Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders.

abstract：AIMS:To investigate the incidence of depression at different time points within the first year after stroke in mainland China and to identify risk factors related to a poor 1-year prognosis in stroke patients. METHODS:Subjects with acute cerebrovascular diseases were recruited and enrolled from 56 hospitals in mainlan...

journal_title：CNS neuroscience & therapeutics

authors： Zhang N,Wang CX,Wang AX,Bai Y,Zhou Y,Wang YL,Zhang T,Zhou J,Yu X,Sun XY,Liu ZR,Zhao XQ,Wang YJ,Prospective Cohort study on Incidence and Outcome of Patients with Poststroke Depression in China (PRIOD) Investigators.

更新日期：2012-06-01 00:00:00

abstract：AIMS:To develop and validate a novel score for prediction of 3-month functional outcome in neurocritically ill patients. METHODS:The development of the novel score was based on two widely used scores for general critical illnesses (Acute Physiology and Chronic Health Evaluation II, APACHE II; Simplified Acute Physiolo...

journal_title：CNS neuroscience & therapeutics

authors： Gao Q,Yuan F,Yang XA,Zhu JW,Song L,Bi LJ,Jiao ZY,Kang XG,Yang F,Jiang W

更新日期：2020-01-01 00:00:00

abstract：AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

journal_title：CNS neuroscience & therapeutics

authors： Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

更新日期：2019-02-01 00:00:00

abstract：AIMS:Blood-borne monocytes/macrophages infiltrate the brain in massive numbers after ischemic stroke, but their impact on poststroke brain injury and recovery remains elusive. This study examined the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, ...

journal_title：CNS neuroscience & therapeutics

authors： Zhang W,Zhao J,Wang R,Jiang M,Ye Q,Smith AD,Chen J,Shi Y

更新日期：2019-12-01 00:00:00

abstract：AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

journal_title：CNS neuroscience & therapeutics

authors： Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

更新日期：2013-09-01 00:00:00

abstract：:Vinpocetine (ethyl-apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis-apovincaminic acid (cAVA) exert a neur...

journal_title：CNS neuroscience & therapeutics

authors： Nyakas C,Felszeghy K,Szabó R,Keijser JN,Luiten PG,Szombathelyi Z,Tihanyi K

更新日期：2009-07-01 00:00:00

abstract：AIMS:Glutamatergic transmission may play a critical role in the pathogenesis of Parkinson's disease (PD). Electroacupuncture (EA) has been demonstrated to effectively alleviate PD symptoms. In this study, a potential glutamate-dependent mechanism underlying the therapeutic action of EA was investigated. METHODS:The ef...

journal_title：CNS neuroscience & therapeutics

authors： Jia YJ,Deng JH,Zhang WZ,Sun ZL,Yang J,Yu Y,Gong XL,Jia J,Wang XM

更新日期：2017-01-01 00:00:00

abstract：AIMS:The MS-275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not well defined. In this study, we examined ...

journal_title：CNS neuroscience & therapeutics

authors： Cao P,Liang Y,Gao X,Zhao MG,Liang GB

更新日期：2013-05-01 00:00:00

abstract：AIMS:Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain. In our study, we aimed to investigate the expression patterns of Sema7A in epilepsy and further explore the roles of Sema7A in the regulation of seizure activity and the inflammatory response in PTZ-kindled epileptic rats. METHODS...

journal_title：CNS neuroscience & therapeutics

authors： Deng J,Xu T,Yang J,Zhang KM,Li Q,Yu XY,Li R,Fu J,Jiang Q,Ma JX,Chen YM

更新日期：2020-01-01 00:00:00

abstract：:Lithium is a monovalent cation that was introduced in 1949 by John Cade for the treatment of bipolar disorder. Clinical reports and subsequent studies confirmed this application and the beneficial effects of this compound. However, over the last 15 years, various authors have also demonstrated the neuroprotective effe...

journal_title：CNS neuroscience & therapeutics

authors： Camins A,Verdaguer E,Junyent F,Yeste-Velasco M,Pelegrí C,Vilaplana J,Pallás M

更新日期：2009-01-01 00:00:00

abstract：AIMS:Activated microglia have been found in the forebrains and hippocampi of temporal lobe epilepsy (TLE) patients and status epileptic (SE) animal models. The peroxisome proliferator-activated receptor γ (PPAR γ) agonist rosiglitazone has been shown to prevent microglial activation. However, its role in pilocarpine-in...

journal_title：CNS neuroscience & therapeutics

authors： Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

更新日期：2019-12-01 00:00:00

abstract：:Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of oc...

journal_title：CNS neuroscience & therapeutics

authors： Wang L,Xiong X,Zhang L,Shen J

更新日期：2021-01-02 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder with an estimated 4 million patients worldwide. L-dopa is standard, and often initial, therapy for patients with this condition; however, with continued dopaminergic treatment and as the disease progresses, the majority of patients experienc...

journal_title：CNS neuroscience & therapeutics

authors： Papapetropoulos SS

更新日期：2012-05-01 00:00:00

abstract：AIM:To compare atomoxetine (ATX) length of therapy (LoT) among adults with ADHD who reached the recommended dose of 80 mg/day (ATX ≥ 80) versus those who did not (ATX < 80) analyzed separately in patients prescribed ATX as monotherapy (mono) and in combination with other ADHD medications (combo). METHODS:This was a re...

journal_title：CNS neuroscience & therapeutics

authors： Clemow DB,Nyhuis AW,Robinson RL

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). METHODS:Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of vari...

journal_title：CNS neuroscience & therapeutics

authors： You Z,Wu YY,Wu R,Xu ZX,Wu X,Wang XP

更新日期：2020-09-01 00:00:00

abstract：AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...

journal_title：CNS neuroscience & therapeutics

authors： Yang H,Han L,Zhou YJ,Ding J,Cai Y,Hong RH,Hao Y,Zhu DS,Shen XF,Guan YT

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with co...

journal_title：CNS neuroscience & therapeutics

authors： Sidhu MK,Thompson PJ,Wandschneider B,Foulkes A,de Tisi J,Stretton J,Perona M,Thom M,Bonelli SB,Burdett J,Williams E,Duncan JS,Matarin M

更新日期：2019-02-01 00:00:00

abstract：:Appropriate and reliable classification of mental illness is crucial for advancing the field of psychiatry as agreement on diagnosis has broad implications for treatment of mental disorders and research into the etiopathophysiology of mental disorders. Since schizophrenia was first recognized by Kraepelin (as dementia...

journal_title：CNS neuroscience & therapeutics

authors： Keller WR,Fischer BA,Carpenter WT Jr

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydro...

journal_title：CNS neuroscience & therapeutics

authors： Feng J,Wang JX,Du YH,Liu Y,Zhang W,Chen JF,Liu YJ,Zheng M,Wang KJ,He GQ

更新日期：2018-12-01 00:00:00

abstract：AIMS:Depression is a highly prevalent disorder in the elderly and one of the risk factors for developing dementia. The present study involves patients with Alzheimer's disease (AD), geriatric major depressive disorder (MDD) and cognitively healthy controls aiming to compare baseline cerebrospinal fluid (CSF) biomarkers...

journal_title：CNS neuroscience & therapeutics

authors： Reis T,Brandão CO,Freire Coutinho ES,Engelhardt E,Laks J

更新日期：2012-07-01 00:00:00

abstract：AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...

journal_title：CNS neuroscience & therapeutics

authors： Mazumder MK,Paul R,Borah A

更新日期：2013-08-01 00:00:00

abstract：:Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-5...

journal_title：CNS neuroscience & therapeutics

authors： Tietje KR,Anderson DJ,Bitner RS,Blomme EA,Brackemeyer PJ,Briggs CA,Browman KE,Bury D,Curzon P,Drescher KU,Frost JM,Fryer RM,Fox GB,Gronlien JH,Håkerud M,Gubbins EJ,Halm S,Harris R,Helfrich RJ,Kohlhaas KL,Law D,M

更新日期：2008-04-01 00:00:00

abstract：:Adenosine-dopamine interactions in the central nervous system (CNS) have been studied for many years in view of their relevance for disorders of the CNS and their treatments. The discovery of adenosine and dopamine receptor containing receptor mosaics (RM, higher-order receptor heteromers) in the striatum opened up a ...

journal_title：CNS neuroscience & therapeutics

authors： Fuxe K,Marcellino D,Borroto-Escuela DO,Guescini M,Fernández-Dueñas V,Tanganelli S,Rivera A,Ciruela F,Agnati LF

更新日期：2010-06-01 00:00:00

abstract：AIMS:Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid-β (Aβ) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl al...

journal_title：CNS neuroscience & therapeutics

authors： Li LS,Lu YL,Nie J,Xu YY,Zhang W,Yang WJ,Gong QH,Lu YF,Lu Y,Shi JS

更新日期：2017-04-01 00:00:00

abstract：:Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anato...

journal_title：CNS neuroscience & therapeutics

authors： Zhang FF,Peng W,Sweeney JA,Jia ZY,Gong QY

更新日期：2018-11-01 00:00:00

abstract：:Central dopaminergic and noradrenergic systems play essential roles in controlling several forebrain functions. Consequently, perturbations of these neurotransmissions may contribute to the pathophysiology of neuropsychiatric disorders. For many years, there was a focus on the serotonin (5-HT) system because of the ef...

journal_title：CNS neuroscience & therapeutics

authors： El Mansari M,Guiard BP,Chernoloz O,Ghanbari R,Katz N,Blier P

更新日期：2010-06-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...

journal_title：CNS neuroscience & therapeutics

authors： Torika N,Asraf K,Apte RN,Fleisher-Berkovich S

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Clearance of damaged cells and debris is beneficial for the functional recovery after ischemic brain injury. However, the specific phagocytic receptor that mediates microglial phagocytosis after ischemic stroke is unknown. AIM:To investigate whether P2Y6 receptor-mediated microglial phagocytosis is benefi...

journal_title：CNS neuroscience & therapeutics

authors： Wen RX,Shen H,Huang SX,Wang LP,Li ZW,Peng P,Mamtilahun M,Tang YH,Shen FX,Tian HL,Yang GY,Zhang ZJ

更新日期：2020-04-01 00:00:00

abstract：AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...

journal_title：CNS neuroscience & therapeutics

authors： Wen XD,Li HF,Wang HX,Ni W,Dong Y,Wu ZY

更新日期：2015-08-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a global health issue, with prevalence rates ranging from 1.3% to 37.4%. As there is little current data on PTSD in Canada, an epidemiological study was conducted examining PTSD and related comorbid conditions. Modified versions of the Composite International Diagnostic...

journal_title：CNS neuroscience & therapeutics

authors： Van Ameringen M,Mancini C,Patterson B,Boyle MH

更新日期：2008-10-01 00:00:00