Pathological changes in neurovascular units: Lessons from cases of vascular dementia.

abstract：:Tolerance development after successful long-term treatment of bipolar disorder is under recognized, as are ways to prevent or show its occurrence or reverse it once it has occurred. We review the clinical literature which suggests that tolerance can develop to most treatment approaches in bipolar illness and present a...

journal_title：CNS neuroscience & therapeutics

authors： Post RM,Weiss SR

更新日期：2011-12-01 00:00:00

abstract：:The blood-brain barrier is a dynamic and complex neurovascular unit that protects neurons from somatic circulatory factors as well as regulates the internal environmental stability of the central nervous system. Endothelial glycocalyx is a critical component of an extended neurovascular unit that influences the struct...

journal_title：CNS neuroscience & therapeutics

authors： Zhao F,Zhong L,Luo Y

更新日期：2020-12-30 00:00:00

abstract：:Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final co...

journal_title：CNS neuroscience & therapeutics

authors： Furukawa A,Koriyama Y

更新日期：2016-01-01 00:00:00

abstract：AIMS:To investigate if CIQ, a positive allosteric modulator of N-methyl-d-aspartate receptors (NMDARs) containing GluN2C/D subunits, rescues the loss of long-term potentiation (LTP) and forelimb-use asymmetry in a mouse model of Parkinson's disease (PD). METHODS:We have used electrophysiology in brain slices and the c...

journal_title：CNS neuroscience & therapeutics

authors： Nouhi M,Zhang X,Yao N,Chergui K

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable...

journal_title：CNS neuroscience & therapeutics

authors： Kandiah N,Chan YF,Chen C,Dasig D,Dominguez J,Han SH,Jia J,Kim S,Limpawattana P,Ng LL,Nguyen DT,Ong PA,Raya-Ampil E,Saedon N,Senanarong V,Setiati S,Singh H,Suthisisang C,Trang TM,Turana Y,Venketasubramanian N,Yon

更新日期：2021-02-01 00:00:00

abstract：:The pathophysiological mechanisms of neuroinflammation, angiogenesis, and neuroplasticity are currently the hotspots of researches in ischemic stroke. Regulatory T cells (Tregs), a subset of T cells that control inflammatory and immune responses in the body, are closely related to the pathogenesis of ischemic stroke. ...

journal_title：CNS neuroscience & therapeutics

authors： Wang H,Wang Z,Wu Q,Yuan Y,Cao W,Zhang X

更新日期：2021-01-20 00:00:00

abstract：:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) type glutamate receptors are critical for synaptic plasticity and induction of long-term potentiation (LTP), considered as one of the synaptic mechanisms underlying learning and memory. Positive allosteric modulators of AMPA receptors could provide a the...

journal_title：CNS neuroscience & therapeutics

authors： Bernard K,Danober L,Thomas JY,Lebrun C,Muñoz C,Cordi A,Desos P,Lestage P,Morain P

更新日期：2010-10-01 00:00:00

abstract：AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

journal_title：CNS neuroscience & therapeutics

authors： Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

更新日期：2019-01-01 00:00:00

abstract：:Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-5...

journal_title：CNS neuroscience & therapeutics

authors： Tietje KR,Anderson DJ,Bitner RS,Blomme EA,Brackemeyer PJ,Briggs CA,Browman KE,Bury D,Curzon P,Drescher KU,Frost JM,Fryer RM,Fox GB,Gronlien JH,Håkerud M,Gubbins EJ,Halm S,Harris R,Helfrich RJ,Kohlhaas KL,Law D,M

更新日期：2008-04-01 00:00:00

abstract：AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

journal_title：CNS neuroscience & therapeutics

authors： Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

更新日期：2012-06-01 00:00:00

abstract：:Ginsenosides are a special group of triterpenoid saponins attributed to medical effects of ginseng. Therefore, they have been research targets over the last three decades to explain ginseng actions and a wealth of literature has been presented reporting on ginsenosides' effects on the human body. Recently, there is in...

journal_title：CNS neuroscience & therapeutics

authors： Radad K,Moldzio R,Rausch WD

更新日期：2011-12-01 00:00:00

abstract：:Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

journal_title：CNS neuroscience & therapeutics

authors： Ghosh A,Chen F,Thakur A,Hong H

更新日期：2016-12-01 00:00:00

abstract：:Patients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and of...

journal_title：CNS neuroscience & therapeutics

authors： Burghaus L,Eggers C,Timmermann L,Fink GR,Diederich NJ

更新日期：2012-02-01 00:00:00

abstract：AIMS:In this study, we examined the expression of lncRNA ENST00000413528 in glioma and determined its role in glioma development. METHODS:LncRNA ENST00000413528 was detected in glioma tissues by lncRNA microarray. Then, we performed real-time PCR, CCK-8, colony formation assay, flow cytometry, caspase-3/7 assay and an...

journal_title：CNS neuroscience & therapeutics

authors： Zhang R,Wei RL,Du W,Zhang LW,Du T,Geng YD,Wei XT

更新日期：2019-08-01 00:00:00

abstract：:Research evidence points to the existence of racial-ethnic disparities in both access to and quality of mental health services for African Americans with panic disorder. Current panic disorder evaluation and treatment paradigms are not responsive to the needs of many African Americans. The primary individual, social, ...

journal_title：CNS neuroscience & therapeutics

authors： Johnson M,Mills TL,Deleon JM,Hartzema AG,Haddad J

更新日期：2009-10-01 00:00:00

abstract：AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

journal_title：CNS neuroscience & therapeutics

authors： Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

更新日期：2013-10-01 00:00:00

abstract：AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

journal_title：CNS neuroscience & therapeutics

authors： Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

更新日期：2013-09-01 00:00:00

abstract：AIMS:This study was designed to examine the neuroprotective effects of bakkenolide-IIIa, a major novel compound extracted from the rhizome of P. trichinous. METHODS:Transient focal cerebral damage model in rats and oxygen-glucose deprivation (OGD) in cultured hippocampal neurons were performed. The amount of apoptotic...

journal_title：CNS neuroscience & therapeutics

authors： Jiang Q,Li RP,Tang Y,Wang YQ,Liu C,Guo ML

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-18...

journal_title：CNS neuroscience & therapeutics

authors： Shen LM,Song ZW,Hua Y,Chao X,Liu JB

更新日期：2017-11-01 00:00:00

abstract：AIMS:Endothelial progenitor cells (EPCs) are involved in vascular repair and homeostasis after vascular injuries. In this study, we aimed to explore whether bone marrow (BM)-derived EPCs contribute to neointima formation and reendothelialization in rabbit elastase-induced aneurysm after flow diverter treatment. METHOD...

journal_title：CNS neuroscience & therapeutics

authors： Li ZF,Fang XG,Yang PF,Huang QH,Zhao WY,Liang C,Zhao R,Liu JM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the roles of autophagy and endoplasmic reticulum (ER) stress in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) in rats. METHODS:Autophagy inducer (rapamycin) and inhibitor (3-methyladenine), as well as ER stress activator (tunicamycin, TM) and inhibitor (tau...

journal_title：CNS neuroscience & therapeutics

authors： Duan XC,Wang W,Feng DX,Yin J,Zuo G,Chen DD,Chen ZQ,Li HY,Wang Z,Chen G

更新日期：2017-07-01 00:00:00

abstract：:Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

journal_title：CNS neuroscience & therapeutics

authors： Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

更新日期：2009-07-01 00:00:00

abstract：:Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective and improves long-term function after brain injury. However, its clinical application to neurological disorders is limited by its large molecular size, poor central uptake, and mitogenic potential. Glycine-proline-glutamate (GPE) is naturally cleaved from the IGF...

journal_title：CNS neuroscience & therapeutics

authors： Guan J

更新日期：2011-08-01 00:00:00

abstract：AIMS:Blood-borne monocytes/macrophages infiltrate the brain in massive numbers after ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive. This study examined the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, ...

journal_title：CNS neuroscience & therapeutics

authors： Zhang W,Zhao J,Wang R,Jiang M,Ye Q,Smith AD,Chen J,Shi Y

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：AIMS:Insufficient sleep has been found to result in varying degrees of cognitive impairment and emotional changes. Sleep was reported probably responsible for cleaning metabolic wastes in brain by increasing extracellular bulk flow. Herein, we propose that chronic sleep insufficiency in young adult wild-type mice is al...

journal_title：CNS neuroscience & therapeutics

authors： Xie Y,Ba L,Wang M,Deng SY,Chen SM,Huang LF,Zhang M,Wang W,Ding FF

更新日期：2020-02-01 00:00:00

abstract：:Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a como...

journal_title：CNS neuroscience & therapeutics

authors： Pabón MM,Ji XM,Fernandez JW,Borlongan CV

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...

journal_title：CNS neuroscience & therapeutics

authors： Dong YF,Wang LX,Huang X,Cao WJ,Lu M,Ding JH,Sun XL,Hu G

更新日期：2013-08-01 00:00:00

abstract：AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...

journal_title：CNS neuroscience & therapeutics

authors： Liu Y,Jiang S,Yang PY,Zhang YF,Li TJ,Rui YC

更新日期：2016-10-01 00:00:00

abstract：AIMS:The mouse model of allo-head and body reconstruction (AHBR) has recently been established to further the clinical development of this strategy for patients who are suffering from mortal bodily trauma or disease, yet whose mind remains healthy. Animal model studies are indispensable for developing such novel surgic...

journal_title：CNS neuroscience & therapeutics

authors： Ren XP,Ye YJ,Li PW,Shen ZL,Han KC,Song Y

更新日期：2015-08-01 00:00:00