Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

abstract：:Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a como...

journal_title：CNS neuroscience & therapeutics

authors： Pabón MM,Ji XM,Fernandez JW,Borlongan CV

更新日期：2015-04-01 00:00:00

abstract：AIM:Multiple sclerosis (MS) is a neurological autoimmune disorder characterized by mistaken attacks of inflammatory cells against the central nervous system (CNS), resulting in demyelination and axonal damage. Kv1.3 channel blockers can inhibit T-cell activation and have been designed for MS therapy. However, little is...

journal_title：CNS neuroscience & therapeutics

authors： Yuan XL,Zhao YP,Huang J,Liu JC,Mao WQ,Yin J,Peng BW,Liu WH,Han S,He XH

更新日期：2018-10-01 00:00:00

abstract：AIMS:Endothelial progenitor cells (EPCs) are involved in vascular repair and homeostasis after vascular injuries. In this study, we aimed to explore whether bone marrow (BM)-derived EPCs contribute to neointima formation and reendothelialization in rabbit elastase-induced aneurysm after flow diverter treatment. METHOD...

journal_title：CNS neuroscience & therapeutics

authors： Li ZF,Fang XG,Yang PF,Huang QH,Zhao WY,Liang C,Zhao R,Liu JM

更新日期：2013-05-01 00:00:00

abstract：:Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the cu...

journal_title：CNS neuroscience & therapeutics

authors： Pompili M,Venturini P,Campi S,Seretti ME,Montebovi F,Lamis DA,Serafini G,Amore M,Girardi P

更新日期：2012-09-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a global health issue, with prevalence rates ranging from 1.3% to 37.4%. As there is little current data on PTSD in Canada, an epidemiological study was conducted examining PTSD and related comorbid conditions. Modified versions of the Composite International Diagnostic...

journal_title：CNS neuroscience & therapeutics

authors： Van Ameringen M,Mancini C,Patterson B,Boyle MH

更新日期：2008-10-01 00:00:00

abstract：:The interaction between serotonin (5-HT) and dopamine (DA)-containing neurons in the brain is a research topic that has raised the interest of many scientists working in the field of neuroscience since the first demonstration of the presence of monoamine-containing neurons in the mid 1960. The bulk of neuroanatomical ...

journal_title：CNS neuroscience & therapeutics

authors： Di Giovanni G,Esposito E,Di Matteo V

更新日期：2010-06-01 00:00:00

abstract：:Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

journal_title：CNS neuroscience & therapeutics

authors： Ghosh A,Chen F,Thakur A,Hong H

更新日期：2016-12-01 00:00:00

abstract：AIMS:Glioblastoma multiforme (GBM) is the most lethal tumor with a median patient survival of 14 to 15 months. Glioma stem cells (GSCs) play a critical role in tumor initiation and therapeutic resistance in GBM. B3GNT5 has been suggested as the key glycosyltransferase in the biosynthesis of the (neo-) lacto series of g...

journal_title：CNS neuroscience & therapeutics

authors： Jeong HY,Park SY,Kim HJ,Moon S,Lee S,Lee SH,Kim SH

更新日期：2020-11-01 00:00:00

abstract：:Central dopaminergic and noradrenergic systems play essential roles in controlling several forebrain functions. Consequently, perturbations of these neurotransmissions may contribute to the pathophysiology of neuropsychiatric disorders. For many years, there was a focus on the serotonin (5-HT) system because of the ef...

journal_title：CNS neuroscience & therapeutics

authors： El Mansari M,Guiard BP,Chernoloz O,Ghanbari R,Katz N,Blier P

更新日期：2010-06-01 00:00:00

abstract：AIMS:Recently, mutations in COQ2 encoding para-hydroxybenzoate-polyprenyl transferase have been identified to increase the risk of multiple system atrophy (MSA) in multiplex families and sporadic cases. The prevalence of COQ2 mutations was showed to be higher in cerebellar subtype (MSA-C) than parkinsonism subtype (MSA...

journal_title：CNS neuroscience & therapeutics

authors： Wen XD,Li HF,Wang HX,Ni W,Dong Y,Wu ZY

更新日期：2015-08-01 00:00:00

abstract：AIMS:Streptococcus pneumoniae infection in acute bacterial meningitis can lead to widespread brain damage and mortality. Inflammatory responses by immune cells in the brain are thought to determine the degree of brain injury. Yet, the mechanisms underlying host responses to pneumococcal meningitis are largely unknown. ...

journal_title：CNS neuroscience & therapeutics

authors： Lee S,Lee SO,Kim GL,Rhee DK

更新日期：2018-10-01 00:00:00

abstract：AIMS:Neuroinflammation contributed to the pathogenesis of multiple system atrophy (MSA). We aimed to detect the correlation between inflammatory mediators, such as Klotho (Klt), vitamin D (25(OH)D) and homocysteine (Hcy), and disease severity among MSA patients. METHODS:A total of 53 MSA patients, 65 PD patients, and ...

journal_title：CNS neuroscience & therapeutics

authors： Guo Y,Zhuang XD,Xian WB,Wu LL,Huang ZN,Hu X,Zhang XS,Chen L,Liao XX

更新日期：2017-08-01 00:00:00

abstract：:Epigenetics involves molecular mechanisms related to gene expression independent of DNA sequence, mostly mediated by modification of chromatin histones. It has recently been suggested that these transcriptional changes may be implicated in the pathophysiology of mood disorders. In addition, histone deacetylase (HDAC) ...

journal_title：CNS neuroscience & therapeutics

authors： Machado-Vieira R,Ibrahim L,Zarate CA Jr

更新日期：2011-12-01 00:00:00

abstract：AIMS:Prior studies have demonstrated the involvement of leptin and cannabinoids in food intake and metabolism. However, the interaction between leptin and cannabinoids in epilepsy has not been studied. This study elucidated the relationship between leptin and cannabinoids in penicillin-induced epileptiform activity in ...

journal_title：CNS neuroscience & therapeutics

authors： Arslan G,Alici SK,Ayyildiz M,Agar E

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM:We sought to determine whether white matter hypoperfusion (WMHP) on perfusion...

journal_title：CNS neuroscience & therapeutics

authors： Bivard A,Cheng X,Lin LT,Levi C,Spratt N,Kleinig T,O'Brien B,Butcher K,Lou M,Zhang JF,Sylaja PN,Cao WJ,Jannes J,Dong Q,Parsons M

更新日期：2016-03-01 00:00:00

abstract：AIMS:To evaluate the immunogenicity and safety of a seasonal influenza vaccine in a cohort of multiple sclerosis (MS) patients receiving different immunomodulating/immunosuppressive therapies and assess predictors of immune response. METHODS:A prospective, multicenter, non-randomized observational study including 108 ...

journal_title：CNS neuroscience & therapeutics

authors： Metze C,Winkelmann A,Loebermann M,Hecker M,Schweiger B,Reisinger EC,Zettl UK

更新日期：2019-02-01 00:00:00

abstract：:Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anato...

journal_title：CNS neuroscience & therapeutics

authors： Zhang FF,Peng W,Sweeney JA,Jia ZY,Gong QY

更新日期：2018-11-01 00:00:00

abstract：:Patients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and of...

journal_title：CNS neuroscience & therapeutics

authors： Burghaus L,Eggers C,Timmermann L,Fink GR,Diederich NJ

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：:Melatonin plays a neuroprotective role in models of neurodegenerative diseases. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Apoptotic cell death in the central nervous system is a feature of neurodegenerative diseases. The intrinsic and extrinsic apoptotic pathway...

journal_title：CNS neuroscience & therapeutics

authors： Wang X

更新日期：2009-01-01 00:00:00

abstract：:Research on the potential impact of high salt intake on health has grown rapidly over the last decades. Recent studies have suggested that high salt intake could also be associated with adverse effects on cardiovascular system. The review evaluated the current level of epidemiologic evidence on the association between...

journal_title：CNS neuroscience & therapeutics

authors： Li XY,Cai XL,Bian PD,Hu LR

更新日期：2012-08-01 00:00:00

abstract：AIMS:Our laboratory previously reported that olanzapine treatment inhibited growth of glioma cell lines and hypothesized that autophagy may be involved in the proliferation inhibitory effects of olanzapine. However, the mechanisms of olanzapine-contributed autophagy activation are unclear. METHODS:The inhibitory effec...

journal_title：CNS neuroscience & therapeutics

authors： Zhu Y,Zhao YF,Liu RS,Xiong YJ,Shen X,Wang Y,Liang ZQ

更新日期：2019-09-01 00:00:00

abstract：AIMS:The mouse model of allo-head and body reconstruction (AHBR) has recently been established to further the clinical development of this strategy for patients who are suffering from mortal bodily trauma or disease, yet whose mind remains healthy. Animal model studies are indispensable for developing such novel surgic...

journal_title：CNS neuroscience & therapeutics

authors： Ren XP,Ye YJ,Li PW,Shen ZL,Han KC,Song Y

更新日期：2015-08-01 00:00:00

abstract：AIMS:The exact pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) remains unclear. A variety of cytokines are involved, but few studies have been performed to explore the novel roles of interleukin-22 (IL-22) and interleukin-35 (IL-35) in NMOSD. Therefore, this study was designed to investigate serum levels...

journal_title：CNS neuroscience & therapeutics

authors： Yang H,Han L,Zhou YJ,Ding J,Cai Y,Hong RH,Hao Y,Zhu DS,Shen XF,Guan YT

更新日期：2020-02-01 00:00:00

abstract：AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

journal_title：CNS neuroscience & therapeutics

authors： Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

更新日期：2019-01-01 00:00:00

abstract：:Status epilepticus (SE), a neurological emergency both in adults and in children, could lead to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most common and severe form, an example of which is that induced by organophosphorus nerve agents. First- and second-line pharmacotherapies a...

journal_title：CNS neuroscience & therapeutics

authors： Dorandeu F,Dhote F,Barbier L,Baccus B,Testylier G

更新日期：2013-06-01 00:00:00

abstract：AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

journal_title：CNS neuroscience & therapeutics

authors： Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

更新日期：2013-09-01 00:00:00

abstract：:Neurodegenerative diseases result from the gradual and progressive loss of neural cells and lead to nervous system dysfunction. The rapidly advancing stem cell field is providing attractive alternative options for fighting these diseases. Results have provided proof of principle that cell replacement can work in human...

journal_title：CNS neuroscience & therapeutics

authors： Feng Z,Gao F

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with co...

journal_title：CNS neuroscience & therapeutics

authors： Sidhu MK,Thompson PJ,Wandschneider B,Foulkes A,de Tisi J,Stretton J,Perona M,Thom M,Bonelli SB,Burdett J,Williams E,Duncan JS,Matarin M

更新日期：2019-02-01 00:00:00

abstract：AIMS:In our previous study, eEF1A1 was identified to be a new target for protecting brain ischemia injury, but the mechanism remains largely unknown. In this study, we screened the downstream cellular protein molecules interacted with eEF1A1 and found mechanism of eEF1A1 in brain ischemia protection. METHODS AND RESUL...

journal_title：CNS neuroscience & therapeutics

authors： Liu Y,Jiang S,Yang PY,Zhang YF,Li TJ,Rui YC

更新日期：2016-10-01 00:00:00