A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis.

abstract：INTRODUCTION:Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with co...

journal_title：CNS neuroscience & therapeutics

authors： Sidhu MK,Thompson PJ,Wandschneider B,Foulkes A,de Tisi J,Stretton J,Perona M,Thom M,Bonelli SB,Burdett J,Williams E,Duncan JS,Matarin M

更新日期：2019-02-01 00:00:00

abstract：:Adenosine-dopamine interactions in the central nervous system (CNS) have been studied for many years in view of their relevance for disorders of the CNS and their treatments. The discovery of adenosine and dopamine receptor containing receptor mosaics (RM, higher-order receptor heteromers) in the striatum opened up a ...

journal_title：CNS neuroscience & therapeutics

authors： Fuxe K,Marcellino D,Borroto-Escuela DO,Guescini M,Fernández-Dueñas V,Tanganelli S,Rivera A,Ciruela F,Agnati LF

更新日期：2010-06-01 00:00:00

abstract：:Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

journal_title：CNS neuroscience & therapeutics

authors： Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：:Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final co...

journal_title：CNS neuroscience & therapeutics

authors： Furukawa A,Koriyama Y

更新日期：2016-01-01 00:00:00

abstract：AIMS:Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this s...

journal_title：CNS neuroscience & therapeutics

authors： Li RR,Lyu HL,Liu F,Lian N,Wu RR,Zhao JP,Guo WB

更新日期：2018-12-01 00:00:00

abstract：:Status epilepticus (SE), a neurological emergency both in adults and in children, could lead to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most common and severe form, an example of which is that induced by organophosphorus nerve agents. First- and second-line pharmacotherapies a...

journal_title：CNS neuroscience & therapeutics

authors： Dorandeu F,Dhote F,Barbier L,Baccus B,Testylier G

更新日期：2013-06-01 00:00:00

abstract：AIMS:To investigate if CIQ, a positive allosteric modulator of N-methyl-d-aspartate receptors (NMDARs) containing GluN2C/D subunits, rescues the loss of long-term potentiation (LTP) and forelimb-use asymmetry in a mouse model of Parkinson's disease (PD). METHODS:We have used electrophysiology in brain slices and the c...

journal_title：CNS neuroscience & therapeutics

authors： Nouhi M,Zhang X,Yao N,Chergui K

更新日期：2018-02-01 00:00:00

abstract：AIMS:Glioblastoma multiforme (GBM) is the most lethal tumor with a median patient survival of 14 to 15 months. Glioma stem cells (GSCs) play a critical role in tumor initiation and therapeutic resistance in GBM. B3GNT5 has been suggested as the key glycosyltransferase in the biosynthesis of the (neo-) lacto series of g...

journal_title：CNS neuroscience & therapeutics

authors： Jeong HY,Park SY,Kim HJ,Moon S,Lee S,Lee SH,Kim SH

更新日期：2020-11-01 00:00:00

abstract：:Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the cu...

journal_title：CNS neuroscience & therapeutics

authors： Pompili M,Venturini P,Campi S,Seretti ME,Montebovi F,Lamis DA,Serafini G,Amore M,Girardi P

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...

journal_title：CNS neuroscience & therapeutics

authors： Torre-Fuentes L,Matías-Guiu JA,Pytel V,Montero-Escribano P,Maietta P,Álvarez S,Gómez-Pinedo U,Matías-Guiu J

更新日期：2020-11-01 00:00:00

abstract：AIMS:The mouse model of allo-head and body reconstruction (AHBR) has recently been established to further the clinical development of this strategy for patients who are suffering from mortal bodily trauma or disease, yet whose mind remains healthy. Animal model studies are indispensable for developing such novel surgic...

journal_title：CNS neuroscience & therapeutics

authors： Ren XP,Ye YJ,Li PW,Shen ZL,Han KC,Song Y

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the roles of autophagy and endoplasmic reticulum (ER) stress in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) in rats. METHODS:Autophagy inducer (rapamycin) and inhibitor (3-methyladenine), as well as ER stress activator (tunicamycin, TM) and inhibitor (tau...

journal_title：CNS neuroscience & therapeutics

authors： Duan XC,Wang W,Feng DX,Yin J,Zuo G,Chen DD,Chen ZQ,Li HY,Wang Z,Chen G

更新日期：2017-07-01 00:00:00

abstract：:Neurodegenerative diseases represent, nowadays, one of the main causes of death in the industrialized country. They are characterized by a loss of neurons in particular regions of the nervous system. It is believed that this nerve cell loss underlies the subsequent decline in cognitive and motor function that patients...

journal_title：CNS neuroscience & therapeutics

authors： Iuvone T,Esposito G,De Filippis D,Scuderi C,Steardo L

更新日期：2009-01-01 00:00:00

abstract：AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

journal_title：CNS neuroscience & therapeutics

authors： Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

更新日期：2013-10-01 00:00:00

abstract：AIMS:Depression is a highly prevalent disorder in the elderly and one of the risk factors for developing dementia. The present study involves patients with Alzheimer's disease (AD), geriatric major depressive disorder (MDD) and cognitively healthy controls aiming to compare baseline cerebrospinal fluid (CSF) biomarkers...

journal_title：CNS neuroscience & therapeutics

authors： Reis T,Brandão CO,Freire Coutinho ES,Engelhardt E,Laks J

更新日期：2012-07-01 00:00:00

abstract：:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) type glutamate receptors are critical for synaptic plasticity and induction of long-term potentiation (LTP), considered as one of the synaptic mechanisms underlying learning and memory. Positive allosteric modulators of AMPA receptors could provide a the...

journal_title：CNS neuroscience & therapeutics

authors： Bernard K,Danober L,Thomas JY,Lebrun C,Muñoz C,Cordi A,Desos P,Lestage P,Morain P

更新日期：2010-10-01 00:00:00

abstract：:Understanding the neural substrates of depression is crucial for diagnosis and treatment. Here, we review recent studies of functional and effective connectivity in depression, in terms of functional integration in the brain. Findings from these studies, including our own, point to the involvement of at least four net...

journal_title：CNS neuroscience & therapeutics

authors： Li BJ,Friston K,Mody M,Wang HN,Lu HB,Hu DW

更新日期：2018-11-01 00:00:00

abstract：AIMS:Neuroinflammation contributed to the pathogenesis of multiple system atrophy (MSA). We aimed to detect the correlation between inflammatory mediators, such as Klotho (Klt), vitamin D (25(OH)D) and homocysteine (Hcy), and disease severity among MSA patients. METHODS:A total of 53 MSA patients, 65 PD patients, and ...

journal_title：CNS neuroscience & therapeutics

authors： Guo Y,Zhuang XD,Xian WB,Wu LL,Huang ZN,Hu X,Zhang XS,Chen L,Liao XX

更新日期：2017-08-01 00:00:00

abstract：AIMS:Exposure to recurrent hypoglycemia (RH) is common in diabetic patients receiving glucose-lowering therapies and is implicated in causing cognitive impairments. Despite the significant effect of RH on hippocampal function, the underlying mechanisms are currently unknown. Our goal was to determine the effect of RH e...

journal_title：CNS neuroscience & therapeutics

authors： Dewan N,Shukla V,Rehni AK,Koronowski KB,Klingbeil KD,Stradecki-Cohan H,Garrett TJ,Rundek T,Perez-Pinzon MA,Dave KR

更新日期：2020-01-01 00:00:00

abstract：AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

journal_title：CNS neuroscience & therapeutics

authors： Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

更新日期：2019-02-01 00:00:00

abstract：AIMS:Inflammation and apoptosis play important roles in increasing vascular permeability following subarachnoid hemorrhage (SAH). The objective of this study was to evaluate whether urinary trypsin inhibitor (UTI), a serine protease inhibitor, attenuates vascular permeability by its antiinflammatory and antiapoptotic e...

journal_title：CNS neuroscience & therapeutics

authors： Zhou N,Xu T,Bai Y,Prativa S,Xu JZ,Li K,Han HB,Yan JH

更新日期：2013-09-01 00:00:00

abstract：:5-HT(1A) receptors have long been implicated in the pathogenesis and treatment of anxiety and depressive disorders. Recently, several lines of studies have revealed new insights into the therapeutic role of 5-HT(1A) receptors in treating schizophrenia and Parkinson's disease. Specifically, 5-HT(1A) receptors seem to b...

journal_title：CNS neuroscience & therapeutics

authors： Ohno Y

更新日期：2011-02-01 00:00:00

abstract：AIMS:The MS-275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not well defined. In this study, we examined ...

journal_title：CNS neuroscience & therapeutics

authors： Cao P,Liang Y,Gao X,Zhao MG,Liang GB

更新日期：2013-05-01 00:00:00

abstract：AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

journal_title：CNS neuroscience & therapeutics

authors： Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

更新日期：2012-06-01 00:00:00

abstract：:Epigenetics involves molecular mechanisms related to gene expression independent of DNA sequence, mostly mediated by modification of chromatin histones. It has recently been suggested that these transcriptional changes may be implicated in the pathophysiology of mood disorders. In addition, histone deacetylase (HDAC) ...

journal_title：CNS neuroscience & therapeutics

authors： Machado-Vieira R,Ibrahim L,Zarate CA Jr

更新日期：2011-12-01 00:00:00

abstract：:Melatonin plays a neuroprotective role in models of neurodegenerative diseases. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Apoptotic cell death in the central nervous system is a feature of neurodegenerative diseases. The intrinsic and extrinsic apoptotic pathway...

journal_title：CNS neuroscience & therapeutics

authors： Wang X

更新日期：2009-01-01 00:00:00

abstract：AIMS:Intracellular calcium plays an important role in neuronal hyperexcitability that leads to seizures. One calcium influx route of interest is the transient receptor potential vanilloid type 1 (TRPV1) channel. Here, we evaluated the effects of capsazepine (CPZ), a potent blocker of TRPV1 channels on acoustically evok...

journal_title：CNS neuroscience & therapeutics

authors： Cho SJ,Vaca MA,Miranda CJ,N'Gouemo P

更新日期：2018-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a global health issue, with prevalence rates ranging from 1.3% to 37.4%. As there is little current data on PTSD in Canada, an epidemiological study was conducted examining PTSD and related comorbid conditions. Modified versions of the Composite International Diagnostic...

journal_title：CNS neuroscience & therapeutics

authors： Van Ameringen M,Mancini C,Patterson B,Boyle MH

更新日期：2008-10-01 00:00:00

abstract：AIMS:Recovery after peripheral nerve injury (PNI) is often difficult, and there is no optimal treatment. Schwann cells (SCs) are important for peripheral nerve regeneration, so SC-targeting treatments have gained importance. Adipose-derived stem cells (ADSCs) and their exosomes can promote peripheral nerve repair, but ...

journal_title：CNS neuroscience & therapeutics

authors： Liu CY,Yin G,Sun YD,Lin YF,Xie Z,English AW,Li QF,Lin HD

更新日期：2020-02-01 00:00:00