Octodon degus: a model for the cognitive impairment associated with Alzheimer's disease.

abstract：:Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

journal_title：CNS neuroscience & therapeutics

authors： Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

更新日期：2009-07-01 00:00:00

abstract：AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

journal_title：CNS neuroscience & therapeutics

authors： Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). METHODS:Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of vari...

journal_title：CNS neuroscience & therapeutics

authors： You Z,Wu YY,Wu R,Xu ZX,Wu X,Wang XP

更新日期：2020-09-01 00:00:00

abstract：AIM:Anticoagulants are commonly used to treat ischemic stroke. Its impact on cerebellar infarction has not been fully understood. METHODS:In the clinical study, we reviewed a consecutive series of patients with large-sized cerebellar infarction (diameter > 3 cm, n = 30) treated with or without anticoagulation. In anim...

journal_title：CNS neuroscience & therapeutics

authors： Zhang SQ,Wang W,Ma XL,Xia YY,Liu AJ

更新日期：2014-09-01 00:00:00

abstract：:Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a como...

journal_title：CNS neuroscience & therapeutics

authors： Pabón MM,Ji XM,Fernandez JW,Borlongan CV

更新日期：2015-04-01 00:00:00

abstract：AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

journal_title：CNS neuroscience & therapeutics

authors： Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

更新日期：2013-09-01 00:00:00

abstract：:Appropriate and reliable classification of mental illness is crucial for advancing the field of psychiatry as agreement on diagnosis has broad implications for treatment of mental disorders and research into the etiopathophysiology of mental disorders. Since schizophrenia was first recognized by Kraepelin (as dementia...

journal_title：CNS neuroscience & therapeutics

authors： Keller WR,Fischer BA,Carpenter WT Jr

更新日期：2011-04-01 00:00:00

abstract：:Research evidence points to the existence of racial-ethnic disparities in both access to and quality of mental health services for African Americans with panic disorder. Current panic disorder evaluation and treatment paradigms are not responsive to the needs of many African Americans. The primary individual, social, ...

journal_title：CNS neuroscience & therapeutics

authors： Johnson M,Mills TL,Deleon JM,Hartzema AG,Haddad J

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:The relationship between blood metabolites and hemoglobin degradation products (BMHDPs) formed in the cerebrospinal fluid and the development of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been the focus of several previous studies, but their molecular ...

journal_title：CNS neuroscience & therapeutics

authors： Albanna W,Neumaier F,Lüke JN,Kotliar K,Conzen C,Lindauer U,Hescheler J,Clusmann H,Schneider T,Schubert GA

更新日期：2018-03-01 00:00:00

abstract：AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

journal_title：CNS neuroscience & therapeutics

authors： Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

更新日期：2019-02-01 00:00:00

abstract：:Status epilepticus (SE), a neurological emergency both in adults and in children, could lead to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most common and severe form, an example of which is that induced by organophosphorus nerve agents. First- and second-line pharmacotherapies a...

journal_title：CNS neuroscience & therapeutics

authors： Dorandeu F,Dhote F,Barbier L,Baccus B,Testylier G

更新日期：2013-06-01 00:00:00

abstract：AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

journal_title：CNS neuroscience & therapeutics

authors： Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

更新日期：2012-06-01 00:00:00

abstract：AIMS:Exposure to recurrent hypoglycemia (RH) is common in diabetic patients receiving glucose-lowering therapies and is implicated in causing cognitive impairments. Despite the significant effect of RH on hippocampal function, the underlying mechanisms are currently unknown. Our goal was to determine the effect of RH e...

journal_title：CNS neuroscience & therapeutics

authors： Dewan N,Shukla V,Rehni AK,Koronowski KB,Klingbeil KD,Stradecki-Cohan H,Garrett TJ,Rundek T,Perez-Pinzon MA,Dave KR

更新日期：2020-01-01 00:00:00

abstract：AIMS:The MS-275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not well defined. In this study, we examined ...

journal_title：CNS neuroscience & therapeutics

authors： Cao P,Liang Y,Gao X,Zhao MG,Liang GB

更新日期：2013-05-01 00:00:00

abstract：:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) type glutamate receptors are critical for synaptic plasticity and induction of long-term potentiation (LTP), considered as one of the synaptic mechanisms underlying learning and memory. Positive allosteric modulators of AMPA receptors could provide a the...

journal_title：CNS neuroscience & therapeutics

authors： Bernard K,Danober L,Thomas JY,Lebrun C,Muñoz C,Cordi A,Desos P,Lestage P,Morain P

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...

journal_title：CNS neuroscience & therapeutics

authors： Torre-Fuentes L,Matías-Guiu JA,Pytel V,Montero-Escribano P,Maietta P,Álvarez S,Gómez-Pinedo U,Matías-Guiu J

更新日期：2020-11-01 00:00:00

abstract：:Patients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and of...

journal_title：CNS neuroscience & therapeutics

authors： Burghaus L,Eggers C,Timmermann L,Fink GR,Diederich NJ

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM:We sought to determine whether white matter hypoperfusion (WMHP) on perfusion...

journal_title：CNS neuroscience & therapeutics

authors： Bivard A,Cheng X,Lin LT,Levi C,Spratt N,Kleinig T,O'Brien B,Butcher K,Lou M,Zhang JF,Sylaja PN,Cao WJ,Jannes J,Dong Q,Parsons M

更新日期：2016-03-01 00:00:00

abstract：:Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the cu...

journal_title：CNS neuroscience & therapeutics

authors： Pompili M,Venturini P,Campi S,Seretti ME,Montebovi F,Lamis DA,Serafini G,Amore M,Girardi P

更新日期：2012-09-01 00:00:00

abstract：AIMS:Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin-induced epileptiform activity in ...

journal_title：CNS neuroscience & therapeutics

authors： Arslan G,Alici SK,Ayyildiz M,Agar E

更新日期：2013-04-01 00:00:00

abstract：AIMS:To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy. METHODS:We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy. RESULTS:The cohort ...

journal_title：CNS neuroscience & therapeutics

authors： Inocente CO,Gustin MP,Lavault S,Guignard-Perret A,Raoux A,Christol N,Gerard D,Dauvilliers Y,Reimão R,Bat-Pitault F,Lin JS,Arnulf I,Lecendreux M,Franco P

更新日期：2014-08-01 00:00:00

abstract：AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...

journal_title：CNS neuroscience & therapeutics

authors： Mazumder MK,Paul R,Borah A

更新日期：2013-08-01 00:00:00

abstract：AIMS:Blood-borne monocytes/macrophages infiltrate the brain in massive numbers after ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive. This study examined the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, ...

journal_title：CNS neuroscience & therapeutics

authors： Zhang W,Zhao J,Wang R,Jiang M,Ye Q,Smith AD,Chen J,Shi Y

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the roles of autophagy and endoplasmic reticulum (ER) stress in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) in rats. METHODS:Autophagy inducer (rapamycin) and inhibitor (3-methyladenine), as well as ER stress activator (tunicamycin, TM) and inhibitor (tau...

journal_title：CNS neuroscience & therapeutics

authors： Duan XC,Wang W,Feng DX,Yin J,Zuo G,Chen DD,Chen ZQ,Li HY,Wang Z,Chen G

更新日期：2017-07-01 00:00:00

abstract：:Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease (AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main causes of VD. Neurovascular unit (NVU) is a vessel-centered concept, emphasizing all the cellular components play an integrated role in mainta...

journal_title：CNS neuroscience & therapeutics

authors： Li C,Wang Y,Yan XL,Guo ZN,Yang Y

更新日期：2021-01-10 00:00:00

abstract：:The blood-brain barrier is a dynamic and complex neurovascular unit that protects neurons from somatic circulatory factors as well as regulates the internal environmental stability of the central nervous system. Endothelial glycocalyx is a critical component of an extended neurovascular unit that influences the struct...

journal_title：CNS neuroscience & therapeutics

authors： Zhao F,Zhong L,Luo Y

更新日期：2020-12-30 00:00:00

abstract：:Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP...

journal_title：CNS neuroscience & therapeutics

authors： Singh Y,Gupta G,Shrivastava B,Dahiya R,Tiwari J,Ashwathanarayana M,Sharma RK,Agrawal M,Mishra A,Dua K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydro...

journal_title：CNS neuroscience & therapeutics

authors： Feng J,Wang JX,Du YH,Liu Y,Zhang W,Chen JF,Liu YJ,Zheng M,Wang KJ,He GQ

更新日期：2018-12-01 00:00:00

abstract：:The interaction between serotonin (5-HT) and dopamine (DA)-containing neurons in the brain is a research topic that has raised the interest of many scientists working in the field of neuroscience since the first demonstration of the presence of monoamine-containing neurons in the mid 1960. The bulk of neuroanatomical ...

journal_title：CNS neuroscience & therapeutics

authors： Di Giovanni G,Esposito E,Di Matteo V

更新日期：2010-06-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder with an estimated 4 million patients worldwide. L-dopa is standard, and often initial, therapy for patients with this condition; however, with continued dopaminergic treatment and as the disease progresses, the majority of patients experienc...

journal_title：CNS neuroscience & therapeutics

authors： Papapetropoulos SS

更新日期：2012-05-01 00:00:00