Small-pool high-yield factor VIII production.

abstract：:Cardiac diseases have been extensively studied following diabetes and altered metabolism has been implicated in its initiation. In this context, there is a shift from glucose utilization to predominantly fatty acid metabolism. We have focused on the micro- and macro-environments that the heart uses to provide fatty ac...

journal_title：Critical reviews in clinical laboratory sciences

authors： Puthanveetil P,Wan A,Rodrigues B

更新日期：2015-01-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) comprises a group of inherited disorders of iron metabolism that can result in progressive iron overload, morbidity, and mortality, generally in adulthood. HFE-related HH is the most common type of HH and will form the core of this discussion. The discovery of new proteins and gene muta...

journal_title：Critical reviews in clinical laboratory sciences

authors： Ayonrinde OT,Milward EA,Chua AC,Trinder D,Olynyk JK

更新日期：2008-01-01 00:00:00

abstract：:Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of thi...

journal_title：Critical reviews in clinical laboratory sciences

authors： Estrela JM,Ortega A,Mena S,Rodriguez ML,Asensi M

更新日期：2013-05-01 00:00:00

abstract：:As the primary interface between the blood and various tissues of the body, the vascular endothelium exhibits a diverse range of roles and activities, all of which contribute to the overall health and function of the cardiovascular system. In this focused review, we discuss several key aspects of endothelial function,...

journal_title：Critical reviews in clinical laboratory sciences

authors： Khaddaj Mallat R,Mathew John C,Kendrick DJ,Braun AP

更新日期：2017-01-01 00:00:00

abstract：:Crohn's disease (CD) and ulcerative colitis (UC) are the two principal forms of inflammatory bowel disease (IBD). Animal studies show that bacteria are involved in the etiology of IBD, and much is now known about the inflammatory processes associated with CD and UC, as well as the underlying genetic, environmental, an...

journal_title：Critical reviews in clinical laboratory sciences

authors： Macfarlane S,Steed H,Macfarlane GT

更新日期：2009-01-01 00:00:00

abstract：:Vitamin D has been attributed roles in the pathogenesis and prevention of several diseases such as cancer, cardiovascular disease, multiple sclerosis, diabetes, autism and autoimmune diseases. The concomitant expression of the 25-hydroxyvitamin D3-1α-hydroxylase and of the vitamin D3 receptor in animal and human tissu...

journal_title：Critical reviews in clinical laboratory sciences

authors： Delvin E,Souberbielle JC,Viard JP,Salle B

更新日期：2014-08-01 00:00:00

abstract：:Estrone sulfate (E1S) is the most abundant circulating estrogen and it has the potential to be used as a biomarker in certain conditions where estimation of low levels of estrogen or changes in relative levels of estrogens are important. This review will critically consider the role of estimating E1S for clinical labo...

journal_title：Critical reviews in clinical laboratory sciences

authors： Rezvanpour A,Don-Wauchope AC

更新日期：2017-03-01 00:00:00

abstract：:Acute pancreatitis is an acute inflammatory condition of the pancreas, which might extend to local and distant extrapancreatic tissues. The global incidence varies between 17.5 and 73.4 cases per 100,000 and the pathogenesis recognizes alcohol exposure and biliary tract disease as the leading causes, ahead of post-end...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lippi G,Valentino M,Cervellin G

更新日期：2012-01-01 00:00:00

abstract：:Hypophosphatasia is a rare inherited disorder in which the activity of the bone/liver/kidney or tissue nonspecific form of alkaline phosphatase (ALP) is reduced. The clinical expression of the disease is highly variable, but in early life the severity tends to reflect the age of onset. Accordingly, the disease is ofte...

journal_title：Critical reviews in clinical laboratory sciences

authors： Caswell AM,Whyte MP,Russell RG

更新日期：1991-01-01 00:00:00

abstract：:Regarding the widespread progression of diabetes, its related complications and detrimental effects on human health, investigations on this subject seems compulsory. AMP-activated protein kinase (AMPK) is a serine/threonine kinase and a key player in energy metabolism regulation. AMPK is also considered as a prime tar...

journal_title：Critical reviews in clinical laboratory sciences

authors： Momtaz S,Salek-Maghsoudi A,Abdolghaffari AH,Jasemi E,Rezazadeh S,Hassani S,Ziaee M,Abdollahi M,Behzad S,Nabavi SM

更新日期：2019-11-01 00:00:00

abstract：:Fluoride has the potential to increase skeletal mass to a greater extent than any other pharmacologic agent, yet it has proven difficult to translate this into therapeutic benefit for patients with low bone mass in diseases such as osteoporosis. This apparent paradox can be explained in part by toxic actions of the io...

journal_title：Critical reviews in clinical laboratory sciences

authors： Kleerekoper M

更新日期：1996-01-01 00:00:00

abstract：:The constrained economic context leads laboratories to centralize their routine analyses on high-throughput platforms, to which blood collection tubes are sent from peripheral sampling sites that are sometimes distantly located. Providing biochemistry results as quickly as possible implies to consolidate the maximum n...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lima-Oliveira G,Monneret D,Guerber F,Guidi GC

更新日期：2018-11-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) constitute a heterogeneous group of autoantibodies that share the ability to bind phospholipids (PL) alone, protein-PL complexes, or PL-binding proteins. They have been detected in isolation, in association with autoimmune diseases such as systemic lupus erythematosus (SLE), and durin...

journal_title：Critical reviews in clinical laboratory sciences

authors： Vlachoyiannopoulos PG,Samarkos M,Sikara M,Tsiligros P

更新日期：2007-01-01 00:00:00

abstract：:Cancer is a major and increasing public health problem worldwide. Traditionally, the diagnosis and staging of cancer, as well as the evaluation of response to therapy have been primarily based on morphology, with relatively few cancer biomarkers currently in use. Conventional biomarker studies have been focused on sin...

journal_title：Critical reviews in clinical laboratory sciences

authors： Feng Q,Yu M,Kiviat NB

更新日期：2006-01-01 00:00:00

abstract：:Urinary nucleosides offer a number of useful laboratory and clinical applications in the study and analysis of leukemia. There are significant differences in the excretion of modified nucleosides between normal individuals and individuals with various forms of leukemia, as well as between leukemia patients at opposite...

journal_title：Critical reviews in clinical laboratory sciences

authors： Trewyn RW,Grever MR

更新日期：1986-01-01 00:00:00

abstract：:Isoelectric focusing (IEF) as a method for differentiating macromolecules with minor differences in isoelectric points has demonstrated an increase in the degree of genetic polymorphisms of the blood. Studies over the last 5 to 6 years have shown that genetic marker systems such as transferrin (TF), phosphoglucomutase...

journal_title：Critical reviews in clinical laboratory sciences

authors： Dykes DD,Polesky HF

更新日期：1984-01-01 00:00:00

abstract：:Microcytic red blood cell states are common clinical problems in both adult and pediatric age groups. The recent widespread availability of electronic blood cell counters for performing routine blood counts has increased the detection of microcytic red blood cells. Physicians must workup both symptomatic and asymptoma...

journal_title：Critical reviews in clinical laboratory sciences

authors： Marsh WL Jr,Koenig HM

更新日期：1982-01-01 00:00:00

abstract：:The kallikrein-related peptidases (KLKs) represent the largest family of serine proteases within the human genome and are expressed in various tissues. Although they regulate several important physiological functions, KLKs have also been implicated in numerous pathophysiological processes, including cancer. Growing ev...

journal_title：Critical reviews in clinical laboratory sciences

authors： Filippou PS,Karagiannis GS,Musrap N,Diamandis EP

更新日期：2016-08-01 00:00:00

abstract：:Despite great progress in prevention strategies, pharmacotherapy and interventional treatment of coronary artery disease (CAD), cardiovascular events still constitute the leading cause of mortality and morbidity in the modern world. Traditional risk factors, including hypertension, diabetes mellitus, smoking, obesity,...

journal_title：Critical reviews in clinical laboratory sciences

authors： Krintus M,Kozinski M,Kubica J,Sypniewska G

更新日期：2014-10-01 00:00:00

abstract：:High-density lipoprotein (HDL), the most abundant human plasma lipoprotein, plays a major role in reverse cholesterol transport, which recycles cholesterol from peripheral cells to the liver. HDL constitutes a heterogeneous group of particles differing in density, size, electrophoretic mobility, and apolipoprotein con...

journal_title：Critical reviews in clinical laboratory sciences

authors： Tailleux A,Fruchart JC

更新日期：1996-01-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common age-related cancers among men. Various environmental and genetic factors are involved in the development and progression of PCa. In most cases, the primary symptoms of disease are not severe. Therefore, it is common for patients to be referred with severe clinical manife...

journal_title：Critical reviews in clinical laboratory sciences

authors： Ghayour-Mobarhan M,Ferns GA,Moghbeli M

更新日期：2020-01-01 00:00:00

abstract：:The physical properties and chemical composition of urine are highly variable and are determined in large measure by the quantity and the type of food consumed. The specific gravity is the ratio of the density to that of water, and it is dependent on the number and weight of solute particles and on the temperature of ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Pradella M,Dorizzi RM,Rigolin F

更新日期：1988-01-01 00:00:00

abstract：:Leptin is a 16-kDa cytokine secreted in humans primarily but not exclusively by adipose tissues. Its concentration in blood is usually proportional to body fat mass, but is higher in women than in men not only because of a different distribution of and greater fat mass in women, but also because testosterone reduces i...

journal_title：Critical reviews in clinical laboratory sciences

authors： Himms-Hagen J

更新日期：1999-12-01 00:00:00

abstract：:Alpha fetoprotein (AFP) is the major protein of fetal serum and most resembles albumen, which replaces it shortly after birth. It is produced by fetal liver and passes into the amniotic fluid (AF) via fetal urine. A small amount crosses the membranes into the maternal circulation. Excluding fetal blood contamination, ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Crandall BF

更新日期：1981-01-01 00:00:00

abstract：:Iron deficiency is the most common micronutrient deficiency in the world and represents a major challenge for public health, notably in terms of morbidity and mortality. It remains largely under-diagnosed due to the low level of exploration and the absence of international harmonization for biological tests and thresh...

journal_title：Critical reviews in clinical laboratory sciences

authors： Cacoub P,Vandewalle C,Peoc'h K

更新日期：2019-12-01 00:00:00

abstract：:Muscle wasting in patients with sepsis, severe injury, and cancer is associated with increased transcription of several genes regulating different proteolytic pathways. The involvement of gene activation in muscle wasting suggests that transcription factors and nuclear cofactors play important roles in the regulation ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Aversa Z,Alamdari N,Hasselgren PO

更新日期：2011-03-01 00:00:00

abstract：:Maximum stability of analytes in chemistry control materials is desired. Stability testing is customarily performed by manufacturers, both prior to distribution of products and during the period following distribution when the products are in the field. Users and evaluators of such materials periodically have reported...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lawson NS,Haven GT,Williams GW

更新日期：1982-01-01 00:00:00

abstract：:Reviewed are the phosphorylation events reporting activation of protein kinases and the key substrates critical for the DNA damage signaling (DDS). These DDS events are detected immunocytochemically using phospho-specific Abs; flow cytometry or image-assisted cytometry provide the means to quantitatively assess them o...

journal_title：Critical reviews in clinical laboratory sciences

authors： Darzynkiewicz Z,Zhao H,Halicka HD,Rybak P,Dobrucki J,Wlodkowic D

更新日期：2012-09-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lianidou ES,Strati A,Markou A

更新日期：2014-06-01 00:00:00

abstract：:The deoxyuridine suppression (dU) test, first described in 1964, has gained an important place both in the diagnosis of megaloblastic anemias and in the study of vitamin B12 folate interrelationships in the pathogenesis of megaloblastic anemia. The test measures the integrity of the de novo synthetic pathway of DNA sy...

journal_title：Critical reviews in clinical laboratory sciences

authors： Metz J

更新日期：1984-01-01 00:00:00