Pterostilbene: Biomedical applications.

Abstract:

:Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of this stilbene in inflammatory dermatoses and photoprotection, cancer prevention and therapy, insulin sensitivity, blood glycemia and lipid levels, cardiovascular diseases, aging, and memory and cognition are addressed. Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed. This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol. Potential benefits of using combinations of different polyphenols are considered. Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.

journal_name

Crit Rev Clin Lab Sci

authors

Estrela JM,Ortega A,Mena S,Rodriguez ML,Asensi M

doi

10.3109/10408363.2013.805182

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

65-78

issue

3

eissn

1040-8363

issn

1549-781X

journal_volume

50

pub_type

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