A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration.


:Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final common end stage is photoreceptor cell death. Unfortunately, no effective treatments or therapeutic agents have been discovered. Heat shock protein 70 (HSP70) is highly conserved and has antiapoptotic activities. A few reports have shown that HSP70 plays a role in RDs. Thus, we focused on the role of HSP70 in photoreceptor cell death. Using the N-methyl-N-nitrosourea (MNU)-induced photoreceptor cell death model in mice, we could examine two stages of the novel cell death mechanism; the early stage, including HSP70 cleavage through protein carbonylation by production of reactive oxygen species, lipid peroxidation and Ca(2+) influx/calpain activation, and the late stage of cathepsin and/or caspase activation. The upregulation of intact HSP70 expression by its inducer is likely to protect photoreceptor cells. In this review, we focus on the role of HSP70 and the novel cell death signaling process in RDs. We also describe candidate therapeutic agents for RDs.


CNS Neurosci Ther


Furukawa A,Koriyama Y




Has Abstract


2016-01-01 00:00:00












  • Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment in Asia: Expert consensus.

    abstract:BACKGROUND:Mild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Kandiah N,Chan YF,Chen C,Dasig D,Dominguez J,Han SH,Jia J,Kim S,Limpawattana P,Ng LL,Nguyen DT,Ong PA,Raya-Ampil E,Saedon N,Senanarong V,Setiati S,Singh H,Suthisisang C,Trang TM,Turana Y,Venketasubramanian N,Yon

    更新日期:2021-02-01 00:00:00

  • Mitochondrial dysfunction and cerebral metabolic abnormalities in patients with mitochondrial encephalomyopathy subtypes: Evidence from proton MR spectroscopy and muscle biopsy.

    abstract:AIMS:Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy (1 H-MRS), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy (ME). The metabolite ratios of lactate (lac)/Cr, N-acetyl aspartate (NAA)/creatine (Cr), t...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Niu FN,Meng HL,Chang LL,Wu HY,Li WP,Liu RY,Wang HT,Zhang B,Xu Y

    更新日期:2017-08-01 00:00:00

  • β-phenethylamine--a phenylalanine derivative in brain--contributes to oxidative stress by inhibiting mitochondrial complexes and DT-diaphorase: an in silico study.

    abstract:AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Mazumder MK,Paul R,Borah A

    更新日期:2013-08-01 00:00:00

  • The Role of Group II Metabotropic Glutamate Receptors in the Striatum in Electroacupuncture Treatment of Parkinsonian Rats.

    abstract:AIMS:Glutamatergic transmission may play a critical role in the pathogenesis of Parkinson's disease (PD). Electroacupuncture (EA) has been demonstrated to effectively alleviate PD symptoms. In this study, a potential glutamate-dependent mechanism underlying the therapeutic action of EA was investigated. METHODS:The ef...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Jia YJ,Deng JH,Zhang WZ,Sun ZL,Yang J,Yu Y,Gong XL,Jia J,Wang XM

    更新日期:2017-01-01 00:00:00

  • Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.

    abstract::Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

    更新日期:2009-07-01 00:00:00

  • Altered functional connectivity strength and its correlations with cognitive function in subjects with ultra-high risk for psychosis at rest.

    abstract:AIMS:Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this s...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Li RR,Lyu HL,Liu F,Lian N,Wu RR,Zhao JP,Guo WB

    更新日期:2018-12-01 00:00:00

  • Limited versus extended cocaine intravenous self-administration: Behavioral effects and electrophysiological changes in insular cortex.

    abstract:AIMS:Limited vs extended drug exposure has been proposed as one of the key factors in determining the risk of relapse, which is the primary characteristic of addiction behaviors. The current studies were designed to explore the related behavioral effects and neuronal alterations in the insular cortex (IC), an important...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Luo YX,Huang D,Guo C,Ma YY

    更新日期:2021-02-01 00:00:00

  • Hallucinations in neurodegenerative diseases.

    abstract::Patients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and of...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Burghaus L,Eggers C,Timmermann L,Fink GR,Diederich NJ

    更新日期:2012-02-01 00:00:00

  • Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy-prone rat.

    abstract:AIMS:Intracellular calcium plays an important role in neuronal hyperexcitability that leads to seizures. One calcium influx route of interest is the transient receptor potential vanilloid type 1 (TRPV1) channel. Here, we evaluated the effects of capsazepine (CPZ), a potent blocker of TRPV1 channels on acoustically evok...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Cho SJ,Vaca MA,Miranda CJ,N'Gouemo P

    更新日期:2018-01-01 00:00:00

  • Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

    abstract:AIMS:Activated microglia have been found in the forebrains and hippocampi of temporal lobe epilepsy (TLE) patients and status epileptic (SE) animal models. The peroxisome proliferator-activated receptor γ (PPAR γ) agonist rosiglitazone has been shown to prevent microglial activation. However, its role in pilocarpine-in...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

    更新日期:2019-12-01 00:00:00

  • Endothelial glycocalyx as an important factor in composition of blood-brain barrier.

    abstract::The blood-brain barrier is a dynamic and complex neurovascular unit that protects neurons from somatic circulatory factors as well as regulates the internal environmental stability of the central nervous system. Endothelial glycocalyx is a critical component of an extended neurovascular unit that influences the struct...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Zhao F,Zhong L,Luo Y

    更新日期:2020-12-30 00:00:00

  • Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year.

    abstract:OBJECTIVE:To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). METHODS:Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of vari...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: You Z,Wu YY,Wu R,Xu ZX,Wu X,Wang XP

    更新日期:2020-09-01 00:00:00

  • Functional study and pathogenicity classification of PRRT2 missense variants in PRRT2-related disorders.

    abstract:AIMS:PRRT2 variants are associated with various paroxysmal disorders. To date, more than 90 PRRT2 variants have been reported in PRRT2-related disorders. Lack of functional study in majority of missense variants makes their pathogenicity uncertain. We aim to evaluate the clinical significance of PRRT2 missense variants...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Zhao SY,Li LX,Chen YL,Chen YJ,Liu GL,Dong HL,Chen DF,Li HF,Wu ZY

    更新日期:2020-01-01 00:00:00

  • Immunogenicity and predictors of response to a single dose trivalent seasonal influenza vaccine in multiple sclerosis patients receiving disease-modifying therapies.

    abstract:AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,多中心研究


    authors: Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

    更新日期:2019-02-01 00:00:00

  • The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats.

    abstract:AIMS:Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin-induced epileptiform activity in ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Arslan G,Alici SK,Ayyildiz M,Agar E

    更新日期:2013-04-01 00:00:00

  • Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.

    abstract:BACKGROUND:Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydro...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Feng J,Wang JX,Du YH,Liu Y,Zhang W,Chen JF,Liu YJ,Zheng M,Wang KJ,He GQ

    更新日期:2018-12-01 00:00:00

  • Endothelial progenitor cells contribute to neointima formation in rabbit elastase-induced aneurysm after flow diverter treatment.

    abstract:AIMS:Endothelial progenitor cells (EPCs) are involved in vascular repair and homeostasis after vascular injuries. In this study, we aimed to explore whether bone marrow (BM)-derived EPCs contribute to neointima formation and reendothelialization in rabbit elastase-induced aneurysm after flow diverter treatment. METHOD...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Li ZF,Fang XG,Yang PF,Huang QH,Zhao WY,Liang C,Zhao R,Liu JM

    更新日期:2013-05-01 00:00:00

  • High salt intake and stroke: meta-analysis of the epidemiologic evidence.

    abstract::Research on the potential impact of high salt intake on health has grown rapidly over the last decades. Recent studies have suggested that high salt intake could also be associated with adverse effects on cardiovascular system. The review evaluated the current level of epidemiologic evidence on the association between...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,meta分析,评审


    authors: Li XY,Cai XL,Bian PD,Hu LR

    更新日期:2012-08-01 00:00:00

  • Candesartan ameliorates brain inflammation associated with Alzheimer's disease.

    abstract:AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Torika N,Asraf K,Apte RN,Fleisher-Berkovich S

    更新日期:2018-03-01 00:00:00

  • Octodon degus: a model for the cognitive impairment associated with Alzheimer's disease.

    abstract::Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Tarragon E,Lopez D,Estrada C,Ana GC,Schenker E,Pifferi F,Bordet R,Richardson JC,Herrero MT

    更新日期:2013-09-01 00:00:00

  • Role of serotonin in central dopamine dysfunction.

    abstract::The interaction between serotonin (5-HT) and dopamine (DA)-containing neurons in the brain is a research topic that has raised the interest of many scientists working in the field of neuroscience since the first demonstration of the presence of monoamine-containing neurons in the mid 1960. The bulk of neuroanatomical ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Di Giovanni G,Esposito E,Di Matteo V

    更新日期:2010-06-01 00:00:00

  • Anticoagulation therapy is harmful to large-sized cerebellar infarction.

    abstract:AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJ

    更新日期:2014-09-01 00:00:00

  • Pathological changes in neurovascular units: Lessons from cases of vascular dementia.

    abstract::Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease (AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main causes of VD. Neurovascular unit (NVU) is a vessel-centered concept, emphasizing all the cellular components play an integrated role in mainta...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Li C,Wang Y,Yan XL,Guo ZN,Yang Y

    更新日期:2021-01-10 00:00:00

  • Lower serum interleukin-22 and interleukin-35 levels are associated with disease status in neuromyelitis optica spectrum disorders.

    abstract:AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Yang H,Han L,Zhou YJ,Ding J,Cai Y,Hong RH,Hao Y,Zhu DS,Shen XF,Guan YT

    更新日期:2020-02-01 00:00:00

  • Variants of genes encoding TNF receptors and ligands and proteins regulating TNF activation in familial multiple sclerosis.

    abstract:INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Torre-Fuentes L,Matías-Guiu JA,Pytel V,Montero-Escribano P,Maietta P,Álvarez S,Gómez-Pinedo U,Matías-Guiu J

    更新日期:2020-11-01 00:00:00

  • Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.

    abstract::Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Ghosh A,Chen F,Thakur A,Hong H

    更新日期:2016-12-01 00:00:00

  • A novel, nonbinary evaluation of success and failure reveals bupropion efficacy versus methamphetamine dependence: reanalysis of a multisite trial.

    abstract::A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetamine-free urines each we...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: McCann DJ,Li SH

    更新日期:2012-05-01 00:00:00

  • Early increase of neutrophil-to-lymphocyte ratio predicts 30-day mortality in patients with spontaneous intracerebral hemorrhage.

    abstract:AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

    更新日期:2019-01-01 00:00:00

  • Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-κB Activation.

    abstract:AIMS:This study was designed to examine the neuroprotective effects of bakkenolide-IIIa, a major novel compound extracted from the rhizome of P. trichinous. METHODS:Transient focal cerebral damage model in rats and oxygen-glucose deprivation (OGD) in cultured hippocampal neurons were performed. The amount of apoptotic...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章


    authors: Jiang Q,Li RP,Tang Y,Wang YQ,Liu C,Guo ML

    更新日期:2015-12-01 00:00:00

  • Calcitonin gene-related peptide (CGRP): A novel target for Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP...

    journal_title:CNS neuroscience & therapeutics

    pub_type: 杂志文章,评审


    authors: Singh Y,Gupta G,Shrivastava B,Dahiya R,Tiwari J,Ashwathanarayana M,Sharma RK,Agrawal M,Mishra A,Dua K

    更新日期:2017-06-01 00:00:00