Abstract:
:There have been numerous publications on the coagulopathy of cardiopulmonary bypass (CPB). This review provides an introduction to the history and main components of current CPB circuits and summarizes the current knowledge of pathogenesis, prevention, and treatment of the CPB coagulopathy. It encompasses an overview of intra- and postoperative monitoring of coagulation with special emphasis on the near-patient testing, its main complications, and the transfusion support, while taking into account the major changes in the technology used and supportive care provided since its inception.
journal_name
Crit Rev Clin Lab Scijournal_title
Critical reviews in clinical laboratory sciencesauthors
Besser MW,Klein AAdoi
10.3109/10408363.2010.549291subject
Has Abstractpub_date
2010-12-01 00:00:00pages
197-212issue
5-6eissn
1040-8363issn
1549-781Xjournal_volume
47pub_type
杂志文章,评审abstract::Oncogenes and tumor suppressor genes are genes involved in cell proliferation and differentiation. They play a crucial role in the initiation and progression of cancer. Some of these genes are found to be altered in human cancers, i.e., mutated, amplified, deleted, translocated, or abnormally regulated. Recently, the ...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408369209114603
更新日期:1992-01-01 00:00:00
abstract::Urinary nucleosides offer a number of useful laboratory and clinical applications in the study and analysis of leukemia. There are significant differences in the excretion of modified nucleosides between normal individuals and individuals with various forms of leukemia, as well as between leukemia patients at opposite...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368609111597
更新日期:1986-01-01 00:00:00
abstract::The genes of the human leukocyte antigen (HLA) region, the major histocompatibility complex (MHC) of humans, control a variety of functions involved in immune response and influence susceptibility to over 40 diseases. Theoretical studies in the development of models to determine the modes of inheritance of the HLA-ass...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408369509084684
更新日期:1995-01-01 00:00:00
abstract::The CK-BB isoenzyme is ubiquitous in neoplastic tissue, but with low activity. Accordingly, it might be a nonspecific and insensitive tumor marker. Evaluation of BB isoenzyme in serum might indicate the extent of diseases or the response to therapy. The presence of CK-MB in patients with cancers may cause confusion wi...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368609165795
更新日期:1986-01-01 00:00:00
abstract::This manuscript offers a broad overview of the state of emergency toxicology testing in clinical laboratories. We summarize the specific challenges of performing emergency toxicology testing, introduce a variety of currently used methods including mass spectrometry, and compare and contrast the utility of different ty...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408363.2019.1585415
更新日期:2019-06-01 00:00:00
abstract::The discovery of a G protein-coupled, calcium-sensing receptor (CaR) a decade ago and of diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical role in the maintenance of systemic calcium homeostasis. On the cell membrane of the chief cells of the parathyroid glands, the CaR "senses" t...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408360590886606
更新日期:2005-01-01 00:00:00
abstract::The deoxyuridine suppression (dU) test, first described in 1964, has gained an important place both in the diagnosis of megaloblastic anemias and in the study of vitamin B12 folate interrelationships in the pathogenesis of megaloblastic anemia. The test measures the integrity of the de novo synthetic pathway of DNA sy...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368409165775
更新日期:1984-01-01 00:00:00
abstract::Isoforms of the receptor for advanced glycation end-product (RAGE) protein, which lack the transmembrane and the signaling (soluble RAGE or sRAGE) domains are hypothesized to counteract the detrimental action of the full-length receptor by acting as a decoy, and they provide a potential tool to treat RAGE-associated d...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章
doi:10.1080/10408363.2020.1791045
更新日期:2020-07-15 00:00:00
abstract::Cancer is a major and increasing public health problem worldwide. Traditionally, the diagnosis and staging of cancer, as well as the evaluation of response to therapy have been primarily based on morphology, with relatively few cancer biomarkers currently in use. Conventional biomarker studies have been focused on sin...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408360600922632
更新日期:2006-01-01 00:00:00
abstract::Complement is a humoral effector system composed of 21 plasma proteins that was identified initially because of its cytolytic effects. In addition to cytolysis, complement has a number of different functions related to inflammatory and other host defense processes. The description of the reaction mechanism includes: (...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368609110272
更新日期:1986-01-01 00:00:00
abstract::Management of chronic diseases represents a leading health and economic issue worldwide. Biomarkers are critical for the diagnosis and management of both communicable and non-communicable chronic diseases, and mobile health (mHealth) technologies are about to change the "game" with regard to the management of patients...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2016.1167163
更新日期:2016-10-01 00:00:00
abstract::Acute pancreatitis is an acute inflammatory condition of the pancreas, which might extend to local and distant extrapancreatic tissues. The global incidence varies between 17.5 and 73.4 cases per 100,000 and the pathogenesis recognizes alcohol exposure and biliary tract disease as the leading causes, ahead of post-end...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2012.658354
更新日期:2012-01-01 00:00:00
abstract::Prostate cancer (PCa) is one of the most common age-related cancers among men. Various environmental and genetic factors are involved in the development and progression of PCa. In most cases, the primary symptoms of disease are not severe. Therefore, it is common for patients to be referred with severe clinical manife...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章
doi:10.1080/10408363.2019.1657061
更新日期:2020-01-01 00:00:00
abstract::Isoelectric focusing (IEF) as a method for differentiating macromolecules with minor differences in isoelectric points has demonstrated an increase in the degree of genetic polymorphisms of the blood. Studies over the last 5 to 6 years have shown that genetic marker systems such as transferrin (TF), phosphoglucomutase...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368409165772
更新日期:1984-01-01 00:00:00
abstract::Despite great progress in prevention strategies, pharmacotherapy and interventional treatment of coronary artery disease (CAD), cardiovascular events still constitute the leading cause of mortality and morbidity in the modern world. Traditional risk factors, including hypertension, diabetes mellitus, smoking, obesity,...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2014.913549
更新日期:2014-10-01 00:00:00
abstract::As the primary interface between the blood and various tissues of the body, the vascular endothelium exhibits a diverse range of roles and activities, all of which contribute to the overall health and function of the cardiovascular system. In this focused review, we discuss several key aspects of endothelial function,...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408363.2017.1394267
更新日期:2017-01-01 00:00:00
abstract::Maximum stability of analytes in chemistry control materials is desired. Stability testing is customarily performed by manufacturers, both prior to distribution of products and during the period following distribution when the products are in the field. Users and evaluators of such materials periodically have reported...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368209107031
更新日期:1982-01-01 00:00:00
abstract::Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1/PD-L1-mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceutical...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408363.2018.1522292
更新日期:2019-01-01 00:00:00
abstract::Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a mole...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408360490504934
更新日期:2004-01-01 00:00:00
abstract::The kallikrein-related peptidases (KLKs) represent the largest family of serine proteases within the human genome and are expressed in various tissues. Although they regulate several important physiological functions, KLKs have also been implicated in numerous pathophysiological processes, including cancer. Growing ev...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2016.1154643
更新日期:2016-08-01 00:00:00
abstract::The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide ...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2014.896316
更新日期:2014-06-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis not due to excess alcohol consumption. The prevalence of NAFLD is up to 30% in developed countries and nearly 10% in developing nations, making NAFLD the most common liver condition in the world. The pathogenesis of NAFLD is rela...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2011.596521
更新日期:2011-05-01 00:00:00
abstract::The aim of this review is to summarize present evidence of an association between circulating levels of C-reactive protein (CRP) and cancer risk, and to evaluate whether elevated circulating CRP levels cause cancer. Additionally, the review provides background information on the acute-phase response, chronic inflammat...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2011.599831
更新日期:2011-07-01 00:00:00
abstract::Acute leukemias (ALs) are often associated with chromosomal translocations, in particular, KMT2A/MLL gene rearrangements. Identification or confirmation of these translocations is carried out by a number of genetic and molecular methods, some of which are routinely used in clinical practice, while others are primarily...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章
doi:10.1080/10408363.2020.1844135
更新日期:2020-11-18 00:00:00
abstract::Cardiac diseases have been extensively studied following diabetes and altered metabolism has been implicated in its initiation. In this context, there is a shift from glucose utilization to predominantly fatty acid metabolism. We have focused on the micro- and macro-environments that the heart uses to provide fatty ac...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408363.2014.997931
更新日期:2015-01-01 00:00:00
abstract::Homologous blood transfusion has been implicated as a modulator of the host immune system in a number of clinical settings. Improved renal allograft survival is observed in patients receiving pretransplant transfusions. Decreased recurrence of active inflammatory bowel disease has been recently reported in transfused ...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408369009105899
更新日期:1990-01-01 00:00:00
abstract::Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408363.2017.1414142
更新日期:2018-01-01 00:00:00
abstract::Antiphospholipid antibodies (aPL) constitute a heterogeneous group of autoantibodies that share the ability to bind phospholipids (PL) alone, protein-PL complexes, or PL-binding proteins. They have been detected in isolation, in association with autoimmune diseases such as systemic lupus erythematosus (SLE), and durin...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/10408360601079549
更新日期:2007-01-01 00:00:00
abstract::Fluoride has the potential to increase skeletal mass to a greater extent than any other pharmacologic agent, yet it has proven difficult to translate this into therapeutic benefit for patients with low bone mass in diseases such as osteoporosis. This apparent paradox can be explained in part by toxic actions of the io...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408369609083059
更新日期:1996-01-01 00:00:00
abstract::Our understanding of risk factors for atherogenesis has changed significantly over the last decade. In addition to better grasp of the mechanism of action of the "classic" (causal) risk factors, a number of potentially important new factors has emerged. In this review we briefly summarize the evidence of the relation ...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.1080/20014091084245
更新日期:2001-10-01 00:00:00