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Opiate antagonists in erectile dysfunction: a possible new treatment option? Results of a pilot study with naltrexone.

Abstract：

:Opioids have an inhibitory effect on sexual functions in both animals and humans. Twenty patients with idiopathic, nonvascular, nonneurogenic erectile dysfunction were treated with the opiate receptor antagonist naltrexone in a randomized, placebo-controlled, double-blind study for 8 weeks. Libido and frequency of sexual intercourse were not significantly altered, but early-morning erections increased significantly under naltrexone therapy. This response was not related to levels of androgens or gonadotropins, neither was it dose dependent. There was no change in any of the measured parameters under placebo. Further clinical studies with the substance should be conducted to evaluate its possible role in the oral treatment of male impotence.

journal_name

Eur Urol

journal_title

European urology

authors

van Ahlen H,Piechota HJ,Kias HJ,Brennemann W,Klingmüller D

doi

10.1159/000475059

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

246-50

issue

3

eissn

0302-2838

issn

1873-7560

journal_volume

28

pub_type

临床试验,杂志文章,随机对照试验

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