Abstract:
BACKGROUND:The second to fourth digit ratio (2D:4D) is assumed to be a biomarker of prenatal sex steroid exposure, correlating negatively with prenatal testosterone and positively with prenatal estrogen. The ratio has been suggested to be influenced by endocrine disrupting chemicals (EDCs). However, evidence regarding effects of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on 2D:4D of children was sparse. OBJECTIVES:We investigated the associations between prenatal exposure to PBDEs and 2D:4D of children aged 4 years. METHODS:Participants were mother-child pairs from the Shanghai-Minhang Birth Cohort Study (S-MBCS) which enrolled pregnant women at 12-16 weeks of gestation from April to December 2012. Nine PBDE congeners in venous umbilical cord plasma of 340 children were measured. Digit lengths were measured using a vernier caliper in children aged 4 years and 2D:4D for left and right hands and average 2D:4D value of both hands were calculated. A total of 281 children (160 boys and 121 girls) who had data on both 2D:4D and PBDE concentrations were included in the final analysis. Associations between prenatal PBDE exposures and 2D:4D were investigated using multiple linear regression models. RESULTS:Among the nine congeners, BDE-47 had the highest detection rate of 86.12% with the highest median concentration of 0.20 ng/ml lipid. Five PBDE congeners with detection rates greater than or close to 50% (BDE-28, -47, -99, -100 and -153) and Σ5PBDEs (the sum of them) were included in final analysis. For girls, a consistent pattern for the positive associations between prenatal PBDE exposures and 2D:4D of children was observed mainly for the left hand, where those in the highest exposure groups had higher 2D:4D compared to the lowest exposure groups (a feminizing effect), with statistically significant associations observed for BDE-47 (β = 0.0247, 95% confidence interval (CI): 0.0017, 0.0477), -100 (β = 0.0264, 95% CI: 0.0087, 0.0441) and Σ5PBDEs (β = 0.0201, 95% CI: 0.0027, 0.0374). For boys, compared with the lowest exposure groups, statistically significantly higher (feminized) 2D:4D for both hands was observed in those with the highest exposure levels of BDE-100 (β = 0.0147, 95% CI: 0.0005, 0.0289 for the left hand; β = 0.0182, 95% CI: 0.0046, 0.0318 for the right hand) and those with the middle and the highest exposure levels of BDE-153 (middle vs. undetected, β = 0.0215, 95% CI: 0.0072, 0.0358 for the left hand; β = 0.0155, 95% CI: 0.0015, 0.0295 for the right hand; highest vs. undetected, β = 0.0162, 95% CI: 0.0017, 0.0307 for the left hand; β = 0.0152, 95% CI: 0.0011, 0.0294 for the right hand). CONCLUSIONS:Our study provides preliminary evidence that prenatal exposure to PBDEs might be associated with higher 2D:4D in boys and girls.
journal_name
Int J Hyg Environ Healthauthors
Chen Y,Miao M,Liang H,Chen Y,Ji H,Ren Y,Liu X,Zhou Y,Wang Z,Yuan Wdoi
10.1016/j.ijheh.2020.113639subject
Has Abstractpub_date
2021-01-01 00:00:00pages
113639eissn
1438-4639issn
1618-131Xpii
S1438-4639(20)30585-Xjournal_volume
231pub_type
杂志文章abstract:BACKGROUND:Even though increased environmental platinum levels were found since the introduction of automobile catalytic converters, little is known about the pathways of corporal uptake and the bioavailability of platinum in the general adult population. The aim of this study is to identify and quantify the main expos...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:IMPORTANCE:Although studies in western countries suggest that ambient air pollution is positively associated with adverse pregnancy outcomes, the upper levels of pollutant exposures have been relatively low, thus eroding confidence in the conclusions. Meanwhile, in Asia, where upper levels of exposure have been greater...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2015.11.003
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Some fragrance compounds are severe contact allergens. According to the so-called "26 allergens rule" (Article 1 (10) of Directive 2003/15/EC) (EC, 2003), 26 supposedly allergenic fragrances must be listed on the containers of cosmetics products if they are present above certain mass percentages in the produ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2010.04.001
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The Korean government implemented partial smoke-free regulations in hospitality venues ≥150 m2 in July 2013 and in venues ≥100 m2 in February 2014. This study examined changes in urinary cotinine concentrations in the Korean non-smoking adult population, and socio-demographic subgroups thereof, between 2012 ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2019.113419
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In utero exposure to perfluorooctanoic acid (PFOA) has been associated with decreases in birth weight. We aimed to estimate the proportion of PFOA-attributable low birth weight (LBW) births and associated costs in the US from 2003 to 2014, a period during which there were industry-initiated and...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.11.004
更新日期:2018-03-01 00:00:00
abstract::Contribution of diet and selected risk factors to the levels of four polyfluorinated compounds was evaluated. Data from National Health and Nutrition Examination Survey for the years 2003-2008 were used. Dietary factors accounted for 10.4% to 21.2% of the explained variation. Amount of milk consumed was found to be po...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2013.03.008
更新日期:2014-01-01 00:00:00
abstract::Urbanization is occurring at an explosive rate, and many cities, especially in low-income countries, are struggling to control growth and stop the development of unplanned communities. This research investigates the in-home environmental health risks associated with planned and unplanned growth in peri-urban communiti...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00314
更新日期:2004-10-01 00:00:00
abstract::Levoglucosan is a sugar anhydride produced by combustion of carbohydrates. In ambient monitoring it serves as an indicator for wood smoke. Its use in human biomonitoring, however, is not yet widespread. This study investigated whether levoglucosan in urine is a suitable biomarker for regional differences in wood smoke...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2012.05.001
更新日期:2013-06-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) and organochlorine pesticides are persistent organic pollutants that have a widespread distribution in the environment. Human biomonitoring is a suitable tool to assess the burden of humans with these substances. Over a time span of 8 years, a free analysis of their milk was offered to...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2008.04.001
更新日期:2008-10-01 00:00:00
abstract::Di(2-ethylhexyl)phthalate (DEHP) is the main plasticizer for polyvinyl chloride (PVC) products. It has become widely spread in our environment and among people. DEHP is suspected to be responsible for endocrine-disruptor-like effects in mankind. Children are probably most susceptible to these endocrine effects. In thi...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00270
更新日期:2004-01-01 00:00:00
abstract::The aim of this study was to characterize the mediator release in the whole blood assay induced by stimulation with an extract of the indoor mold A. versicolor. In addition, the effect of concomitant stimulation with E. coli endotoxin and A. versicolor, and the involvement of the relevant Toll-like receptors were inve...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2012.11.001
更新日期:2013-07-01 00:00:00
abstract::Reference values (RV95) are statistically derived values comprising the rounded 95th percentiles within the 95% confidence interval and indicate the upper margin of background exposure to chemical substances in a population at a given time period. Based on representative national human biomonitoring data on several ur...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2018.06.001
更新日期:2018-07-01 00:00:00
abstract::Parabens are widely used as antimicrobial preservatives in personal care and consumer products, food and pharmaceuticals. Due to their ubiquity, humans are constantly exposed to these chemicals. We assessed exposure to nine parabens (methyl-, ethyl-, n- and iso-propyl-, n- and iso-butyl-, benzyl-, pentyl- and heptyl p...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2015.07.005
更新日期:2015-10-01 00:00:00
abstract::Possible adverse health effects of exposure to electric, magnetic and electromagnetic fields (EMF), and especially the question of whether there exists a special vulnerability of children, have been a much discussed topic during the last two decades. Static fields produce health effects only in very rare and exception...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1016/j.ijheh.2007.07.007
更新日期:2007-10-01 00:00:00
abstract::The results of the study demonstrate that the weak estrogenic action of bisphenol A (a daily subcutaneous dose of 200 mg/kg on 4 consecutive days, administered before or after decidual induction that occurs on day 4 of pseudopregnancy) on deciduoma growth in pseudopregnant Sprague-Dawley rats, was functionally associa...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00115
更新日期:2002-02-01 00:00:00
abstract::Water, sanitation, and hygiene (WASH) in schools are important for child health, development, and educational performance; yet coverage in Indonesian schools remains low. To address this deficiency, UNICEF and partners conducted a WASH intervention in 450 schools across three provinces in Indonesia. A survey evaluatin...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.02.001
更新日期:2017-05-01 00:00:00
abstract::In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose-response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed control in Shandong Province northern...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2012.02.008
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:There are a growing number of reports on the association between air pollution and the risk of congenital anomalies. However, the results are inconsistent and most studies have only focused on the association of air pollution with congenital heart defects and orofacial clefts. OBJECTIVES:Using an explorator...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2018.07.008
更新日期:2018-08-01 00:00:00
abstract::The production and use of the plasticisers Hexamoll® DINCH (di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate) and DPHP (di-(2-propylheptyl) phthalate) have increased after both chemicals were introduced into the market in the early 2000s as substitutes for restricted high molecular weight phthalates. During the population...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2019.09.004
更新日期:2020-08-01 00:00:00
abstract::This paper reviews the existing literature on human exposure to polybrominated diphenyl ethers (PBDEs), with particular focus on external exposure routes (e.g. dust, diet, and air) and the resulting internal exposure to PBDEs (e.g. breast milk and blood). Being lipophilic and persistent organic compounds, PBDEs accumu...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1016/j.ijheh.2008.04.005
更新日期:2009-03-01 00:00:00
abstract::Among the 3rd Seminar for PhD students working on Water and Health which was held in Cannes on 27–29 June 2011, experts from a number of universities and research institutes took the opportunity to discuss the emergence of Escherichia coli O104:H4 in Europe. Especially, possible threats for European water suppliers we...
journal_title:International journal of hygiene and environmental health
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.ijheh.2011.08.001
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine the accuracy of questions in identifying subjects occupationally exposed to high noise level and those with hearing loss using noise dosimeter and pure-tone air conduction audiometry as the gold standards. DESIGN:A cross-sectional study involving 259 noise-exposed workers selected randomly from ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00291
更新日期:2004-07-01 00:00:00
abstract::E-liquids generally contain four main components: nicotine, flavours, water and carrier liquids. The carrier liquid dissolves flavours and nicotine and vaporises at a certain temperature on the atomizer of the e-cigarette. Propylene glycol and glycerol, the principal carriers used in e-liquids, undergo decomposition i...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2016.01.004
更新日期:2016-05-01 00:00:00
abstract::Indoor air quality (IAQ) and exposure to indoor chemicals are widely discussed in terms of personal discomfort and health risks. In contrast to ambient air and working environments, legally binding regulations are only partially established for indoor contaminants, and other available European guidelines are limited. ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1016/j.ijheh.2018.12.012
更新日期:2019-04-01 00:00:00
abstract::Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2016.12.010
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine if artificial neural networks (ANNs) may be useful to analyse a complex and large set of data derived from smoking welders for the purpose of finding relationships between parameters describing respiratory system efficiency and antioxidant defence. METHODS:A group of 94 ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2006.03.004
更新日期:2006-07-01 00:00:00
abstract::Whereas several studies evaluate MRSA in inpatients, for outpatients there are merely expert recommendations, but no systematic studies. Mostly, MRSA in outpatients is tolerated but not eradicated. Particularly, for risk patients with chronic wounds some experts postulate that MRSA-eradication is even impossible. For ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2010.01.001
更新日期:2010-03-01 00:00:00
abstract::A number of prospective cohort studies are ongoing worldwide to investigate the impact of foetal and neonatal exposures to chemical substances on child health. To assess multiple exposure (mixture) effects and low prevalence health outcomes it is useful to pool data from several studies and conduct mega-data-analysis....
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2019.07.005
更新日期:2019-09-01 00:00:00
abstract::A multiparametric analysis of immune components was performed in blood and serum of 61 voluntary persons before and after (1 day, 3 days, 4-6 months, 10-12 months) a professional pest control operation (PCO) using pyrethroids. Following parameters were included in the study (1) immunological parameters of the humoral ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00201
更新日期:2003-03-01 00:00:00
abstract::Asthma is a heterogeneous disease with varying severity and subtypes. Recent reviews of epidemiologic studies have identified cleaning and disinfecting activities (CDAs) as important risk factors for asthma-related outcomes among healthcare workers. However, the complexity of CDAs in healthcare settings has rarely bee...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2019.04.001
更新日期:2019-06-01 00:00:00