Abstract:
AIMS:This study determines whether assessment with compound action potentials (CAPs) can distinguish two different forms of cerebral white matter injury at the functional levels. METHODS:A pure demyelination model was induced in C57/BL6 adult mice by dietary supplementation of cuprizone (0.2%) for 6 weeks. Callosal L-N5-(1-Iminoethyl) ornithine (L-NIO) hydrochloride (27 mg/mL) was injected into the corpus callosum (CC) to induce a focal white matter stroke (WMS), resulting in both demyelination and axonal injury. White matter integrity was assessed by performing CAP recording, electron microscopy, and immunohistological and luxol fast blue (LFB) staining. RESULTS:Immunohistological and electron microscopic analyses confirmed the induction of robust demyelination in CC with cuprizone, and mixed demyelination and axonal damage with L-NIO. Electrophysiologically, cuprizone-induced demyelination significantly reduced the amplitude of negative peak 1 (N1), but increased the amplitude of negative peak 2 (N2), of the CAPs compared to the sham controls. However, cuprizone did not affect the axonal conduction velocity. In contrast, the amplitude and area of both N1 and N2 along with N1 axonal conduction velocity were dramatically decreased in L-NIO-induced WMS. CONCLUSIONS:Concertedly, parameters of the CAPs offer a novel functional assessment strategy for cerebral white matter injury in rodent models.
journal_name
CNS Neurosci Therjournal_title
CNS neuroscience & therapeuticsauthors
Mu HF,Gao XG,Li SC,Wei PJ,Zhao YF,Zhang WT,Wang Y,Gao YQdoi
10.1111/cns.13155subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1018-1029issue
9eissn
1755-5930issn
1755-5949journal_volume
25pub_type
杂志文章abstract:AIMS:To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy. METHODS:We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy. RESULTS:The cohort ...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/cns.12291
更新日期:2014-08-01 00:00:00
abstract::Research on the potential impact of high salt intake on health has grown rapidly over the last decades. Recent studies have suggested that high salt intake could also be associated with adverse effects on cardiovascular system. The review evaluated the current level of epidemiologic evidence on the association between...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,meta分析,评审
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abstract:INTRODUCTION:Patients with temporal lobe epilepsy (TLE) often suffer from comorbid psychiatric diagnoses such as depression, anxiety, or impaired cognitive performance. Endocannabinoid (eCB) signaling is a key regulator of synaptic neurotransmission and has been implicated in the mechanisms of epilepsy as well as sever...
journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
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abstract::Retinal degenerative diseases (RDs) such as retinitis pigmentosa (RP) are a genetically heterogeneous group of disorders characterized by night blindness and peripheral vision loss, which caused by the dysfunction and death of photoreceptor cells. Although many causative gene mutations have been reported, the final co...
journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
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更新日期:2019-01-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
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doi:10.1111/j.1755-5949.2009.00088.x
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
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更新日期:2013-04-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
doi:10.1111/j.1755-5949.2008.00049.x
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journal_title:CNS neuroscience & therapeutics
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更新日期:2013-03-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
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更新日期:2020-04-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
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更新日期:2018-02-01 00:00:00
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journal_title:CNS neuroscience & therapeutics
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章,评审
doi:10.1111/j.1755-5949.2011.00247.x
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journal_title:CNS neuroscience & therapeutics
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00