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Aminoglutethimide for advanced prostatic cancer resistant to conventional hormonal therapy.

Abstract：

:Aminoglutethimide (AG) and hydrocortisone (HC) were given to 20 patients with advanced prostatic cancer resistant to conventional hormonal therapy. Most patients had painful bone metastases and were heavily pretreated. 12 of 16 patients required narcotic analgetics. 8 of 20 were bedridden. AG + HC produced relief of bone pain in 12 patients (75%) and only 4 required narcotics after treatment. The performance status improved in 8 of 20 patients (40%). However, the number of bone metastases seen in bone scans decreased in only 4 patients (22%). The level of serum alkaline phosphatase decreased in 11 of 18 patients and that of acid phosphatase in 8 of 16 patients. The reduction of bone pain lasted approximately 4 months (range 1-15 months). The median lifespan between the start of AG treatment and death was 8 months (range 2-22 months). There was no difference in survival between responders and nonresponders. 3 patients had skin rash, 1 lethargy and 1 thrombocytopenia.

journal_name

Eur Urol

journal_title

European urology

authors

Elomaa I,Taube T,Blomqvist C,Rissanen P,Rannikko S,Alfthan O

doi

10.1159/000472913

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

104-6

issue

2

eissn

0302-2838

issn

1873-7560

journal_volume

14

pub_type

杂志文章

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