A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration.


:Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final common end stage is photoreceptor cell death. Unfortunately, no effective treatments or therapeutic agents have been discovered. Heat shock protein 70 (HSP70) is highly conserved and has antiapoptotic activities. A few reports have shown that HSP70 plays a role in RDs. Thus, we focused on the role of HSP70 in photoreceptor cell death. Using the N-methyl-N-nitrosourea (MNU)-induced photoreceptor cell death model in mice, we could examine two stages of the novel cell death mechanism; the early stage, including HSP70 cleavage through protein carbonylation by production of reactive oxygen species, lipid peroxidation and Ca(2+) influx/calpain activation, and the late stage of cathepsin and/or caspase activation. The upregulation of intact HSP70 expression by its inducer is likely to protect photoreceptor cells. In this review, we focus on the role of HSP70 and the novel cell death signaling process in RDs. We also describe candidate therapeutic agents for RDs.


CNS Neurosci Ther


Furukawa A,Koriyama Y




Has Abstract


2016-01-01 00:00:00












  • Roles of autophagy and endoplasmic reticulum stress in intracerebral hemorrhage-induced secondary brain injury in rats.

    abstract:OBJECTIVES:This study aimed to evaluate the roles of autophagy and endoplasmic reticulum (ER) stress in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) in rats. METHODS:Autophagy inducer (rapamycin) and inhibitor (3-methyladenine), as well as ER stress activator (tunicamycin, TM) and inhibitor (tau...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Duan XC,Wang W,Feng DX,Yin J,Zuo G,Chen DD,Chen ZQ,Li HY,Wang Z,Chen G

    更新日期:2017-07-01 00:00:00

  • Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25-35 in hippocampus neurons in vitro.

    abstract:AIMS:Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid-β (Aβ) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl al...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Li LS,Lu YL,Nie J,Xu YY,Zhang W,Yang WJ,Gong QH,Lu YF,Lu Y,Shi JS

    更新日期:2017-04-01 00:00:00

  • Brain structure alterations in depression: Psychoradiological evidence.

    abstract::Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anato...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Zhang FF,Peng W,Sweeney JA,Jia ZY,Gong QY

    更新日期:2018-11-01 00:00:00

  • P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis.

    abstract:INTRODUCTION:Clearance of damaged cells and debris is beneficial for the functional recovery after ischemic brain injury. However, the specific phagocytic receptor that mediates microglial phagocytosis after ischemic stroke is unknown. AIM:To investigate whether P2Y6 receptor-mediated microglial phagocytosis is benefi...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Wen RX,Shen H,Huang SX,Wang LP,Li ZW,Peng P,Mamtilahun M,Tang YH,Shen FX,Tian HL,Yang GY,Zhang ZJ

    更新日期:2020-04-01 00:00:00

  • Ginsenosides and their CNS targets.

    abstract::Ginsenosides are a special group of triterpenoid saponins attributed to medical effects of ginseng. Therefore, they have been research targets over the last three decades to explain ginseng actions and a wealth of literature has been presented reporting on ginsenosides' effects on the human body. Recently, there is in...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Radad K,Moldzio R,Rausch WD

    更新日期:2011-12-01 00:00:00

  • Long noncoding RNA ENST00000413528 sponges microRNA-593-5p to modulate human glioma growth via polo-like kinase 1.

    abstract:AIMS:In this study, we examined the expression of lncRNA ENST00000413528 in glioma and determined its role in glioma development. METHODS:LncRNA ENST00000413528 was detected in glioma tissues by lncRNA microarray. Then, we performed real-time PCR, CCK-8, colony formation assay, flow cytometry, caspase-3/7 assay and an...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Zhang R,Wei RL,Du W,Zhang LW,Du T,Geng YD,Wei XT

    更新日期:2019-08-01 00:00:00

  • Altered functional connectivity strength and its correlations with cognitive function in subjects with ultra-high risk for psychosis at rest.

    abstract:AIMS:Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this s...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Li RR,Lyu HL,Liu F,Lian N,Wu RR,Zhao JP,Guo WB

    更新日期:2018-12-01 00:00:00

  • Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats.

    abstract:AIMS:Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain. In our study, we aimed to investigate the expression patterns of Sema7A in epilepsy and further explore the roles of Sema7A in the regulation of seizure activity and the inflammatory response in PTZ-kindled epileptic rats. METHODS...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Deng J,Xu T,Yang J,Zhang KM,Li Q,Yu XY,Li R,Fu J,Jiang Q,Ma JX,Chen YM

    更新日期:2020-01-01 00:00:00

  • Quality of life in children with narcolepsy.

    abstract:AIMS:To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy. METHODS:We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy. RESULTS:The cohort ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Inocente CO,Gustin MP,Lavault S,Guignard-Perret A,Raoux A,Christol N,Gerard D,Dauvilliers Y,Reimão R,Bat-Pitault F,Lin JS,Arnulf I,Lecendreux M,Franco P

    更新日期:2014-08-01 00:00:00

  • Revisiting the diagnosis of schizophrenia: where have we been and where are we going?

    abstract::Appropriate and reliable classification of mental illness is crucial for advancing the field of psychiatry as agreement on diagnosis has broad implications for treatment of mental disorders and research into the etiopathophysiology of mental disorders. Since schizophrenia was first recognized by Kraepelin (as dementia...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Keller WR,Fischer BA,Carpenter WT Jr

    更新日期:2011-04-01 00:00:00

  • Candesartan ameliorates brain inflammation associated with Alzheimer's disease.

    abstract:AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Torika N,Asraf K,Apte RN,Fleisher-Berkovich S

    更新日期:2018-03-01 00:00:00

  • The role of tau in Alzheimer's disease and related disorders.

    abstract::Tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Medeiros R,Baglietto-Vargas D,LaFerla FM

    更新日期:2011-10-01 00:00:00

  • A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis.

    abstract:AIM:Multiple sclerosis (MS) is a neurological autoimmune disorder characterized by mistaken attacks of inflammatory cells against the central nervous system (CNS), resulting in demyelination and axonal damage. Kv1.3 channel blockers can inhibit T-cell activation and have been designed for MS therapy. However, little is...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Yuan XL,Zhao YP,Huang J,Liu JC,Mao WQ,Yin J,Peng BW,Liu WH,Han S,He XH

    更新日期:2018-10-01 00:00:00

  • Effects of combination therapy with levamlodipine and bisoprolol on stroke in rats.

    abstract:AIM:To examine the effects of combination with levamlodipine and bisoprolol on stroke in rats. METHODS:For acute study, Systolic blood pressure (SBP) and heart period (HP) were monitored in conscious stroke prone-spontaneously hypertensive rats (SHR-SP) and sinoaortic denervation (SAD) rats before and after intragastr...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Gui H,Guo YF,Liu X,Zhang JM,Yang YL,Huang GZ,Liu JG

    更新日期:2013-03-01 00:00:00

  • Hallucinations in neurodegenerative diseases.

    abstract::Patients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and of...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Burghaus L,Eggers C,Timmermann L,Fink GR,Diederich NJ

    更新日期:2012-02-01 00:00:00

  • Do stroke patients have an increased risk of developing suicidal ideation or dying by suicide? An overview of the current literature.

    abstract::Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the cu...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Pompili M,Venturini P,Campi S,Seretti ME,Montebovi F,Lamis DA,Serafini G,Amore M,Girardi P

    更新日期:2012-09-01 00:00:00

  • The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.

    abstract:AIMS:Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin-induced epileptiform activity in ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Arslan G,Alici SK,Ayyildiz M,Agar E

    更新日期:2013-04-01 00:00:00

  • Cerebrospinal fluid biomarkers in Alzheimer's disease and geriatric depression: preliminary findings from Brazil.

    abstract:AIMS:Depression is a highly prevalent disorder in the elderly and one of the risk factors for developing dementia. The present study involves patients with Alzheimer's disease (AD), geriatric major depressive disorder (MDD) and cognitively healthy controls aiming to compare baseline cerebrospinal fluid (CSF) biomarkers...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Reis T,Brandão CO,Freire Coutinho ES,Engelhardt E,Laks J

    更新日期:2012-07-01 00:00:00

  • A 24-week, randomized, controlled trial of rivastigmine patch 13.3 mg/24 h versus 4.6 mg/24 h in severe Alzheimer's dementia.

    abstract:AIMS:The 24-week, prospective, randomized, double-blind ACTION study investigated the efficacy, safety, and tolerability of 13.3 versus 4.6 mg/24 h rivastigmine patch in patients with severe Alzheimer's disease (AD). METHODS:Patients had probable AD and Mini-Mental State Examination scores ≥3-≤12. Primary outcome meas...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Farlow MR,Grossberg GT,Sadowsky CH,Meng X,Somogyi M

    更新日期:2013-10-01 00:00:00

  • Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.

    abstract::Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Ghosh A,Chen F,Thakur A,Hong H

    更新日期:2016-12-01 00:00:00

  • Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy.

    abstract:INTRODUCTION:Patients with temporal lobe epilepsy (TLE) often suffer from comorbid psychiatric diagnoses such as depression, anxiety, or impaired cognitive performance. Endocannabinoid (eCB) signaling is a key regulator of synaptic neurotransmission and has been implicated in the mechanisms of epilepsy as well as sever...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Ma L,Wang L,Yang F,Meng XD,Wu C,Ma H,Jiang W

    更新日期:2014-10-01 00:00:00

  • Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Cav 2.3 voltage-gated calcium channel.

    abstract:INTRODUCTION:The relationship between blood metabolites and hemoglobin degradation products (BMHDPs) formed in the cerebrospinal fluid and the development of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been the focus of several previous studies, but their molecular ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Albanna W,Neumaier F,Lüke JN,Kotliar K,Conzen C,Lindauer U,Hescheler J,Clusmann H,Schneider T,Schubert GA

    更新日期:2018-03-01 00:00:00

  • Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice.

    abstract:AIMS:Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin-1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage mitigates the degene...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Suto N,Mieda T,Iizuka A,Nakamura K,Hirai H

    更新日期:2016-08-01 00:00:00

  • Pathological changes in neurovascular units: Lessons from cases of vascular dementia.

    abstract::Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease (AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main causes of VD. Neurovascular unit (NVU) is a vessel-centered concept, emphasizing all the cellular components play an integrated role in mainta...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Li C,Wang Y,Yan XL,Guo ZN,Yang Y

    更新日期:2021-01-10 00:00:00

  • EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity.

    abstract:AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Liu Y,Jiang S,Yang PY,Zhang YF,Li TJ,Rui YC

    更新日期:2016-10-01 00:00:00

  • Kir6.1 knockdown aggravates cerebral ischemia/reperfusion-induced neural injury in mice.

    abstract:BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Dong YF,Wang LX,Huang X,Cao WJ,Lu M,Ding JH,Sun XL,Hu G

    更新日期:2013-08-01 00:00:00

  • Neurovascular Unit: A critical role in ischemic stroke.

    abstract::Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of oc...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Wang L,Xiong X,Zhang L,Shen J

    更新日期:2021-01-02 00:00:00

  • CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.

    abstract:AIMS:To investigate if CIQ, a positive allosteric modulator of N-methyl-d-aspartate receptors (NMDARs) containing GluN2C/D subunits, rescues the loss of long-term potentiation (LTP) and forelimb-use asymmetry in a mouse model of Parkinson's disease (PD). METHODS:We have used electrophysiology in brain slices and the c...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Nouhi M,Zhang X,Yao N,Chergui K

    更新日期:2018-02-01 00:00:00

  • Calcitonin gene-related peptide (CGRP): A novel target for Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Singh Y,Gupta G,Shrivastava B,Dahiya R,Tiwari J,Ashwathanarayana M,Sharma RK,Agrawal M,Mishra A,Dua K

    更新日期:2017-06-01 00:00:00

  • Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation.

    abstract:AIMS:Insufficient sleep has been found to result in varying degrees of cognitive impairment and emotional changes. Sleep was reported probably responsible for cleaning metabolic wastes in brain by increasing extracellular bulk flow. Herein, we propose that chronic sleep insufficiency in young adult wild-type mice is al...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Xie Y,Ba L,Wang M,Deng SY,Chen SM,Huang LF,Zhang M,Wang W,Ding FF

    更新日期:2020-02-01 00:00:00