Abstract:
AIMS:Neuroinflammation contributed to the pathogenesis of multiple system atrophy (MSA). We aimed to detect the correlation between inflammatory mediators, such as Klotho (Klt), vitamin D (25(OH)D) and homocysteine (Hcy), and disease severity among MSA patients. METHODS:A total of 53 MSA patients, 65 PD patients, and 62 normal subjects were recruited in our cross-sectional study. Serum Klotho (Klt), vitamin D (25(OH)D), and homocysteine (Hcy) levels were measured. Several scales were undertaken to assess the motor/nonmotor function and cognitive impairment of MSA. RESULTS:Decreased Serum Klt and 25(OH)D levels and increased Hcy levels were found in patients with MSA, compared with healthy controls. These results were more pronounced in male patients. The three biomarkers also displayed differences between MSA and PD subgroups based on genders. Interestingly, Klt, 25(OH)D and Hcy levels associated with cognition impairment, motor dysfunction, mood/cardiovascular disorder among MSA patients. In addition, the combination of Klt, 25(OH)D and Hcy had a better diagnostic ability for distinguishing MSA patients from healthy subjects, as well as distinguishing male MSA patients from male PD patients. CONCLUSION:This study suggested that Klt, 25(OH)D and Hcy levels could be a potential predictor for MSA severity evaluation.
journal_name
CNS Neurosci Therjournal_title
CNS neuroscience & therapeuticsauthors
Guo Y,Zhuang XD,Xian WB,Wu LL,Huang ZN,Hu X,Zhang XS,Chen L,Liao XXdoi
10.1111/cns.12711subject
Has Abstractpub_date
2017-08-01 00:00:00pages
657-666issue
8eissn
1755-5930issn
1755-5949journal_volume
23pub_type
杂志文章abstract::Appropriate and reliable classification of mental illness is crucial for advancing the field of psychiatry as agreement on diagnosis has broad implications for treatment of mental disorders and research into the etiopathophysiology of mental disorders. Since schizophrenia was first recognized by Kraepelin (as dementia...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2010.00229.x
更新日期:2011-04-01 00:00:00
abstract:AIMS:Streptococcus pneumoniae infection in acute bacterial meningitis can lead to widespread brain damage and mortality. Inflammatory responses by immune cells in the brain are thought to determine the degree of brain injury. Yet, the mechanisms underlying host responses to pneumococcal meningitis are largely unknown. ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12842
更新日期:2018-10-01 00:00:00
abstract:AIMS:Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin-1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage mitigates the degene...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12560
更新日期:2016-08-01 00:00:00
abstract:AIMS:In this study, we examined the expression of lncRNA ENST00000413528 in glioma and determined its role in glioma development. METHODS:LncRNA ENST00000413528 was detected in glioma tissues by lncRNA microarray. Then, we performed real-time PCR, CCK-8, colony formation assay, flow cytometry, caspase-3/7 assay and an...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13121
更新日期:2019-08-01 00:00:00
abstract::The interaction between serotonin (5-HT) and dopamine (DA)-containing neurons in the brain is a research topic that has raised the interest of many scientists working in the field of neuroscience since the first demonstration of the presence of monoamine-containing neurons in the mid 1960. The bulk of neuroanatomical ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2010.00135.x
更新日期:2010-06-01 00:00:00
abstract::A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetamine-free urines each we...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1755-5949.2011.00263.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydro...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12983
更新日期:2018-12-01 00:00:00
abstract:INTRODUCTION:miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-18...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12761
更新日期:2017-11-01 00:00:00
abstract:AIMS:This study determines whether assessment with compound action potentials (CAPs) can distinguish two different forms of cerebral white matter injury at the functional levels. METHODS:A pure demyelination model was induced in C57/BL6 adult mice by dietary supplementation of cuprizone (0.2%) for 6 weeks. Callosal L-...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13155
更新日期:2019-09-01 00:00:00
abstract:AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12412
更新日期:2015-08-01 00:00:00
abstract:AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12802
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12117
更新日期:2013-08-01 00:00:00
abstract:AIMS:To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes. METHODS:Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional ou...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12274
更新日期:2014-06-01 00:00:00
abstract::Neurodegenerative diseases represent, nowadays, one of the main causes of death in the industrialized country. They are characterized by a loss of neurons in particular regions of the nervous system. It is believed that this nerve cell loss underlies the subsequent decline in cognitive and motor function that patients...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2008.00065.x
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13456
更新日期:2020-11-01 00:00:00
abstract:AIMS:Our laboratory previously reported that olanzapine treatment inhibited growth of glioma cell lines and hypothesized that autophagy may be involved in the proliferation inhibitory effects of olanzapine. However, the mechanisms of olanzapine-contributed autophagy activation are unclear. METHODS:The inhibitory effec...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13127
更新日期:2019-09-01 00:00:00
abstract::Tolerance development after successful long-term treatment of bipolar disorder is under recognized, as are ways to prevent or show its occurrence or reverse it once it has occurred. We review the clinical literature which suggests that tolerance can develop to most treatment approaches in bipolar illness and present a...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2010.00215.x
更新日期:2011-12-01 00:00:00
abstract::Lithium is a monovalent cation that was introduced in 1949 by John Cade for the treatment of bipolar disorder. Clinical reports and subsequent studies confirmed this application and the beneficial effects of this compound. However, over the last 15 years, various authors have also demonstrated the neuroprotective effe...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2009.00086.x
更新日期:2009-01-01 00:00:00
abstract:AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12113
更新日期:2013-08-01 00:00:00
abstract:AIMS:Blood-borne monocytes/macrophages infiltrate the brain in massive numbers after ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive. This study examined the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13256
更新日期:2019-12-01 00:00:00
abstract::Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-5...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1527-3458.2008.00037.x
更新日期:2008-04-01 00:00:00
abstract:AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12129
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12203
更新日期:2014-03-01 00:00:00
abstract::Understanding the neural substrates of depression is crucial for diagnosis and treatment. Here, we review recent studies of functional and effective connectivity in depression, in terms of functional integration in the brain. Findings from these studies, including our own, point to the involvement of at least four net...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/cns.12998
更新日期:2018-11-01 00:00:00
abstract:AIM:To examine the effects of combination with levamlodipine and bisoprolol on stroke in rats. METHODS:For acute study, Systolic blood pressure (SBP) and heart period (HP) were monitored in conscious stroke prone-spontaneously hypertensive rats (SHR-SP) and sinoaortic denervation (SAD) rats before and after intragastr...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12057
更新日期:2013-03-01 00:00:00
abstract::Adenosine-dopamine interactions in the central nervous system (CNS) have been studied for many years in view of their relevance for disorders of the CNS and their treatments. The discovery of adenosine and dopamine receptor containing receptor mosaics (RM, higher-order receptor heteromers) in the striatum opened up a ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2009.00126.x
更新日期:2010-06-01 00:00:00
abstract:AIMS:In this study, we examined the expression of GINS2 in glioma and determined its role in glioma development. METHODS:The protein expression of GINS2 was assessed in 120 human glioma samples via immunohistochemistry. Then, we suppressed the expression of GINS2 in glioma cell strains U87 and U251 using a short hairp...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13064
更新日期:2019-02-01 00:00:00
abstract:AIMS:Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy (1 H-MRS), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy (ME). The metabolite ratios of lactate (lac)/Cr, N-acetyl aspartate (NAA)/creatine (Cr), t...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12714
更新日期:2017-08-01 00:00:00
abstract:AIMS:Limited vs extended drug exposure has been proposed as one of the key factors in determining the risk of relapse, which is the primary characteristic of addiction behaviors. The current studies were designed to explore the related behavioral effects and neuronal alterations in the insular cortex (IC), an important...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13469
更新日期:2021-02-01 00:00:00
abstract:AIMS:Recovery after peripheral nerve injury (PNI) is often difficult, and there is no optimal treatment. Schwann cells (SCs) are important for peripheral nerve regeneration, so SC-targeting treatments have gained importance. Adipose-derived stem cells (ADSCs) and their exosomes can promote peripheral nerve repair, but ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13187
更新日期:2020-02-01 00:00:00