Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-κB Activation.

abstract：INTRODUCTION:Patients with temporal lobe epilepsy (TLE) often suffer from comorbid psychiatric diagnoses such as depression, anxiety, or impaired cognitive performance. Endocannabinoid (eCB) signaling is a key regulator of synaptic neurotransmission and has been implicated in the mechanisms of epilepsy as well as sever...

journal_title：CNS neuroscience & therapeutics

authors： Ma L,Wang L,Yang F,Meng XD,Wu C,Ma H,Jiang W

更新日期：2014-10-01 00:00:00

abstract：:Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective and improves long-term function after brain injury. However, its clinical application to neurological disorders is limited by its large molecular size, poor central uptake, and mitogenic potential. Glycine-proline-glutamate (GPE) is naturally cleaved from the IGF...

journal_title：CNS neuroscience & therapeutics

authors： Guan J

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated ...

journal_title：CNS neuroscience & therapeutics

authors： Torre-Fuentes L,Matías-Guiu JA,Pytel V,Montero-Escribano P,Maietta P,Álvarez S,Gómez-Pinedo U,Matías-Guiu J

更新日期：2020-11-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) pathology is associated with brain inflammation involving microglia and astrocytes. The renin-angiotensin system contributes to brain inflammation associated with AD pathology. This study aimed to investigate the role of candesartan, an angiotensin II type 1 receptor blocker, in modulation...

journal_title：CNS neuroscience & therapeutics

authors： Torika N,Asraf K,Apte RN,Fleisher-Berkovich S

更新日期：2018-03-01 00:00:00

abstract：:We will review all available studies on the use of lacosamide in the treatment of partial-onset seizures. The available evidence includes two open-label studies and three randomized controlled trials evaluating the safety and efficacy of oral lacosamide. One open-label study and one randomized controlled trial evaluat...

journal_title：CNS neuroscience & therapeutics

authors： Harris JA,Murphy JA

更新日期：2011-12-01 00:00:00

abstract：AIMS:To conduct a large-scale analysis on epidemiology, management, and outcomes of spontaneous subarachnoid hemorrhage (SAH), and to investigate the current situation of aneurysm obliteration in China. METHODS:A multicenter prospective cohort study involving 132 hospitals throughout China from September 2007 to Augus...

journal_title：CNS neuroscience & therapeutics

authors： Bian LH,Liu YF,Nichols LT,Wang CX,Wang YL,Liu GF,Wang WJ,Zhao XQ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS:Cerebellar granule neurons (CGNs) and SH-SY5Y...

journal_title：CNS neuroscience & therapeutics

authors： Cui W,Zhang ZJ,Hu SQ,Mak SH,Xu DP,Choi CL,Wang YQ,Tsim WK,Lee MY,Rong JH,Han YF

更新日期：2014-03-01 00:00:00

abstract：:Research on the potential impact of high salt intake on health has grown rapidly over the last decades. Recent studies have suggested that high salt intake could also be associated with adverse effects on cardiovascular system. The review evaluated the current level of epidemiologic evidence on the association between...

journal_title：CNS neuroscience & therapeutics

authors： Li XY,Cai XL,Bian PD,Hu LR

更新日期：2012-08-01 00:00:00

abstract：AIMS:Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin-1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage mitigates the degene...

journal_title：CNS neuroscience & therapeutics

authors： Suto N,Mieda T,Iizuka A,Nakamura K,Hirai H

更新日期：2016-08-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a global health issue, with prevalence rates ranging from 1.3% to 37.4%. As there is little current data on PTSD in Canada, an epidemiological study was conducted examining PTSD and related comorbid conditions. Modified versions of the Composite International Diagnostic...

journal_title：CNS neuroscience & therapeutics

authors： Van Ameringen M,Mancini C,Patterson B,Boyle MH

更新日期：2008-10-01 00:00:00

abstract：AIMS:This study determines whether assessment with compound action potentials (CAPs) can distinguish two different forms of cerebral white matter injury at the functional levels. METHODS:A pure demyelination model was induced in C57/BL6 adult mice by dietary supplementation of cuprizone (0.2%) for 6 weeks. Callosal L-...

journal_title：CNS neuroscience & therapeutics

authors： Mu HF,Gao XG,Li SC,Wei PJ,Zhao YF,Zhang WT,Wang Y,Gao YQ

更新日期：2019-09-01 00:00:00

abstract：AIMS:Endothelial progenitor cells (EPCs) are involved in vascular repair and homeostasis after vascular injuries. In this study, we aimed to explore whether bone marrow (BM)-derived EPCs contribute to neointima formation and reendothelialization in rabbit elastase-induced aneurysm after flow diverter treatment. METHOD...

journal_title：CNS neuroscience & therapeutics

authors： Li ZF,Fang XG,Yang PF,Huang QH,Zhao WY,Liang C,Zhao R,Liu JM

更新日期：2013-05-01 00:00:00

abstract：AIMS:This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis. METHODS:We employed 8-week-old male σ1 R knockout (σ1 R(-/-) ) mice to examine the proliferation and differentiation of progenitor cells, and the survival and neurite growth of newborn neurons in hippocampal dentate...

journal_title：CNS neuroscience & therapeutics

authors： Sha S,Qu WJ,Li L,Lu ZH,Chen L,Yu WF,Chen L

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable...

journal_title：CNS neuroscience & therapeutics

authors： Kandiah N,Chan YF,Chen C,Dasig D,Dominguez J,Han SH,Jia J,Kim S,Limpawattana P,Ng LL,Nguyen DT,Ong PA,Raya-Ampil E,Saedon N,Senanarong V,Setiati S,Singh H,Suthisisang C,Trang TM,Turana Y,Venketasubramanian N,Yon

更新日期：2021-02-01 00:00:00

abstract：AIMS:Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain. In our study, we aimed to investigate the expression patterns of Sema7A in epilepsy and further explore the roles of Sema7A in the regulation of seizure activity and the inflammatory response in PTZ-kindled epileptic rats. METHODS...

journal_title：CNS neuroscience & therapeutics

authors： Deng J,Xu T,Yang J,Zhang KM,Li Q,Yu XY,Li R,Fu J,Jiang Q,Ma JX,Chen YM

更新日期：2020-01-01 00:00:00

abstract：AIMS:To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS:This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and ...

journal_title：CNS neuroscience & therapeutics

authors： Wang F,Xu F,Quan Y,Wang L,Xia JJ,Jiang TT,Shen LJ,Kang WH,Ding Y,Mei LX,Ju XF,Hu SY,Wu X

更新日期：2019-01-01 00:00:00

abstract：AIMS:Inflammation and apoptosis play important roles in increasing vascular permeability following subarachnoid hemorrhage (SAH). The objective of this study was to evaluate whether urinary trypsin inhibitor (UTI), a serine protease inhibitor, attenuates vascular permeability by its antiinflammatory and antiapoptotic e...

journal_title：CNS neuroscience & therapeutics

authors： Zhou N,Xu T,Bai Y,Prativa S,Xu JZ,Li K,Han HB,Yan JH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ATP-sensitive potassium (K-ATP) channels couple energy metabolism with electric activity, which play important roles in brain diseases including stroke. However, the impacts of Kir6.1-containing K-ATP channels that mainly expressed on glia in stroke remain unclear. METHODS AND RESULTS:In this st...

journal_title：CNS neuroscience & therapeutics

authors： Dong YF,Wang LX,Huang X,Cao WJ,Lu M,Ding JH,Sun XL,Hu G

更新日期：2013-08-01 00:00:00

abstract：:Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of oc...

journal_title：CNS neuroscience & therapeutics

authors： Wang L,Xiong X,Zhang L,Shen J

更新日期：2021-01-02 00:00:00

abstract：AIMS:To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes. METHODS:Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional ou...

journal_title：CNS neuroscience & therapeutics

authors： Pan YS,Jing J,Wang YL,Zhao XQ,Song B,Wang WJ,Wang D,Liu GF,Liu LP,Wang CX,Wang YJ,CNSR investigators.

更新日期：2014-06-01 00:00:00

abstract：AIMS:In this study, we examined the expression of lncRNA ENST00000413528 in glioma and determined its role in glioma development. METHODS:LncRNA ENST00000413528 was detected in glioma tissues by lncRNA microarray. Then, we performed real-time PCR, CCK-8, colony formation assay, flow cytometry, caspase-3/7 assay and an...

journal_title：CNS neuroscience & therapeutics

authors： Zhang R,Wei RL,Du W,Zhang LW,Du T,Geng YD,Wei XT

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Presence of white matter hyperintensity (WMH) on MRI is a marker of cerebral small vessel disease and is associated with increased small vessel stroke and increased risk of hemorrhagic transformation (HT) after thrombolysis. AIM:We sought to determine whether white matter hypoperfusion (WMHP) on perfusion...

journal_title：CNS neuroscience & therapeutics

authors： Bivard A,Cheng X,Lin LT,Levi C,Spratt N,Kleinig T,O'Brien B,Butcher K,Lou M,Zhang JF,Sylaja PN,Cao WJ,Jannes J,Dong Q,Parsons M

更新日期：2016-03-01 00:00:00

abstract：:The pathophysiological mechanisms of neuroinflammation, angiogenesis, and neuroplasticity are currently the hotspots of researches in ischemic stroke. Regulatory T cells (Tregs), a subset of T cells that control inflammatory and immune responses in the body, are closely related to the pathogenesis of ischemic stroke. ...

journal_title：CNS neuroscience & therapeutics

authors： Wang H,Wang Z,Wu Q,Yuan Y,Cao W,Zhang X

更新日期：2021-01-20 00:00:00

abstract：AIM:Till date, the mode of action of β-PEA on neurons is not well illustrated. We tested the hypothesis that β-PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT-diaphorase and mitochondrial complexes (Complex-I and complex-III). METHODS:Using molecular docking as a tool, we here stu...

journal_title：CNS neuroscience & therapeutics

authors： Mazumder MK,Paul R,Borah A

更新日期：2013-08-01 00:00:00

abstract：AIMS:Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this stu...

journal_title：CNS neuroscience & therapeutics

authors： Ryu V,Ha RY,Lee SJ,Ha K,Cho HS

更新日期：2017-03-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder with an estimated 4 million patients worldwide. L-dopa is standard, and often initial, therapy for patients with this condition; however, with continued dopaminergic treatment and as the disease progresses, the majority of patients experienc...

journal_title：CNS neuroscience & therapeutics

authors： Papapetropoulos SS

更新日期：2012-05-01 00:00:00

abstract：:Central dopaminergic and noradrenergic systems play essential roles in controlling several forebrain functions. Consequently, perturbations of these neurotransmissions may contribute to the pathophysiology of neuropsychiatric disorders. For many years, there was a focus on the serotonin (5-HT) system because of the ef...

journal_title：CNS neuroscience & therapeutics

authors： El Mansari M,Guiard BP,Chernoloz O,Ghanbari R,Katz N,Blier P

更新日期：2010-06-01 00:00:00

abstract：:The focus of this review is on the efficacy of antidepressants as preventive treatments for migraine and chronic tension-type headache (TTH). Pharmacologic prophylaxis may be indicated for patients with frequent headaches, who respond insufficiently to acute therapies, or for whom medication overuse is a concern. The ...

journal_title：CNS neuroscience & therapeutics

authors： Smitherman TA,Walters AB,Maizels M,Penzien DB

更新日期：2011-10-01 00:00:00

abstract：:Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the ...

journal_title：CNS neuroscience & therapeutics

authors： Ghosh A,Chen F,Thakur A,Hong H

更新日期：2016-12-01 00:00:00

abstract：:Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concer...

journal_title：CNS neuroscience & therapeutics

authors： Tarragon E,Lopez D,Estrada C,Ana GC,Schenker E,Pifferi F,Bordet R,Richardson JC,Herrero MT

更新日期：2013-09-01 00:00:00