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Procollagen: intermediate forms containing several types of peptide chains and non-collagen peptide extensions at NH2 and COOH ends.

Abstract：

:A population of procollagen molecules has been isolated from the culture medium of a clonal line of calf dermatosparactic cells and shown to have the amino-acid composition, physical properties, and molecular structure consistent with collagen precursors. Although this procollagen population shares immunologic determinants with the procollagen obtained from dermatosparactic skin, it differs from the latter in aminoacid composition, in subunit properties, and by its content of both amino and carboxyl terminal non-collagen peptide appendages. We propose that the cell culture procollagen contains earlier biosynthetic forms of dermatosparactic procollagen.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Tanzer ML,Church RL,Yaeger JA,Wampler DE,Park E

doi

10.1073/pnas.71.8.3009

subject

Has Abstract

pub_date

1974-08-01 00:00:00

pages

3009-13

issue

8

eissn

0027-8424

issn

1091-6490

journal_volume

71

pub_type

杂志文章

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