Crosslinked histone octamer as a model of the nucleosome core.

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were inters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes DS,Bonner J

更新日期：1974-04-01 00:00:00

abstract：:Recently, several proteins have been identified that are related in their sequence to the p53 tumor-suppressor protein. One of these proteins, which is termed p73, exhibits sequence homology to the p53 transcriptional activation, DNA binding, and oligomerization domains. The adenovirus E1B 55-kDa protein, the adenovir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higashino F,Pipas JM,Shenk T

更新日期：1998-12-22 00:00:00

abstract：:The B-cell antigen receptor is composed of membrane immunoglobulin sheathed by an alpha/beta heterodimer. The complex is noncovalently associated with protein kinase activity, and crosslinking of the receptor leads to capping and transmembrane signaling. Here we show that the sheath is not necessary either for this ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams GT,Peaker CJ,Patel KJ,Neuberger MS

更新日期：1994-01-18 00:00:00

abstract：:UDPglucuronosyltransferase [UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific), EC 2.4.1.17] is a group of enzymes with distinct but partially overlapping substrate specificity. A rabbit antiserum raised against one purified rat liver UDPglycuronosyltransferase isoform was specific for UDPglucuronosyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chowdhury JR,Novikoff PM,Chowdhury NR,Novikoff AB

更新日期：1985-05-01 00:00:00

abstract：:Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) is an eight-carbon sugar mostly confined to Gram-negative bacteria. It is often involved in attaching surface polysaccharides to their lipid anchors. α-Kdo provides a bridge between lipid A and the core oligosaccharide in all bacterial LPSs, whereas an oligosaccharide of β-Kdo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ovchinnikova OG,Mallette E,Koizumi A,Lowary TL,Kimber MS,Whitfield C

更新日期：2016-05-31 00:00:00

abstract：:The neurotrophin (NT) brain-derived neurotrophic factor (BDNF) plays an essential role in the formation of long-term potentiation (LTP). Here, we address whether this modulation by BDNF requires its continuous presence, or whether a local increase in BDNF is necessary during a specific time period of LTP initiation. U...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gärtner A,Staiger V

更新日期：2002-04-30 00:00:00

abstract：:A hierarchy of residue density assessments and packing properties in protein structures are contrasted, including a regular density, a variety of charge densities, a hydrophobic density, a polar density, and an aromatic density. These densities are investigated by alternative distance measures and also at the interfac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baud F,Karlin S

更新日期：1999-10-26 00:00:00

abstract：:We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of mycoplasmas by alveolar macrophages (AMs) from resistant C57BL/6 mice through a nitric oxide (.NO)-dependent mechanism. Herein, SP-A-deficient [SP-A(-/-)] and inducible.NO synthase-deficient [iNOS(-/-)] mice were infected intranasal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickman-Davis J,Gibbs-Erwin J,Lindsey JR,Matalon S

更新日期：1999-04-27 00:00:00

abstract：:Genetic manipulation of the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, alpha(2)-agonist treatment of mice heterozygous for the alpha(2A)-AR (alpha(2A)-AR(+/-)) lowers blood pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan CM,Wilson MH,MacMillan LB,Kobilka BK,Limbird LE

更新日期：2002-09-17 00:00:00

abstract：:Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang P,Miska J,Lee-Chang C,Rashidi A,Panek WK,An S,Zannikou M,Lopez-Rosas A,Han Y,Xiao T,Pituch KC,Kanojia D,Balyasnikova IV,Lesniak MS

更新日期：2019-11-19 00:00:00

abstract：:p-Coumaric acid is the precursor of phenylpropanoids, which are plant secondary metabolites that are beneficial to human health. Tyrosine ammonia lyase catalyzes the production of p-coumaric acid from tyrosine. Because of their photosynthetic ability and biosynthetic versatility, cyanobacteria are promising candidates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue Y,Zhang Y,Cheng D,Daddy S,He Q

更新日期：2014-07-01 00:00:00

abstract：:Chromosome rearrangements, such as large deletions, inversions, or translocations, mediate migration of large DNA segments within or between chromosomes, which can have major effects on cellular genetic control. A method for chromosome manipulation would be very useful for studying the consequences of large-scale DNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Deursen J,Fornerod M,Van Rees B,Grosveld G

更新日期：1995-08-01 00:00:00

abstract：:The 23S twisted circular form of ColE(1) DNA has been isolated from Escherichia coli as a tightly associated DNA-protein complex with a sedimentation coefficient of approximately 24S. Treatment of this complex with pronase, trypsin, sodium dodecyl sulfate, Sarkosyl, or heat results in a conversion to a slower sediment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clewell DB,Helinski DR

更新日期：1969-04-01 00:00:00

abstract：:In the plant Nicotiana plumbaginifolia, manganese superoxide dismutase (MnSOD) is synthesized in the cytoplasm as a preprotein and is subsequently translocated to the mitochondrial matrix with corresponding cleavage of an NH2-terminal leader sequence. To determine whether the plant enzyme could replace the endogenous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowler C,Alliotte T,Van den Bulcke M,Bauw G,Vandekerckhove J,Van Montagu M,Inzé D

更新日期：1989-05-01 00:00:00

abstract：:An essential element in the web-trap architecture, the capture silk spun by ecribellate orb spiders consists of glue droplets sitting astride a silk filament. Mechanically this thread presents a mixed solid-liquid behavior unknown to date. Under extension, capture silk behaves as a particularly stretchy solid, owing t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elettro H,Neukirch S,Vollrath F,Antkowiak A

更新日期：2016-05-31 00:00:00

abstract：:Fetal exposure to environmental insults increases the susceptibility to late-onset neuropsychiatric disorders. Alcohol is listed as one of such prenatal environmental risk factors and known to exert devastating teratogenetic effects on the developing brain, leading to complex neurological and psychiatric symptoms obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto-Torii K,Kawasawa YI,Kuhn A,Rakic P

更新日期：2011-03-08 00:00:00

abstract：:Covalent attachment of myristic acid (C14:0) to the NH2-terminal glycine residue of a number of cellular, viral, and oncogene-encoded proteins is essential for full expression of their biological function. Substitution of oxygen for methylene groups in this fatty acid does not produce a significant change in chain len...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DR,Cox AD,Solski PA,Devadas B,Adams SP,Leimgruber RM,Heuckeroth RO,Buss JE,Gordon JI

更新日期：1990-11-01 00:00:00

abstract：:During mitosis, the mammalian Golgi vesiculates and, upon partitioning, reassembles in each daughter cell; however, it is not clear whether the disassembly process per se is important for partitioning or is merely an outcome of mitotic entry. Here, we show that Golgi vesiculation is required for progression to metapha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guizzunti G,Seemann J

更新日期：2016-10-25 00:00:00

abstract：:Using data from the North American Breeding Bird Survey, we determined that most neotropical migrant bird species that breed in forests of the eastern United States and Canada have recently (1978-1987) declined in abundance after a period of stable or increasing populations. Most permanent residents and temperate-zone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbins CS,Sauer JR,Greenberg RS,Droege S

更新日期：1989-10-01 00:00:00

abstract：:Hypoxia, reoxygenation, and the tyrosine phosphatase inhibitor pervanadate activate the transcription factor NF-kappaB, involving phosphorylation of its inhibitor IkappaB-alpha on tyrosine 42. This modification does not lead to degradation of IkappaB by the proteasome/ubiquitin pathway, as is seen on stimulation of ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Béraud C,Henzel WJ,Baeuerle PA

更新日期：1999-01-19 00:00:00

abstract：:Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu H,Fagnant PM,Bookwalter CS,Joel P,Trybus KM

更新日期：2015-08-04 00:00:00

abstract：:Human P-glycoprotein (Pgp) confers multidrug resistance to cancer cells by ATP-dependent extrusion of a great many structurally dissimilar hydrophobic compounds. The manner in which Pgp recognizes these different substrates is unknown. The protein shows internal homology between its N- and C-terminal halves, each comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dey S,Ramachandra M,Pastan I,Gottesman MM,Ambudkar SV

更新日期：1997-09-30 00:00:00

abstract：:Human X chromosome DNA was partially purified from a mouse-human hybrid cell line containing a single human chromosome, the X. Enrichment of such DNA was accomplished by two sequential reassociations of radiolabeled hybrid cell DNA with large excesses of mouse DNA. Unreassociated hybrid cell DNA was used as a probe fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmeckpeper BJ,Smith KD,Dorman BP,Ruddle FH,Talbot CC Jr

更新日期：1979-12-01 00:00:00

abstract：:We provide evidence for an interaction between mouse class I major histocompatibility complex antigens and insulin receptors. Antibodies against class I but not class II major histocompatibility complex antigens immunoprecipitate photoaffinity-labeled hepatic insulin receptors. Haplotype specificity is demonstrated by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips ML,Moule ML,Delovitch TL,Yip CC

更新日期：1986-05-01 00:00:00

abstract：:The in situ stimulation of Fe(III) oxide reduction by Geobacter bacteria leads to the concomitant precipitation of hexavalent uranium [U(VI)] from groundwater. Despite its promise for the bioremediation of uranium contaminants, the biological mechanism behind this reaction remains elusive. Because Fe(III) oxide reduct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cologgi DL,Lampa-Pastirk S,Speers AM,Kelly SD,Reguera G

更新日期：2011-09-13 00:00:00

abstract：:To initiate transcription from specific promoters, the bacterial RNA polymerase (RNAP) core enzyme must associate with the initiation factor sigma, which contains determinants that allow sequence-specific interactions with promoter DNA. Most bacteria contain several sigma factors, each of which directs recognition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan AH,Nickels BE,Hochschild A

更新日期：2009-04-21 00:00:00

abstract：:The presynaptic plasma membrane protein SNAP-25 (synaptosome-associated protein of 25 kDa) has been implicated as one of several neural-specific components that direct constitutive fusion mechanisms to the regulated vesicle trafficking and exocytosis of neurotransmitter release. There exist two alternatively spliced i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bark IC,Hahn KM,Ryabinin AE,Wilson MC

更新日期：1995-02-28 00:00:00

abstract：:Plasmids that contain synthetic genes coding for small oligoribonucleotides called external guide sequences (EGSs) have been introduced into strains of Escherichia coli harboring antibiotic resistance genes. The EGSs direct RNase P to cleave the mRNAs transcribed from these genes thereby converting the phenotype of dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerrier-Takada C,Salavati R,Altman S

更新日期：1997-08-05 00:00:00

abstract：:The chloride permeability of airway and sweat ductal epithelium of cystic fibrosis (CF) patients is decreased. This abnormality could represent an intrinsic characteristic of the epithelial cell or the response to a tonic extrinsic stimulus, in vivo. We cultured airway epithelial cells derived from CF and non-CF indiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stutts MJ,Cotton CU,Yankaskas JR,Cheng E,Knowles MR,Gatzy JT,Boucher RC

更新日期：1985-10-01 00:00:00