Delayed-type hypersensitivity to rabies virus in mice: assay of active or passive sensitization by the footpad test.

Abstract:

:With a purified beta-propiolactone-inactivated rabies virus, a significant increase in footpad swelling was elicited in normal or in BCG-pretreated mice after immunization with varying doses of rabies vaccine. These footpad reactions were shown to peak at 24 h and to be associated with an infiltration of newly formed blood monocytes demonstrated by histology and [125I]deoxyuridine labeling. A relationship between the lymphoproliferation and the degree of sensitization is described, and the susceptibility to cyclophosphamide treatment is also examined. Adoptive transfer of specific reactivity to normal recipient mice with immune lymphoid cells, but not with immune serum, was demonstrated, and the results represent another argument for a cell-mediated immunological mechanism.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Lagrange PH,Tsiang H,Hurtrel B,Ravisse P

doi

10.1128/IAI.21.3.931-939.1978

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

931-9

issue

3

eissn

0019-9567

issn

1098-5522

journal_volume

21

pub_type

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