Effects of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on the second to fourth digit ratio in children aged 4 years.

Abstract:

BACKGROUND:The second to fourth digit ratio (2D:4D) is assumed to be a biomarker of prenatal sex steroid exposure, correlating negatively with prenatal testosterone and positively with prenatal estrogen. The ratio has been suggested to be influenced by endocrine disrupting chemicals (EDCs). However, evidence regarding effects of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on 2D:4D of children was sparse. OBJECTIVES:We investigated the associations between prenatal exposure to PBDEs and 2D:4D of children aged 4 years. METHODS:Participants were mother-child pairs from the Shanghai-Minhang Birth Cohort Study (S-MBCS) which enrolled pregnant women at 12-16 weeks of gestation from April to December 2012. Nine PBDE congeners in venous umbilical cord plasma of 340 children were measured. Digit lengths were measured using a vernier caliper in children aged 4 years and 2D:4D for left and right hands and average 2D:4D value of both hands were calculated. A total of 281 children (160 boys and 121 girls) who had data on both 2D:4D and PBDE concentrations were included in the final analysis. Associations between prenatal PBDE exposures and 2D:4D were investigated using multiple linear regression models. RESULTS:Among the nine congeners, BDE-47 had the highest detection rate of 86.12% with the highest median concentration of 0.20 ng/ml lipid. Five PBDE congeners with detection rates greater than or close to 50% (BDE-28, -47, -99, -100 and -153) and Σ5PBDEs (the sum of them) were included in final analysis. For girls, a consistent pattern for the positive associations between prenatal PBDE exposures and 2D:4D of children was observed mainly for the left hand, where those in the highest exposure groups had higher 2D:4D compared to the lowest exposure groups (a feminizing effect), with statistically significant associations observed for BDE-47 (β = 0.0247, 95% confidence interval (CI): 0.0017, 0.0477), -100 (β = 0.0264, 95% CI: 0.0087, 0.0441) and Σ5PBDEs (β = 0.0201, 95% CI: 0.0027, 0.0374). For boys, compared with the lowest exposure groups, statistically significantly higher (feminized) 2D:4D for both hands was observed in those with the highest exposure levels of BDE-100 (β = 0.0147, 95% CI: 0.0005, 0.0289 for the left hand; β = 0.0182, 95% CI: 0.0046, 0.0318 for the right hand) and those with the middle and the highest exposure levels of BDE-153 (middle vs. undetected, β = 0.0215, 95% CI: 0.0072, 0.0358 for the left hand; β = 0.0155, 95% CI: 0.0015, 0.0295 for the right hand; highest vs. undetected, β = 0.0162, 95% CI: 0.0017, 0.0307 for the left hand; β = 0.0152, 95% CI: 0.0011, 0.0294 for the right hand). CONCLUSIONS:Our study provides preliminary evidence that prenatal exposure to PBDEs might be associated with higher 2D:4D in boys and girls.

authors

Chen Y,Miao M,Liang H,Chen Y,Ji H,Ren Y,Liu X,Zhou Y,Wang Z,Yuan W

doi

10.1016/j.ijheh.2020.113639

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

113639

eissn

1438-4639

issn

1618-131X

pii

S1438-4639(20)30585-X

journal_volume

231

pub_type

杂志文章
  • Overview of international environmental health.

    abstract::Ultimately, the health and quality of life of all human beings depend upon the environment and ecosystems to which we are directly and indirectly connected. The papers in this special edition address a number of the critical environmental health issues on which U.S. government agencies and their collaborating partners...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1078/1438-4639-00221

    authors: Borrazzo J,Walling R,Falk H

    更新日期:2003-08-01 00:00:00

  • Survival of epidemic strains of healthcare (HA-MRSA) and community-associated (CA-MRSA) meticillin-resistant Staphylococcus aureus (MRSA) in river-, sea- and swimming pool water.

    abstract::The aim of this study was to examine the survival dynamics of several epidemic healthcare (HA) and community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) in river, sea and swimming pool waters. Six different phage-types of HA-MRSA (Irish 1, Irish 2, EMRSA 15, EMRSA 16, distinct type and non-typabl...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2007.06.003

    authors: Tolba O,Loughrey A,Goldsmith CE,Millar BC,Rooney PJ,Moore JE

    更新日期:2008-07-01 00:00:00

  • PCB in air, dust and surface wipes in 73 Danish homes.

    abstract::As part of an investigation of the total indoor exposure of residents in PCB contaminated apartments in a building estate in Denmark, 73 homes were visited. Samples of air, vacuum cleaner dust and surface wipes were taken and analysed for 15 PCB congeners. The 53 apartments located in high-rise buildings with indoor P...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2019.113429

    authors: Andersen HV,Gunnarsen L,Knudsen LE,Frederiksen M

    更新日期:2020-08-01 00:00:00

  • The U.S. National Health and Nutrition Examination Survey and human exposure to environmental chemicals.

    abstract::Researchers are increasingly interested in using human biomonitoring - the measurement of chemicals, their metabolites or specific reaction products in biological specimens/body fluids - for investigating exposure to environmental chemicals. General population human biomonitoring programs are useful for investigating ...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2011.08.014

    authors: Calafat AM

    更新日期:2012-02-01 00:00:00

  • Prenatal bisphenol A and birth outcomes: MOCEH (Mothers and Children's Environmental Health) study.

    abstract::Bisphenol A (BPA) is used primarily in the production of polycarbonate plastics and epoxy resins. Widespread exposure to BPA has created a great deal of concern regarding its potential adverse effects on human health. This study examined the relationship between prenatal BPA exposure and birth outcomes, including birt...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2013.07.005

    authors: Lee BE,Park H,Hong YC,Ha M,Kim Y,Chang N,Kim BN,Kim YJ,Yu SD,Ha EH

    更新日期:2014-03-01 00:00:00

  • Perfluorooctanoic acid and low birth weight: Estimates of US attributable burden and economic costs from 2003 through 2014.

    abstract:BACKGROUND AND OBJECTIVE:In utero exposure to perfluorooctanoic acid (PFOA) has been associated with decreases in birth weight. We aimed to estimate the proportion of PFOA-attributable low birth weight (LBW) births and associated costs in the US from 2003 to 2014, a period during which there were industry-initiated and...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2017.11.004

    authors: Malits J,Blustein J,Trasande L,Attina TM

    更新日期:2018-03-01 00:00:00

  • Comparison of different model approaches for a hygiene early warning system at the lower Ruhr River, Germany.

    abstract::The lower Ruhr River is located in a densely populated and industrialized area in Northrhine-Westphalia (NRW) in western Germany. Due to upgrades of sanitary infrastructure, such as wastewater treatment plants (WWTPs) and combined sewer overflows (CSOs), and a decline of industrial production, water quality of Ruhr Ri...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2015.06.005

    authors: Mälzer HJ,Aus der Beek T,Müller S,Gebhardt J

    更新日期:2016-10-01 00:00:00

  • Quantitative analysis of organophosphate insecticide metabolites in urine extracted from disposable diapers of toddlers in Japan.

    abstract:BACKGROUND AND AIM:Epidemiological studies linking insecticide exposure to childhood neurodevelopment have been gaining global attention. Despite the rapid development of the central nervous system in early childhood, studies regarding the biological monitoring of insecticide exposure in diapered children are limited. ...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2016.10.009

    authors: Oya N,Ito Y,Hioki K,Asai Y,Aoi A,Sugiura Y,Ueyama J,Oguri T,Kato S,Ebara T,Kamijima M

    更新日期:2017-03-01 00:00:00

  • Critical working tasks and determinants of exposure to bioaerosols and MVOC at composting facilities.

    abstract::Airborne bioaerosols and Microbial Volatile Organic Compounds (MVOC) concentrations were simultaneously monitored at a composting facility and the main determinants of atmospheric concentrations were characterised, in order to help protect workers from potential adverse health effects. Microorganisms and MVOC were sam...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2010.06.001

    authors: Persoons R,Parat S,Stoklov M,Perdrix A,Maitre A

    更新日期:2010-09-01 00:00:00

  • School environmental conditions and links to academic performance and absenteeism in urban, mid-Atlantic public schools.

    abstract::School facility conditions, environment, and perceptions of safety and learning have been investigated for their impact on child development. However, it is important to consider how the environment separately influences academic performance and attendance after controlling for school and community factors. Using resu...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2018.04.015

    authors: Berman JD,McCormack MC,Koehler KA,Connolly F,Clemons-Erby D,Davis MF,Gummerson C,Leaf PJ,Jones TD,Curriero FC

    更新日期:2018-06-01 00:00:00

  • Prevalence, structure and expression of urease genes in Shiga toxin-producing Escherichia coli from humans and the environment.

    abstract::A component of the ure gene cluster in E. coli, ureC, encodes a subunit of urease. We have investigated the distribution of ureC in 202 Shiga toxin-producing E. coli (STEC) strains from Austria belonging to 61 different serotypes. These strains were of human (n=150), animal (n=38), and food (n=14) origin. ureC was pre...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2006.06.003

    authors: Orth D,Grif K,Dierich MP,Würzner R

    更新日期:2006-11-01 00:00:00

  • Health risks of early swimming pool attendance.

    abstract::Swimming pool attendance and exposure to chlorination by-products showed adverse health effects on children. We assessed whether early swimming pool attendance, especially baby swimming, is related to higher rates of early infections and to the development of allergic diseases. In 2003-2005, 2192 children were analyse...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2007.08.001

    authors: Schoefer Y,Zutavern A,Brockow I,Schäfer T,Krämer U,Schaaf B,Herbarth O,von Berg A,Wichmann HE,Heinrich J,LISA study group.

    更新日期:2008-07-01 00:00:00

  • Differentiating the effects of characteristics of PM pollution on mortality from ischemic and hemorrhagic strokes.

    abstract::Though increasing evidence supports significant association between particulate matter (PM) air pollution and stroke, it remains unclear what characteristics, such as particle size and chemical constituents, are responsible for this association. A time-series model with quasi-Poisson function was applied to assess the...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2015.11.002

    authors: Lin H,Tao J,Du Y,Liu T,Qian Z,Tian L,Di Q,Zeng W,Xiao J,Guo L,Li X,Xu Y,Ma W

    更新日期:2016-03-01 00:00:00

  • Water quality at points-of-use in the Galapagos Islands.

    abstract::Piped drinking water is often considered a gold standard for protecting public health but research is needed to explicitly evaluate the effect of centralized treatment systems on water quality in developing world settings. This study examined the effect of a new drinking water treatment plant (DWTP) on microbial drink...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2017.01.010

    authors: Gerhard WA,Choi WS,Houck KM,Stewart JR

    更新日期:2017-04-01 00:00:00

  • Hexamoll® DINCH and DPHP metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017.

    abstract::The production and use of the plasticisers Hexamoll® DINCH (di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate) and DPHP (di-(2-propylheptyl) phthalate) have increased after both chemicals were introduced into the market in the early 2000s as substitutes for restricted high molecular weight phthalates. During the population...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2019.09.004

    authors: Schwedler G,Conrad A,Rucic E,Koch HM,Leng G,Schulz C,Schmied-Tobies MIH,Kolossa-Gehring M

    更新日期:2020-08-01 00:00:00

  • Adaptation of office workers to a new building - impaired well-being as part of the sick-building-syndrome.

    abstract:AIM:The focus of our study was the assessment of the effects of spatial relocation on office staff. Our aim was to investigate whether psychosocial or personal factors are better predictors of the occurrence of impaired well-being. METHODS:Before relocation the administration of the university hospital of Ulm (Germany...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2006.03.005

    authors: Neuner R,Seidel HJ

    更新日期:2006-07-01 00:00:00

  • Developing an easy-to-apply model for identifying relevant pathogen pathways into surface waters used for recreational purposes.

    abstract::Swimming in inner-city surface waters is popular in the warm season, but can have negative consequences such as gastro-intestinal, ear and skin infections. The pathogens causing these infections commonly enter surface waters via several point source discharges such as the effluents from wastewater treatment plants and...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2015.11.005

    authors: Tondera K,Klaer K,Roder S,Brueckner I,Strathmann M,Kistemann T,Schreiber C,Pinnekamp J

    更新日期:2016-10-01 00:00:00

  • Human metabolism and excretion kinetics of the fragrance 7-hydroxycitronellal after a single oral or dermal dosage.

    abstract::7-Hydroxy-3,7-dimethyl-1-octanal, also known as 7-hydroxycitronellal (7-HC, CAS No. 107-75-5) is a synthetic fragrance widely used in cosmetic and hygiene products. Due to its large scope, 7-HC was selected for the development of a biomonitoring method suitable for the general population within the frame of the cooper...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2017.10.015

    authors: Stoeckelhuber M,Krnac D,Pluym N,Scherer M,Peschel O,Leibold E,Scherer G

    更新日期:2018-03-01 00:00:00

  • Ambient air pollution and preterm birth: A prospective birth cohort study in Wuhan, China.

    abstract:IMPORTANCE:Although studies in western countries suggest that ambient air pollution is positively associated with adverse pregnancy outcomes, the upper levels of pollutant exposures have been relatively low, thus eroding confidence in the conclusions. Meanwhile, in Asia, where upper levels of exposure have been greater...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2015.11.003

    authors: Qian Z,Liang S,Yang S,Trevathan E,Huang Z,Yang R,Wang J,Hu K,Zhang Y,Vaughn M,Shen L,Liu W,Li P,Ward P,Yang L,Zhang W,Chen W,Dong G,Zheng T,Xu S,Zhang B

    更新日期:2016-03-01 00:00:00

  • Occurrence of perfluorinated compounds (PFCs) in drinking water of North Rhine-Westphalia, Germany and new approach to assess drinking water contamination by shorter-chained C4-C7 PFCs.

    abstract::After detection of perfluorooctanoate (PFOA) in drinking water at concentrations up to 0.64 microg/l in Arnsberg, Sauerland, Germany, the German Drinking Water Commission (TWK) assessed perfluorinated compounds (PFCs) in drinking water and set for the first time worldwide in June 2006 a health-based guide value for sa...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2010.05.004

    authors: Wilhelm M,Bergmann S,Dieter HH

    更新日期:2010-06-01 00:00:00

  • Is physical activity a modifier of the association between air pollution and arterial stiffness in older adults: The SAPALDIA cohort study.

    abstract:INTRODUCTION AND OBJECTIVES:Air pollution and insufficient physical activity have been associated with inflammation and oxidative stress, molecular mechanisms linked to arterial stiffness and cardiovascular disease. There are no studies on how physical activity modifies the association between air pollution and arteria...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ijheh.2017.06.001

    authors: Endes S,Schaffner E,Caviezel S,Dratva J,Stolz D,Schindler C,Künzli N,Schmidt-Trucksäss A,Probst-Hensch N

    更新日期:2017-08-01 00:00:00

  • Chronic low level arsenic exposure evokes inflammatory responses and DNA damage.

    abstract::The cross-sectional study investigated the impact of chronic low level arsenic (As) exposure (11-50μg/L) on CD14 expression and other inflammatory responses in rural women of West Bengal enrolled from control (As level <10μg/L; N, 131) and exposed area (As level 11-50μg/L, N, 142). Atomic absorption spectroscopy revea...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2015.06.003

    authors: Dutta K,Prasad P,Sinha D

    更新日期:2015-08-01 00:00:00

  • Influence of indoor factors in dwellings on the development of childhood asthma.

    abstract::Asthma has become the most common, childhood chronic disease in the industrialized world, and it is also increasing in developing regions. There are huge differences in the prevalence of childhood asthma across countries and continents, and there is no doubt that the prevalence of asthma was strongly increasing during...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijheh.2010.08.009

    authors: Heinrich J

    更新日期:2011-01-01 00:00:00

  • Childhood hypersensitivity pneumonitis associated with fungal contamination of indoor hydroponics.

    abstract::Childhood hypersensitivity pneumonitis (HP) is often associated with exposure to antigens in the home environment. We describe a case of HP associated with indoor hydroponics in a 14-year-old girl. Water samples from hydroponics revealed Aureobasidium pullulans as the dominant fungal micro-organism (10(4)CFU/ml). The ...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2008.01.001

    authors: Engelhart S,Rietschel E,Exner M,Lange L

    更新日期:2009-01-01 00:00:00

  • Exploring the half-life of glyphosate in human urine samples.

    abstract:BACKGROUND:The International Agency for Research on Cancer (IARC) has recently classified glyphosate as a Group 2A 'probably carcinogenic to humans'. Due to this carcinogenic classification and resulting international debate, there is an increased demand for studies evaluating human health effects from glyphosate expos...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2018.09.004

    authors: Connolly A,Jones K,Basinas I,Galea KS,Kenny L,McGowan P,Coggins MA

    更新日期:2019-03-01 00:00:00

  • Occurrence and speciation of chlorination byproducts in marine waters and sediments of a semi-enclosed bay exposed to industrial chlorinated effluents.

    abstract::Chlorination of seawater is one of the most effective technologies for industrial biofouling control. However, chlorination leads to the formation of halogenated chlorination byproducts (CBPs) associated with potential risks to environmental and human health. The present study investigated the occurrence and distribut...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2018.06.008

    authors: Manasfi T,Lebaron K,Verlande M,Dron J,Demelas C,Vassalo L,Revenko G,Quivet E,Boudenne JL

    更新日期:2019-01-01 00:00:00

  • An outbreak of foodborne botulism in Taiwan.

    abstract::Botulism is a rare but serious paralytic disease caused by botulinum toxin. We report an outbreak of type B botulism in Taiwan in 2006. There were five cases involved in this outbreak. They present ileus and acute cranial nerve dysfunction including dysphagia and blurred vision. One of them had severe neurologic impai...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2008.01.002

    authors: Tseng CK,Tsai CH,Tseng CH,Tseng YC,Lee FY,Huang WS

    更新日期:2009-01-01 00:00:00

  • Eradication of MRSA in chronic wounds of outpatients with leg ulcers is accelerated by antiseptic washes--results of a pilot study.

    abstract::Whereas several studies evaluate MRSA in inpatients, for outpatients there are merely expert recommendations, but no systematic studies. Mostly, MRSA in outpatients is tolerated but not eradicated. Particularly, for risk patients with chronic wounds some experts postulate that MRSA-eradication is even impossible. For ...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2010.01.001

    authors: Reich-Schupke S,Warneke K,Altmeyer P,Stücker M

    更新日期:2010-03-01 00:00:00

  • Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study.

    abstract::Prenatal exposure to polybrominated diphenyl ethers (PBDEs) have been reported to impair executive function in children, but little is known whether childhood PBDE exposures play a role. Using the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort in the greater Cincinnati area, w...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2017.10.006

    authors: Vuong AM,Yolton K,Poston KL,Xie C,Webster GM,Sjödin A,Braun JM,Dietrich KN,Lanphear BP,Chen A

    更新日期:2018-01-01 00:00:00

  • Prenatal and postnatal tobacco smoke exposure and development of insulin resistance in 10 year old children.

    abstract::In this study, we evaluated the association between prenatal and postnatal exposure to environmental tobacco smoke and the development of insulin resistance in 10 year old children. Fasting blood samples were collected from 470 children participating in two prospective birth cohorts. Of those 276 were selected populat...

    journal_title:International journal of hygiene and environmental health

    pub_type: 杂志文章

    doi:10.1016/j.ijheh.2011.04.004

    authors: Thiering E,Brüske I,Kratzsch J,Thiery J,Sausenthaler S,Meisinger C,Koletzko S,Bauer CP,Schaaf B,von Berg A,Berdel D,Lehmann I,Herbarth O,Krämer U,Wichmann HE,Heinrich J,GINIplus and LISAplus Study Groups.

    更新日期:2011-09-01 00:00:00