P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis.

abstract：:Post-traumatic stress disorder (PTSD) has become a global health issue, with prevalence rates ranging from 1.3% to 37.4%. As there is little current data on PTSD in Canada, an epidemiological study was conducted examining PTSD and related comorbid conditions. Modified versions of the Composite International Diagnostic...

journal_title：CNS neuroscience & therapeutics

authors： Van Ameringen M,Mancini C,Patterson B,Boyle MH

更新日期：2008-10-01 00:00:00

abstract：:Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease (AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main causes of VD. Neurovascular unit (NVU) is a vessel-centered concept, emphasizing all the cellular components play an integrated role in mainta...

journal_title：CNS neuroscience & therapeutics

authors： Li C,Wang Y,Yan XL,Guo ZN,Yang Y

更新日期：2021-01-10 00:00:00

abstract：:Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anato...

journal_title：CNS neuroscience & therapeutics

authors： Zhang FF,Peng W,Sweeney JA,Jia ZY,Gong QY

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...

journal_title：CNS neuroscience & therapeutics

authors： Torre-Fuentes L,Matías-Guiu JA,Pytel V,Montero-Escribano P,Maietta P,Álvarez S,Gómez-Pinedo U,Matías-Guiu J

更新日期：2020-11-01 00:00:00

abstract：AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

journal_title：CNS neuroscience & therapeutics

authors： Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

更新日期：2012-06-01 00:00:00

abstract：AIMS:Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this stu...

journal_title：CNS neuroscience & therapeutics

authors： Ryu V,Ha RY,Lee SJ,Ha K,Cho HS

更新日期：2017-03-01 00:00:00

abstract：:Cerebral ischemia is a severe outcome that could cause cognitive and motor dysfunction, neurodegenerative diseases and even acute death. Although the existence of autophagy in cerebral ischemia is undisputable, the consensus has not yet been reached regarding the exact functions and influence of autophagy in cerebral ...

journal_title：CNS neuroscience & therapeutics

authors： Wei K,Wang P,Miao CY

更新日期：2012-11-01 00:00:00

abstract：AIMS:Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin-1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage mitigates the degene...

journal_title：CNS neuroscience & therapeutics

authors： Suto N,Mieda T,Iizuka A,Nakamura K,Hirai H

更新日期：2016-08-01 00:00:00

abstract：AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...

journal_title：CNS neuroscience & therapeutics

authors： Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJ

更新日期：2014-09-01 00:00:00

abstract：AIMS:To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) on motor recovery after stroke using a prospective, double-blind, randomized, sham-controlled study. METHODS:Patients with unilateral subcortical infarction in the middle cerebral artery territory within 1 week after onset were e...

journal_title：CNS neuroscience & therapeutics

authors： Guan YZ,Li J,Zhang XW,Wu S,Du H,Cui LY,Zhang WH

更新日期：2017-12-01 00:00:00

abstract：AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...

journal_title：CNS neuroscience & therapeutics

authors： Liu Y,Jiang S,Yang PY,Zhang YF,Li TJ,Rui YC

更新日期：2016-10-01 00:00:00

abstract：AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...

journal_title：CNS neuroscience & therapeutics

authors： Mazumder MK,Paul R,Borah A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：:The pathophysiological mechanisms of neuroinflammation, angiogenesis, and neuroplasticity are currently the hotspots of researches in ischemic stroke. Regulatory T cells (Tregs), a subset of T cells that control inflammatory and immune responses in the body, are closely related to the pathogenesis of ischemic stroke. ...

journal_title：CNS neuroscience & therapeutics

authors： Wang H,Wang Z,Wu Q,Yuan Y,Cao W,Zhang X

更新日期：2021-01-20 00:00:00

abstract：AIMS:Glioblastoma multiforme (GBM) is the most lethal tumor with a median patient survival of 14 to 15 months. Glioma stem cells (GSCs) play a critical role in tumor initiation and therapeutic resistance in GBM. B3GNT5 has been suggested as the key glycosyltransferase in the biosynthesis of the (neo-) lacto series of g...

journal_title：CNS neuroscience & therapeutics

authors： Jeong HY,Park SY,Kim HJ,Moon S,Lee S,Lee SH,Kim SH

更新日期：2020-11-01 00:00:00

abstract：AIM:Multiple sclerosis (MS) is a neurological autoimmune disorder characterized by mistaken attacks of inflammatory cells against the central nervous system (CNS), resulting in demyelination and axonal damage. Kv1.3 channel blockers can inhibit T-cell activation and have been designed for MS therapy. However, little is...

journal_title：CNS neuroscience & therapeutics

authors： Yuan XL,Zhao YP,Huang J,Liu JC,Mao WQ,Yin J,Peng BW,Liu WH,Han S,He XH

更新日期：2018-10-01 00:00:00

abstract：:Understanding the neural substrates of depression is crucial for diagnosis and treatment. Here, we review recent studies of functional and effective connectivity in depression, in terms of functional integration in the brain. Findings from these studies, including our own, point to the involvement of at least four net...

journal_title：CNS neuroscience & therapeutics

authors： Li BJ,Friston K,Mody M,Wang HN,Lu HB,Hu DW

更新日期：2018-11-01 00:00:00

abstract：:Neurodegenerative diseases result from the gradual and progressive loss of neural cells and lead to nervous system dysfunction. The rapidly advancing stem cell field is providing attractive alternative options for fighting these diseases. Results have provided proof of principle that cell replacement can work in human...

journal_title：CNS neuroscience & therapeutics

authors： Feng Z,Gao F

更新日期：2012-02-01 00:00:00

abstract：AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

journal_title：CNS neuroscience & therapeutics

authors： Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

更新日期：2013-10-01 00:00:00

abstract：AIMS:To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes. METHODS:Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional ou...

journal_title：CNS neuroscience & therapeutics

authors： Pan YS,Jing J,Wang YL,Zhao XQ,Song B,Wang WJ,Wang D,Liu GF,Liu LP,Wang CX,Wang YJ,CNSR investigators.

更新日期：2014-06-01 00:00:00

abstract：AIMS:Streptococcus pneumoniae infection in acute bacterial meningitis can lead to widespread brain damage and mortality. Inflammatory responses by immune cells in the brain are thought to determine the degree of brain injury. Yet, the mechanisms underlying host responses to pneumococcal meningitis are largely unknown. ...

journal_title：CNS neuroscience & therapeutics

authors： Lee S,Lee SO,Kim GL,Rhee DK

更新日期：2018-10-01 00:00:00

abstract：AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...

journal_title：CNS neuroscience & therapeutics

authors： Wen XD,Li HF,Wang HX,Ni W,Dong Y,Wu ZY

更新日期：2015-08-01 00:00:00

abstract：:Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of oc...

journal_title：CNS neuroscience & therapeutics

authors： Wang L,Xiong X,Zhang L,Shen J

更新日期：2021-01-02 00:00:00

abstract：AIMS:To conduct a large-scale analysis on epidemiology, management, and outcomes of spontaneous subarachnoid hemorrhage (SAH), and to investigate the current situation of aneurysm obliteration in China. METHODS:A multicenter prospective cohort study involving 132 hospitals throughout China from September 2007 to Augus...

journal_title：CNS neuroscience & therapeutics

authors： Bian LH,Liu YF,Nichols LT,Wang CX,Wang YL,Liu GF,Wang WJ,Zhao XQ

更新日期：2012-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP...

journal_title：CNS neuroscience & therapeutics

authors： Singh Y,Gupta G,Shrivastava B,Dahiya R,Tiwari J,Ashwathanarayana M,Sharma RK,Agrawal M,Mishra A,Dua K

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-18...

journal_title：CNS neuroscience & therapeutics

authors： Shen LM,Song ZW,Hua Y,Chao X,Liu JB

更新日期：2017-11-01 00:00:00

abstract：AIMS:Blood-borne monocytes/macrophages infiltrate the brain in massive numbers after ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive. This study examined the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, ...

journal_title：CNS neuroscience & therapeutics

authors： Zhang W,Zhao J,Wang R,Jiang M,Ye Q,Smith AD,Chen J,Shi Y

更新日期：2019-12-01 00:00:00

abstract：:Tolerance development after successful long-term treatment of bipolar disorder is under recognized, as are ways to prevent or show its occurrence or reverse it once it has occurred. We review the clinical literature which suggests that tolerance can develop to most treatment approaches in bipolar illness and present a...

journal_title：CNS neuroscience & therapeutics

authors： Post RM,Weiss SR

更新日期：2011-12-01 00:00:00

abstract：AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

journal_title：CNS neuroscience & therapeutics

authors： Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

更新日期：2019-01-01 00:00:00

abstract：:The focus of this review is on the efficacy of antidepressants as preventive treatments for migraine and chronic tension-type headache (TTH). Pharmacologic prophylaxis may be indicated for patients with frequent headaches, who respond insufficiently to acute therapies, or for whom medication overuse is a concern. The ...

journal_title：CNS neuroscience & therapeutics

authors： Smitherman TA,Walters AB,Maizels M,Penzien DB

更新日期：2011-10-01 00:00:00