Patterns and mechanisms of localized bone invasion by tumors: studies with squamous carcinomas of the head and neck.

abstract：:Alpha fetoprotein (AFP) is the major protein of fetal serum and most resembles albumen, which replaces it shortly after birth. It is produced by fetal liver and passes into the amniotic fluid (AF) via fetal urine. A small amount crosses the membranes into the maternal circulation. Excluding fetal blood contamination, ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Crandall BF

更新日期：1981-01-01 00:00:00

abstract：:International standards and practice guidelines recommend the use of delta check alerts for laboratory test result interpretation and quality control. The value of contemporary applications of simple univariate delta checks determined as an absolute change, percentage change, or rate of change to recognize specimen mi...

journal_title：Critical reviews in clinical laboratory sciences

authors： Randell EW,Yenice S

更新日期：2019-03-01 00:00:00

abstract：:Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and ma...

journal_title：Critical reviews in clinical laboratory sciences

authors： Whitfield JB

更新日期：2001-08-01 00:00:00

abstract：:Complement is a humoral effector system composed of 21 plasma proteins that was identified initially because of its cytolytic effects. In addition to cytolysis, complement has a number of different functions related to inflammatory and other host defense processes. The description of the reaction mechanism includes: (...

journal_title：Critical reviews in clinical laboratory sciences

authors： Dalmasso AP

更新日期：1986-01-01 00:00:00

abstract：:The physical properties and chemical composition of urine are highly variable and are determined in large measure by the quantity and the type of food consumed. The specific gravity is the ratio of the density to that of water, and it is dependent on the number and weight of solute particles and on the temperature of ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Pradella M,Dorizzi RM,Rigolin F

更新日期：1988-01-01 00:00:00

abstract：:This review focuses on the laboratory biochemical tests that are useful in the diagnostic approach to the hypertensive patient. A "minimal" diagnostic laboratory work-up, including a small number of tests that are simple and relatively inexpensive, is first described. Because these tests provide basic information on t...

journal_title：Critical reviews in clinical laboratory sciences

authors： Seccia TM,Rossi GP

更新日期：2005-01-01 00:00:00

abstract：:High-density lipoprotein (HDL), the most abundant human plasma lipoprotein, plays a major role in reverse cholesterol transport, which recycles cholesterol from peripheral cells to the liver. HDL constitutes a heterogeneous group of particles differing in density, size, electrophoretic mobility, and apolipoprotein con...

journal_title：Critical reviews in clinical laboratory sciences

authors： Tailleux A,Fruchart JC

更新日期：1996-01-01 00:00:00

abstract：:There have been numerous publications on the coagulopathy of cardiopulmonary bypass (CPB). This review provides an introduction to the history and main components of current CPB circuits and summarizes the current knowledge of pathogenesis, prevention, and treatment of the CPB coagulopathy. It encompasses an overview ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Besser MW,Klein AA

更新日期：2010-12-01 00:00:00

abstract：:Oncogenes and tumor suppressor genes are genes involved in cell proliferation and differentiation. They play a crucial role in the initiation and progression of cancer. Some of these genes are found to be altered in human cancers, i.e., mutated, amplified, deleted, translocated, or abnormally regulated. Recently, the ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Diamandis EP

更新日期：1992-01-01 00:00:00

abstract：:Despite the ever growing collection of data concerning the function of the immune system in patients with epidermoid carcinoma of the head and neck, the precise mechanism by which these tumors effect the body's surveillance against foreign antigen is as yet unidentified. If these specific immunological characteristics...

journal_title：Critical reviews in clinical laboratory sciences

authors： Newbill ET,Johns ME

更新日期：1983-01-01 00:00:00

abstract：:Hemophilia care depends on several factors for the production of purified FVIII: plasma procurement, plasma logistics, production method, and efficacy. The latter two are restrictive factors, both for the supply and the safety of FVIII preparations. Conventional production methodology unavoidably recovers only 10 to 2...

journal_title：Critical reviews in clinical laboratory sciences

authors： Smit Sibinga CT

更新日期：1986-01-01 00:00:00

abstract：:Iron deficiency is the most common micronutrient deficiency in the world and represents a major challenge for public health, notably in terms of morbidity and mortality. It remains largely under-diagnosed due to the low level of exploration and the absence of international harmonization for biological tests and thresh...

journal_title：Critical reviews in clinical laboratory sciences

authors： Cacoub P,Vandewalle C,Peoc'h K

更新日期：2019-12-01 00:00:00

abstract：:Acute leukemias (ALs) are often associated with chromosomal translocations, in particular, KMT2A/MLL gene rearrangements. Identification or confirmation of these translocations is carried out by a number of genetic and molecular methods, some of which are routinely used in clinical practice, while others are primarily...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lomov N,Zerkalenkova E,Lebedeva S,Viushkov V,Rubtsov MA

更新日期：2020-11-18 00:00:00

abstract：:The genes of the human leukocyte antigen (HLA) region, the major histocompatibility complex (MHC) of humans, control a variety of functions involved in immune response and influence susceptibility to over 40 diseases. Theoretical studies in the development of models to determine the modes of inheritance of the HLA-ass...

journal_title：Critical reviews in clinical laboratory sciences

authors： Thomson G

更新日期：1995-01-01 00:00:00

abstract：:Leptin is a 16-kDa cytokine secreted in humans primarily but not exclusively by adipose tissues. Its concentration in blood is usually proportional to body fat mass, but is higher in women than in men not only because of a different distribution of and greater fat mass in women, but also because testosterone reduces i...

journal_title：Critical reviews in clinical laboratory sciences

authors： Himms-Hagen J

更新日期：1999-12-01 00:00:00

abstract：:Despite great progress in prevention strategies, pharmacotherapy and interventional treatment of coronary artery disease (CAD), cardiovascular events still constitute the leading cause of mortality and morbidity in the modern world. Traditional risk factors, including hypertension, diabetes mellitus, smoking, obesity,...

journal_title：Critical reviews in clinical laboratory sciences

authors： Krintus M,Kozinski M,Kubica J,Sypniewska G

更新日期：2014-10-01 00:00:00

abstract：:This manuscript offers a broad overview of the state of emergency toxicology testing in clinical laboratories. We summarize the specific challenges of performing emergency toxicology testing, introduce a variety of currently used methods including mass spectrometry, and compare and contrast the utility of different ty...

journal_title：Critical reviews in clinical laboratory sciences

authors： Van Wijk XMR,Goodnough R,Colby JM

更新日期：2019-06-01 00:00:00

abstract：:Crohn's disease (CD) and ulcerative colitis (UC) are the two principal forms of inflammatory bowel disease (IBD). Animal studies show that bacteria are involved in the etiology of IBD, and much is now known about the inflammatory processes associated with CD and UC, as well as the underlying genetic, environmental, an...

journal_title：Critical reviews in clinical laboratory sciences

authors： Macfarlane S,Steed H,Macfarlane GT

更新日期：2009-01-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lianidou ES,Strati A,Markou A

更新日期：2014-06-01 00:00:00

abstract：:The constrained economic context leads laboratories to centralize their routine analyses on high-throughput platforms, to which blood collection tubes are sent from peripheral sampling sites that are sometimes distantly located. Providing biochemistry results as quickly as possible implies to consolidate the maximum n...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lima-Oliveira G,Monneret D,Guerber F,Guidi GC

更新日期：2018-11-01 00:00:00

abstract：:Management of chronic diseases represents a leading health and economic issue worldwide. Biomarkers are critical for the diagnosis and management of both communicable and non-communicable chronic diseases, and mobile health (mHealth) technologies are about to change the "game" with regard to the management of patients...

journal_title：Critical reviews in clinical laboratory sciences

authors： Gruson D,Ko G

更新日期：2016-10-01 00:00:00

abstract：:Maximum stability of analytes in chemistry control materials is desired. Stability testing is customarily performed by manufacturers, both prior to distribution of products and during the period following distribution when the products are in the field. Users and evaluators of such materials periodically have reported...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lawson NS,Haven GT,Williams GW

更新日期：1982-01-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common age-related cancers among men. Various environmental and genetic factors are involved in the development and progression of PCa. In most cases, the primary symptoms of disease are not severe. Therefore, it is common for patients to be referred with severe clinical manife...

journal_title：Critical reviews in clinical laboratory sciences

authors： Ghayour-Mobarhan M,Ferns GA,Moghbeli M

更新日期：2020-01-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) comprises a group of inherited disorders of iron metabolism that can result in progressive iron overload, morbidity, and mortality, generally in adulthood. HFE-related HH is the most common type of HH and will form the core of this discussion. The discovery of new proteins and gene muta...

journal_title：Critical reviews in clinical laboratory sciences

authors： Ayonrinde OT,Milward EA,Chua AC,Trinder D,Olynyk JK

更新日期：2008-01-01 00:00:00

abstract：:The discovery of vitamin D receptor (VDR) expression in immune cells has opened up a new area of research into immunoregulation by vitamin D, a niche that is distinct from its classical role in skeletal health. Today, about three decades since this discovery, numerous cellular and molecular targets of vitamin D in the...

journal_title：Critical reviews in clinical laboratory sciences

authors： Sarkar S,Hewison M,Studzinski GP,Li YC,Kalia V

更新日期：2016-01-01 00:00:00

abstract：:Cancer is a major and increasing public health problem worldwide. Traditionally, the diagnosis and staging of cancer, as well as the evaluation of response to therapy have been primarily based on morphology, with relatively few cancer biomarkers currently in use. Conventional biomarker studies have been focused on sin...

journal_title：Critical reviews in clinical laboratory sciences

authors： Feng Q,Yu M,Kiviat NB

更新日期：2006-01-01 00:00:00

abstract：:Our understanding of risk factors for atherogenesis has changed significantly over the last decade. In addition to better grasp of the mechanism of action of the "classic" (causal) risk factors, a number of potentially important new factors has emerged. In this review we briefly summarize the evidence of the relation ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Frohlich J,Dobiasova M,Lear S,Lee KW

更新日期：2001-10-01 00:00:00

abstract：:Fluoride has the potential to increase skeletal mass to a greater extent than any other pharmacologic agent, yet it has proven difficult to translate this into therapeutic benefit for patients with low bone mass in diseases such as osteoporosis. This apparent paradox can be explained in part by toxic actions of the io...

journal_title：Critical reviews in clinical laboratory sciences

authors： Kleerekoper M

更新日期：1996-01-01 00:00:00

abstract：:Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1/PD-L1-mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceutical...

journal_title：Critical reviews in clinical laboratory sciences

authors： Wang X,Wu M,Cao Y,Zhang Z,Guo F,Li X,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:Most clinical chemical analytes vary in a random manner around a homeostatic set point. Replicate analyses of a series of specimens collected from a group of subjects allows estimation of analytical, within and between subject components of variation. The preferred experimental procedures and statistical methods for e...

journal_title：Critical reviews in clinical laboratory sciences

authors： Fraser CG,Harris EK

更新日期：1989-01-01 00:00:00