Ginsenosides and their CNS targets.

abstract：:Tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau ...

journal_title：CNS neuroscience & therapeutics

authors： Medeiros R,Baglietto-Vargas D,LaFerla FM

更新日期：2011-10-01 00:00:00

abstract：:Fingolimod is a sphingosine 1-phosphate (S1P) receptor modulator approved to treat relapsing-remitting multiple sclerosis (MS). Initiation of treatment with fingolimod has been found to produce transient bradycardia and/or slowing of atrioventricular impulse conduction in a small proportion of patients. This effect is...

journal_title：CNS neuroscience & therapeutics

authors： Vanoli E,Pentimalli F,Botto G

更新日期：2014-06-01 00:00:00

abstract：:Epigenetics involves molecular mechanisms related to gene expression independent of DNA sequence, mostly mediated by modification of chromatin histones. It has recently been suggested that these transcriptional changes may be implicated in the pathophysiology of mood disorders. In addition, histone deacetylase (HDAC) ...

journal_title：CNS neuroscience & therapeutics

authors： Machado-Vieira R,Ibrahim L,Zarate CA Jr

更新日期：2011-12-01 00:00:00

abstract：:Neurodegenerative diseases represent, nowadays, one of the main causes of death in the industrialized country. They are characterized by a loss of neurons in particular regions of the nervous system. It is believed that this nerve cell loss underlies the subsequent decline in cognitive and motor function that patients...

journal_title：CNS neuroscience & therapeutics

authors： Iuvone T,Esposito G,De Filippis D,Scuderi C,Steardo L

更新日期：2009-01-01 00:00:00

abstract：AIMS:Coagulation abnormality is one of the primary concerns for patients with spontaneous intracerebral hemorrhage admitted to ER. Conventional laboratory indicators require hours for coagulopathy diagnosis, which brings difficulties for appropriate intervention within the optimal window. This study evaluates the possi...

journal_title：CNS neuroscience & therapeutics

authors： Zhu F,Pan Z,Tang Y,Fu P,Cheng S,Hou W,Zhang Q,Huang H,Sun Y

更新日期：2020-11-28 00:00:00

abstract：:Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

journal_title：CNS neuroscience & therapeutics

authors： Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM:We sought to determine whether white matter hypoperfusion (WMHP) on perfusion...

journal_title：CNS neuroscience & therapeutics

authors： Bivard A,Cheng X,Lin LT,Levi C,Spratt N,Kleinig T,O'Brien B,Butcher K,Lou M,Zhang JF,Sylaja PN,Cao WJ,Jannes J,Dong Q,Parsons M

更新日期：2016-03-01 00:00:00

abstract：AIMS:PRRT2 variants are associated with various paroxysmal disorders. To date, more than 90 PRRT2 variants have been reported in PRRT2-related disorders. Lack of functional study in majority of missense variants makes their pathogenicity uncertain. We aim to evaluate the clinical significance of PRRT2 missense variants...

journal_title：CNS neuroscience & therapeutics

authors： Zhao SY,Li LX,Chen YL,Chen YJ,Liu GL,Dong HL,Chen DF,Li HF,Wu ZY

更新日期：2020-01-01 00:00:00

abstract：AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...

journal_title：CNS neuroscience & therapeutics

authors： Yang H,Han L,Zhou YJ,Ding J,Cai Y,Hong RH,Hao Y,Zhu DS,Shen XF,Guan YT

更新日期：2020-02-01 00:00:00

abstract：AIMS:To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes. METHODS:Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional ou...

journal_title：CNS neuroscience & therapeutics

authors： Pan YS,Jing J,Wang YL,Zhao XQ,Song B,Wang WJ,Wang D,Liu GF,Liu LP,Wang CX,Wang YJ,CNSR investigators.

更新日期：2014-06-01 00:00:00

abstract：AIMS:Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid-β (Aβ) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl al...

journal_title：CNS neuroscience & therapeutics

authors： Li LS,Lu YL,Nie J,Xu YY,Zhang W,Yang WJ,Gong QH,Lu YF,Lu Y,Shi JS

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Patients with temporal lobe epilepsy (TLE) often suffer from comorbid psychiatric diagnoses such as depression, anxiety, or impaired cognitive performance. Endocannabinoid (eCB) signaling is a key regulator of synaptic neurotransmission and has been implicated in the mechanisms of epilepsy as well as sever...

journal_title：CNS neuroscience & therapeutics

authors： Ma L,Wang L,Yang F,Meng XD,Wu C,Ma H,Jiang W

更新日期：2014-10-01 00:00:00

abstract：:Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

journal_title：CNS neuroscience & therapeutics

authors： Ghosh A,Chen F,Thakur A,Hong H

更新日期：2016-12-01 00:00:00

abstract：:Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...

journal_title：CNS neuroscience & therapeutics

authors： Tarragon E,Lopez D,Estrada C,Ana GC,Schenker E,Pifferi F,Bordet R,Richardson JC,Herrero MT

更新日期：2013-09-01 00:00:00

abstract：:Central dopaminergic and noradrenergic systems play essential roles in controlling several forebrain functions. Consequently, perturbations of these neurotransmissions may contribute to the pathophysiology of neuropsychiatric disorders. For many years, there was a focus on the serotonin (5-HT) system because of the ef...

journal_title：CNS neuroscience & therapeutics

authors： El Mansari M,Guiard BP,Chernoloz O,Ghanbari R,Katz N,Blier P

更新日期：2010-06-01 00:00:00

abstract：:Research evidence points to the existence of racial-ethnic disparities in both access to and quality of mental health services for African Americans with panic disorder. Current panic disorder evaluation and treatment paradigms are not responsive to the needs of many African Americans. The primary individual, social, ...

journal_title：CNS neuroscience & therapeutics

authors： Johnson M,Mills TL,Deleon JM,Hartzema AG,Haddad J

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：:Cerebral ischemia is a severe outcome that could cause cognitive and motor dysfunction, neurodegenerative diseases and even acute death. Although the existence of autophagy in cerebral ischemia is undisputable, the consensus has not yet been reached regarding the exact functions and influence of autophagy in cerebral ...

journal_title：CNS neuroscience & therapeutics

authors： Wei K,Wang P,Miao CY

更新日期：2012-11-01 00:00:00

abstract：AIMS:Our laboratory previously reported that olanzapine treatment inhibited growth of glioma cell lines and hypothesized that autophagy may be involved in the proliferation inhibitory effects of olanzapine. However, the mechanisms of olanzapine-contributed autophagy activation are unclear. METHODS:The inhibitory effec...

journal_title：CNS neuroscience & therapeutics

authors： Zhu Y,Zhao YF,Liu RS,Xiong YJ,Shen X,Wang Y,Liang ZQ

更新日期：2019-09-01 00:00:00

abstract：AIMS:In this study, we examined the expression of GINS2 in glioma and determined its role in glioma development. METHODS:The protein expression of GINS2 was assessed in 120 human glioma samples via immunohistochemistry. Then, we suppressed the expression of GINS2 in glioma cell strains U87 and U251 using a short hairp...

journal_title：CNS neuroscience & therapeutics

authors： Shen YL,Li HZ,Hu YW,Zheng L,Wang Q

更新日期：2019-02-01 00:00:00

abstract：AIMS:Glioblastoma multiforme (GBM) is the most lethal tumor with a median patient survival of 14 to 15 months. Glioma stem cells (GSCs) play a critical role in tumor initiation and therapeutic resistance in GBM. B3GNT5 has been suggested as the key glycosyltransferase in the biosynthesis of the (neo-) lacto series of g...

journal_title：CNS neuroscience & therapeutics

authors： Jeong HY,Park SY,Kim HJ,Moon S,Lee S,Lee SH,Kim SH

更新日期：2020-11-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...

journal_title：CNS neuroscience & therapeutics

authors： Torika N,Asraf K,Apte RN,Fleisher-Berkovich S

更新日期：2018-03-01 00:00:00

abstract：AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

journal_title：CNS neuroscience & therapeutics

authors： Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

更新日期：2013-10-01 00:00:00

abstract：:Neurodegenerative diseases result from the gradual and progressive loss of neural cells and lead to nervous system dysfunction. The rapidly advancing stem cell field is providing attractive alternative options for fighting these diseases. Results have provided proof of principle that cell replacement can work in human...

journal_title：CNS neuroscience & therapeutics

authors： Feng Z,Gao F

更新日期：2012-02-01 00:00:00

abstract：:Adenosine-dopamine interactions in the central nervous system (CNS) have been studied for many years in view of their relevance for disorders of the CNS and their treatments. The discovery of adenosine and dopamine receptor containing receptor mosaics (RM, higher-order receptor heteromers) in the striatum opened up a ...

journal_title：CNS neuroscience & therapeutics

authors： Fuxe K,Marcellino D,Borroto-Escuela DO,Guescini M,Fernández-Dueñas V,Tanganelli S,Rivera A,Ciruela F,Agnati LF

更新日期：2010-06-01 00:00:00

abstract：:Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-5...

journal_title：CNS neuroscience & therapeutics

authors： Tietje KR,Anderson DJ,Bitner RS,Blomme EA,Brackemeyer PJ,Briggs CA,Browman KE,Bury D,Curzon P,Drescher KU,Frost JM,Fryer RM,Fox GB,Gronlien JH,Håkerud M,Gubbins EJ,Halm S,Harris R,Helfrich RJ,Kohlhaas KL,Law D,M

更新日期：2008-04-01 00:00:00

abstract：:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) type glutamate receptors are critical for synaptic plasticity and induction of long-term potentiation (LTP), considered as one of the synaptic mechanisms underlying learning and memory. Positive allosteric modulators of AMPA receptors could provide a the...

journal_title：CNS neuroscience & therapeutics

authors： Bernard K,Danober L,Thomas JY,Lebrun C,Muñoz C,Cordi A,Desos P,Lestage P,Morain P

更新日期：2010-10-01 00:00:00

abstract：AIMS:Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this s...

journal_title：CNS neuroscience & therapeutics

authors： Li RR,Lyu HL,Liu F,Lian N,Wu RR,Zhao JP,Guo WB

更新日期：2018-12-01 00:00:00

abstract：:Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final co...

journal_title：CNS neuroscience & therapeutics

authors： Furukawa A,Koriyama Y

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Clearance of damaged cells and debris is beneficial for the functional recovery after ischemic brain injury. However, the specific phagocytic receptor that mediates microglial phagocytosis after ischemic stroke is unknown. AIM:To investigate whether P2Y6 receptor-mediated microglial phagocytosis is benefi...

journal_title：CNS neuroscience & therapeutics

authors： Wen RX,Shen H,Huang SX,Wang LP,Li ZW,Peng P,Mamtilahun M,Tang YH,Shen FX,Tian HL,Yang GY,Zhang ZJ

更新日期：2020-04-01 00:00:00