A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.

abstract：:Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray DT,Zhou X,Kato M,Xiang S,Tycko R,McKnight SL

更新日期：2018-10-16 00:00:00

abstract：:Enhancing immune responses with immune-modulatory monoclonal antibodies directed to inhibitory immune receptors is a promising modality in cancer therapy. Clinical efficacy has been demonstrated with antibodies blocking inhibitory immune checkpoints such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) or PD-1/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romano E,Kusio-Kobialka M,Foukas PG,Baumgaertner P,Meyer C,Ballabeni P,Michielin O,Weide B,Romero P,Speiser DE

更新日期：2015-05-12 00:00:00

abstract：:microRNA-146a (miR-146a) has been previously implicated as an essential molecular brake, preventing immune overreaction and malignant transformation by attenuating NF-κB signaling, putatively via repression of the Traf6 and Irak1 genes. The exact contribution of miR-146a-mediated silencing of these genes to the contro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Magilnick N,Reyes EY,Wang WL,Vonderfecht SL,Gohda J,Inoue JI,Boldin MP

更新日期：2017-08-22 00:00:00

abstract：:Nuclear proteins contain specific regions that are required for entry into the nucleus. Using ligand blotting, we have shown that a 67-kDa yeast nuclear envelope protein (p67) recognizes synthetic peptides containing the yeast histone H2B or simian virus 40 large tumor antigen nuclear localization sequence. Both free ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee WC,Mélèse T

更新日期：1989-11-01 00:00:00

abstract：:The transformation of human cells was examined by transfection of cloned oncogenic DNAs derived from the tumor virus simian virus 40 and from the human bladder carcinoma cell line EJ into diploid fibroblasts derived from foreskin (FS-2 cells). The simian virus 40 DNA was found to induce a morphologically transformed p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sager R,Tanaka K,Lau CC,Ebina Y,Anisowicz A

更新日期：1983-12-01 00:00:00

abstract：:The stability of an immunogen against enzymatic degradation is considered an important factor for the design of synthetic vaccines. For our studies, we have selected an epitope from the tandem-repeat unit of the high-molecular-weight MUC2 mucin glycoprotein, which can be underglycosylated in case of colon cancer. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tugyi R,Uray K,Iván D,Fellinger E,Perkins A,Hudecz F

更新日期：2005-01-11 00:00:00

abstract：:The role of microtubules in 3H-labeled protein secretion in rat lacrimal glands was probed by the use of colchicine and two of its analogues that reversibly bind to tubulin. These analogues were 2-methoxy-5-(2,3,4,4'-trimethoxyphenyl)-2,4,6-cycloheptatriene-1-o ne and 2,3,4,4'-tetramethoxy-1,1'-biphenyl, the latter ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herman G,Busson S,Gorbunoff MJ,Mauduit P,Timasheff SN,Rossignol B

更新日期：1989-06-01 00:00:00

abstract：:Visual development is thought to be completed at an early age. We suggest that the maturation of the visual brain is not homogeneous: functions with greater need for early availability, such as visuomotor control, mature earlier, and the development of other visual functions may extend well into childhood. We found si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovács I,Kozma P,Fehér A,Benedek G

更新日期：1999-10-12 00:00:00

abstract：:Mutations in the gene encoding the transcription factor autoimmune regulator (AIRE) are responsible for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome. AIRE directs expression of tissue-restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contribu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pomié C,Vicente R,Vuddamalay Y,Lundgren BA,van der Hoek M,Enault G,Kagan J,Fazilleau N,Scott HS,Romagnoli P,van Meerwijk JP

更新日期：2011-07-26 00:00:00

abstract：:The peroxisome biogenesis disorders (PBDs), including Zellweger syndrome (ZS) and neonatal adrenoleukodystrophy (NALD), are autosomal recessive diseases caused by defects in peroxisome assembly, for which at least 10 complementation groups have been reported. We have isolated a human PEX1 cDNA (HsPEX1) by functional c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura S,Okumoto K,Toyama R,Shimozawa N,Tsukamoto T,Suzuki Y,Osumi T,Kondo N,Fujiki Y

更新日期：1998-04-14 00:00:00

abstract：:The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen PP,Kabat EA,Wu TT,Fong S,Carson DA

更新日期：1985-04-01 00:00:00

abstract：:The use of profiling by ethnicity or nationality to trigger secondary security screening is a controversial social and political issue. Overlooked is the question of whether such actuarial methods are in fact mathematically justified, even under the most idealized assumptions of completely accurate prior probabilities...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Press WH

更新日期：2009-02-10 00:00:00

abstract：:The engineering of structures across different length scales is central to the design of novel materials with controlled macroscopic properties. Herein, we introduce a unique class of self-assembling materials, which are built upon shape- and volume-persistent molecular nanoparticles and other structural motifs, such ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu X,Yue K,Hsieh IF,Li Y,Dong XH,Liu C,Xin Y,Wang HF,Shi AC,Newkome GR,Ho RM,Chen EQ,Zhang WB,Cheng SZ

更新日期：2013-06-18 00:00:00

abstract：:Efficient and controllable expression of a transgene usually requires the presence of intron sequences and much efforts have been made to produce retrovirus vectors that can transduce and integrate genes with introns. However, this has proven difficult because the viral RNA is spliced when it is synthesized in the nuc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li KJ,Garoff H

更新日期：1998-03-31 00:00:00

abstract：:The Suppressor of Fused [Su(fu)] protein plays a conserved role in the regulation of Gli transcription factors of the hedgehog (Hh) signaling pathway that controls cell fate and tissue patterning during development. In both Drosophila and mammals, Su(fu) represses Gli-mediated transcription, but the mode of its action...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng SY,Bishop JM

更新日期：2002-04-16 00:00:00

abstract：:The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as the Drosophila melanogaster transverse filament protein C(3)G, causes a complete loss of SC structure and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Billmyre KK,Cahoon CK,Heenan GM,Wesley ER,Yu Z,Unruh JR,Takeo S,Hawley RS

更新日期：2019-10-22 00:00:00

abstract：:Simian virus 40 (SV40)-transformed hamster cells were relatively resistant to the lytic effect of activated macrophages from animals with chronic intracellular infections. Conversely, SV40-transformed mouse and rat cells and adenovirus 2-transformed hamster cells were highly susceptible to destruction by tumoricidal a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JL,Hibbs JB Jr,Lewis AM Jr

更新日期：1980-11-01 00:00:00

abstract：:Recent advances indicate that, in various chronic inflammatory disorders, the activation of the immune system is triggered locally rather than in lymphoid organs. In this study, we have evaluated whether the humoral alloimmune response involved in chronic rejection is elicited within the graft. We used the rat aortic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thaunat O,Field AC,Dai J,Louedec L,Patey N,Bloch MF,Mandet C,Belair MF,Bruneval P,Meilhac O,Bellon B,Joly E,Michel JB,Nicoletti A

更新日期：2005-10-11 00:00:00

abstract：:Polyketides represent an extremely diverse class of secondary metabolites often explored for their bioactive traits. These molecules are also attractive building blocks for chemical catalysis and polymerization. However, the use of polyketides in larger scale chemistry applications is stymied by limited titers and yie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markham KA,Palmer CM,Chwatko M,Wagner JM,Murray C,Vazquez S,Swaminathan A,Chakravarty I,Lynd NA,Alper HS

更新日期：2018-02-27 00:00:00

abstract：:By using a mixture of synthetic oligodeoxyribonucleotides as a probe, cloned cDNA sequences specific for low molecular weight (LMW) kininogen have been isolated from a cDNA library of bovine liver mRNA sequences. Nucleotide sequence analyses of cloned cDNA inserts have revealed that bovine liver LMW kininogens are enc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nawa H,Kitamura N,Hirose T,Asai M,Inayama S,Nakanishi S

更新日期：1983-01-01 00:00:00

abstract：:This paper is the second of three describing a two-fluid theory of binary liquid mixtures. The general theory presented in the preceding paper is used to derive a model for calculating thermodynamic properties of hard-sphere mixtures. Calculations indicate that desirable boundary conditions are satisfied. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandani V,Prausnitz JM

更新日期：1982-08-01 00:00:00

abstract：:The genome of the defective avian tumor virus MH2 was identified as a RNA of 5.7 kilobases by its presence in different MH2-helper virus complexes and its absence from pure helper virus, by its unique fingerprint pattern of RNase T1-resistant (T1) oligonucleotides that differed from those of two helper virus RNAs, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duesberg PH,Vogt PK

更新日期：1979-04-01 00:00:00

abstract：:Site-specific heritable mutations in maize genes were engineered by introducing chimeric RNA/DNA oligonucleotides. Two independent targets within the endogenous maize acetohydroxyacid synthase gene sequence were modified in a site-specific fashion, thereby conferring resistance to either imidazolinone or sulfonylurea ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu T,Peterson DJ,Tagliani L,St Clair G,Baszczynski CL,Bowen B

更新日期：1999-07-20 00:00:00

abstract：:The double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is induced as part of the IFN response in mammals and acts to shut down protein synthesis by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). In fish, a PKR-like kinase activity has been detected, but the enzyme responsible has elude...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothenburg S,Deigendesch N,Dittmar K,Koch-Nolte F,Haag F,Lowenhaupt K,Rich A

更新日期：2005-02-01 00:00:00

abstract：:Separation of cells is a critical process for studying cell properties, disease diagnostics, and therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of their size and physical properties in a label-free, contactless, and biocompatible manner. The separation sensitivity and effici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding X,Peng Z,Lin SC,Geri M,Li S,Li P,Chen Y,Dao M,Suresh S,Huang TJ

更新日期：2014-09-09 00:00:00

abstract：:Efficiently regenerated single colonies from mixed multiply auxotrophic Bacillus subtilis protoplasts, fused with polyethylene glycol, reveal colonies carrying each of the parent types (biparentals) and recombinant colonies. The latter appear in high yields (up to 1% of certain recombinant classes); the yield of bipar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hotchkiss RD,Gabor MH

更新日期：1980-06-01 00:00:00

abstract：:The type VI secretion system (T6SS) is a lethal weapon used by many bacteria to kill eukaryotic predators or prokaryotic competitors. Killing by the T6SS results from repetitive delivery of toxic effectors. Despite their importance in dictating bacterial fitness, systematic prediction of T6SS effectors remains challen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang X,Moore R,Wilton M,Wong MJ,Lam L,Dong TG

更新日期：2015-07-21 00:00:00

abstract：:The activation of additional promoter sites by production of an alternative sigma subunit for RNA polymerase is a common strategy for the coordinate regulation of gene expression. Many alternative sigma factors control genes for specialized, and often narrowly distributed, functions. For example, most of the alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YF,Helmann JD

更新日期：1992-06-01 00:00:00

abstract：:Several gene fusions have been constructed in which coding sequences for antigenic regions of the pre-S sequences of hepatitis B virus, hepatitis B surface antigen, and the envelope protein of human immunodeficiency virus were linked to the 3' end of that for the first 144 residues of hepatitis B core antigen. The seq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stahl SJ,Murray K

更新日期：1989-08-01 00:00:00

abstract：:Neuronal signal integration as well as synaptic transmission and plasticity highly depend on the morphology of dendrites and their spines. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. Nogo-A is also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrinovic MM,Hourez R,Aloy EM,Dewarrat G,Gall D,Weinmann O,Gaudias J,Bachmann LC,Schiffmann SN,Vogt KE,Schwab ME

更新日期：2013-01-15 00:00:00