Abstract:
:International standards and practice guidelines recommend the use of delta check alerts for laboratory test result interpretation and quality control. The value of contemporary applications of simple univariate delta checks determined as an absolute change, percentage change, or rate of change to recognize specimen misidentification or other laboratory errors has not received much study. This review addresses these three modes of calculation, but in line with the majority of published work, most attention is focused on the identification of specimen misidentification errors. Investigation of delta check alerts are time-consuming and the yield of identified errors is usually small compared to the number of delta check alerts; however, measured analytes with low indices of individuality frequently perform better. While multivariate approaches to delta checks suggest improved usefulness over simple univariate delta check strategies, some of these are complex and not easily applied in contemporary laboratory information systems and middleware. Nevertheless, a simple application of delta checks may hold value in identifying clinically significant changes in several clinical situations: for acute kidney injury using changes in serum creatinine, for risk of osmotic demyelination syndrome using rapid acute changes in serum sodium levels, or for early triage of chest pain patients using high sensitivity troponin assays. A careful and highly selective approach to identifying delta check analytes, calculation modes, and thresholds before putting them into practice is warranted; then follow-up with careful monitoring of performance and balancing true positives, false negatives, and false positives among delta check alerts is needed.
journal_name
Crit Rev Clin Lab Scijournal_title
Critical reviews in clinical laboratory sciencesauthors
Randell EW,Yenice Sdoi
10.1080/10408363.2018.1540536subject
Has Abstractpub_date
2019-03-01 00:00:00pages
75-97issue
2eissn
1040-8363issn
1549-781Xjournal_volume
56pub_type
杂志文章,评审abstract::There have been major advances in our understanding of thrombosis and antithrombotic drugs. This review focuses on the molecular aspects of thrombus formation and antithrombotic therapy. Molecules involved in arterial thrombosis are derived from inflammatory cells in the atherosclerotic plaque and blood platelets. The...
journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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doi:10.3109/10408363.2014.913549
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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