Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer.

Abstract:

:The discovery of vitamin D receptor (VDR) expression in immune cells has opened up a new area of research into immunoregulation by vitamin D, a niche that is distinct from its classical role in skeletal health. Today, about three decades since this discovery, numerous cellular and molecular targets of vitamin D in the immune system have been delineated. Moreover, strong clinical associations between vitamin D status and the incidence/severity of many immune-regulated disorders (e.g. infectious diseases, cancers and autoimmunity) have prompted the idea of using vitamin D supplementation to manipulate disease outcome. While much is known about the effects of vitamin D on innate immune responses and helper T (T(H)) cell immunity, there has been relatively limited progress on the frontier of cytotoxic T lymphocyte (CTL) immunity--an arm of host cellular adaptive immunity that is crucial for the control of such intracellular pathogens as human immunodeficiency virus (HIV), tuberculosis (TB), malaria, and hepatitis C virus (HCV). In this review, we discuss the strong historical and clinical link between vitamin D and infectious diseases that involves cytotoxic T lymphocyte (CTL) immunity, present our current understanding as well as critical knowledge gaps in the realm of vitamin D regulation of host CTL responses, and highlight potential regulatory connections between vitamin D and effector and memory CD8 T cell differentiation events during infections.

journal_name

Crit Rev Clin Lab Sci

authors

Sarkar S,Hewison M,Studzinski GP,Li YC,Kalia V

doi

10.3109/10408363.2015.1094443

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

132-45

issue

2

eissn

1040-8363

issn

1549-781X

journal_volume

53

pub_type

杂志文章,评审
  • HLA disease associations: models for the study of complex human genetic disorders.

    abstract::The genes of the human leukocyte antigen (HLA) region, the major histocompatibility complex (MHC) of humans, control a variety of functions involved in immune response and influence susceptibility to over 40 diseases. Theoretical studies in the development of models to determine the modes of inheritance of the HLA-ass...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408369509084684

    authors: Thomson G

    更新日期:1995-01-01 00:00:00

  • COVID-19: from an acute to chronic disease? Potential long-term health consequences.

    abstract::Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite pulmonary impairments being the most prevalent, extra-pulmonary manifestations of COVID-19 are abundant. Confirmed COVID-19 cases have now surpassed 57.8 million worldwide as of 22 November 2020. ...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章

    doi:10.1080/10408363.2020.1860895

    authors: Higgins V,Sohaei D,Diamandis EP,Prassas I

    更新日期:2020-12-21 00:00:00

  • Small-pool high-yield factor VIII production.

    abstract::Hemophilia care depends on several factors for the production of purified FVIII: plasma procurement, plasma logistics, production method, and efficacy. The latter two are restrictive factors, both for the supply and the safety of FVIII preparations. Conventional production methodology unavoidably recovers only 10 to 2...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368609111596

    authors: Smit Sibinga CT

    更新日期:1986-01-01 00:00:00

  • The deoxyuridine suppression test.

    abstract::The deoxyuridine suppression (dU) test, first described in 1964, has gained an important place both in the diagnosis of megaloblastic anemias and in the study of vitamin B12 folate interrelationships in the pathogenesis of megaloblastic anemia. The test measures the integrity of the de novo synthetic pathway of DNA sy...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368409165775

    authors: Metz J

    更新日期:1984-01-01 00:00:00

  • Urinary nucleosides in leukemia: laboratory and clinical applications.

    abstract::Urinary nucleosides offer a number of useful laboratory and clinical applications in the study and analysis of leukemia. There are significant differences in the excretion of modified nucleosides between normal individuals and individuals with various forms of leukemia, as well as between leukemia patients at opposite...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368609111597

    authors: Trewyn RW,Grever MR

    更新日期:1986-01-01 00:00:00

  • Antiphospholipid antibodies: laboratory and pathogenetic aspects.

    abstract::Antiphospholipid antibodies (aPL) constitute a heterogeneous group of autoantibodies that share the ability to bind phospholipids (PL) alone, protein-PL complexes, or PL-binding proteins. They have been detected in isolation, in association with autoimmune diseases such as systemic lupus erythematosus (SLE), and durin...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360601079549

    authors: Vlachoyiannopoulos PG,Samarkos M,Sikara M,Tsiligros P

    更新日期:2007-01-01 00:00:00

  • Analyte stability in clinical chemistry quality control materials.

    abstract::Maximum stability of analytes in chemistry control materials is desired. Stability testing is customarily performed by manufacturers, both prior to distribution of products and during the period following distribution when the products are in the field. Users and evaluators of such materials periodically have reported...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368209107031

    authors: Lawson NS,Haven GT,Williams GW

    更新日期:1982-01-01 00:00:00

  • Using transferrin saturation as a diagnostic criterion for iron deficiency: A systematic review.

    abstract::Iron deficiency is the most common micronutrient deficiency in the world and represents a major challenge for public health, notably in terms of morbidity and mortality. It remains largely under-diagnosed due to the low level of exploration and the absence of international harmonization for biological tests and thresh...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章

    doi:10.1080/10408363.2019.1653820

    authors: Cacoub P,Vandewalle C,Peoc'h K

    更新日期:2019-12-01 00:00:00

  • Clinical implications of estrone sulfate measurement in laboratory medicine.

    abstract::Estrone sulfate (E1S) is the most abundant circulating estrogen and it has the potential to be used as a biomarker in certain conditions where estimation of low levels of estrogen or changes in relative levels of estrogens are important. This review will critically consider the role of estimating E1S for clinical labo...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408363.2016.1252310

    authors: Rezvanpour A,Don-Wauchope AC

    更新日期:2017-03-01 00:00:00

  • Role of vitamin D in acquired immune and autoimmune diseases.

    abstract::Vitamin D has been attributed roles in the pathogenesis and prevention of several diseases such as cancer, cardiovascular disease, multiple sclerosis, diabetes, autism and autoimmune diseases. The concomitant expression of the 25-hydroxyvitamin D3-1α-hydroxylase and of the vitamin D3 receptor in animal and human tissu...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408363.2014.901291

    authors: Delvin E,Souberbielle JC,Viard JP,Salle B

    更新日期:2014-08-01 00:00:00

  • What the lab can and cannot do: clinical interpretation of drug testing results.

    abstract::Urine drug testing is one of the objective tools available to assess adherence. To monitor adherence, quantitative urinary results can assist in differentiating "new" drug use from "previous" (historical) drug use. "Spikes" in urinary concentration can assist in identifying patterns of drug use. Coupled chromatographi...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章

    doi:10.1080/10408363.2020.1774493

    authors: Kapur BM,Aleksa K

    更新日期:2020-12-01 00:00:00

  • Osteocalcin: diagnostic methods and clinical applications.

    abstract::Osteocalcin is a small (Mr 5800), very interesting bone specific protein, synthesized by osteoblasts and measured in plasma as a biochemical indicator of bone formation. Many immunoassays for osteocalcin have been developed, including radio- and enzymoimmunoassays, with the use of monoclonal and polyclonal antibodies....

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408369109106867

    authors: Power MJ,Fottrell PF

    更新日期:1991-01-01 00:00:00

  • Non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis not due to excess alcohol consumption. The prevalence of NAFLD is up to 30% in developed countries and nearly 10% in developing nations, making NAFLD the most common liver condition in the world. The pathogenesis of NAFLD is rela...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408363.2011.596521

    authors: Smith BW,Adams LA

    更新日期:2011-05-01 00:00:00

  • Hepatitis delta virus: the molecular basis of laboratory diagnosis.

    abstract::Infection with hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is associated with severe and sometimes fulminant hepatitis. The traditional methods for the diagnosis of HDV infection, such as detection of serum anti-HD antibodies, are sufficient for the clinical diagnosis of delta infection....

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360091174178

    authors: Modahl LE,Lai MM

    更新日期:2000-02-01 00:00:00

  • Allogeneic bone marrow transplantation.

    abstract::Allogeneic bone marrow transplantation now has an established place in the treatment of severe aplastic anemia and acute leukemia. Major problems to be overcome in transplantation in patients with aplastic anemia are marrow graft rejection and graft vs. host disease. Results are better in younger patients and in patie...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368309165762

    authors: Weiden PL

    更新日期:1983-01-01 00:00:00

  • Kallikrein-related peptidases (KLKs) and the hallmarks of cancer.

    abstract::The kallikrein-related peptidases (KLKs) represent the largest family of serine proteases within the human genome and are expressed in various tissues. Although they regulate several important physiological functions, KLKs have also been implicated in numerous pathophysiological processes, including cancer. Growing ev...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408363.2016.1154643

    authors: Filippou PS,Karagiannis GS,Musrap N,Diamandis EP

    更新日期:2016-08-01 00:00:00

  • The role of risk factors in the development of atherosclerosis.

    abstract::Our understanding of risk factors for atherogenesis has changed significantly over the last decade. In addition to better grasp of the mechanism of action of the "classic" (causal) risk factors, a number of potentially important new factors has emerged. In this review we briefly summarize the evidence of the relation ...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/20014091084245

    authors: Frohlich J,Dobiasova M,Lear S,Lee KW

    更新日期:2001-10-01 00:00:00

  • Complement in the pathophysiology and diagnosis of human diseases.

    abstract::Complement is a humoral effector system composed of 21 plasma proteins that was identified initially because of its cytolytic effects. In addition to cytolysis, complement has a number of different functions related to inflammatory and other host defense processes. The description of the reaction mechanism includes: (...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368609110272

    authors: Dalmasso AP

    更新日期:1986-01-01 00:00:00

  • Gamma glutamyl transferase.

    abstract::Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and ma...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/20014091084227

    authors: Whitfield JB

    更新日期:2001-08-01 00:00:00

  • Neonatal cytomegalovirus infections due to blood.

    abstract::Infants with very low birthweights (less than 1250g) are immunocompromised and have immature hematopoietic systems. They require frequent blood transfusions and have an increased susceptibility to infection. These very low birthweight infants who lack passively acquired antibody against CMV, acquire transfusion-associ...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368609165792

    authors: Adler SP

    更新日期:1986-01-01 00:00:00

  • Hypersensitivity pneumonitis.

    abstract::Hypersensitivity pneumonitis (HP) is a group of immunologically mediated lung diseases caused by the inhalation of environmental agents in susceptible individuals. Most HP patients are non-smokers and have been exposed to organic dusts from vegetable or animal products. Some HP cases are associated with exposures to r...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360290795583

    authors: Yi ES

    更新日期:2002-11-01 00:00:00

  • Biomarkers of sepsis.

    abstract::Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. A hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is sus...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408363.2013.764490

    authors: Faix JD

    更新日期:2013-01-01 00:00:00

  • DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis.

    abstract::Reviewed are the phosphorylation events reporting activation of protein kinases and the key substrates critical for the DNA damage signaling (DDS). These DDS events are detected immunocytochemically using phospho-specific Abs; flow cytometry or image-assisted cytometry provide the means to quantitatively assess them o...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408363.2012.738808

    authors: Darzynkiewicz Z,Zhao H,Halicka HD,Rybak P,Dobrucki J,Wlodkowic D

    更新日期:2012-09-01 00:00:00

  • Molecular biomarkers for cancer detection in blood and bodily fluids.

    abstract::Cancer is a major and increasing public health problem worldwide. Traditionally, the diagnosis and staging of cancer, as well as the evaluation of response to therapy have been primarily based on morphology, with relatively few cancer biomarkers currently in use. Conventional biomarker studies have been focused on sin...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360600922632

    authors: Feng Q,Yu M,Kiviat NB

    更新日期:2006-01-01 00:00:00

  • Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery.

    abstract::Regarding the widespread progression of diabetes, its related complications and detrimental effects on human health, investigations on this subject seems compulsory. AMP-activated protein kinase (AMPK) is a serine/threonine kinase and a key player in energy metabolism regulation. AMPK is also considered as a prime tar...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408363.2019.1648376

    authors: Momtaz S,Salek-Maghsoudi A,Abdolghaffari AH,Jasemi E,Rezazadeh S,Hassani S,Ziaee M,Abdollahi M,Behzad S,Nabavi SM

    更新日期:2019-11-01 00:00:00

  • The role of von Willebrand factor in hemorrhagic and thrombotic disorders.

    abstract::von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion as well as platelet aggregation at sites of vascular injury and acts as a carrier of factor VIII. Although acquired or inherited VWF deficiency is associated with a bleeding tendency, there is increasing evidence that VWF has a ...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360600966753

    authors: Franchini M,Lippi G

    更新日期:2007-01-01 00:00:00

  • Lipoprotein lipase and angiopoietin-like 4 - Cardiomyocyte secretory proteins that regulate metabolism during diabetic heart disease.

    abstract::Cardiac diseases have been extensively studied following diabetes and altered metabolism has been implicated in its initiation. In this context, there is a shift from glucose utilization to predominantly fatty acid metabolism. We have focused on the micro- and macro-environments that the heart uses to provide fatty ac...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408363.2014.997931

    authors: Puthanveetil P,Wan A,Rodrigues B

    更新日期:2015-01-01 00:00:00

  • Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor.

    abstract::Trypsinogens and PSTI/TATI/SPINK1 are expressed, usually together, at high levels by the pancreas but also by many other normal and malignant tissues. The present review describes studies on the expression and putative functions of trypsinogens and PSTI/TATI/SPINK1 in the human body. The clinical aspects are discussed...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360500523852

    authors: Paju A,Stenman UH

    更新日期:2006-01-01 00:00:00

  • Generation and application of data on biological variation in clinical chemistry.

    abstract::Most clinical chemical analytes vary in a random manner around a homeostatic set point. Replicate analyses of a series of specimens collected from a group of subjects allows estimation of analytical, within and between subject components of variation. The preferred experimental procedures and statistical methods for e...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.3109/10408368909106595

    authors: Fraser CG,Harris EK

    更新日期:1989-01-01 00:00:00

  • Biochemistry and clinical role of human cystatin C.

    abstract::Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a mole...

    journal_title:Critical reviews in clinical laboratory sciences

    pub_type: 杂志文章,评审

    doi:10.1080/10408360490504934

    authors: Mussap M,Plebani M

    更新日期:2004-01-01 00:00:00