:00:00

abstract：:Fluorescent bisretinoids, such as A2E and all-trans-retinal dimer, form as a by-product of vitamin A cycling in retina and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin pigments. These pigments are implicated in pathological mechanisms involved in several vision-threatening diseases including age-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Yanase E,Feng X,Siegel MM,Sparrow JR

更新日期：2010-04-20 00:00:00

abstract：:A specific lipoprotein of the E. coli outer membrane has been synthesized in a cell-free system directed by purified messenger RNA. The mRNA for the lipoprotein was purified as 7S RNA about 250-fold from exponentially growing cells. Protein synthesis of the cell-free system was totally dependent upon the addition of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirashima A,Wang S,Inouye M

更新日期：1974-10-01 00:00:00

abstract：:Intestinal CD103(-) dendritic cells (DCs) are pathogenic for colitis. Unveiling molecular mechanisms that render these cells proinflammatory is important for the design of specific immunotherapies. In this report, we demonstrated that mesenteric lymph node CD103(-) DCs express, among other proinflammatory cytokines, h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kourepini E,Aggelakopoulou M,Alissafi T,Paschalidis N,Simoes DC,Panoutsakopoulou V

更新日期：2014-03-04 00:00:00

abstract：:In Caenorhabditis elegans, the small nuclear ribonucleoprotein (snRNP)-associated proteins U1A and U2B'' are approximately 50% identical to each other, and neither bears signature characteristics of mammalian U1A or U2B'' or the single Drosophila homolog, SNF. We show here that the genes that encode these proteins (rn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saldi T,Wilusz C,MacMorris M,Blumenthal T

更新日期：2007-06-05 00:00:00

abstract：:The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer. We find that miR-182, member of a miRNA cluster in a chromosomal locus (7q31-34) frequently amplified in melanoma, is commonly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segura MF,Hanniford D,Menendez S,Reavie L,Zou X,Alvarez-Diaz S,Zakrzewski J,Blochin E,Rose A,Bogunovic D,Polsky D,Wei J,Lee P,Belitskaya-Levy I,Bhardwaj N,Osman I,Hernando E

更新日期：2009-02-10 00:00:00