Abstract:
AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In animal study, cerebellar infarction operation was performed in 12 Cynomolgus monkeys. Then the animals were administrated with low molecular weight heparin (LMWH) or vehicle for 14 days. RESULTS:Six patients died during the following treatment. All the subjects that died received anticoagulation therapy, while nobody in the survival group received such a therapy. Compared with sham-operated animals, all monkeys with cerebellar infarction have obvious neurological deficits. The number and size of the Purkinje cells in the cerebellar area were also reduced. Two animals in the LMWH group (33%) died, while all animals in the vehicle control group survived. Compared with the vehicle group, the neurological score in the LMWH group was significantly increased (P < 0.05). The water content in the cerebella was also significantly higher (P < 0.05). Edema, hemorrhage, and subarachnoid hemorrhage occurred in the cerebella as well as brainstem of all the LMWH treated animals. CONCLUSIONS:These results indicated the harmful effects of anticoagulation therapy on large-sized cerebellar infarction.
journal_name
CNS Neurosci Therjournal_title
CNS neuroscience & therapeuticsauthors
Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJdoi
10.1111/cns.12299subject
Has Abstractpub_date
2014-09-01 00:00:00pages
867-73issue
9eissn
1755-5930issn
1755-5949journal_volume
20pub_type
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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