CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.

Abstract:

AIMS:To investigate if CIQ, a positive allosteric modulator of N-methyl-d-aspartate receptors (NMDARs) containing GluN2C/D subunits, rescues the loss of long-term potentiation (LTP) and forelimb-use asymmetry in a mouse model of Parkinson's disease (PD). METHODS:We have used electrophysiology in brain slices and the cylinder test to examine the effect of CIQ on glutamatergic synaptic transmission, synaptic plasticity, and forelimb-use in the unilateral 6-hydroxydopamine-lesion mouse model of PD. RESULTS:CIQ, applied in the perfusion solution, reversibly reduced glutamatergic synaptic transmission in the dopamine-depleted striatum and had no effect in the dopamine-intact striatum. LTP, a dopamine- and NMDAR-dependent form of synaptic plasticity, was induced in the dopamine-intact striatum but was lost in the dopamine-depleted striatum. This impaired LTP was restored in the presence of CIQ applied in the perfusion solution. This treatment, however, prevented LTP induction in control slices. In brain slices from mice which received single and chronic intraperitoneal injections of CIQ, LTP was restored in the dopamine-depleted striatum and unaffected in the dopamine-intact striatum. Forelimb-use asymmetry, a test which assesses deficits in paw usage in the unilateral lesion model of PD, was reversed by systemic chronic treatment with CIQ. CONCLUSION:A positive allosteric modulator of GluN2C/D-containing NMDARs rescues LTP and forelimb-use asymmetry in a mouse model of PD. This study proposes GluN2D as a potential candidate for therapeutic intervention in PD.

journal_name

CNS Neurosci Ther

authors

Nouhi M,Zhang X,Yao N,Chergui K

doi

10.1111/cns.12784

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

144-153

issue

2

eissn

1755-5930

issn

1755-5949

journal_volume

24

pub_type

杂志文章
  • Lower serum interleukin-22 and interleukin-35 levels are associated with disease status in neuromyelitis optica spectrum disorders.

    abstract:AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13198

    authors: Yang H,Han L,Zhou YJ,Ding J,Cai Y,Hong RH,Hao Y,Zhu DS,Shen XF,Guan YT

    更新日期:2020-02-01 00:00:00

  • Mitochondrial dysfunction and cerebral metabolic abnormalities in patients with mitochondrial encephalomyopathy subtypes: Evidence from proton MR spectroscopy and muscle biopsy.

    abstract:AIMS:Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy (1 H-MRS), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy (ME). The metabolite ratios of lactate (lac)/Cr, N-acetyl aspartate (NAA)/creatine (Cr), t...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12714

    authors: Niu FN,Meng HL,Chang LL,Wu HY,Li WP,Liu RY,Wang HT,Zhang B,Xu Y

    更新日期:2017-08-01 00:00:00

  • Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-κB Activation.

    abstract:AIMS:This study was designed to examine the neuroprotective effects of bakkenolide-IIIa, a major novel compound extracted from the rhizome of P. trichinous. METHODS:Transient focal cerebral damage model in rats and oxygen-glucose deprivation (OGD) in cultured hippocampal neurons were performed. The amount of apoptotic...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12470

    authors: Jiang Q,Li RP,Tang Y,Wang YQ,Liu C,Guo ML

    更新日期:2015-12-01 00:00:00

  • Anticoagulation therapy is harmful to large-sized cerebellar infarction.

    abstract:AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12299

    authors: Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJ

    更新日期:2014-09-01 00:00:00

  • Use of statin during hospitalization improves the outcome after intracerebral hemorrhage.

    abstract:AIMS:To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes. METHODS:Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional ou...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12274

    authors: Pan YS,Jing J,Wang YL,Zhao XQ,Song B,Wang WJ,Wang D,Liu GF,Liu LP,Wang CX,Wang YJ,CNSR investigators.

    更新日期:2014-06-01 00:00:00

  • Immunogenicity and predictors of response to a single dose trivalent seasonal influenza vaccine in multiple sclerosis patients receiving disease-modifying therapies.

    abstract:AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,多中心研究

    doi:10.1111/cns.13034

    authors: Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

    更新日期:2019-02-01 00:00:00

  • Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

    abstract:AIMS:Activated microglia have been found in the forebrains and hippocampi of temporal lobe epilepsy (TLE) patients and status epileptic (SE) animal models. The peroxisome proliferator-activated receptor γ (PPAR γ) agonist rosiglitazone has been shown to prevent microglial activation. However, its role in pilocarpine-in...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13265

    authors: Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

    更新日期:2019-12-01 00:00:00

  • A novel, nonbinary evaluation of success and failure reveals bupropion efficacy versus methamphetamine dependence: reanalysis of a multisite trial.

    abstract::A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetamine-free urines each we...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1755-5949.2011.00263.x

    authors: McCann DJ,Li SH

    更新日期:2012-05-01 00:00:00

  • Time course of depression and one-year prognosis of patients with stroke in mainland China.

    abstract:AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1755-5949.2012.00312.x

    authors: Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

    更新日期:2012-06-01 00:00:00

  • Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25-35 in hippocampus neurons in vitro.

    abstract:AIMS:Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid-β (Aβ) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl al...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12678

    authors: Li LS,Lu YL,Nie J,Xu YY,Zhang W,Yang WJ,Gong QH,Lu YF,Lu Y,Shi JS

    更新日期:2017-04-01 00:00:00

  • Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.

    abstract:BACKGROUND:Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydro...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12983

    authors: Feng J,Wang JX,Du YH,Liu Y,Zhang W,Chen JF,Liu YJ,Zheng M,Wang KJ,He GQ

    更新日期:2018-12-01 00:00:00

  • Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.

    abstract::Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-5...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1527-3458.2008.00037.x

    authors: Tietje KR,Anderson DJ,Bitner RS,Blomme EA,Brackemeyer PJ,Briggs CA,Browman KE,Bury D,Curzon P,Drescher KU,Frost JM,Fryer RM,Fox GB,Gronlien JH,Håkerud M,Gubbins EJ,Halm S,Harris R,Helfrich RJ,Kohlhaas KL,Law D,M

    更新日期:2008-04-01 00:00:00

  • Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation.

    abstract:AIMS:Insufficient sleep has been found to result in varying degrees of cognitive impairment and emotional changes. Sleep was reported probably responsible for cleaning metabolic wastes in brain by increasing extracellular bulk flow. Herein, we propose that chronic sleep insufficiency in young adult wild-type mice is al...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13218

    authors: Xie Y,Ba L,Wang M,Deng SY,Chen SM,Huang LF,Zhang M,Wang W,Ding FF

    更新日期:2020-02-01 00:00:00

  • The role of tau in Alzheimer's disease and related disorders.

    abstract::Tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-5949.2010.00177.x

    authors: Medeiros R,Baglietto-Vargas D,LaFerla FM

    更新日期:2011-10-01 00:00:00

  • The antiapoptotic activity of melatonin in neurodegenerative diseases.

    abstract::Melatonin plays a neuroprotective role in models of neurodegenerative diseases. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Apoptotic cell death in the central nervous system is a feature of neurodegenerative diseases. The intrinsic and extrinsic apoptotic pathway...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-5949.2009.00105.x

    authors: Wang X

    更新日期:2009-01-01 00:00:00

  • Brain structure alterations in depression: Psychoradiological evidence.

    abstract::Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anato...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/cns.12835

    authors: Zhang FF,Peng W,Sweeney JA,Jia ZY,Gong QY

    更新日期:2018-11-01 00:00:00

  • Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy.

    abstract:INTRODUCTION:Patients with temporal lobe epilepsy (TLE) often suffer from comorbid psychiatric diagnoses such as depression, anxiety, or impaired cognitive performance. Endocannabinoid (eCB) signaling is a key regulator of synaptic neurotransmission and has been implicated in the mechanisms of epilepsy as well as sever...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12302

    authors: Ma L,Wang L,Yang F,Meng XD,Wu C,Ma H,Jiang W

    更新日期:2014-10-01 00:00:00

  • Patient diaries as a clinical endpoint in Parkinson's disease clinical trials.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder with an estimated 4 million patients worldwide. L-dopa is standard, and often initial, therapy for patients with this condition; however, with continued dopaminergic treatment and as the disease progresses, the majority of patients experienc...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-5949.2011.00253.x

    authors: Papapetropoulos SS

    更新日期:2012-05-01 00:00:00

  • EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity.

    abstract:AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12581

    authors: Liu Y,Jiang S,Yang PY,Zhang YF,Li TJ,Rui YC

    更新日期:2016-10-01 00:00:00

  • Kir6.1 knockdown aggravates cerebral ischemia/reperfusion-induced neural injury in mice.

    abstract:BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12117

    authors: Dong YF,Wang LX,Huang X,Cao WJ,Lu M,Ding JH,Sun XL,Hu G

    更新日期:2013-08-01 00:00:00

  • Sigma-1 receptor knockout impairs neurogenesis in dentate gyrus of adult hippocampus via down-regulation of NMDA receptors.

    abstract:AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12129

    authors: Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

    更新日期:2013-09-01 00:00:00

  • Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year.

    abstract:OBJECTIVE:To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). METHODS:Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of vari...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13392

    authors: You Z,Wu YY,Wu R,Xu ZX,Wu X,Wang XP

    更新日期:2020-09-01 00:00:00

  • Octodon degus: a model for the cognitive impairment associated with Alzheimer's disease.

    abstract::Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/cns.12125

    authors: Tarragon E,Lopez D,Estrada C,Ana GC,Schenker E,Pifferi F,Bordet R,Richardson JC,Herrero MT

    更新日期:2013-09-01 00:00:00

  • Lives in isolation: stories and struggles of low-income African American women with panic disorder.

    abstract::Research evidence points to the existence of racial-ethnic disparities in both access to and quality of mental health services for African Americans with panic disorder. Current panic disorder evaluation and treatment paradigms are not responsive to the needs of many African Americans. The primary individual, social, ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1755-5949.2009.00079.x

    authors: Johnson M,Mills TL,Deleon JM,Hartzema AG,Haddad J

    更新日期:2009-10-01 00:00:00

  • Pathological changes in neurovascular units: Lessons from cases of vascular dementia.

    abstract::Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease (AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main causes of VD. Neurovascular unit (NVU) is a vessel-centered concept, emphasizing all the cellular components play an integrated role in mainta...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13572

    authors: Li C,Wang Y,Yan XL,Guo ZN,Yang Y

    更新日期:2021-01-10 00:00:00

  • Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats.

    abstract:INTRODUCTION:The aim of this study was to explore whether the antibrain edema of hypertonic saline (HS) is associated with alleviating ischemic blood-brain barrier (BBB) permeability by downregulating astrocyte-derived vascular endothelial growth factor (VEGF), which is mediated by microglia-derived NOD-like receptor p...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13427

    authors: Wang QS,Ding HG,Chen SL,Liu XQ,Deng YY,Jiang WQ,Li Y,Huang LQ,Han YL,Wen MY,Wang MQ,Zeng HK

    更新日期:2020-06-12 00:00:00

  • Lacosamide and epilepsy.

    abstract::We will review all available studies on the use of lacosamide in the treatment of partial-onset seizures. The available evidence includes two open-label studies and three randomized controlled trials evaluating the safety and efficacy of oral lacosamide. One open-label study and one randomized controlled trial evaluat...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1755-5949.2010.00198.x

    authors: Harris JA,Murphy JA

    更新日期:2011-12-01 00:00:00

  • A 24-week, randomized, controlled trial of rivastigmine patch 13.3 mg/24 h versus 4.6 mg/24 h in severe Alzheimer's dementia.

    abstract:AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/cns.12158

    authors: Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

    更新日期:2013-10-01 00:00:00

  • Long noncoding RNA ENST00000413528 sponges microRNA-593-5p to modulate human glioma growth via polo-like kinase 1.

    abstract:AIMS:In this study, we examined the expression of lncRNA ENST00000413528 in glioma and determined its role in glioma development. METHODS:LncRNA ENST00000413528 was detected in glioma tissues by lncRNA microarray. Then, we performed real-time PCR, CCK-8, colony formation assay, flow cytometry, caspase-3/7 assay and an...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.13121

    authors: Zhang R,Wei RL,Du W,Zhang LW,Du T,Geng YD,Wei XT

    更新日期:2019-08-01 00:00:00

  • Mutation Analysis of COQ2 in Chinese Patients with Cerebellar Subtype of Multiple System Atrophy.

    abstract:AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章

    doi:10.1111/cns.12412

    authors: Wen XD,Li HF,Wang HX,Ni W,Dong Y,Wu ZY

    更新日期:2015-08-01 00:00:00