Abstract:
:Appropriate and reliable classification of mental illness is crucial for advancing the field of psychiatry as agreement on diagnosis has broad implications for treatment of mental disorders and research into the etiopathophysiology of mental disorders. Since schizophrenia was first recognized by Kraepelin (as dementia praecox), there has been much discussion about what does and does not diagnostically constitute the disorder. The importance placed upon different symptoms and course types associated with schizophrenia has been as heterogeneous as the disorder itself. This article focuses upon the classification of schizophrenia over the last 100 years, the current diagnosis of schizophrenia, changes for schizophrenia planned in the upcoming DSM 5, future directions for improving the diagnosis of schizophrenia, and the implications of a new diagnostic paradigm for the illness.
journal_name
CNS Neurosci Therjournal_title
CNS neuroscience & therapeuticsauthors
Keller WR,Fischer BA,Carpenter WT Jrdoi
10.1111/j.1755-5949.2010.00229.xsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
83-8issue
2eissn
1755-5930issn
1755-5949journal_volume
17pub_type
杂志文章,评审abstract:INTRODUCTION:Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM:We sought to determine whether white matter hypoperfusion (WMHP) on perfusion...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,多中心研究
doi:10.1111/cns.12491
更新日期:2016-03-01 00:00:00
abstract::The blood-brain barrier is a dynamic and complex neurovascular unit that protects neurons from somatic circulatory factors as well as regulates the internal environmental stability of the central nervous system. Endothelial glycocalyx is a critical component of an extended neurovascular unit that influences the struct...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13560
更新日期:2020-12-30 00:00:00
abstract:AIMS:Our laboratory previously reported that olanzapine treatment inhibited growth of glioma cell lines and hypothesized that autophagy may be involved in the proliferation inhibitory effects of olanzapine. However, the mechanisms of olanzapine-contributed autophagy activation are unclear. METHODS:The inhibitory effec...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13127
更新日期:2019-09-01 00:00:00
abstract:AIMS:In this study, we examined the expression of lncRNA ENST00000413528 in glioma and determined its role in glioma development. METHODS:LncRNA ENST00000413528 was detected in glioma tissues by lncRNA microarray. Then, we performed real-time PCR, CCK-8, colony formation assay, flow cytometry, caspase-3/7 assay and an...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13121
更新日期:2019-08-01 00:00:00
abstract::Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/cns.12596
更新日期:2016-12-01 00:00:00
abstract:AIMS:In this study, we examined the expression of GINS2 in glioma and determined its role in glioma development. METHODS:The protein expression of GINS2 was assessed in 120 human glioma samples via immunohistochemistry. Then, we suppressed the expression of GINS2 in glioma cell strains U87 and U251 using a short hairp...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13064
更新日期:2019-02-01 00:00:00
abstract::Fingolimod is a sphingosine 1-phosphate (S1P) receptor modulator approved to treat relapsing-remitting multiple sclerosis (MS). Initiation of treatment with fingolimod has been found to produce transient bradycardia and/or slowing of atrioventricular impulse conduction in a small proportion of patients. This effect is...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/cns.12283
更新日期:2014-06-01 00:00:00
abstract:AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13198
更新日期:2020-02-01 00:00:00
abstract:AIMS:To develop and validate a novel score for prediction of 3-month functional outcome in neurocritically ill patients. METHODS:The development of the novel score was based on two widely used scores for general critical illnesses (Acute Physiology and Chronic Health Evaluation II, APACHE II; Simplified Acute Physiolo...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13134
更新日期:2020-01-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) has become a global health issue, with prevalence rates ranging from 1.3% to 37.4%. As there is little current data on PTSD in Canada, an epidemiological study was conducted examining PTSD and related comorbid conditions. Modified versions of the Composite International Diagnostic...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/j.1755-5949.2008.00049.x
更新日期:2008-10-01 00:00:00
abstract::Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a como...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/cns.12339
更新日期:2015-04-01 00:00:00
abstract::Tolerance development after successful long-term treatment of bipolar disorder is under recognized, as are ways to prevent or show its occurrence or reverse it once it has occurred. We review the clinical literature which suggests that tolerance can develop to most treatment approaches in bipolar illness and present a...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2010.00215.x
更新日期:2011-12-01 00:00:00
abstract:AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12129
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12117
更新日期:2013-08-01 00:00:00
abstract::Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective and improves long-term function after brain injury. However, its clinical application to neurological disorders is limited by its large molecular size, poor central uptake, and mitogenic potential. Glycine-proline-glutamate (GPE) is naturally cleaved from the IGF...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2009.00128.x
更新日期:2011-08-01 00:00:00
abstract:AIM:Multiple sclerosis (MS) is a neurological autoimmune disorder characterized by mistaken attacks of inflammatory cells against the central nervous system (CNS), resulting in demyelination and axonal damage. Kv1.3 channel blockers can inhibit T-cell activation and have been designed for MS therapy. However, little is...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12848
更新日期:2018-10-01 00:00:00
abstract::Research evidence points to the existence of racial-ethnic disparities in both access to and quality of mental health services for African Americans with panic disorder. Current panic disorder evaluation and treatment paradigms are not responsive to the needs of many African Americans. The primary individual, social, ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/j.1755-5949.2009.00079.x
更新日期:2009-10-01 00:00:00
abstract::Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-5...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1527-3458.2008.00037.x
更新日期:2008-04-01 00:00:00
abstract::Epigenetics involves molecular mechanisms related to gene expression independent of DNA sequence, mostly mediated by modification of chromatin histones. It has recently been suggested that these transcriptional changes may be implicated in the pathophysiology of mood disorders. In addition, histone deacetylase (HDAC) ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2010.00203.x
更新日期:2011-12-01 00:00:00
abstract:AIMS:Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this stu...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12671
更新日期:2017-03-01 00:00:00
abstract:AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12581
更新日期:2016-10-01 00:00:00
abstract::The pathophysiological mechanisms of neuroinflammation, angiogenesis, and neuroplasticity are currently the hotspots of researches in ischemic stroke. Regulatory T cells (Tregs), a subset of T cells that control inflammatory and immune responses in the body, are closely related to the pathogenesis of ischemic stroke. ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/cns.13611
更新日期:2021-01-20 00:00:00
abstract:AIMS:Blood-borne monocytes/macrophages infiltrate the brain in massive numbers after ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive. This study examined the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13256
更新日期:2019-12-01 00:00:00
abstract::Tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2010.00177.x
更新日期:2011-10-01 00:00:00
abstract::Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/cns.12125
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12203
更新日期:2014-03-01 00:00:00
abstract:AIMS:PRRT2 variants are associated with various paroxysmal disorders. To date, more than 90 PRRT2 variants have been reported in PRRT2-related disorders. Lack of functional study in majority of missense variants makes their pathogenicity uncertain. We aim to evaluate the clinical significance of PRRT2 missense variants...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.13147
更新日期:2020-01-01 00:00:00
abstract:AIMS:Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin-induced epileptiform activity in ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12075
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-18...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12761
更新日期:2017-11-01 00:00:00
abstract:AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12299
更新日期:2014-09-01 00:00:00