Functional organization of the cat's visual cortex after prenatal interruption of binocular interactions.

abstract：:The solution conformations of 2-substituted derivatives of 1-(beta-D-ribofuranosyl)benzimidazole have been determined by circular dichroism spectroscopy in aqueous solutions. It is shown that analogs with methyl, amino, or methylamino substituents at position 2 of the benzimidazole ring (position 8 of the purine ring)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Townsend LB,Miles DL,Eyring H

更新日期：1979-02-01 00:00:00

abstract：:An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blenis J

更新日期：1993-07-01 00:00:00

abstract：:Mosquito repellency data on acylpiperidines derived from the U.S. Department of Agriculture archives were modeled by using molecular descriptors calculated by CODESSA PRO software. An artificial neural network model was developed for the correlation of these archival results and used to predict the repellent activity ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katritzky AR,Wang Z,Slavov S,Tsikolia M,Dobchev D,Akhmedov NG,Hall CD,Bernier UR,Clark GG,Linthicum KJ

更新日期：2008-05-27 00:00:00

abstract：:It is unknown whether cross-regulatory interactions between homeotic genes, which have been shown to play an important role in the maintenance of their expression domains during Drosophila development, are also important during mammalian development. We have analyzed here the expression of Hox genes in Hoxa-1 (Hox-1.6...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dollé P,Lufkin T,Krumlauf R,Mark M,Duboule D,Chambon P

更新日期：1993-08-15 00:00:00

abstract：:Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wortis HH,Teutsch M,Higer M,Zheng J,Parker DC

更新日期：1995-04-11 00:00:00

abstract：:We report two instances of selective accumulation of herpes simplex 1 RNA transcripts in different compartments of infected HEp-2 cells. In the first, transcripts derived from about 50% of the viral DNA accumulated in the nuclei of cells 8 hr after infection. However, only 40-42% of the DNA was represented in transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozak M,Roizman B

更新日期：1974-11-01 00:00:00

abstract：:The electrical response of a pigmented lipid bilayer to a short laser pulse is measured by a tunable voltage clamp method. In this method, a variable access impedance permits "tuning" of the observed relaxations for optimal measurements. Analysis of the data so obtained leads to an equivalent circuit that contains a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong FT,Mauzerall D

更新日期：1974-04-01 00:00:00

abstract：:Plants adapt to alterations in light conditions by controlling their gene expression profiles. Expression of light-inducible genes is transcriptionally induced by transcription factors such as HY5. However, few detailed analyses have been carried out on the control of transcription start sites (TSSs). Of the various w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurihara Y,Makita Y,Kawashima M,Fujita T,Iwasaki S,Matsui M

更新日期：2018-07-24 00:00:00

abstract：:Compressional waves that sample the lowermost mantle west of Central America show a rapid change in travel times of up to 4 s over a sampling distance of 300 km and a change in waveforms. The differential travel times of the PKP waves (which traverse Earth's core) correlate remarkably well with predictions for S-wave ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun X,Song X,Zheng S,Helmberger DV

更新日期：2007-01-02 00:00:00

abstract：:Watching someone scratch himself can induce feelings of itchiness in the perceiver. This provides a unique opportunity to characterize the neural basis of subjective experiences of itch, independent of changes in peripheral inputs. In this study, we first established that the social contagion of itch is essentially a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holle H,Warne K,Seth AK,Critchley HD,Ward J

更新日期：2012-11-27 00:00:00

abstract：:The causes of major and rapid transitions observed in biological macroevolution as well as in the evolution of social systems are a subject of much debate. Here we identify the proximate causes of crashes and recoveries that arise dynamically in a model system in which populations of (molecular) species coevolve with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jain S,Krishna S

更新日期：2002-02-19 00:00:00

abstract：:Melanopsin, the photopigment of the "circadian" receptors that regulate the biological clock and the pupillary reflex in mammals, is homologous to invertebrate rhodopsins. Evidence supporting the involvement of phosphoinositides in light-signaling has been garnered, but the downstream effectors that control the light-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peinado G,Osorno T,Gomez Mdel P,Nasi E

更新日期：2015-06-23 00:00:00

abstract：:The relatively short read lengths associated with the most cost-effective DNA sequencing technologies have limited their use in de novo genome assembly, structural variation detection, and haplotype-resolved genome sequencing. Consequently, there is a strong need for methods that capture various scales of contiguity i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz JJ,Lee C,Hiatt JB,Adey A,Shendure J

更新日期：2012-11-13 00:00:00

abstract：:In this paper I review the ways in which the glassy state is obtained both in nature and in materials science and highlight a "new twist"--the recent recognition of polymorphism within the glassy state. The formation of glass by continuous cooling (viscous slowdown) is then examined, the strong/fragile liquids classif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angell CA

更新日期：1995-07-18 00:00:00

abstract：:A pure population of mast cells was obtained after 14 days of culturing mouse bone marrow cells in the presence of medium derived from concanavalin A-stimulated mouse spleen cells. The cells were characterized as mast cells by their morphologic appearance and histologic staining, by their histamine content (450 ng per...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin E,Cordon-Cardo C,Good RA

更新日期：1981-04-01 00:00:00

abstract：:We demonstrate that poly(dA-dT) can adopt two conformations in solution, with the relative proportions dependent on the nature and concentration of the counter ion and cationic ligands. The synthetic DNA exhibits a dinucleotide repeat conformation on addition of CsF and Me4NCl at molar concentrations, with the NMR spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Kozlowski SA,Suggs JW,Cox SD

更新日期：1981-07-01 00:00:00

abstract：:Following over 3 decades of gradual but uneven increases in sea ice coverage, the yearly average Antarctic sea ice extents reached a record high of 12.8 × 106 km2 in 2014, followed by a decline so precipitous that they reached their lowest value in the 40-y 1979-2018 satellite multichannel passive-microwave record, 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkinson CL

更新日期：2019-07-16 00:00:00

abstract：:Based on structural information derived from the F NMR data of labeled rhodopsins, rhodopsin crystal structure, and excited-state properties of model polyenes, we propose a molecular mechanism that accounts specifically for the causes of the well-known enhanced photoreactivity of rhodopsin (increased rates and quantum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RS,Colmenares LU

更新日期：2003-12-09 00:00:00

abstract：:A lysine-to-arginine substitution at amino acid 65 (K65R) in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is associated with resistance to 2',3'-dideoxycytidine (ddC), 2',3'-dideoxyinosine (ddI), and the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine (3TC). To further characterize the molecu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Z,Arts EJ,Parniak MA,Wainberg MA

更新日期：1995-03-28 00:00:00

abstract：:Pertussis toxin (PT), a protein produced by Bordetella pertussis, was studied for its effect on lipolysis in isolated rat epididymal adipocytes. Exposure of adipocytes to pertussis toxin resulted in a significant increase in cyclic AMP levels and lipolysis after a lag of 1-2 hr. Both the maximal rate of lipolysis and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olansky L,Myers GA,Pohl SL,Hewlett EL

更新日期：1983-11-01 00:00:00

abstract：:The six individual catalytic polypeptide chains within the two catalytic trimers of Escherichia coli aspartate transcarbamoylase (ATCase; EC 2.1.3.2) are folded into two discrete structural domains interconnected in part by helix 12, which comprises residues 285-305 and is located near the carboxyl terminus of the cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson CB,Schachman HK

更新日期：1991-01-15 00:00:00

abstract：:The calcium-dependent phosphatase calcineurin and its downstream transcriptional effector nuclear factor of activated T cells (NFAT) are important regulators of inducible gene expression in multiple cell types. In T cells, calcineurin-NFAT signaling represents a critical event for mediating cellular activation and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bueno OF,Brandt EB,Rothenberg ME,Molkentin JD

更新日期：2002-07-09 00:00:00

abstract：:A generic modeling framework to infer the failure-spreading process based on failure times of individual nodes is proposed and tested in four simulation studies: one for cascading failures in interdependent power and transportation networks, one for influenza epidemics, one benchmark test case for congestion cascade i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan X,Chen C

更新日期：2018-08-28 00:00:00

abstract：:It is becoming common practice to partition glass-forming liquids into two classes based on the dependence of the shear viscosity η on temperature T. In an Arrhenius plot, ln η vs 1/T, a strong liquid shows linear behavior whereas a fragile liquid exhibits an upward curvature [super-Arrhenius (SA) behavior], a situati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallamace F,Branca C,Corsaro C,Leone N,Spooren J,Chen SH,Stanley HE

更新日期：2010-12-28 00:00:00

abstract：:The conserved Ndc80 complex is an essential microtubule-binding component of the kinetochore. Recent findings suggest that the Ndc80 complex influences microtubule dynamics at kinetochores in vivo. However, it was unclear if the Ndc80 complex mediates these effects directly, or by affecting other factors localized at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Umbreit NT,Gestaut DR,Tien JF,Vollmar BS,Gonen T,Asbury CL,Davis TN

更新日期：2012-10-02 00:00:00

abstract：:Heat shock locus V (HslV; also called ClpQ) is the proteolytic core of the ATP-dependent protease HslVU in Escherichia coli. It has sequence similarity with the beta-type subunits of the eukaryotic and archaebacterial proteasomes. Unlike these particles, which display 72-point symmetry, it is a dimer of hexamers with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bochtler M,Ditzel L,Groll M,Huber R

更新日期：1997-06-10 00:00:00

abstract：:The emergence of resistance to multiple unrelated chemotherapeutic drugs impedes the treatment of several cancers. Although the involvement of ATP-binding cassette transporters has long been known, there is no in situ method capable of tracking this transporter-related resistance at the single-cell level without inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuss S,Polcari D,Geissler M,Brassard D,Mauzeroll J

更新日期：2013-06-04 00:00:00

abstract：:30S ribosomal proteins from Bacillus stearothermophilus (B. proteins) have been fractionated and characterized with respect to their ability to replace various E. coli 30S proteins (E. proteins) in the E. coli 30S ribosome reconstitution system. The functional counterparts of all the E. proteins, except S1, S6, S9, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higo K,Held W,Kahan L,Nomura M

更新日期：1973-03-01 00:00:00

abstract：:When histones in chromatin core particles were crosslinked with dimethylsuberimidate, the resulting particles had properties closely similar to those of native core particles. A crosslinked octameric histone complex was isolated from these particles under nondenaturing conditions. Upon reaction with DNA, this octameri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein A,Bina-Stein M,Simpson RT

更新日期：1977-07-01 00:00:00

abstract：:General optimization results from physics indicate that maximum efficiency of a process, in the sense of minimum overall entropy production, is achieved when the rate of entropy production is constant over time, however not in ordinary clock time but on an, in general varying, "eigen time" scale, intrinsic to the syst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andresen B,Shiner JS,Uehlinger DE

更新日期：2002-04-30 00:00:00