Abstract：
OBJECTIVES:In women, aging is associated with profound hormonal changes. Menopause has been implicated in the etiology of urinary tract complaints including incontinence, urgency and recurrent urinary tract infections. However, the use of hormone replacement therapy for these conditions has given conflicting and disappointing results. The role of androgen changes on urinary continence in perimenopausal women has not been studied. We studied the presence of androgen receptors in pudendal motoneurons controlling the external urethral sphincter of female rats. MATERIALS AND METHODS:A combination of retrograde labeling of pudendal motoneurons from the external urethral sphincter and immunohistochemistry for the N-terminal portion of androgen receptors on spinal cord sections was performed in adult female rats. RESULTS:Androgen receptors were identified in the nuclei of the ventral horn of the L5-L6 spinal cord. Pudendal motoneurons, retrogradely labeled from the external urethral sphincter, were identified in the dorsolateral nucleus of the ventral horn at the same levels. Confocal microscopy demonstrated the presence of nuclear and cytoplasmic androgen receptors in the cell bodies of these retrogradely labeled pudendal motoneurons. CONCLUSION:Our study demonstrated the presence of androgen receptors in the cell bodies of retrogradely labeled pudendal motoneurons controlling the urethral sphincter of female rats suggesting a role of androgens in the neuromodulation of urethral sphincter function at the spinal level.
journal_name
Eur Uroljournal_title
European urologyauthors
Blanchet P,Yaici el-D,Cayzergues L,Giuliano F,Jardin A,Benoit G,Droupy Sdoi
10.1016/j.eururo.2004.07.004keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
118-24issue
1eissn
0302-2838issn
1873-7560pii
S0302-2838(04)00343-4journal_volume
47pub_type
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