Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin-induced diabetic rats.

abstract：AIMS:PRRT2 variants are associated with various paroxysmal disorders. To date, more than 90 PRRT2 variants have been reported in PRRT2-related disorders. Lack of functional study in majority of missense variants makes their pathogenicity uncertain. We aim to evaluate the clinical significance of PRRT2 missense variants...

journal_title：CNS neuroscience & therapeutics

authors： Zhao SY,Li LX,Chen YL,Chen YJ,Liu GL,Dong HL,Chen DF,Li HF,Wu ZY

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...

journal_title：CNS neuroscience & therapeutics

authors： Torre-Fuentes L,Matías-Guiu JA,Pytel V,Montero-Escribano P,Maietta P,Álvarez S,Gómez-Pinedo U,Matías-Guiu J

更新日期：2020-11-01 00:00:00

abstract：AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...

journal_title：CNS neuroscience & therapeutics

authors： Yang H,Han L,Zhou YJ,Ding J,Cai Y,Hong RH,Hao Y,Zhu DS,Shen XF,Guan YT

更新日期：2020-02-01 00:00:00

abstract：AIMS:Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin-1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage mitigates the degene...

journal_title：CNS neuroscience & therapeutics

authors： Suto N,Mieda T,Iizuka A,Nakamura K,Hirai H

更新日期：2016-08-01 00:00:00

abstract：:Adenosine-dopamine interactions in the central nervous system (CNS) have been studied for many years in view of their relevance for disorders of the CNS and their treatments. The discovery of adenosine and dopamine receptor containing receptor mosaics (RM, higher-order receptor heteromers) in the striatum opened up a ...

journal_title：CNS neuroscience & therapeutics

authors： Fuxe K,Marcellino D,Borroto-Escuela DO,Guescini M,Fernández-Dueñas V,Tanganelli S,Rivera A,Ciruela F,Agnati LF

更新日期：2010-06-01 00:00:00

abstract：:We will review all available studies on the use of lacosamide in the treatment of partial-onset seizures. The available evidence includes two open-label studies and three randomized controlled trials evaluating the safety and efficacy of oral lacosamide. One open-label study and one randomized controlled trial evaluat...

journal_title：CNS neuroscience & therapeutics

authors： Harris JA,Murphy JA

更新日期：2011-12-01 00:00:00

abstract：AIMS:In this study, we examined the expression of GINS2 in glioma and determined its role in glioma development. METHODS:The protein expression of GINS2 was assessed in 120 human glioma samples via immunohistochemistry. Then, we suppressed the expression of GINS2 in glioma cell strains U87 and U251 using a short hairp...

journal_title：CNS neuroscience & therapeutics

authors： Shen YL,Li HZ,Hu YW,Zheng L,Wang Q

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...

journal_title：CNS neuroscience & therapeutics

authors： Dong YF,Wang LX,Huang X,Cao WJ,Lu M,Ding JH,Sun XL,Hu G

更新日期：2013-08-01 00:00:00

abstract：AIMS:Insufficient sleep has been found to result in varying degrees of cognitive impairment and emotional changes. Sleep was reported probably responsible for cleaning metabolic wastes in brain by increasing extracellular bulk flow. Herein, we propose that chronic sleep insufficiency in young adult wild-type mice is al...

journal_title：CNS neuroscience & therapeutics

authors： Xie Y,Ba L,Wang M,Deng SY,Chen SM,Huang LF,Zhang M,Wang W,Ding FF

更新日期：2020-02-01 00:00:00

abstract：:Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

journal_title：CNS neuroscience & therapeutics

authors： Ghosh A,Chen F,Thakur A,Hong H

更新日期：2016-12-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...

journal_title：CNS neuroscience & therapeutics

authors： Torika N,Asraf K,Apte RN,Fleisher-Berkovich S

更新日期：2018-03-01 00:00:00

abstract：AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...

journal_title：CNS neuroscience & therapeutics

authors： Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJ

更新日期：2014-09-01 00:00:00

abstract：:Appropriate and reliable classification of mental illness is crucial for advancing the field of psychiatry as agreement on diagnosis has broad implications for treatment of mental disorders and research into the etiopathophysiology of mental disorders. Since schizophrenia was first recognized by Kraepelin (as dementia...

journal_title：CNS neuroscience & therapeutics

authors： Keller WR,Fischer BA,Carpenter WT Jr

更新日期：2011-04-01 00:00:00

abstract：AIMS:Intracellular calcium plays an important role in neuronal hyperexcitability that leads to seizures. One calcium influx route of interest is the transient receptor potential vanilloid type 1 (TRPV1) channel. Here, we evaluated the effects of capsazepine (CPZ), a potent blocker of TRPV1 channels on acoustically evok...

journal_title：CNS neuroscience & therapeutics

authors： Cho SJ,Vaca MA,Miranda CJ,N'Gouemo P

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-18...

journal_title：CNS neuroscience & therapeutics

authors： Shen LM,Song ZW,Hua Y,Chao X,Liu JB

更新日期：2017-11-01 00:00:00

abstract：AIMS:Activated microglia have been found in the forebrains and hippocampi of temporal lobe epilepsy (TLE) patients and status epileptic (SE) animal models. The peroxisome proliferator-activated receptor γ (PPAR γ) agonist rosiglitazone has been shown to prevent microglial activation. However, its role in pilocarpine-in...

journal_title：CNS neuroscience & therapeutics

authors： Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

更新日期：2019-12-01 00:00:00

abstract：:The pathophysiological mechanisms of neuroinflammation, angiogenesis, and neuroplasticity are currently the hotspots of researches in ischemic stroke. Regulatory T cells (Tregs), a subset of T cells that control inflammatory and immune responses in the body, are closely related to the pathogenesis of ischemic stroke. ...

journal_title：CNS neuroscience & therapeutics

authors： Wang H,Wang Z,Wu Q,Yuan Y,Cao W,Zhang X

更新日期：2021-01-20 00:00:00

abstract：:Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anato...

journal_title：CNS neuroscience & therapeutics

authors： Zhang FF,Peng W,Sweeney JA,Jia ZY,Gong QY

更新日期：2018-11-01 00:00:00

abstract：AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

journal_title：CNS neuroscience & therapeutics

authors： Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

更新日期：2019-01-01 00:00:00

abstract：AIMS:Limited vs extended drug exposure has been proposed as one of the key factors in determining the risk of relapse, which is the primary characteristic of addiction behaviors. The current studies were designed to explore the related behavioral effects and neuronal alterations in the insular cortex (IC), an important...

journal_title：CNS neuroscience & therapeutics

authors： Luo YX,Huang D,Guo C,Ma YY

更新日期：2021-02-01 00:00:00

abstract：AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

journal_title：CNS neuroscience & therapeutics

authors： Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

更新日期：2019-02-01 00:00:00

abstract：:Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a como...

journal_title：CNS neuroscience & therapeutics

authors： Pabón MM,Ji XM,Fernandez JW,Borlongan CV

更新日期：2015-04-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder with an estimated 4 million patients worldwide. L-dopa is standard, and often initial, therapy for patients with this condition; however, with continued dopaminergic treatment and as the disease progresses, the majority of patients experienc...

journal_title：CNS neuroscience & therapeutics

authors： Papapetropoulos SS

更新日期：2012-05-01 00:00:00

abstract：AIMS:To develop and validate a novel score for prediction of 3-month functional outcome in neurocritically ill patients. METHODS:The development of the novel score was based on two widely used scores for general critical illnesses (Acute Physiology and Chronic Health Evaluation II, APACHE II; Simplified Acute Physiolo...

journal_title：CNS neuroscience & therapeutics

authors： Gao Q,Yuan F,Yang XA,Zhu JW,Song L,Bi LJ,Jiao ZY,Kang XG,Yang F,Jiang W

更新日期：2020-01-01 00:00:00

abstract：:Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

journal_title：CNS neuroscience & therapeutics

authors： Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

更新日期：2009-07-01 00:00:00

abstract：AIMS:The MS-275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not well defined. In this study, we examined ...

journal_title：CNS neuroscience & therapeutics

authors： Cao P,Liang Y,Gao X,Zhao MG,Liang GB

更新日期：2013-05-01 00:00:00

abstract：:Neurodegenerative diseases represent, nowadays, one of the main causes of death in the industrialized country. They are characterized by a loss of neurons in particular regions of the nervous system. It is believed that this nerve cell loss underlies the subsequent decline in cognitive and motor function that patients...

journal_title：CNS neuroscience & therapeutics

authors： Iuvone T,Esposito G,De Filippis D,Scuderi C,Steardo L

更新日期：2009-01-01 00:00:00

abstract：AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...

journal_title：CNS neuroscience & therapeutics

authors： Wen XD,Li HF,Wang HX,Ni W,Dong Y,Wu ZY

更新日期：2015-08-01 00:00:00

abstract：:Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...

journal_title：CNS neuroscience & therapeutics

authors： Tarragon E,Lopez D,Estrada C,Ana GC,Schenker E,Pifferi F,Bordet R,Richardson JC,Herrero MT

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Clearance of damaged cells and debris is beneficial for the functional recovery after ischemic brain injury. However, the specific phagocytic receptor that mediates microglial phagocytosis after ischemic stroke is unknown. AIM:To investigate whether P2Y6 receptor-mediated microglial phagocytosis is benefi...

journal_title：CNS neuroscience & therapeutics

authors： Wen RX,Shen H,Huang SX,Wang LP,Li ZW,Peng P,Mamtilahun M,Tang YH,Shen FX,Tian HL,Yang GY,Zhang ZJ

更新日期：2020-04-01 00:00:00